95 research outputs found
Double Majors: One for Me, One for the Parents?
- Author
- Adeline Delavande
- Adeline Delavande
- Alice Gomstyn
- Basit Zafar
- Basit Zafar
- Basit Zafar
- Basit Zafar
- Bruine De Bruin
- Catherine Weinberger
- Charles Bellemare
- Charles Manski
- Charles Manski
- Charles Manski
- Charles Manski
- David Brownstone
- David Revelt
- Del Rosi
- Flavio Cunha
- Helena Nielsen
- Jack Fiorito
- Je� Dominitz
- Joseph Altonji
- Lance Lochner
- Ofer Malamud
- Peter Arcidiacono
- Peter Arcidiacono
- Richard Easterlin
- Richard Freeman
- Robert Willis
- Tamar Lewin
- Thomas Daymont
- Thomas Juster
- Todd Stinebrickner
- Wilbert Van Der Klaauw
- Wilbert Van Der Klaauw
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2010
- Field of study
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
- Author
- Aarno Palotie
- Aaron R. Wolen
- Abraham Reichenberg
- Adriano Chio
- Aiden Corvin
- Alan Pittman
- Alan R. Sanders
- Albert C. Ludolph
- Albert Hofman
- Aleksey Shatunov
- Alessandro Padovani
- Alexander L. Richards
- Alexandra Dürr
- Alexis Brice
- Alkes Price
- Ammar Al-Chalabi
- An Goris
- Anders D. Børglum
- Andre Franke
- Andre G. Uitterlinden
- Andrea Calvo
- Andrea Hofman
- Andrea Malaspina
- Andres Metspalu
- Andrew J. Pocklington
- Andrew M. McIntosh
- Andrew McQuillin
- Andrey Khrunin
- Anil K. Malhotra
- Ann E. Pulver
- Ann Olincy
- Anna K. Kähler
- Anneke J. van der Kooi
- Annelie Nordin
- Annelot M. Dekker
- Annette M. Hartmann
- Antonia Ratti
- Antonio Julià
- Ariel Darvasi
- Ashley R. Jones
- Assen V. Jablensky
- Ayman H. Fanous
- Bela Melegh
- Benjamin M. Neale
- Bernard Lerer
- Bernhard Landwehrmeyer
- Bertram Müller-Myhsok
- Bettina Konte
- Bradley N. Smith
- Bradley T. Webb
- Brandon K. Wormley
- Brendan Bulik-Sullivan
- Brien P. Riley
- Brion S. Maher
- Bryan J. Mowry
- C Robert Cloninger
- Carin J. Meijer
- Carlos N. Pato
- Carmel M. Loughland
- Carsten Drepper
- Catherine Lomen-Hoerth
- Cathryn M. Lewis
- Charles Curtis
- Chiara Zecca
- Chris C. A. Spencer
- Christian Hammer
- Christian Lunetta
- Christian R. Andres
- Christian R. Schubert
- Christina M. Hultman
- Christine A. M. Payan
- Christophe Tzourio
- Christopher E. Shaw
- Christos Pantelis
- Cindy Maurel
- Cinzia Bertolin
- Cinzia Gellera
- Cinzia Tiloca
- Claudine Laurent
- Clement C. Zai
- Colm McDonald
- Colm O’Dushlaine
- Cristina Cereda
- Cristina Moglia
- Dai Wang
- Dan Rujescu
- Daniel G. Bradley
- Daniel R. Weinberger
- Danielle Posthuma
- David A. Collier
- David Cohen
- David Curtis
- David Kavanagh
- David M. Hougaard
- David St Clair
- Deborah A. Nertney
- Denis Bauer
- Derek W. Morris
- Dermot Walsh
- Diana O. Perkins
- Dick Schijven
- Dieter B. Wildenauer
- Digby Quested
- Dimitris Dikeos
- Ditte Demontis
- Dominic B. Rowe
- Dominique Campion
- Donald W. Black
- Douglas F. Levinson
- Douglas H. R. Blackwood
- Douglas M. Ruderfer
- Draga Toncheva
- Dragan M. Svrakic
- Eadbhard O’Callaghan
- Edward M. Scolnick
- Elena Parkhomenko
- Eli A. Stahl
- Elisabeth Stogmann
- Elisabetta Pupillo
- Elizabeth Bevilacqua
- Elodie Drapeau
- Elvira Bramon
- Emily H. M. Wong
- Engilbert Sigurdsson
- Enrico Domenici
- Eric F. C. Cheung
- Eric Strengman
- Eric Y. H. Chen
- Erik G. Jönsson
- Erik Söderman
- Esben Agerbo
- Ettore Beghi
- F Anthony O’Neill
- Farooq Amin
- Federico Casale
- Fernando Rivadeneira
- Filip Eftimov
- Frank Dudbridge
- Frank P. Diekstra
- Frans A. Henskens
- Franziska Degenhardt
- François Salachas
- Fritz Zimprich
- Garth A. Nicholson
- Gary Donohoe
- George Kirov
- George N. Papadimitriou
- Gerald Nestadt
- Gerome Breen
- Giacomo P. Comi
- Giancarlo Logroscino
- Gianni Sorarù
- Gilbert Bensimon
- Giulio Genovese
- Guiqing Cai
- Hailiang Huang
- Hana Kuzelova-Ptackova
- Hannelore Ehrenreich
- Henrik B. Rasmussen
- Hon-Cheong So
- Hreinn Stefansson
- Hualin Simon Xi
- Hugh Gurling
- Ian Blair
- Igor Nenadic
- Ina Giegling
- Inez Myin-Germeys
- Inge Joa
- Ingrid Agartz
- Ingrid Melle
- Isabella Fogh
- Jaana Suvisaari
- Jacob Gratten
- Jacqueline I. Goldstein
- Jacques Mallet
- James A. Knowles
- James J. Crowley
- James L. Kennedy
- James T. R. Walters
- Jan H. Veldink
- Jan Lubinski
- Jana Strohmaier
- Janis Klovins
- Jean- François Dartigues
- Jeffrey Lieberman
- Jennifer L. Moran
- Jens R. Wendland
- Jeremy M. Silverman
- Jesus S. Mora
- Jianjun Liu
- Jianxin Shi
- Jim Van Os
- Jimmy Lee
- Jin P. Szatkiewicz
- Jo Knight
- Jochen H. Weishaupt
- Joel N. Hirschhorn
- Johan Eriksson
- John E. Landers
- John Hardy
- John Powell
- John Q. Trojanowski
- John Waddington
- Jonathan Glass
- Jonathan Pimm
- Jordan W. Smoller
- Josef Frank
- Joseph D. Buxbaum
- Joseph I. Friedman
- Joshua L. Roffman
- Jouko Lönnqvist
- Jubao Duan
- Judit Bene
- Juha Karjalainen
- Juha Veijola
- Jurgen Del Favero
- Jurjen J. Luykx
- Kai-How Farh
- Kang Sim
- Karen E. Morrison
- Kari Stefansson
- Karol Estrada
- Katie Sidle
- Kelly Williams
- Kenneth L. Davis
- Kenneth S. Kendler
- Kieran C. Murphy
- Kimberley D. Chambert
- Kristel R. van Eijk
- Kristin K. Nicodemus
- Kuang Lin
- Kung-Yee Liang
- Larry J. Seidman
- Laura Nisenbaum
- Lauren Elman
- Laurent Essioux
- Leo McCluskey
- Leonard H. van den Berg
- Letizia Mazzini
- Liene Nikitina-Zake
- Lieuwe de Haan
- Lili Milani
- Line Olsen
- Luba Kalaydjieva
- Lude Franke
- Lukas Tittmann
- Lyudmila Georgieva
- Madeline Alexander
- Mads V. Hollegaard
- Mamede de Carvalho
- Manuel Mattheisen
- Marcella Rietschel
- Margaret O’Brien
- Margot Albus
- Mari Nelis
- Marian L. Hamshere
- Marianne de Visser
- Marion Friedl
- Mark A. Reimers
- Mark Hansen
- Mark J. Daly
- Mark Weiser
- Markus M. Nöuthen
- Markus Weber
- Martilias S. Farrell
- Martin Begemann
- Martina Wiedau-Pazos
- Masashi Ikeda
- Massimiliano Filosto
- Matthew C. Keller
- Matthew C. Kiernan
- Maura Brunetti
- Menachem Fromer
- Meraida Polak
- Miaoxin Li
- Michael A. van Es
- Michael C. O’Donovan
- Michael Davidson
- Michael Gill
- Michael J. Owen
- Michael Sendtner
- Michele T. Pato
- Milan Macek
- Milena Blagojevic-Radivojkov
- Milica Pejovic-Milovancevic
- Morten Mattingsdal
- Mythily Subramaniam
- Nadine Cohen
- Nakao Iwata
- Nancy G. Buccola
- Naomi R. Wray
- Naser Durmishi
- Nazli Basak
- Nelson B. Freimer
- Nicholas Wood
- Nick Craddock
- Nicola Ticozzi
- Nigel M. Williams
- Nilo Riva
- Noa Carrera
- null null
- null null
- Ole A. Andreassen
- Ole Mors
- Olli Pietiläinen
- Orietta Pansarasa
- Orla Hardiman
- P Nigel Leigh
- Pablo V. Gejman
- Pak C. Sham
- Pamela J. Shaw
- Pamela Sklar
- Panos Roussos
- Paola Giusti-Rodríguez
- Patricia T. Michie
- Patrick F. Sullivan
- Patrick Vourc'h
- Patrik K. E. Magnusson
- Paul Cormican
- Per Hoffmann
- Perry T. C. van Doormaal
- Peter A Holmans
- Peter Eichhammer
- Peter Lichtner
- Peter M. Andersen
- Peter M. Visscher
- Petr Slominsky
- Phil Lee
- Philip Van Damme
- Philippe Amouyel
- Philippe Corcia
- Pietro Fratta
- Preben B. Mortensen
- Qiang Wang
- Qingqin S. Li
- R Jeroen Pasterkamp
- Randy L. Buckner
- Raquelle I. Mesholam-Gately
- Raymond C. K. Chan
- René S. Kahn
- Ricardo Rojas-García
- Richard A. Belliveau
- Richard Bruggeman
- Richard E. Straub
- Richard W. Orrell
- Rick A. A. van der Spek
- Rita M. Cantor
- Robert Freedman
- Robert H. Brown
- Robert Swingler
- Robert W. McCarley
- Roberto Del Bo
- Robin M. Murray
- Rodney J. Scott
- Roel A. Ophoff
- Roger Pamphlett
- Rolf Adolfsson
- Ronald Y. L. Chan
- Rosa Capozzo
- Rosanna Tortelli
- Russell L. McLaughlin
- S Hong Lee
- Safa Saker-Delye
- Sandra D’Alfonso
- Sandra Meier
- Sang-Yun Oh
- Sara L. Pulit
- Sara Marsal
- Sarah E. Bergen
- Sarah Tosato
- Sena Karachanak-Yankova
- Sergi Papiol
- Shaun M. Purcell
- Shuna Colville
- Sibylle G. Schwab
- Siddharthan Chandran
- Silvana Penco
- Silviu A. Bacanu
- Simon Arcuti
- Siow Ann Chong
- Sophie E. Legge
- Srdjan Djurovic
- Srihari Gopal
- Srinivas Thirumalai
- Stacy Steinberg
- Stanley V. Catts
- Stefan Herms
- Stephan Ripke
- Stephanie Godard
- Stephanie H. Witt
- Stephanie Williams
- Steven A. McCarroll
- Stéphanie Millecamps
- Susana Pinto
- Susanna Abdulla
- Susanne Petri
- Sven Cichon
- Svetlana Limborska
- T Scott Stroup
- Tao Li
- Teimuraz Silagadze
- Thomas G. Schulze
- Thomas Hansen
- Thomas Meitinger
- Thomas Meyer
- Thomas Werge
- Tiina Paunio
- Tim B. Bigdeli
- Tim Kahlke
- Timothy Dinan
- Todd Lencz
- Tracey L. Petryshen
- Tune H. Pers
- Tõnu Esko
- Ulrich Schall
- Vahram Haroutunian
- Vaidutis Kucinskas
- Valentina Escott-Price
- Vaughan J. Carr
- Veikko Salomaa
- Vera Golimbet
- Vihra Milanova
- Vincent Meininger
- Vincenzo Silani
- Viviana Pensato
- Vivianna M. Van Deerlin
- Wei Cheng
- Wiepke Cahn
- William Byerley
- William Sproviero
- Wim Robberecht
- Wolfgang Lieb
- Wolfgang Maier
- Wouter van Rheenen
- Xuebin Zheng
- Younes Mokrab
- Yunjung Kim
- Zita Ausrele Kucinskiene
- Publication venue
- Publication date
- 01/01/2017
- Field of study
A. Palotie on työryhmän Schizophrenia Working Grp Psychiat jäsen.We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P = 1 x 10(-4)) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P = 8.4 x 10(-7)). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.Peer reviewe
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
- Author
- Adams Mark
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Al Eissa Mariam
- Albus Margot
- Alexander Madeline
- Alizadeh Behrooz Z
- Alptekin Köksal
- Als Thomas D
- Amin Farooq
- Andreassen Ole A
- Arango Celso
- Arolt Volker
- Arrojo Manuel
- Atbaşoğlu Eşref Cem
- Athanasiu Lavinia
- Atkinson Elizabeth G
- Awasthi Swapnil
- Ayub Muhammad
- Azevedo Maria Helena
- Bacanu Silviu A
- Bass Nicholas J
- Baune Bernhard T
- Begemann Martin
- Belangero Sintia Iole
- Belliveau Richard A
- Bene Judit
- Benner Christian
- Benyamin Beben
- Bergen Sarah E
- Bertolino Alessandro
- Bigdeli Tim B
- Black Donald W
- Blasi Giuseppe
- Bobes Julio
- Bonassi Stefano
- Braff David
- Bramon Elvira
- Braun Alice
- Bray Nicholas J
- Breen Gerome
- Bressan Rodrigo Affonseca
- Bromet Evelyn J
- Bruggeman Richard
- Bryois Julien
- Buccola Nancy G
- Buckley Peter F
- Buckner Randy L
- Buxbaum Joseph D
- Bybjerg-Grauholm Jonas
- Byerley William F
- Børglum Anders D
- Cahn Wiepke
- Cairns Murray J
- Calkins Monica E
- Campion Dominique
- Carr Vaughan J
- Castle David
- Catts Stanley V
- Cervilla Jorge A
- Chambert Kimberley D
- Chan Raymond CK
- Chaumette Boris
- Chen Chia-Yen
- Chen Wei J
- Cheng Wei
- Cheung Eric FC
- Chong Siow Ann
- Cichon Sven
- Cloninger C Robert
- Cohen David
- Collier David A
- Consoli Angèle
- Cordeiro Quirino
- Corvin Aiden
- Costas Javier
- Crespo-Facorro Benedicto
- Curtis Charles
- Curtis David
- Daly Mark J
- Davidson Michael
- Davis Kenneth L
- de Haan Lieuwe
- Degenhardt Franziska
- DeLisi Lynn E
- Demontis Ditte
- Dennison Charlotte A
- Dickerson Faith
- Dikeos Dimitris
- Dinan Timothy
- Djurovic Srdjan
- Domenici Enrico
- Donohoe Gary
- Duan Jubao
- Ducci Giuseppe
- Dudbridge Frank
- Ehrenreich Hannelore
- Eriksson Johan G
- Escott-Price Valentina
- Esko Tõnu
- Fanous Ayman H
- Faraone Stephen V
- Fañanás Lourdes
- Fiorentino Alessia
- Forstner Andreas
- Forti Marta Di
- Frank Josef
- Freedman Robert
- Frei Oleksandr
- Freimer Nelson B
- Fromer Menachem
- Frustaci Alessandra
- Gadelha Ary
- Galletly Cherrie
- Gandal Michael J
- Gareeva Anna
- Gawlik Micha
- Ge Tian
- Gejman Pablo V
- Gennarelli Massimo
- Genovese Giulio
- Gershon Elliot S
- Giannitelli Marianna
- Giegling Ina
- Gill Michael
- Giusti-Rodríguez Paola
- Glatt Stephen J
- Godard Stephanie
- Goldstein Jacqueline I
- Golimbet Vera
- González Peñas Javier
- González-Pinto Ana
- Gopal Srihari
- Gratten Jacob
- Green Michael F
- Greenwood Tiffany A
- Grove Jakob
- Guillin Olivier
- Gur Raquel E
- Gur Ruben C
- Gutiérrez Blanca
- Gülöksüz Sinan
- Hahn Eric
- Hakonarson Hakon
- Hall Lynsey S
- Haroutunian Vahram
- Hartmann Annette M
- Harvey Carol
- Harwood Janet C
- Hayward Caroline
- Henskens Frans A
- Herms Stefan
- Hoffmann Per
- Holmans Peter A
- Hong Kyung Sue
- Hougaard David M
- Howrigan Daniel P
- Huang Hailiang
- Hultman Christina M
- Hwu Hai-Gwo
- Hyman Steven E
- Ikeda Masashi
- Indonesia Schizophrenia Consortium
- Iwata Nakao
- Iyegbe Conrad
- Jablensky Assen V
- Joa Inge
- Julià Antonio
- Jönsson Erik G
- Kahn René S
- Kam-Thong Tony
- Kamatani Yoichiro
- Karachanak-Yankova Sena
- Kebir Oussama
- Keller Matthew C
- Kelly Brian J
- Kendler Kenneth S
- Kennedy James L
- Khrunin Andrey
- Khusnutdinova Elza
- Kim Minsoo
- Kim Sung-Wan
- Kirov George
- Klovins Janis
- Knowles James A
- Kondratiev Nikolay
- Konte Bettina
- Koopmans Frank
- Kraft Julia
- Krebs Marie-Odile
- Kubo Michiaki
- Kusumawardhani Agung
- Kuzelova-Ptackova Hana
- Kučinskas Vaidutis
- Kučinskiene Zita Ausrele
- Kähler Anna K
- Lam Max
- Landi Stefano
- Laurent-Levinson Claudine
- Lazzeroni Laura C
- Lee Jimmy
- Lee Phil H
- Legge Sophie E
- Lehrer Douglas S
- Lencer Rebecca
- Lencz Todd
- Lerer Bernard
- Levinson Douglas F
- Li Miaoxin
- Li Qingqin S
- Li Zhiqiang
- Lieberman Jeffrey
- Light Gregory A
- Limborska Svetlana
- Liu Chih-Min
- Liu Jianjun
- Loughland Carmel M
- Lubinski Jan
- Luykx Jurjen J
- Lynham Amy
- Lönnqvist Jouko
- Macek Milan
- Mackinnon Andrew
- Magnusson Patrik KE
- Magnusson Sigurdur
- Maher Brion S
- Maier Wolfgang
- Malaspina Dolores
- Malhotra Anil K
- Malhotra Dheeraj
- Mallet Jacques
- Marder Stephen R
- Marsal Sara
- Martin Alicia R
- Martorell Lourdes
- Mattheisen Manuel
- McCarley Robert W
- McCarroll Steven A
- McDonald Colm
- McGrath John J
- McIntosh Andrew
- McQuillin Andrew
- Medeiros Helena
- Meier Sandra
- Melegh Bela
- Melle Ingrid
- Menezes Paulo R
- Mesholam-Gately Raquelle I
- Metspalu Andres
- Michie Patricia T
- Milani Lili
- Milanova Vihra
- Mitjans Marina
- Molden Espen
- Molina Esther
- Molto María Dolores
- Mondelli Valeria
- Moran Jennifer L
- Moreno Carmen
- Morgan Vera A
- Morley Christopher P
- Morris Derek W
- Mors Ole
- Mortensen Preben B
- Mowry Bryan J
- Muntané Gerard
- Murphy Kieran C
- Murray Robin M
- Myin-Germeys Inez
- Müller-Myhsok Bertram
- Neale Benjamin M
- Neil Amanda L
- Nenadić Igor
- Nestadt Gerald
- Nikitina-Zake Liene
- Nimgaonkar Vishwajit
- Nordentoft Merete
- Noto Cristiano
- Nuechterlein Keith H
- Nöthen Markus M
- O'Brien Niamh Louise
- O'Donovan Michael C
- O'Neill F Anthony
- Oh Sang-Yun
- Olincy Ann
- Ophoff Roel A
- Ota Vanessa Kiyomi
- Owen Michael J
- Paciga Sara A
- Palotie Aarno
- Panagiotaropoulou Georgia
- Pantelis Christos
- Papadimitriou George N
- Pardiñas Antonio F
- Parellada Mara
- Pato Carlos N
- Pato Michele T
- Paunio Tiina
- Pellegrino Renata
- Periyasamy Sathish
- Perkins Diana O
- Petryshen Tracey L
- Pfuhlmann Bruno
- Pietiläinen Olli
- Pimm Jonathan
- Pirinen Matti
- Pocklington Andrew J
- Porteous David
- Posthuma Danielle
- Powell John
- PsychENCODE
- Psychosis Endophenotypes International Consortium
- Pulver Ann E
- Qi Ting
- Qin Shengying
- Quattrone Diego
- Quested Digby
- Radant Allen D
- Rampino Antonio
- Rapaport Mark H
- Rautanen Anna
- Reichenberg Abraham
- Richards Alexander L
- Rietschel Marcella
- Riley Brien P
- Ripke Stephan
- Rivera Margarita
- Roe Cheryl
- Roffman Joshua L
- Roth Julian
- Rothermundt Matthias
- Roussos Panos
- Rujescu Dan
- Rutten Bart PF
- Saka Meram C
- Saker-Delye Safaa
- Salomaa Veikko
- Sanders Alan R
- Sanjuan Julio
- Santoro Marcos Leite
- Savitz Adam
- Schall Ulrich
- Schizophrenia Working Group of the Psychiatric Genomics Consorti
- Schulze Thomas G
- Schwab Sibylle G
- Scott Rodney J
- Seidman Larry J
- Serretti Alessandro
- Sham Pak C
- Sharp Sally Isabel
- Shi Jianxin
- Shi Yongyong
- Sidorenko Julia
- Siever Larry J
- Sigurdsson Engilbert
- Silverman Jeremy M
- Sim Kang
- Skarabis Nora
- Slominsky Petr
- Smoller Jordan W
- So Hon-Cheong
- Sobell Janet L
- St Clair David
- Stahl Eli A
- Stain Helen J
- Steen Nils Eiel
- Stefansson Kari
- Stefánsson Hreinn
- Steixner-Kumar Agnes A
- Stone William S
- Straub Richard E
- Streit Fabian
- Strengman Eric
- Stroup T Scott
- Stögmann Elisabeth
- Subramaniam Mythily
- Sugar Catherine A
- Sullivan Patrick F
- Suvisaari Jaana
- Svrakic Dragan M
- Swerdlow Neal R
- SynGO Consortium
- Szatkiewicz Jin P
- Söderman Erik
- Ta Thi Minh Tam
- Takahashi Atsushi
- Terao Chikashi
- Thibaut Florence
- Toncheva Draga
- Tooney Paul A
- Torretta Silvia
- Tosato Sarah
- Trubetskoy Vassily
- Tsuang Debby W
- Tsuang Ming T
- Tura Gian Battista
- Turetsky Bruce I
- Vaaler Arne
- van Amelsvoort Therese
- van Os Jim
- van Winkel Ruud
- Vassos Evangelos
- Vawter Marquis P
- Veijola Juha
- Verhage Matthijs
- Vilella Elisabet
- Visscher Peter M
- Voloudakis Georgios
- Waddington John
- Walter Henrik
- Walters James TR
- Wang Shi-Heng
- Watanabe Kyoko
- Waterreus Anna
- Webb Bradley T
- Weinberger Daniel R
- Weiser Mark
- Werge Thomas
- Wildenauer Dieter B
- Williams Nigel M
- Witt Stephanie H
- Wormley Brandon K
- Wray Naomi R
- Wu Jing Qin
- Wu Yang
- Xu Shuhua
- Xu Zhida
- Yang Jian
- Yolken Robert
- Yu Xin
- Yue Weihua
- Zai Clement C
- Zeng Jian
- Zhang Wen
- Zhou Wei
- Zhu Feng
- Zimprich Fritz
- Üçok Alp
- Publication venue
- NATURE PORTFOLIO
- Publication date
- 21/04/2022
- Field of study
Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H H
- Adams Hieab H H
- Agartz Ingrid
- Ahlijanian Michael
- Ahmad Shahzad
- Ainscough Susan
- Aisen Paul
- Albers Colleen S
- Albert Marilyn
- Alhusaini Saud
- Allard Joanne
- Almeida Marcio A A
- Alnæs Dag
- Alvim Marina K M
- Ames David
- Ames David
- Amin Najaf
- Amlien Inge K
- Amouyel Philippe
- Ances Beau
- Anderson Karen
- Anderson Tim J
- Andersson Micael
- Andreassen Ole A
- Andreassen Ole A
- Apostolova Liana
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J
- Armstrong Nicola J
- Arnedo Vanessa
- Arnold Steven E
- Artiges Eric
- Artiges Eric
- Ashley-Koch Allison
- Assaly Michele
- Assareh Amelia A
- Asthana Sanjay
- Atkins Joshua R
- Aydin Semiha
- Ayesa-Arriola Rosa
- Baca Marne
- Bachman David
- Banaschewski Tobias
- Barbot Alexis
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- Stein Dan J
- Stein Jason L
- Stern Matthew
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- Swerdlow Russell H
- Sämann Philipp G
- Sønderby Ida E
- Tanner Caroline
- Tansey Katherine E
- Tarawneh Rawan
- Tariot Pierre
- Tatsuoka Curtis
- Taylor Joy L
- Taylor Peggy
- Taylor-Reinwald Lisa
- Teng Edmond
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- Tetrud James
- Teumer Alexander
- Teumer Alexander
- Thai Gaby
- Thal Leon
- Thalamuthu Anbupalam
- Thalamuthu Anbupalam
- Thomas Cathi-Ann
- Thomopoulos Sophia I
- Thompson Paul
- Thompson Paul M
- Tingus Kathleen
- Tinklenberg Jared
- Todd Gretchen
- Toga Arthur
- Toga Arthur W
- Toga Arthur W
- Tolosa Eduardo
- Tooney Paul A
- Tordesillas-Gutiérrez Diana
- Torres Fábio R
- Tran Baochan
- Tremont Geoffrey
- Trncic Nadira
- Trojanowki John Q
- Trollor Julian
- Trollor Julian N
- Turner Jessica A
- Turner Raymond Scott
- Tzourio Christophe
- Uhlmann Anne
- Uitterlinden André G
- Ulysse Anaztasia
- Umek Robert
- Uribe Liz
- Vaishnavi Sanjeev
- Vallerga Costanza Ludovica
- van 't Ent Dennis
- van der Brug Marcel
- van der Lee Sven J
- van der Meer Dennis
- Van der Wee Nic J A
- van Donkelaar Marjolein M J
- van Duijn Cornelia M
- van Dyck Christopher H
- van Eijk Liza
- van Erp Theo G M
- van Haren Neeltje E M
- van Noort Betteke
- van Rooij Daan
- van Tol Marie-José
- Vanderswag Helen
- Varma Pradeep
- Veillette Suzanne
- Veldink Jan H
- Veltman Dick J
- Vemuri Prashanthi
- Venkov Heli
- Verhoef Ellen
- Vernooij Meike W
- Villena Teresa
- Villringer Arno
- Voyvodic James T
- Völker Uwe
- Völzke Henry
- Walter Henrik
- Walter Henrik
- Walter Sarah
- Walton Esther
- Wang Mingyuan
- Wang Yunpeng
- Ward Chad
- Wardlaw Joanna M
- Wardlaw Joanna M
- Weber Bernd
- Weinberger Daniel R
- Weiner Michael
- Weiner Michael W
- Weintraub Sandra
- Wen Wei
- Wen Wei
- Westlye Lars T
- Whelan Christopher D
- Whelan Robert
- Whelan Robert
- White Tonya
- Willeke Diana
- Williams Karen
- Williams Steve
- Wilson Renee
- Winkfield David
- Witbracht Megan
- Witt Stephanie H
- Witte A Veronica
- Wittfeld Katharina
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wolk David A
- Womack Kyle
- Wong Terence Z
- Woo Ellen
- Wright Margaret J
- Wright Margaret J
- Wu Chuang-Kuo
- Wu Jing Qin
- Wurster Isabel
- Xia Rui
- Yamamori Hidenaga
- Yanez Beatriz
- Yang Mia
- Yang Qiong
- Yang Qiong
- Yankey Jon
- Yasuda Clarissa L
- Yeh Randy
- Yesavage Jerome
- Zamrini Edward
- Zare Habil
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H
- Zimmerman Earl A
- Ziolkowski Jaimie
- Zsembik Leo C P
- Zwiers Marcel P
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
Mitochondrial physiology
- Author
- Aasander Frostner Eleonor
- Abdel-Rahman Engy Ali
- Abdul Karim Norwahidah
- Abumrad Nada A
- Acuna-Castroviejo Dario
- Adiele Reginald C
- Ahn Bumsoo
- Alencar Mayke Bezerra
- Ali Sameh S
- Almeida Angeles
- Alton Lesley
- Alves Marco G
- Amati Francesca
- Amoedo Nivea Dias
- Amorim Ricardo
- Anderson Ethan J
- Andreadou Ioanna
- Antunes Diana
- Arago Marc
- Aral Cenk
- Arandarcikaite Odeta
- Arias-Reyes Christian
- Armand Anne-Sophie
- Arnould Thierry
- Avram Vlad F
- Axelrod Christopher L
- Bailey Damian M
- Bairam Aida
- Bajpeyi Sudip
- Bajzikova Martina
- Bakker Barbara M
- Banni Aml
- Bardal Tora
- Barlow J
- Bastos Sant'Anna Silva Ana Carolina
- Batterson Philip M
- Battino Maurizio
- Bazil Jason N
- Beard Daniel A
- Bednarczyk Piotr
- Beleza Jorge
- Bello Fiona
- Ben-Shachar Dorit
- Bento Guida Jose Freitas
- Bergdahl Andreas
- Berge Rolf K
- Bergmeister Lisa
- Bernardi Paolo
- Berridge Michael V
- Bettinazzi Stefano
- Bishop David J
- Blier Pierre U
- Blindheim Dan Filip
- Boardman Neoma T
- Boersheim Elisabet
- Boetker Hans Erik
- Borchard Sabine
- Boros Mihaly
- Borras Consuelo
- Borutaite Vilma
- Botella Javier
- Bouillaud Frederic
- Bouitbir Jamal
- Boushel Robert C
- Bovard Josh
- Bravo-Sagua Roberto
- Breton Sophie
- Brown David A
- Brown Guy C
- Brown Robert Andrew
- Brozinick Joseph T
- Buettner Garry R
- Burtscher Johannes
- Bustos Matilde
- Calabria Elisa
- Calbet Jose AL
- Calzia Enrico
- Cannon Daniel T
- Cano Sanchez Maria Consolacion
- Canto Alvarez Carles
- Cardinale Daniele A
- Cardoso Luiza HD
- Carvalho Eugenia
- Casado Pinna Marta
- Cassar Samantha
- Castelo Rueda Maria Paulina
- Castilho Roger F
- Cavalcanti-de-Albuquerque Joao Paulo
- Cecatto Cristiane
- Celen Murat C
- Cervinkova Zuzana
- Chabi Beatrice
- Chakrabarti Lisa
- Chakrabarti Sasanka
- Chaurasia Bhagirath
- Chen Quan
- Chicco Adam J
- Chinopoulos Christos
- Chowdhury Subir Kumar
- Cizmarova Beata
- Clementi Emilio
- Coen Paul M
- Cohen Bruce H
- Coker Robert H
- Collin-Chenot Anne
- Coughlan Melinda T
- Coxito Pedro
- Crisostomo Luis
- Crispim Marcell
- Crossland Hannah
- Dahdah Norma Ramon
- Dalgaard Louise T
- Dambrova Maija
- Danhelovska Tereza
- Darveau Charles-A
- Darwin Paula M
- Das Anibh Martin
- Dash Ranjan K
- Davidova Eliska
- Davis Michael S
- Dayanidhi Sudarshan
- De Bem Andreza Fabro
- De Goede Paul
- De Palma Clara
- De Pinto Vito
- Dela Flemming
- Dembinska-Kiec Aldona
- Detraux Damian
- Devaux Yvan
- Di Marcello Marco
- Di Paola Floriana Jessica
- Dias Candida
- Dias Tania R
- Diederich Marc
- Distefano Giovanna
- Djafarzadeh Siamak
- Doermann Niklas
- Doerrier Carolina
- Dong Lan-Feng
- Donnelly Chris
- Drahota Zdenek
- Duarte Filipe Valente
- Dubouchaud Herve
- Duchen Michael R
- Dumas Jean-Francois
- Durham William J
- Dymkowska Dorota
- Dyrstad Sissel E
- Dyson Alex
- Dzialowski Edward M
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- Sokolova Inna
- Solesio Maria E
- Soliz Jorge
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- Tanaka Masashi
- Tandler Bernard
- Tarnopolsky Mark A
- Tausan Daniel
- Tavernarakis Nektarios
- Teodoro Joao Soeiro
- Tepp Kersti
- Thakkar Himani
- Thapa Maheshwor
- Thyfault John P
- Tomar Dhanendra
- Ton Riccardo
- Torp May-Kristin
- Torres-Quesada Omar
- Towheed Atif
- Treberg Jason R
- Tretter Laszlo
- Trewin Adam J
- Trifunovic Aleksandra
- Trivigno Catherine
- Tronstad Karl Johan
- Trougakos Ioannis P
- Truu Laura
- Tuncay Erkan
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- Urban Tomas
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- Valentine Joseph Marco
- Van Bergen Nicole J
- Van der Ende Miranda
- Varricchio Frederick
- Vaupel Peter
- Vella Joanna
- Vendelin Marko
- Vercesi Anibal E
- Verdaguer Ignasi Bofill
- Vernerova Andrea
- Victor Victor Manuel
- Vidimce Josif
- Vieira Ligo Teixeira Camila
- Viel Christian
- Vieyra Adalberto
- Vilks Karlis
- Villena Josep A
- Vincent Vinnyfred
- Vinogradov Andrey D
- Viscomi Carlo
- Vitorino Rui Miguel Pinheiro
- Vlachaki Walker Julia
- Vogt Sebastian
- Volani Chiara
- Volska Kristine
- Votion Dominique-Marie
- Vujacic-Mirski Ksenija
- Wagner Brett A
- Ward Marie Louise
- Warnsmann Verena
- Wasserman David H
- Watala Cezary
- Wei Yau-Huei
- Weinberger Klaus M
- Weissig Volkmar
- White Sarah Haverty
- Whitfield Jamie
- Wickert Anika
- Wieckowski Mariusz R
- Wiesner Rudolf J
- Williams Caroline M
- Winwood-Smith Hugh
- Wohlgemuth Stephanie E
- Wohlwend Martin
- Wolff Jonci Nikolai
- Wrutniak-Cabello Chantal
- Wuest Rob CI
- Yokota Takashi
- Zablocki Krzysztof
- Zanon Alessandra
- Zanou Nadege
- Zaugg Kathrin
- Zaugg Michael
- Zdrazilova Lucie
- Zhang Yizhu
- Zhang Yong
- Zikova Alena
- Zischka Hans
- Zorzano Antonio
- Zujovic Tijana
- Zurmanova Jitka
- Zvejniece Liga
- Publication venue
- Publication date
- 01/01/2020
- Field of study
As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery
Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Acosta Darin
- Acosta Jhon Gabriel
- Adam Nadia
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Afanasiev Serguei
- Agostino Lorenzo
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Aguilo Ernest
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alexander James
- Aliev Takhmasib
- Almeida Nuno
- Alver Burak
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Jacob
- Anderson Michael
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Anghel Ioana Maria
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Aranyi Attila
- Arce Pedro
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arisaka Katsushi
- Arneodo Michele
- Asaadi Jonathan
- Asghar Muhammad Irfan
- Askew Andrew
- Assran Yasser
- Ata Metin
- Atac Muzaffer
- Atramentov Oleksiy
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian Tobias
- Auzinger Georg
- Avery Paul
- Avetisyan Aram
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Babb John
- Bacchetta Nicola
- Bachtis Michail
- Baden Drew
- Baesso Paolo
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bai Yuting
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Bakken Jon Alan
- Balazs Michael
- Ball Austin
- Ball Gordon
- Ballin Jamie
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Banzuzi Kukka
- Barbagli Giuseppe
- Barberis Emanuela
- Barbone Lucia
- Bardak Cemile
- Barfuss Anne-fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barnes Virgil E.
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Barrett Matthew
- Bartalini Paolo
- Barth Christian
- Basegmez Suzan
- Basso Lorenzo
- Battilana Carlo
- Baty Clement
- Bauer Gerry
- Bauer Julia
- Bauerdick Lothar A. T.
- Baumgartel Darin
- Baur Ulrich
- Bazterra Victor Eduardo
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beaupere Nicolas
- Bedjidian Marc
- Behrenhoff Wolf
- Behrens Ulf
- Belforte Stefano
- Beliy Nikita
- Bell Alan James
- Bell Ken W.
- Bellan Paolo
- Bellan Riccardo
- Bellinger James Nugent
- Belyaev Alexander
- Benaglia Andrea
- Bencze Gyorgy
- Bendavid Joshua
- Bender Walter
- Benedetti Daniele
- Benelli Gabriele
- Benhabib Lamia
- Beni Noemi
- Benucci Leonardo
- Benussi Luigi
- Benvenuti Alberto
- Beretvas Andrew
- Bergauer Thomas
- Bergholz Matthias
- Beri Suman Bala
- Bernardini Jacopo
- Bernet Colin
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Berzano Umberto
- Besancon Marc
- Betchart Burton
- Bethani Agni
- Betts Russell Richard
- Beuselinck Raymond
- Bhat Pushpalatha C.
- Bhatnagar Vipin
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhatti Anwar
- Bialas Wojciech
- Bian Jian-Guo
- Bianchini Lorenzo
- Bianco Stefano
- Biasini Maurizio
- Biino Cristina
- Bilei Gian Mario
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- Bilki Burak
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- Blobel Volker
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- Bloch Ingo
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- Bloom Kenneth
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- Bontenackels Michael
- Boos Edouard
- Borcherding Frederick
- Bornheim Adolf
- Borras Kerstin
- Borrello Laura
- Bortignon Pierluigi
- Bortoletto Daniela
- Bose Suvadeep
- Bose Tulika
- Bostock Francis
- Botta Cristina
- Boudoul Gaelle
- Boulahouache Chaouki
- Boumediene Djamel
- Bourilkov Dimitri
- Boutemeur Madjid
- Boutle Sarah
- Braibant-Giacomelli Sylvie
- Branca Antonio
- Branson James G.
- Breedon Richard
- Breuker Horst
- Brew Christopher
- Brigliadori Luca
- Brigljevic Vuko
- Broccolo Giuseppe
- Brochero Cifuentes Javier Andres
- Brom Jean-Marie
- Brona Grzegorz
- Brooke James John
- Broutin Clementine
- Brown Robert M.
- Brownson Eric
- Brun Hugues
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- Buchmuller Oliver
- Buege Volker
- Bunin Pavel
- Bunkowski Karol
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- Busson Philippe
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- Butler Philip H.
- Butt Jamila
- Butz Erik
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- Chadwick Matthew
- Chakaberia Irakli
- Chamizo Llatas Maria
- Chan Matthew
- Chandra Avdhesh
- Chang Paoti
- Chang Sunghyun
- Chang You-Hao
- Chang Yu-Wei
- Chang Yuan-Hann
- Chanon Nicolas
- Chao Yuan
- Charaf Otman
- Charlot Claude
- Chasco Matthew
- Chasserat Julien
- Chatrchyan Serguei
- Chatterjee Avishek
- Chauhan Sushil
- Checchia Paolo
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- Chlebana Frank
- Choi Minkyoo
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- Choi Young Kyu
- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C.
- Choudhury Rajani Kant
- Choudhury Somnath
- Christiansen Tim
- Chuang Shan-Huei
- Chung Jin Hyuk
- Chung Yeon Sei
- Chwalek Thorsten
- Ciesielski Robert
- Cihangir Selcuk
- Cimmino Anna
- Cirino Guy
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R.
- Clare Robert
- Clarida Warren
- Clement Emyr
- Clerbaux Barbara
- Cline David
- CMS Collaboration
- Coarasa Perez Jose Antonio
- Cockerill David J. A.
- Codispoti Giuseppe
- Colafranceschi Stefano
- Colaleo Anna
- Cole Joanne
- Colino Nicanor
- Collard Caroline
- Colling David
- Contardo Didier
- Conte Eric
- Conway John
- Cooper Seth
- Cooper William
- Cortina Gil Eduardo
- Cossutti Fabio
- Costa Marco
- Costa Salvatore
- Costantini Silvia
- Coughlan John A.
- Cousins Robert
- Covarelli Roberto
- Cox Bradley
- Cox Peter Timothy
- Creanza Donato
- Cremaldi Lucien Marcus
- Cripps Nicholas
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- Cuffiani Marco
- Cumalat John Perry
- Cuplov Vesna
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- Cussans David
- Cutajar Michael
- Cutts David
- Cwiok Mikolaj
- Czellar Sandor
- D'Agnolo Raffaele Tito
- D'Alessandro Raffaello
- D'Alfonso Mariarosaria
- D'Enterria David
- D'Hondt Jorgen
- Da Cunha Marinho Franciole
- Dahmes Bryan
- Dahms Torsten
- Dallavalle Gaetano-Marco
- Damgov Jordan
- Dammann Dirk
- Danielson Thomas
- Darmenov Nikolay
- Das Souvik
- Daskalakis Georgios
- Dasu Sridhara
- Daubie Evelyne
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- Davies Gavin
- De Almeida Dias Flavia
- de Barbaro Pawel
- De Benedetti Abraham
- De Boer Wim
- De Cosa Annapaola
- De Favereau De Jeneret Jerome
- De Filippis Nicola
- De Gruttola Michele
- De Guio Federico
- De Jesus Damiao Dilson
- De La Cruz Begona
- De La Cruz-Burelo Eduard
- De Lentdecker Gilles
- De Mattia Marco
- De Moraes Gregores Eduardo
- De Oliveira Martins Carley
- De Palma Mauro
- De Roeck Albert
- de Trocóniz Jorge F.
- De Visscher Simon
- De Wolf Eddi A.
- Deisher Amanda
- Deiters Konrad
- Dejardin Marc
- Del Re Daniele
- Delaere Christophe
- Delgado Peris Antonio
- Deliomeroglu Mehmet
- Dell'Orso Roberto
- Della Negra Michel
- Della Ricca Giuseppe
- Demaria Natale
- Demina Regina
- Demir Durmus
- Demortier Luc
- Denegri Daniel
- Deniz Muhammed
- Depasse Pierre
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- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Marco
- Zang Jingjing
- Zang Shi-Lei
- Zarubin Anatoli
- Zatserklyaniy Andriy
- Zeinali Maryam
- Zeise Manuel
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Linlin
- Zhang Zhen
- Zheng Yu
- Zhokin Alexander
- Zhu Bo
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Ziebarth Eva Barbara
- Ziegler Jill
- Zielinski Marek
- Zito Giuseppe
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou Wei
- Zumerle Gianni
- Zuranski Andrzej
- Zöller Marc Henning
- Publication venue
- Publication date
- 01/01/2011
- Field of study
A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
- Author
- A Gordon Robertson
- Abdullah Kahraman
- Abel Gonzalez-Perez
- Adam A Margolin
- Adam Abeshouse
- Adam Grundhoff
- Adam J Struck
- Adam J Struck
- Adam J Wright
- Adam Lambert
- Adam P Butler
- Adam P Butler
- Adel El-Naggar
- Adnan M Nagrial
- Adrian Ally
- Adrian Baez-Ortega
- Adrian Thorogood
- Adriana Salcedo
- Adrienne M Flanagan
- Ake Borg
- Akihiro Fujimoto
- Akihiro Suzuki
- Akinyemi I Ojesina
- Alain Viari
- Alan J Robertson
- Alan P Hoyle
- Alan Thompson
- Alasdair Stenhouse
- Alastair M Thompson
- Aldo Scarpa
- Alessandro Pastore
- Alex Buchanan
- Alex Buchanan
- Alexander Claviez
- Alexander J Lazar
- Alexander Martinez-Fundichely
- Alfonso Muñoz
- Alfonso Valencia
- Aliaksei Z Holik
- Alice Meng
- Alicia L Bruzos
- Allison Creason
- Allison P Heath
- Alvin Wei Tian Ng
- Alvis Brazma
- Amaro Taylor-Weiner
- Amber L Johns
- Amie Radenbaugh
- Amit G Deshwar
- Ana Dueso-Barroso
- Ana Mijalkovic Mijalkovic-Lazic
- Ana Milovanovic
- Ana Milovanovic
- Andre Kahles
- Andrea Haake
- Andrea Holbrook
- Andrea L Richardson
- Andrea Mafficini
- Andrea Ruzzenente
- Andreas Behren
- Andreas Rosenwald
- Andreia V Pinho
- Andrew Berchuck
- Andrew D Cherniack
- Andrew J Dunford
- Andrew J Mungall
- Andrew J Spillane
- Andrew Menzies
- Andrew Menzies
- Andrew P Barbour
- Andrew Tutt
- Andrew V Biankin
- Andrey Korshunov
- Andrés Lanzós
- Andy Cafferkey
- Andy G Lynch
- Angela Chou
- Angela N Brooks
- Angela Tam
- Angelica Ochoa
- Angelika N Christ
- Angelo P Dei Tos
- Anieta M Sieuwerts
- Anil K Sood
- Anita Langerød
- Anja Füllgrabe
- Anke K Bergmann
- Ann-Marie Patch
- Anna deFazio
- Anna Ehinger
- Anna Fitzgerald
- Anne Hamilton
- Anne Vincent-Salomon
- Anne Y Warren
- Anne-Lise Børresen-Dale
- Annegien Broeks
- Anthony DiBiase
- Anthony J Gill
- Anthony Ng
- Anthony R Green
- Antonia L Pritchard
- Antonio Pea
- Antonios Koures
- Aparna Prasad
- Apurva M Hegde
- Aquila Fatima
- Arcadi Navarro
- Arie B Brinkman
- Arif O Harmanci
- Arindam Maitra
- Armando Lopez-Guillermo
- Arndt Borkhardt
- Arnoud Boot
- Asger Hobolth
- Ashley Williams
- Ashton A Connor
- Atul J Butte
- Aurélien Chateigner
- Austin J Hepperla
- Axel Aretz
- Aya Sasaki-Oku
- Ayellet V Segre
- B F Francis Ouellette
- Bailey Matthew H
- Barbara Hutter
- Barbara Hutter
- Barbara Kremeyer
- Bartha M Knoppers
- Beifang Niu
- Beifang Niu
- Beifang Niu
- Benedikt Brors
- Benita Kiat Tee Tan
- Benjamin J Raphael
- Benjamin P Berman
- Benjamin Raeder
- Bernardo Rodriguez-Martin
- Bernhard Radlwimmer
- Bernice H Wong
- Beth Karlan
- Bin Tean Teh
- Bin Zhu
- Birgit Burkhardt
- Bishoy M Faltas
- Bodil Bjerkehagen
- Bogdan Czerniak
- Boris Winterhoff
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- Brian Craft
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- Chen Hong
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- Chin-Lee Wu
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- Cindy Bell
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- Ding
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- Don Chalmers
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- Eunjung Alice Lee
- Eva G Alvarez
- Eva Hellstrom-Lindberg
- Ewan Birney
- F Germán Rodríguez-González
- Fabien C Lamaze
- Fabien Calvo
- Fabio C P Navarro
- Faiyaz Notta
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- Zachary Heins
- Zechen Chong
- Zechen Chong
- Zemin Zhang
- Zhaohong Chen
- Zhenggang Wu
- Zhenggang Wu
- Zhining Wang
- Zhongming Zhao
- Ziao Lin
- Zsofia Kote-Jarai
- Ólafur Andri Stefánsson
- Øystein Garred
- Publication venue
- Nature Communications
- Publication date
- 01/01/2020
- Field of study
Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts
Cendres d'immortalité. La crémation des veuves en Inde / Ashes of Immortality. The Cremation of Widows in India
- Publication venue
- 'PERSEE Program'
- Publication date
- 01/01/1989
- Field of study
Weinberger-Thomas Catherine. Cendres d'immortalité. La crémation des veuves en Inde / Ashes of Immortality. The Cremation of Widows in India. In: Archives de sciences sociales des religions, n°67/1, 1989. The twists and turns of religion in India. pp. 9-51
Jackie Assayag, L’Inde fabuleuse. Le charme discret de l’exotisme français, Paris, Éditions Kimé, «Le sens de l’histoire», 1999, 249 p.
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- Field of study
The Effect of Same-Gender and Same-Race Role Models on Occupation Choice: Evidence from Randomly Assigned Mentors at West Point
- Author
- Amine Ouazad
- Andreas Ammermueller
- Arcidiacono
- Basit Zafar
- Brandice J Canes
- Catherine J Weinberger
- David Neumark
- Detrick Briscoe
- Elizabeth McGovney
- Eric P Bettinger
- Francine D Blau
- J Baldwin
- Jacqueline S L Escobar
- Jason K Dempsey
- Jay Price
- Michael S. Kofoed
- Robert W Fairlie
- Ronald G Ehrenberg
- Sarah E Turner
- Scott E Carrell
- Scott E Carrell
- Scott E Carrell
- Susan Carter
- Tayfun S�nmez
- Tayfun S�nmez
- Thomas Deleire
- Thomas S Dee
- Thomas S Dee
- Tom Brook
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
- …