148 research outputs found
The Nature of LINERs
We present -band (m) spectroscopy of a sample of nine
galaxies showing some degree of LINER activity (classical LINERs, weak-[O {\sc
i}] LINERs and transition objects), together with -band spectroscopy for
some of them. A careful subtraction of the stellar continuum allows us to
obtain reliable [Fe {\sc ii}]m/Pa line ratios. We conclude
that different types of LINERs (i.e., photoionized by a stellar continuum or by
an AGN) cannot be easily distinguished based solely on the [Fe {\sc ii}]m/Pa line ratio.
The emission line properties of many LINERs can be explained in terms of an
aging starburst. The optical line ratios of these LINERs are reproduced by a
model with a metal-rich H {\sc ii} region component photoionized with a single
stellar temperature K, plus a supernova remnant (SNR) component.
The [Fe {\sc ii}] line is predominantly excited by shocks produced by SNRs in
starbursts and starburst-dominated LINERs, while Pa tracks H {\sc ii}
regions ionized by massive young stars. The contribution from SNRs to the
overall emission line spectrum is constrained by the [Fe {\sc ii}]m/Pa line ratio. Although our models for aging starbursts are
constrained only by these infrared lines, they consistently explain the optical
spectra of the galaxies also.
The LINER-starburst connection is tested by predicting the time dependence of
the ratio of the ionizing luminosity () to the supernova rate
(SNr), /(SNr). We predict the relative number of starbursts to
starburst-dominated LINERs (aging starbursts) and show that it is in
approximate agreement with survey findings for nearby galaxies.Comment: Accepted in ApJ (19 pages, 8 figures, uses emulateapj.sty
Near-infrared line imaging of the starburst galaxies NGC 520, NGC 1614 and NGC 7714
We present high spatial resolution (0.6 arcsec) near-infrared broad-band JHK
images and Br_gamma 2.1661 micron and H_2 1-0 S(1) 2.122 micron emission line
images of the nuclear regions in the interacting starburst galaxies NGC 520,
NGC 1614 and NGC 7714. The near-infrared emission line and radio morphologies
are in general agreement, although there are differences in details. In NGC
1614, we detect a nuclear double structure in Br_gamma, in agreement with the
radio double structure. We derive average extinctions of A(K) = 0.41 and A(K) =
0.18 toward the nuclear regions of NGC 1614 and NGC 7714, respectively. For NGC
520, the extinction is much higher, A(K) = 1.2 - 1.6. The observed H_2/Br_gamma
ratios indicate that the main excitation mechanism of the molecular gas is
fluorescence by intense UV radiation from clusters of hot young stars, while
shock excitation can be ruled out.
The starburst regions in all galaxies exhibit small Br_gamma equivalent
widths. Assuming a constant star formation model, even with a lowered upper
mass cutoff of M_u = 30 M_o, results in rather old ages (10 - 40 Myr), in
disagreement with the clumpy near-infrared morphologies. We prefer a model of
an instantaneous burst of star formation with M_u = 100 M_o, occurring 6 - 7
Myr ago, in agreement with previous determinations and with the detection of
W-R features in NGC 1614 and NGC 7714. Finally, we note a possible systematic
difference in the amount of hot molecular gas between starburst and Seyfert
galaxies.Comment: 13 pages, A&A, accepte
The exposure of the hybrid detector of the Pierre Auger Observatory
The Pierre Auger Observatory is a detector for ultra-high energy cosmic rays.
It consists of a surface array to measure secondary particles at ground level
and a fluorescence detector to measure the development of air showers in the
atmosphere above the array. The "hybrid" detection mode combines the
information from the two subsystems. We describe the determination of the
hybrid exposure for events observed by the fluorescence telescopes in
coincidence with at least one water-Cherenkov detector of the surface array. A
detailed knowledge of the time dependence of the detection operations is
crucial for an accurate evaluation of the exposure. We discuss the relevance of
monitoring data collected during operations, such as the status of the
fluorescence detector, background light and atmospheric conditions, that are
used in both simulation and reconstruction.Comment: Paper accepted by Astroparticle Physic
Comparison of two recombinant erythropoietin formulations in patients with anemia due to end-stage renal disease on hemodialysis: A parallel, randomized, double blind study
BACKGROUND: Recombinant human erythropoietin (EPO) is used for the treatment of last stage renal anemia. A new EPO preparation was obtained in Cuba in order to make this treatment fully nationally available. The aim of this study was to compare the pharmacokinetic, pharmacodynamic and safety properties of two recombinant EPO formulations in patients with anemia due to end-stage renal disease on hemodialysis. METHODS: A parallel, randomized, double blind study was performed. A single 100 IU/Kg EPO dose was administered subcutaneously. Heberitro (Heber Biotec, Havana, formulation A), a newly developed product and Eprex (CILAG AG, Switzerland, formulation B), as reference treatment were compared. Thirty-four patients with anemia due to end-stage renal disease on hemodialysis were included. Patients had not received EPO previously. Serum EPO level was measured by enzyme immunoassay (EIA) during 120 hours after administration. Clinical and laboratory variables were determined as pharmacodynamic and safety criteria until 216 hours. RESULTS: Both groups of patients were similar regarding all demographic and baseline characteristics. EPO kinetics profiles were similar for both formulations; the pharmacokinetic parameters were very close (i.e., AUC: 4667 vs. 4918 mIU.h/mL; Cmax: 119.1 vs. 119.7 mIU/mL; Tmax: 13.9 vs. 18.1 h; half-life, 20.0 vs. 22.5 h for formulations A and B, respectively). The 90% confidence intervals for the ratio between both products regarding these metrics were close to the 0.8 – 1.25 range, considered necessary for bioequivalence. Differences did not reach 20% in any case and were not determined by a formulation effect, but probably by a patients' variability effect. Concerning pharmacodynamic features, a high similitude in reticulocyte counts increments until 216 hours and the percentage decrease in serum iron until 120 hours was observed. There were no differences between formulations regarding the adverse events and their intensity. The more frequent events were pain at injection site (35.3%) and hypertension (29%). Additionally, further treatment of the patients with the study product yielded satisfactory increases in hemoglobin and hematocrit values. CONCLUSION: The formulations are comparable. The newly developed product should be acceptable for long-term application
The effect of the geomagnetic field on cosmic ray energy estimates and large scale anisotropy searches on data from the Pierre Auger Observatory
We present a comprehensive study of the influence of the geomagnetic field on
the energy estimation of extensive air showers with a zenith angle smaller than
, detected at the Pierre Auger Observatory. The geomagnetic field
induces an azimuthal modulation of the estimated energy of cosmic rays up to
the ~2% level at large zenith angles. We present a method to account for this
modulation of the reconstructed energy. We analyse the effect of the modulation
on large scale anisotropy searches in the arrival direction distributions of
cosmic rays. At a given energy, the geomagnetic effect is shown to induce a
pseudo-dipolar pattern at the percent level in the declination distribution
that needs to be accounted for.Comment: 20 pages, 14 figure
Identification and reconstruction of low-energy electrons in the ProtoDUNE-SP detector
Measurements of electrons from interactions are crucial for the Deep
Underground Neutrino Experiment (DUNE) neutrino oscillation program, as well as
searches for physics beyond the standard model, supernova neutrino detection,
and solar neutrino measurements. This article describes the selection and
reconstruction of low-energy (Michel) electrons in the ProtoDUNE-SP detector.
ProtoDUNE-SP is one of the prototypes for the DUNE far detector, built and
operated at CERN as a charged particle test beam experiment. A sample of
low-energy electrons produced by the decay of cosmic muons is selected with a
purity of 95%. This sample is used to calibrate the low-energy electron energy
scale with two techniques. An electron energy calibration based on a cosmic ray
muon sample uses calibration constants derived from measured and simulated
cosmic ray muon events. Another calibration technique makes use of the
theoretically well-understood Michel electron energy spectrum to convert
reconstructed charge to electron energy. In addition, the effects of detector
response to low-energy electron energy scale and its resolution including
readout electronics threshold effects are quantified. Finally, the relation
between the theoretical and reconstructed low-energy electron energy spectrum
is derived and the energy resolution is characterized. The low-energy electron
selection presented here accounts for about 75% of the total electron deposited
energy. After the addition of lost energy using a Monte Carlo simulation, the
energy resolution improves from about 40% to 25% at 50~MeV. These results are
used to validate the expected capabilities of the DUNE far detector to
reconstruct low-energy electrons.Comment: 19 pages, 10 figure
Prediction of protein assemblies, the next frontier: The CASP14-CAPRI experiment
We present the results for CAPRI Round 50, the fourth joint CASP-CAPRI protein assembly prediction challenge. The Round comprised a total of twelve targets, including six dimers, three trimers, and three higher-order oligomers. Four of these were easy targets, for which good structural templates were available either for the full assembly, or for the main interfaces (of the higher-order oligomers). Eight were difficult targets for which only distantly related templates were found for the individual subunits. Twenty-five CAPRI groups including eight automatic servers submitted ~1250 models per target. Twenty groups including six servers participated in the CAPRI scoring challenge submitted ~190 models per target. The accuracy of the predicted models was evaluated using the classical CAPRI criteria. The prediction performance was measured by a weighted scoring scheme that takes into account the number of models of acceptable quality or higher submitted by each group as part of their five top-ranking models. Compared to the previous CASP-CAPRI challenge, top performing groups submitted such models for a larger fraction (70–75%) of the targets in this Round, but fewer of these models were of high accuracy. Scorer groups achieved stronger performance with more groups submitting correct models for 70–80% of the targets or achieving high accuracy predictions. Servers performed less well in general, except for the MDOCKPP and LZERD servers, who performed on par with human groups. In addition to these results, major advances in methodology are discussed, providing an informative overview of where the prediction of protein assemblies currently stands.Cancer Research UK, Grant/Award Number: FC001003; Changzhou Science and Technology Bureau, Grant/Award Number: CE20200503; Department of Energy and Climate Change, Grant/Award Numbers: DE-AR001213, DE-SC0020400, DE-SC0021303; H2020 European Institute of Innovation and Technology, Grant/Award Numbers: 675728, 777536, 823830; Institut national de recherche en informatique et en automatique (INRIA), Grant/Award Number: Cordi-S; Lietuvos Mokslo Taryba, Grant/Award Numbers: S-MIP-17-60, S-MIP-21-35; Medical Research Council, Grant/Award Number: FC001003; Japan Society for the Promotion of Science KAKENHI, Grant/Award Number: JP19J00950; Ministerio de Ciencia e Innovación, Grant/Award Number: PID2019-110167RB-I00; Narodowe Centrum Nauki, Grant/Award Numbers: UMO-2017/25/B/ST4/01026, UMO-2017/26/M/ST4/00044, UMO-2017/27/B/ST4/00926; National Institute of General Medical Sciences, Grant/Award Numbers: R21GM127952, R35GM118078, RM1135136, T32GM132024; National Institutes of Health, Grant/Award Numbers: R01GM074255, R01GM078221, R01GM093123, R01GM109980, R01GM133840, R01GN123055, R01HL142301, R35GM124952, R35GM136409; National Natural Science Foundation of China, Grant/Award Number: 81603152; National Science Foundation, Grant/Award Numbers: AF1645512, CCF1943008, CMMI1825941, DBI1759277, DBI1759934, DBI1917263, DBI20036350, IIS1763246, MCB1925643; NWO, Grant/Award Number: TOP-PUNT 718.015.001; Wellcome Trust, Grant/Award Number: FC00100
Reconstruction of interactions in the ProtoDUNE-SP detector with Pandora
The Pandora Software Development Kit and algorithm libraries provide
pattern-recognition logic essential to the reconstruction of particle
interactions in liquid argon time projection chamber detectors. Pandora is the
primary event reconstruction software used at ProtoDUNE-SP, a prototype for the
Deep Underground Neutrino Experiment far detector. ProtoDUNE-SP, located at
CERN, is exposed to a charged-particle test beam. This paper gives an overview
of the Pandora reconstruction algorithms and how they have been tailored for
use at ProtoDUNE-SP. In complex events with numerous cosmic-ray and beam
background particles, the simulated reconstruction and identification
efficiency for triggered test-beam particles is above 80% for the majority of
particle type and beam momentum combinations. Specifically, simulated 1 GeV/
charged pions and protons are correctly reconstructed and identified with
efficiencies of 86.1% and 84.1%, respectively. The efficiencies
measured for test-beam data are shown to be within 5% of those predicted by the
simulation.Comment: 39 pages, 19 figure
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