Investigation of the Flying Mock-Up of the Consolidated Vultee XP-92 Airplane in the Ames 40- by 80-Foot Wind Tunnel. Force and Moment Characteristics

This report contains the results of the investigation of the aerodynamic characteristics of the flying mock-up of the Consolidated Vultee XP-92 airplane as conducted in the Ames 40- by 80-foot wind tunnel, Data are presented for test conditions which would give information as to the limits of stability and controllability, and also, the effect of Reynolds number. No analysis of the data has been made

Quantification of Alternative Splicing Variants of Human Telomerase Reverse Transcriptase and Correlations with Telomerase Activity in Lung Cancer

Telomerase plays important roles in the development and progression of malignant tumors, and its activity is primarily determined by transcriptional regulation of human telomerase reverse transcriptase (hTERT). Several mRNA alternative splicing variants (ASVs) for hTERT have been identified, but it remains unclear whether telomerase activity is directly associated with hTERT splicing transcripts. In this study, we developed novel real-time PCR protocols using molecular beacons and applied to lung carcinoma cell lines and cancerous tissues for quantification of telomerase activity and three essential hTERT deletion transcripts respectively. The results showed that lung carcinoma cell lines consistently demonstrated telomerase activity (14.22–31.43 TPG units per 100 cells) and various hTERT alternative splicing transcripts. For 165 lung cancer cases, telomerase activity showed significant correlation with tumor differentiation (poorly->moderately->well-differentiated, P<0.01) and with histotypes (combined small cell and squamous cell carcinoma>squamous cell carcinoma>adenosquamous carcinoma>adenocarcinoma, P<0.05). Although the overall hTERT transcripts were detected in all the samples, they were not associated with telomerase activity (r = 0.092, P = 0.24). Telomerase activity was significantly correlated with the transcriptional constituent ratio of α-deletion (r = -0.267, P = 0.026), β-deletion (r = -0.693, P = 0.0001) and γ-deletion (r = –0.614, P = 0.001). The positive rate and average constituent ratio of β-deletion transcripts (92.12%, 0.23) were higher than those of α-deletion (41.82%, 0.12) or γ-deletion (16.36%, 0.18) transcripts. The combined small-cell and squamous cell carcinomas expressed less deletion transcripts, especially β-deletion, than other histotypes, which might explain their higher telomerase activity. In conclusion, the molecular beacon-based real-time PCR protocols are rapid, sensitive and specific methods to quantify telomerase activity and hTERT ASVs. Telomerase activity may serve as a reliable and effective molecular marker to assist the evaluation of histological subtype and differentiation of lung carcinomas. Further studies on hTERT deletion splicing transcripts, rather than the overall hTERT transcripts, may improve our understanding of telomerase regulation

NACA Technical Notes

Note presenting pressure measurements on a triangular wing with an aspect ratio of 2 and an NACA 0012 airfoil section parallel to the center line. The wing angle of attack was varied from 4.3 to 48.1 degrees with the airspeed held constant at approximately 100 miles per hour. Results regarding chordwise pressure distribution, section lift characteristics, span load distribution, centers of pressure, and comparison of pressure data with force-test data are provided

NACA Technical Notes

Note presenting a study of existing experimental and theoretical results for an inclined flat plate of infinite span, and of the extent to which the results are indicative of those for thin airfoil sections. The study included an examination of the flow about an inclined plate, the forces on the plate, and the adequacy of theory in predicting the forces. The results indicate that there are two important ranges of angle of attack differing by the extent of flow separation on the upper surface

NACA Research Memorandums

This report contains the results of the investigation of the aerodynamic characteristics of the flying mock-up of the Consolidated Vultee XP-92 airplane as conducted in the Ames 40- by 80-foot wind tunnel, Data are presented for test conditions which would give information as to the limits of stability and controllability, and also, the effect of Reynolds number. No analysis of the data has been made

NACA Research Memorandums

Memorandum presenting an investigation of the effect of skewed plain nose flaps on a thin, low-aspect-ratio triangular wing in combination with a high fineness-ratio fuselage conducted at low speeds and high Reynolds numbers. The plan form of the flaps was such that the flap chord varied from zero percent of the wing chord at the model center line to 100 percent at about 91-percent wing semispan. The results indicated that the nose flaps provided a significant delay in the occurrence of both the leading-edge type of separation and tip stalling