Escuela Regional de Artes Plásticas, para el fortalecimiento cultural y desarrollo artístico, en la provincia de Chiclayo

En los últimos años la ciudad de Chiclayo se está desarrollando y por ello existe un aumento poblacional, actualmente cuenta con 857,405 pers. (INEI, 2015), pero el desarrollo en su infraestructura y equipamiento urbano no ha ido a la par.El objetivo principal de la presente investigación es demostrar que existen infraestructuras que son acondicionadas para la promoción y enseñanza de las diferentes actividades artísticas relacionadas principalmente al arte plástico además que no cumplen con la gran demanda existente de usuarios por aprender y desarrollar dichas actividades; se considerado emplear el método aplicativo, para poder identificar a fondo la actualidad del arte plástico en el departamento de Lambayeque; donde se identificó que existe una gran demanda de usuarios que gustan en aprender y desarrollar las diferentes actividades artistitas relacionadas al arte plástico, no podemos olvidar que la cultura y el arte es el estímulo indispensable para el desarrollo de nuestra sensibilidad, curiosidad y capacidad crítica, es el mejor antídoto contra la estupidez y la arbitrariedad. La investigación no solo impulsara la difusión del arte y la cultura en la región Lambayeque, también dará a conocer el gran pasado artístico con el que contamos, un pasado inmensamente rico donde existieron grandes orfebres, pintores, artesanos, metalúrgicos, grandes culturas que no se pueden quedar en el olvido. Palabras clave: Infraestructuras acondicionadas, demanda existente.Tesi

Plan de negocio para la comercializaci?n de productos basados en el uso de energ?a solar en el mercado peruano

El presente plan de negocio tiene como objetivo principal evaluar la viabilidad econ?mica y financiera para la creaci?n de RENOVABLE PERU S.A.C. Empresa dedicada a la comercializaci?n de productos basados en el uso de energ?a solar. Los objetivos espec?ficos se presentan a continuaci?n: - Analizar la oferta del mercado y conocer los principales competidores que ofrecen productos basados en el uso de energ?a solar. - Determinar el mercado potencial y las v?as de comercializaci?n acordes con las preferencias de los clientes. - Desarrollar el an?lisis estrat?gico basado en Oportunidades y Amenazas utilizando las herramientas: SEPTEG y Cinco Fuerzas de Porter. - Desarrollar el marketing mix: Producto, Precio, Plaza y Promoci?n. - Presentar los procesos asociados al negocio, desde la importaci?n de los productos hasta la entrega a los clientes finales. - Dise?ar una s?lida y eficiente estructura organizacional y de recursos humanos. - Evaluar la inversi?n requerida, presupuestar los costos asociados, elegir las fuentes de financiamiento adecuadas y proyectar la rentabilidad del negocio

Experiencias de innovación educativa

La creación de un Laboratorio de Innovación Pedagógica es una apuesta que deben implementar todas las instituciones de educación superior para-desarrollar diversas estrategias pedagógicas que emplean herramientas didácticas que permitan a los estudiantes tener experiencias significativas en su proceso de aprendizaje. El laboratorio facilita la integración de las necesidades académicas con, el desarrollo de diversos softwares educativos.Este libro de experiencias de innovación educativa presenta el proceso en cada uno de los proyectos o estrategias de aprendizaje trabajados en el Laboratorio de Innovación Pedagógica Educación, Virtual - LIPEV que da como resultado la construcción, de cinco simuladores (Prospectiva, Diagnóstico empresarial, Análisis financiero, Evaluación de proyectos y Mercado de capitales) y un video juego (Juego gerencial de Balanced Scorecard. De cada proyecto se presenta como fue el diseño pedagógico, la estrategia de, aprendizaje empleada, el modelo de simulación que se utilizó, una explicación del diseño gráfico y la programación

Physical activity in the heat: thermoregulation and hydration: Supporting document to the Consensus Statement, Mexico City, February 1999

This document is not intended to be a thorough scientific review, but rather a useful source of information. While it is based on a sound, updated review of the scientific literature, the major intention is to provide clear statements and practical recommendations that are relevant to the Latin American population. The inquisitive reader is directed to recent excellent reviews on this topic. The document was prepared back in 1999 and has not been updated. It is included here as a record in English of the published paper in Spanish.Gatorade Sports Science InstituteUCR::Vicerrectoría de Docencia::Ciencias Sociales::Facultad de Educación::Escuela de Educación Físic

Negative Modulation of Macroautophagy by Stabilized HERPUD1 is Counteracted by an Increased ER-Lysosomal Network With Impact in Drug-Induced Stress Cell Survival

Macroautophagy and the ubiquitin proteasome system work as an interconnected network in the maintenance of cellular homeostasis. Indeed, efficient activation of macroautophagy upon nutritional deprivation is sustained by degradation of preexisting proteins by the proteasome. However, the specific substrates that are degraded by the proteasome in order to activate macroautophagy are currently unknown. By quantitative proteomic analysis we identified several proteins downregulated in response to starvation independently of ATG5 expression. Among them, the most significant was HERPUD1, an ER membrane protein with low expression and known to be degraded by the proteasome under normal conditions. Contrary, under ER stress, levels of HERPUD1 increased rapidly due to a blockage in its proteasomal degradation. Thus, we explored whether HERPUD1 stability could work as a negative regulator of autophagy. In this work, we expressed a version of HERPUD1 with its ubiquitin-like domain (UBL) deleted, which is known to be crucial for its proteasome degradation. In comparison to HERPUD1-WT, we found the UBL-deleted version caused a negative role on basal and induced macroautophagy. Unexpectedly, we found stabilized HERPUD1 promotes ER remodeling independent of unfolded protein response activation observing an increase in stacked-tubular structures resembling previously described tubular ER rearrangements. Importantly, a phosphomimetic S59D mutation within the UBL mimics the phenotype observed with the UBL-deleted version including an increase in HERPUD1 stability and ER remodeling together with a negative role on autophagy. Moreover, we found UBL-deleted version and HERPUD1-S59D trigger an increase in cellular size, whereas HERPUD1-S59D also causes an increased in nuclear size. Interestingly, ER remodeling by the deletion of the UBL and the phosphomimetic S59D version led to an increase in the number and function of lysosomes. In addition, the UBL-deleted version and phosphomimetic S59D version established a tight ER-lysosomal network with the presence of extended patches of ER-lysosomal membrane-contact sites condition that reveals an increase of cell survival under stress conditions. Altogether, we propose stabilized HERPUD1 downregulates macroautophagy favoring instead a closed interplay between the ER and lysosomes with consequences in drug-cell stress survival

Soil: the great connector of our lives now and beyond COVID-19

Humanity depends on the existence of healthy soils, both for the production of food and for ensuring a healthy, biodiverse environment, among other functions. COVID-19 is threatening food availability in many places of the world due to the disruption of food chains, lack of workforce, closed borders and national lockdowns. As a consequence, more emphasis is being placed on local food production, which may lead to more intensive cultivation of vulnerable areas and to soil degradation. In order to increase the resilience of populations facing this pandemic and future global crises, transitioning to a paradigm that relies more heavily on local food production on soils that are carefully tended and protected through sustainable management is necessary. To reach this goal, the Intergovernmental Technical Panel on Soils (ITPS) of the Food and Agriculture Organization of the United Nations (FAO) recommends five active strategies: improved access to land, sound land use planning, sustainable soil management, enhanced research, and investments in education and extension

Annual Conference on Formative Research on EFL. Practices thar inspire change.

The conference papers of the Annual Conference on Formative Research on EFL. Practices thar inspire change collect pedagogical experiences, research reports, and reflections about social issues, language teaching, teaching training, interculturality under the panorama of the Covid-19 pandemic. Each paper invites the reader to implement changes in their teaching practice through disruptive pedagogies, reflect on the social and emotional consequences of the lockdown, new paths for teacher training and different approaches for teaching interculturality. We expect to inspire new ways to train pre-service teachers and teach languages in this changing times

Long-term thermal sensitivity of Earth’s tropical forests

The sensitivity of tropical forest carbon to climate is a key uncertainty in predicting global climate change. Although short-term drying and warming are known to affect forests, it is unknown if such effects translate into long-term responses. Here, we analyze 590 permanent plots measured across the tropics to derive the equilibrium climate controls on forest carbon. Maximum temperature is the most important predictor of aboveground biomass (−9.1 megagrams of carbon per hectare per degree Celsius), primarily by reducing woody productivity, and has a greater impact per °C in the hottest forests (>32.2°C). Our results nevertheless reveal greater thermal resilience than observations of short-term variation imply. To realize the long-term climate adaptation potential of tropical forests requires both protecting them and stabilizing Earth’s climate

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality