Entrevista al traductor Walter Kerr

Fil: Kerr, Walter. Argentina. Presidencia de la Nación. Departamento de Traducciónes. Dirección; Argentin

Receipt from New York Life Insurance and Trust Company to Ogden Goelet

https://digitalcommons.salve.edu/goelet-personal-expenses/1010/thumbnail.jp

The Strength of Commercial Tincture of Opium as Compared with that of the United States Pharmacopoeia

Laudanum is the commercial name of "Tincture of Opium", or "Tinctura Opii", as recognized by the United States Pharmacopoeia. It contains 10% granulated opium, one of the most powerful and common hypnotics known, or from 1.2 to 1.25% of morphine sulphate, the principal alkaloid found in opium and to which its medicinal activity is largely due

The Relationship Between Dental Disease and Cerebral Vascular Accident in Elderly United States Veterans

We report here information obtained from a crossâ sectional study of 401 veterans, who were at least 60 years of age, which showed that several dental/oral conditions can be significantly associated with the diagnosis of a cerebral vascular accident (CVA), when included in a multivariate logistic regression model with and without many of the known risk factors for a CVA. The dental findings relative to the prevalence of dental caries and periodontal disease were not distinctly different between the subjects with and without a CVA in the bivariate analysis. A higher stimulated salivary flow was negatively associated with a CVA in the multivariate models. The plaque index and oral hygiene habits relating to brushing, flossing, and frequency of having teeth cleaned by a dentist/hygienist were significantly associated with a CVA in the bivariate analysis. Among these oral hygiene parameters, â needing help in brushing one’s teethâ and the reported annual visit to the dentist/hygienist for teeth cleaning remained significant in the multivariate models involving the dependentâ living subjects. The need for help in brushing one’s teeth could reflect the fact that many subjects had reduced manual dexterity as a result of the CVA and required this extra care. However, the finding that those dependentâ living individuals who reported that they did not have their teeth cleaned at least once a year were 4.76 times more likely to have had a CVA, suggests that a pattern of oral neglect might be associated with developing a CVA. The implications of this in terms of an intervention strategy for CVA warrants further consideration. However, caution is recommended because the data were obtained from a convenience sampling of older veterans and may not be generalizable to other populations. Ann Periodontol 1998;3:161â 174.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141992/1/aape0161.pd

Implications of "peak oil" for atmospheric CO2 and climate

Unconstrained CO2 emission from fossil fuel burning has been the dominant cause of observed anthropogenic global warming. The amounts of "proven" and potential fossil fuel reserves are uncertain and debated. Regardless of the true values, society has flexibility in the degree to which it chooses to exploit these reserves, especially unconventional fossil fuels and those located in extreme or pristine environments. If conventional oil production peaks within the next few decades, it may have a large effect on future atmospheric CO2 and climate change, depending upon subsequent energy choices. Assuming that proven oil and gas reserves do not greatly exceed estimates of the Energy Information Administration, and recent trends are toward lower estimates, we show that it is feasible to keep atmospheric CO2 from exceeding about 450 ppm by 2100, provided that emissions from coal, unconventional fossil fuels, and land use are constrained. Coal-fired power plants without sequestration must be phased out before mid-century to achieve this CO2 limit. It is also important to "stretch" conventional oil reserves via energy conservation and efficiency, thus averting strong pressures to extract liquid fuels from coal or unconventional fossil fuels while clean technologies are being developed for the era "beyond fossil fuels". We argue that a rising price on carbon emissions is needed to discourage conversion of the vast fossil resources into usable reserves, and to keep CO2 beneath the 450 ppm ceiling.Comment: (22 pages, 7 figures; final version accepted by Global Biogeochemical Cycles

Synergistic calibration of a hydrological model using discharge and remotely sensed soil moisture in the Paraná river basin

Hydrological models are useful tools for water resources studies, yet their calibration is still a challenge, especially if aiming at improved estimates of multiple components of the water cycle. This has led the hydrologic community to look for ways to constrain models with multiple variables. Remote sensing estimates of soil moisture are very promising in this sense, especially in large areas for which field observations may be unevenly distributed. However, the use of such data to calibrate hydrological models in a synergistic way is still not well understood, especially in tropical humid areas such as those found in South America. Here, we perform multiple scenarios of multiobjective model optimization with in situ discharge and the SMOS L4 root zone soil moisture product for the Upper Paraná River Basin in South America (drainage area > 900,000 km2), for which discharge data for 136 river gauges are used. An additional scenario is used to compare the relative impacts of using all river gauges and a small subset containing nine gauges only. Across the basin, the joint calibration (CAL-DS) using discharge and soil moisture leads to improved precision and accuracy for both variables. The discharges estimated by CAL-DS (median KGE improvement for discharge was 0.14) are as accurate as those obtained with the calibration with discharge only (median equal to 0.14), while the CAL-DS soil moisture retrieval is practically as accurate (median KGE improvement for soil moisture was 0.11) as that estimated using the calibration with soil moisture only (median equal to 0.13). Nonetheless, the individual calibration with discharge rates is not able to retrieve satisfactory soil moisture estimates, and vice versa. These results show the complementarity between these two variables in the model calibration and highlight the benefits of considering multiple variables in the calibration framework. It is also shown that, by considering only nine gauges inst

An Infrared/X-ray Survey for New Members of the Taurus Star-Forming Region

We present the results of a search for new members of the Taurus star-forming region using data from the Spitzer Space Telescope and the XMM-Newton Observatory. We have obtained optical and near-infrared spectra of 44 sources that exhibit red Spitzer colors that are indicative of stars with circumstellar disks and 51 candidate young stars that were identified by Scelsi and coworkers using XMM-Newton. We also performed spectroscopy on four possible companions to members of Taurus that were reported by Kraus and Hillenbrand. Through these spectra, we have demonstrated the youth and membership of 41 sources, 10 of which were independently confirmed as young stars by Scelsi and coworkers. Five of the new Taurus members are likely to be brown dwarfs based on their late spectral types (>M6). One of the brown dwarfs has a spectral type of L0, making it the first known L-type member of Taurus and the least massive known member of the region (M=4-7 M_Jup). Another brown dwarf exhibits a flat infrared spectral energy distribution, which indicates that it could be in the protostellar class I stage (star+disk+envelope). Upon inspection of archival images from various observatories, we find that one of the new young stars has a large edge-on disk (r=2.5=350 AU). The scattered light from this disk has undergone significant variability on a time scale of days in optical images from the Canada-France-Hawaii Telescope. Using the updated census of Taurus, we have measured the initial mass function for the fields observed by XMM-Newton. The resulting mass function is similar to previous ones that we have reported for Taurus, showing a surplus of stars at spectral types of K7-M1 (0.6-0.8 M_sun) relative to other nearby star-forming regions like IC 348, Chamaeleon I, and the Orion Nebula Cluster

Population-scale proteome variation in human induced pluripotent stem cells

Human disease phenotypes are driven primarily by alterations in protein expression and/or function. To date, relatively little is known about the variability of the human proteome in populations and how this relates to variability in mRNA expression and to disease loci. Here, we present the first comprehensive proteomic analysis of human induced pluripotent stem cells (iPSC), a key cell type for disease modelling, analysing 202 iPSC lines derived from 151 donors, with integrated transcriptome and genomic sequence data from the same lines. We characterised the major genetic and non-genetic determinants of proteome variation across iPSC lines and assessed key regulatory mechanisms affecting variation in protein abundance. We identified 654 protein quantitative trait loci (pQTLs) in iPSCs, including disease-linked variants in protein-coding sequences and variants with trans regulatory effects. These include pQTL linked to GWAS variants that cannot be detected at the mRNA level, highlighting the utility of dissecting pQTL at peptide level resolution.Peer reviewe

Boron isotopic composition of olivine-hosted melt inclusions from Gorgona komatiites, Colombia : new evidence supporting wet komatiite origin

Author Posting. © The Author(s), 2011. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Earth and Planetary Science Letters 312 (2011): 201–212, doi:10.1016/j.epsl.2011.09.033.A fundamental question in the genesis of komatiites is whether 30 these rocks originate from partial melting of dry and hot mantle, 400−500°C hotter than typical sources of MORB and OIB magmas, or if they were produced by hydrous melting of the source at much lower temperatures, similar or only moderately higher than those known today. Gorgona Island, Colombia, is a unique place where Phanerozoic komatiites occur and whose origin is directly connected to the formation of the Caribbean Large Igneous Province. The genesis of Gorgona komatiites remains controversial, mostly because of the uncertain origin of volatile components which they appear to contain. These volatiles could equally result from shallow level magma contamination, melting of a “damp” mantle or fluid-induced partial melting of the source due to devolatilization of the ancient subducting plate. We have analyzed boron isotopes of olivine40 hosted melt inclusions from the Gorgona komatiites. These inclusions are characterized by relatively high contents of volatile components and boron (0.2−1.0 wt.% H2O, 0.05−0.08 wt.% S, 0.02−0.03 wt.% Cl, 0.6−2.0 μg/g B), displaying positive anomalies in the overall depleted, primitive mantle (PM) normalized trace element and REE spectra ([La/Sm]n = 0.16−0.35; [H2O/Nb]n = 8−44; [Cl/Nb]n = 27−68; [B/Nb]n = 9-30, assuming 300 μg/g H2O, 8 μg/g Cl and 0.1 μg/g B in PM; Kamenetsky et al., 2010. Composition and temperature of komatiite melts from Gorgona Island constrained from olivine-hosted melt inclusions. Geology 38, 1003–1006). The inclusions range in δ11B values from −11.5 to +15.6 ± 2.2‰ (1 SE), forming two distinct trends in a δ11B vs. B-concentration diagram. Direct assimilation of seawater, seawater-derived components, altered oceanic crust or marine sediments by ascending komatiite magma cannot readily account for the volatile contents and B isotope variations. Alternatively, injection of <3% of a 11B enriched fluid to the mantle source could be a plausible explanation for the δ11B range that also may explain the H2O, Cl and B excess.Financial support to AAG during data acquisition and manuscript preparation was provided by Northeast National Ion Microprobe Facility (Woods Hole Oceanographic Institution, USA) and the Centre de Recherches Pétrographiqueset Géochimiques (France). This research was also supported by the Australian Research Council (Research Fellowship and Discovery grants to VSK). We acknowledge partial support of the Alexander von Humboldt Foundation, Germany (F.W. Bessel Award to VSK and Wolfgang Paul Award to A.V. Sobolev who provided access to the electron microprobe at the Max Planck Institute, Mainz, Germany