86 research outputs found
The Origin of Malarial Parasites in Orangutans
- Author
- AA Escalante
- AA Escalante
- AA Escalante
- AA Escalante
- AA Holder
- AJ Drummond
- Ananias A. Escalante
- Anne Charlotte Gruner
- B Ollomo
- B Singh
- B Singh
- Biruté M. F. Galdikas
- C Mendes
- C Poux
- Carl A. Lowenberger
- CC Huang
- DJ Lohman
- DP Locke
- DR Begun
- E Delson
- F Prugnolle
- F Ronquist
- J Mu
- J Rozas
- JH McDonald
- JR Ali
- K Tamura
- KS Lee
- Lisa Jones-Engel
- M Dhorda
- M Imwong
- M. Andreína Pacheco
- MA Pacheco
- MA Pacheco
- MI Bird
- Michael A. Schillaci
- Michael J. C. Reid
- MJ Benton
- MJ Reid
- MR Galinski
- N Arora
- OE Cornejo
- PCC Garnham
- RG Coatney
- S Guindon
- S Krief
- SL Perkins
- SM Rich
- T Hayakawa
- T Mailund
- V Corredor
- VN Thinh
- W Liu
- W Peters
- WE Collins
- Y Chaimanee
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Background
Recent findings of Plasmodium in African apes have changed our perspectives on the evolution of malarial parasites in hominids. However, phylogenetic analyses of primate malarias are still missing information from Southeast Asian apes. In this study, we report molecular data for a malaria parasite lineage found in orangutans.
Methodology/Principal Findings
We screened twenty-four blood samples from Pongo pygmaeus (Kalimantan, Indonesia) for Plasmodium parasites by PCR. For all the malaria positive orangutan samples, parasite mitochondrial genomes (mtDNA) and two antigens: merozoite surface protein 1 42 kDa (MSP-142) and circumsporozoite protein gene (CSP) were amplified, cloned, and sequenced. Fifteen orangutans tested positive and yielded 5 distinct mitochondrial haplotypes not previously found. The haplotypes detected exhibited low genetic divergence among them, indicating that they belong to one species. We report phylogenetic analyses using mitochondrial genomes, MSP-142 and CSP. We found that the orangutan malaria parasite lineage was part of a monophyletic group that includes all the known non-human primate malaria parasites found in Southeast Asia; specifically, it shares a recent common ancestor with P. inui (a macaque parasite) and P. hylobati (a gibbon parasite) suggesting that this lineage originated as a result of a host switch. The genetic diversity of MSP-142 in orangutans seems to be under negative selection. This result is similar to previous findings in non-human primate malarias closely related to P. vivax. As has been previously observed in the other Plasmodium species found in non-human primates, the CSP shows high polymorphism in the number of repeats. However, it has clearly distinctive motifs from those previously found in other malarial parasites.
Conclusion
The evidence available from Asian apes indicates that these parasites originated independently from those found in Africa, likely as the result of host switches from other non-human primates
The Evolution of Compact Binary Star Systems
- Author
- A Ahmad
- A Blaauw
- A Bragaglia
- A Burrows
- A Burrows
- A Burrows
- A Büning
- A Cooray
- A Corongiu
- A Duquennoy
- A Gianninas
- A Heger
- A Kashi
- A Kusenko
- A Massevitch
- A Menon
- A Nebot Gómez-Morán
- A Noriega-Crespo
- A Noutsos
- A Palacios
- A Skumanich
- A Stroeer
- A Stroeer
- A Tornambé
- A Ulla
- A Wongwathanarat
- AA Zdziarski
- AC Fabian
- AE Rosenbush
- AG Kuranov
- AG Kuranov
- AG Lyne
- AG Lyne
- AG Lyne
- AG Massevich
- AG Massevitch
- AG Riess
- AH Prestwich
- AI Bogomazov
- AI Karakas
- AJ Farmer
- AJ Faulkner
- AJ Faulkner
- AJ Loveridge
- AJ Ruiter
- AJ Ruiter
- AJ Ruiter
- AJT Poelarends
- AL Kraus
- AL Piro
- AL Piro
- AL Piro
- AM Cherepashchuk
- AM Cherepashchuk
- AM Cherepashchuk
- AR King
- AR King
- AS Endal
- AS Oliveira
- AV Fedorova
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AV Tutukov
- AW Hotan
- B Külebi
- B Külebi
- B Paczyński
- B Paczyński
- B Paczyński
- B Paczyński
- B Paczyński
- B Paczyński
- B Paczyński
- B Paczyński
- B Paczyński
- B Paxton
- B Paxton
- B Voss
- B Wang
- B Warner
- B Warner
- B Willems
- B Willems
- B Willems
- B Willems
- B-Q For
- BC Barish
- BD Mason
- BD Mason
- BD Metzger
- BE Schaefer
- BJ Shappee
- BJ Shappee
- BMS Hansen
- BP Flannery
- BS Sathyaprakash
- BT Gänsicke
- BT Hayden
- BW Ritchie
- C Badenes
- C Cutler
- C Foellmi
- C Georgy
- C Georgy
- C Georgy
- C Holcomb
- C Karl
- C Kim
- C Knigge
- C Knigge
- C Motch
- C Palenzuela
- C Raskin
- C Raskin
- C Ritossa
- C Weidner
- C-A Faucher-Giguère
- C-A Faucher-Giguère
- CA Whyte
- CD Bailyn
- CD Bailyn
- CJ Deloye
- CJ Philp
- CL Fryer
- CL Fryer
- CL Fryer
- CL Fryer
- CL Fryer
- CL Rodriguez
- CO Heinke
- CR Evans
- D Bhattacharya
- D Branch
- D Foss
- D Gerosa
- D Grossman
- D Hils
- D Hils
- D Ibeling
- D Kasen
- D Koester
- D Koester
- D Kushnir
- D Lai
- D Lai
- D Levitan
- D Lommen
- D Maoz
- D Prialnik
- D Prialnik
- D Prialnik
- D Raghavan
- D Schiminovich
- D Vanbeveren
- DA Dale
- DA Howell
- DJ Champion
- DJ Nice
- DJ Nice
- DL Kaplan
- DM Townsley
- DM Townsley
- DR Lorimer
- DW Schuerman
- E Bear
- E Berger
- E Cappellaro
- E Cappellaro
- E Donder De
- E Donder De
- E Donder De
- E Ergma
- E Ergma
- E García-Berro
- E Kuulkers
- E Livne
- E Livne
- E Nakar
- E Pfahl
- E Pfahl
- E Pfahl
- E Pylyser
- E Schatzman
- E Schatzman
- E-M Pauli
- EE Salpeter
- EF Keane
- EI Popova
- EI Popova
- EJ Lentz
- EL Robinson
- EL Robinson
- EM Green
- EM Sion
- EM Sion
- EM Sion
- EPJ Heuvel van den
- EPJ Heuvel van den
- EPJ Heuvel van den
- EPJ Heuvel van den
- EPJ Heuvel van den
- EPJ Heuvel van den
- EPJ Heuvel van den
- EPJ Heuvel van den
- EPJ Heuvel van den
- ES Phinney
- F Acernese
- F Camilo
- F D’Antona
- F Espinosa Lara
- F Foucart
- F Herwig
- F Herwig
- F Koliopanos
- F Ozel
- F Ozel
- F Patat
- F Ricci
- F Verbunt
- F Verbunt
- F Yuan
- FB Bianco
- FR Boffi
- FR Stephenson
- FS Kitaura
- FX Timmes
- FX Timmes
- G Duchêne
- G Giampieri
- G Hobbs
- G Lü
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Nelemans
- G Pandey
- G Ramsay
- G Ramsay
- G Stasińska
- G Tovmassian
- GE Brown
- GE Brown
- GE Soberman
- GH Tovmassian
- GHA Roelofs
- GHA Roelofs
- GJ Savonije
- GL Israel
- GP Kuiper
- GS Bisnovatyi-Kogan
- GS Bisnovatyi-Kogan
- GS Bisnovatyi-Kogan
- GS Bisnovatyi-Kogan
- H Belkus
- H Bondi
- H Ge
- H Ge
- H Ritter
- H Saio
- H Saio
- H Sana
- H Sana
- H Susa
- H-T Janka
- H-T Janka
- HA Abt
- HA Bethe
- HA Kobulnicky
- HB Perets
- HC Harris
- HC Spruit
- HC Spruit
- HHB Lau
- HS Zapolsky
- I Brott
- I Dominguez
- I Domínguez
- I Domínguez
- I Hachisu
- I Hachisu
- I Hachisu
- I Hachisu
- I Hachisu
- I Hachisu
- I Iben Jr
- I Iben Jr
- I Iben Jr
- I Iben Jr
- I Iben Jr
- I Iben Jr
- I Iben Jr
- I Iben Jr
- I Iben Jr
- I Iben Jr
- I Iben Jr
- I Idan
- I Kotko
- I Kowalska
- I Mandel
- IF Mirabel
- IF Mirabel
- IH Stairs
- IH Stairs
- IR Seitenzahl
- IS Shklovskii
- J Abadie
- J Abadie
- J Boersma
- J Casares
- J Crowder
- J Faulkner
- J Faulkner
- J Fuller
- J Fuller
- J Girven
- J Guillochon
- J Isern
- J Isern
- J Liebert
- J Nordhaus
- J Papaloizou
- J Schwab
- J Smak
- J Whelan
- J-C Passy
- J-C Passy
- J-E Solheim
- J-E Solheim
- J-E Solheim
- J-P Lasota
- J-U Ness
- JA Edlund
- JA Freitas Pacheco de
- JA Frieman
- JA Orosz
- JA Orosz
- JA Orosz
- JA Orosz
- JB Lamb
- JC Lombardi Jr
- JCA Miller-Jones
- JDM Dewi
- JDM Dewi
- JE Faller
- JE Gunn
- JE McClintock
- JE McClintock
- JE Pringle
- JG Mengel
- JH Shiode
- JH Taylor
- JJ Drake
- JJ Hermes
- JJM Zand in’t
- JM Lattimer
- JM Lattimer
- JM Silverman
- JM Silverman
- JM Silverman
- JM Weisberg
- JM Weisberg
- JP Cox
- JP Greve De
- JPA Clark
- JPA Clark
- JR Hurley
- JR Hurley
- JR Maund
- JS Bloom
- JSW Claeys
- JW Truran
- JW Truran
- K Belczynski
- K Belczynski
- K Belczynski
- K Belczynski
- K Belczynski
- K Belczynski
- K Hotokezaka
- K Lepo
- K Moore
- K Nomoto
- K Nomoto
- K Nomoto
- K Nomoto
- K Riles
- K Siellez
- K Somiya
- K Takahashi
- K Yagi
- K-C Pan
- KA Postnov
- KA Postnov
- KA Postnov
- KJ Shen
- KJ Shen
- KJ Shen
- KJ Shen
- KJ Shen
- KJ Shen
- KK Ghosh
- KM Blundell
- KS Thorne
- KS Thorne
- L Bildsten
- L Bildsten
- L Bildsten
- L Chomiuk
- L Chomiuk
- L Dessart
- L Guillemot
- L Kreidberg
- L Mahy
- L Mestel
- L Mestel
- L Piersanti
- L Piersanti
- L Piersanti
- L Piersanti
- L Siess
- L Siess
- L Siess
- L Trepl
- L-X Li
- LA Nelson
- LD Landau
- LD Landau
- LG Althaus
- LM Close
- LM Haaften van
- LM Haaften van
- LM Haaften van
- LP Grishchuk
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LR Yungelson
- LZ Kelley
- M Bailes
- M Burgay
- M Burgay
- M Dan
- M Dan
- M Dan
- M Dominik
- M Dominik
- M Fink
- M Fukugita
- M Gilfanov
- M Gilfanov
- M Hamuy
- M Henze
- M Hicken
- M Ilkov
- M Kato
- M Kato
- M Kato
- M Kato
- M Kilic
- M Kilic
- M Kilic
- M Kool de
- M Kromer
- M Kromer
- M Livio
- M Livio
- M Nauenberg
- M Plavec
- M Politano
- M Reggiani
- M Rieutord
- M Rigault
- M Rigault
- M Tavani
- M Tsugawa
- M Val-Borro de
- M Yamanaka
- M Zorotovic
- M Zorotovic
- MA Ruderman
- MBN Kouwenhoven
- MBN Kouwenhoven
- MBN Kouwenhoven
- MCP Bours
- MCP Bours
- MCR D’Souza
- ME Alexander
- ME Beer
- ME Prokhorov
- MM Kasliwal
- MM Kasliwal
- MM Phillips
- MM Shara
- MM Shara
- MP Muno
- MR Bate
- MR Drout
- MS Hjellming
- MT Botticella
- MTB Nielsen
- MTB Nielsen
- MV Barkov
- MV Sluys van der
- N Andersson
- N Brandt
- N Chamel
- N Epelstain
- N Gehrels
- N Ivanova
- N Ivanova
- N Ivanova
- N Ivanova
- N Ivanova
- N Ivanova
- N Ivanova
- N Langer
- N Langer
- N Panagia
- N Smith
- N Soker
- N Soker
- N Tominaga
- N Vranesevic
- N Wex
- N Yusof
- NI Shakura
- NJ Cornish
- NM Ashok
- NM Gosnell
- NN Chugai
- NN Chugai
- NN Chugai
- NR Tanvir
- NV Raguzova
- O Birnholtz
- O Graur
- O Graur
- O Marco De
- O Marco De
- O Schnurr
- O Yaron
- OF Dorofeev
- OR Pols
- P Amaro-Seoane
- P Amaro-Seoane
- P André
- P Astier
- P Bagot
- P Eggleton
- P Esposito
- P Gil-Pons
- P Hoeflich
- P Höflich
- P Kahabka
- P Kahabka
- P Lorén-Aguilar
- P Madau
- P Munar-Adrover
- P Podsiadlowski
- P Podsiadlowski
- P Podsiadlowski
- P Podsiadlowski
- P Rodríguez-Gil
- P Ruiz-Lapuente
- P Szypryt
- PA Crowther
- PA Crowther
- PA Crowther
- PA Denissenkov
- PA Woudt
- PA Woudt
- PC Peters
- PD Kiel
- PD Kiel
- PD Sackett
- PE Nugent
- PFL Maxted
- PG Jonker
- PG Pérez-González
- PJ Carter
- PJ Carter
- PJ Carter
- PJ Carter
- PL Bender
- PM Motl
- PM Ricker
- PM Ricker
- PP Eggleton
- R Canal
- R Canal
- R Canal
- R Chini
- R Fender
- R Giacconi
- R Mochkovitch
- R Moll
- R Morrison
- R Napiwotzki
- R Napiwotzki
- R Napiwotzki
- R Narayan
- R Narayan
- R O’Shaughnessy
- R Pakmor
- R Scalzo
- R Scalzo
- R Stefano Di
- R Stefano Di
- R Stefano Di
- R Takahashi
- R Tylenda
- R Voss
- R Waldman
- R Wesson
- RA Chevalier
- RA Chevalier
- RA Chevalier
- RA Chevalier
- RA Hulse
- RA Remillard
- RA Saffer
- RA Saffer
- RA Wade
- RC Kennicutt
- RD Ferdman
- RE Falcon
- RE Taam
- RE Taam
- RE Williams
- RF Webbink
- RF Webbink
- RF Webbink
- RF Webbink
- RF Webbink
- RF Webbink
- RF Webbink
- RH Durisen
- RJ Dewey
- RJ Foley
- RJ Parker
- RK Kopparapu
- RL Barone-Nugent
- RLM Corradi
- RN Manchester
- RP Kraft
- RS Benson
- RW Romani
- RW Romani
- RW Sayer
- S Babak
- S Cassisi
- S Ekström
- S Fabrika
- S Geier
- S Geier
- S Geier
- S Geier
- S Geier
- S Geier
- S Geier
- S Horiuchi
- S Ji
- S Johnston
- S Jones
- S Jones
- S Justham
- S Miyaji
- S Mohamed
- S Neo
- S Nissanke
- S Nissanke
- S Oslowski
- S Perlmutter
- S Rappaport
- S Rappaport
- S Rappaport
- S Refsdal
- S Repetto
- S Rosswog
- S Shah
- S Shah
- S Starrfield
- S Starrfield
- S Starrfield
- S Starrfield
- S Taubenberger
- S Toonen
- S Toonen
- S Vennes
- S Vereshchagin
- S Yu
- S Yu
- S-B Qian
- S-C Yoon
- S-C Yoon
- S-C Yoon
- S-C Yoon
- SA Colgate
- SA Sim
- SB Anderson
- SB Popov
- SC Vila
- SE Thorsett
- SE Timpano
- SE Woosley
- SE Woosley
- SE Woosley
- SF Portegies Zwart
- SF Portegies Zwart
- SF Portegies Zwart
- SH Lubow
- SL Larson
- SL Shapiro
- SN Shore
- SP Littlefair
- SS Kumar
- T Abel
- T Bulik
- T Dermine
- T Fragos
- T Kupfer
- T Linden
- T Linden
- T Nugis
- T Pan
- T Shahbaz
- T Wettig
- T-W Wong
- TA Prince
- TB Littenberg
- TE Woods
- TE Woods
- TE Woods
- TF Cartwright
- TJ Maccarone
- TM Tauris
- TM Tauris
- TM Tauris
- TR Marsh
- TR Marsh
- TR Marsh
- TR Marsh
- TR Marsh
- TR Marsh
- U Heber
- V Gokhale
- V Kalogera
- V Kalogera
- V Kalogera
- V Kalogera
- V Kalogera
- V Kalogera
- VA Brumberg
- VG Kornilov
- VG Kornilov
- VM Kaspi
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VM Lipunov
- VN Mironovskii
- VS Petrov
- VV Davydov
- W Benz
- W Fong
- W Li
- W Li
- W-R Hamann
- WE Kerzendorf
- WE Kerzendorf
- WK Rose
- WM Farr
- WM Sparks
- WM Wolf
- WR Brown
- WR Brown
- X Meng
- X Wang
- X Zhang
- X-J Xu
- X-J Xu
- Y Osaki
- YA Fadeyev
- YA Fadeyev
- YB Zel’dovich
- YV Baryshev
- Z Barkat
- Z Han
- Z Han
- Z Han
- Z Han
- Z Han
- Z Kopal
- Z Li
- Z-W Liu
- ZW Liu
- ÉÉ Flanagan
- Publication venue
- 'Living Reviews'
- Publication date
- 03/01/2007
- Field of study
We review the formation and evolution of compact binary stars consisting of
white dwarfs (WDs), neutron stars (NSs), and black holes (BHs). Binary NSs and
BHs are thought to be the primary astrophysical sources of gravitational waves
(GWs) within the frequency band of ground-based detectors, while compact
binaries of WDs are important sources of GWs at lower frequencies to be covered
by space interferometers (LISA). Major uncertainties in the current
understanding of properties of NSs and BHs most relevant to the GW studies are
discussed, including the treatment of the natal kicks which compact stellar
remnants acquire during the core collapse of massive stars and the common
envelope phase of binary evolution. We discuss the coalescence rates of binary
NSs and BHs and prospects for their detections, the formation and evolution of
binary WDs and their observational manifestations. Special attention is given
to AM CVn-stars -- compact binaries in which the Roche lobe is filled by
another WD or a low-mass partially degenerate helium-star, as these stars are
thought to be the best LISA verification binary GW sources.Comment: 105 pages, 18 figure
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Ackers M
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogan T
- Akesson TPA
- Akimoto G
- Akimov AV
- Alam MA
- Alam MS
- Albrand S
- Aleksa M
- Aleksandrov IN
- Aleppo M
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso J
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Andari N
- Andeen T
- Anders CF
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angerami A
- Anghinolfi F
- Anh TV
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonelli S
- Antos J
- Anulli F
- Aoun S
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Arce ATH
- Archambault JP
- Arfaoui S
- Arguin J-F
- Arik E
- Arik M
- Armbruster AJ
- Arms KE
- Armstrong SR
- Arnaez O
- Arnault C
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Asfandiyarov R
- Ask S
- Asman B
- Asquith L
- Assamagan K
- Astbury A
- Astvatsatourov A
- Atoian G
- Aubert B
- Auerbach B
- Auge E
- Augsten K
- Aurousseau M
- Austin N
- Avramidou R
- Axen D
- Ay C
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Bachy G
- Backes M
- Badescu E
- Bagnaia P
- Bahinipati S
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker OK
- Baker S
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barak L
- Baranov SP
- Barashkou A
- Barber T
- Barberio EL
- Barberis D
- Barbero M
- Bardin DY
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Baroncelli A
- Barr AJ
- Barreiro F
- Barrera CO
- Barrillon P
- Bartoldus R
- Barton AE
- Bartsch D
- Bates RL
- Batkova L
- Batley JR
- Battaglia A
- Battistin M
- Battistoni G
- Bauer F
- Bawa HS
- Beare B
- Beau T
- Beauchemin PH
- Beccherle R
- Bechtle P
- Beck HP
- Beckingham M
- Becks KH
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bee C
- Begel M
- Behera PK
- Beimforde M
- Belanger-Champagne C
- Belenguer MJ
- Belhorma B
- Bell PJ
- Bell WH
- Bella G
- Bella LA
- Bellagamba L
- Bellina F
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- Zhemchugov A
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- Zieminska D
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- Zimmermann S
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- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?
- Author
- A Baguet
- A Bertoni
- A Castello
- A Demuro
- A Emde
- A Khong
- A Molliex
- A Takahashi
- A Zbinden
- AC Elden
- AC Woerner
- AE Bevivino
- AM Ellisdon
- B Kechavarzi
- B Poljšak
- B Wolozin
- B Wolozin
- BD Paul
- BD Paul
- C Nunes
- C Nóbrega
- C Nóbrega
- CA Matos
- CA Matos
- CA Ross
- CD Bryant
- CJ Cummings
- CM Chen
- CP Reina
- D Mateju
- E Bentmann
- F Heyd
- F Wippich
- GV Serpionov
- H Doi
- H Sidibé
- HH Ryu
- I Nascimento-Ferreira
- I Nascimento-Ferreira
- J Araujo
- J Labbadia
- J Lee
- J Leitman
- J Lim
- J Wen
- JG Daigle
- JM Warrick
- JN Sleigh
- JP White
- JR Buchan
- JR Buchan
- JR Buchan
- JR Buchan
- K Arimoto
- K Arimoto-Matsuzaki
- K Ishihara
- K Masuda
- K Mitsui
- K Onomoto
- K Seidel
- K Thedieck
- KE Lukong
- KJ Cowan
- L Liu-yesucevitz
- L Liu-Yesucevitz
- L Nover
- LA Becker
- LC Reineke
- LS Pacheco
- M Chang
- M Corley
- M Fittschen
- M Fournier
- M Ganassi
- M Mallik
- M Ralser
- M Ralser
- M Ramaswami
- M Shibata
- M Takahashi
- M Teplova
- M Yokoshi
- MA Kiebler
- MA Sorolla
- ML Duennwald
- MM Emara
- MN Laço
- MO Krisenko
- MP Wear
- N Bley
- N Cornelius
- N Gilks
- N Kedersha
- N Kedersha
- N Kedersha
- N Kedersha
- N Kedersha
- N Kedersha
- N Stöhr
- NC Collier
- ND Perera
- NP Hoyle
- NR Jana
- NR Jana
- P Anderson
- P Anderson
- P Anderson
- P Anderson
- PA Egorova
- PEA Ash
- PJ Muchowski
- PJS Vig
- R Mazroui
- R Mazroui
- RA Nixon
- RC Wek
- RM De Castilhos
- S Alberti
- S Alves
- S Carmo-Silva
- S Gerstberger
- S Ghosh
- S Gunawardena
- S Hennig
- S Hofmann
- S Jain
- S Koyuncu
- S Martin
- S Mokas
- S Paul
- S Waelter
- SH Satyal
- T Ratovitski
- T Schmidt
- T Uchihara
- T Vanderweyde
- T Vanderweyde
- T Vanderweyde
- T Yamanaka
- TA Cooper
- TR Peskett
- U Nonhoff
- U Rüb
- VN Uversky
- Y Ariumi
- Y Chai
- Y Furukawa
- Y Jiang
- Y Shin
- Z Ignatova
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/06/2021
- Field of study
Stress granules (SGs) are membraneless cell compartments formed in response to different stress stimuli, wherein translation factors, mRNAs, RNA-binding proteins (RBPs) and other proteins coalesce together. SGs assembly is crucial for cell survival, since SGs are implicated in the regulation of translation, mRNA storage and stabilization and cell signalling, during stress. One defining feature of SGs is their dynamism, as they are quickly assembled upon stress and then rapidly dispersed after the stress source is no longer present. Recently, SGs dynamics, their components and their functions have begun to be studied in the context of human diseases. Interestingly, the regulated protein self-assembly that mediates SG formation contrasts with the pathological protein aggregation that is a feature of several neurodegenerative diseases. In particular, aberrant protein coalescence is a key feature of polyglutamine (PolyQ) diseases, a group of nine disorders that are caused by an abnormal expansion of PolyQ tract-bearing proteins, which increases the propensity of those proteins to aggregate. Available data concerning the abnormal properties of the mutant PolyQ disease-causing proteins and their involvement in stress response dysregulation strongly suggests an important role for SGs in the pathogenesis of PolyQ disorders. This review aims at discussing the evidence supporting the existence of a link between SGs functionality and PolyQ disorders, by focusing on the biology of SGs and on the way it can be altered in a PolyQ disease context.ALG-01-0145-FEDER-29480, SFRH/BD/133192/2017, SFRH/BD/133192/2017, SFRH/BD/148533/2019info:eu-repo/semantics/publishedVersio
Measurement of the cross-section for b-jets produced in association with a Z boson at root s=7 TeV with the ATLAS detector ATLAS Collaboration
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogan T
- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angerami A
- Anghinolfi F
- Anh TV
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- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoun S
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Arce ATH
- Archambault JP
- Arfaoui S
- Arguin J-F
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnault C
- Artamonov A
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- Castillo Gimenez V
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- Castro NF
- Cataldia G
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- Publication date
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- Field of study
A measurement is presented of the inclusive cross-section for b-jet production in association with a Z boson in pp collisions at a centre-of-mass energy of root s = 7 TeV. The analysis uses the data sample collected by the ATLAS experiment in 2010, corresponding to an integrated luminosity of approximately 36 pb(-1). The event selection requires a Z boson decaying into high P-T electrons or muons, and at least one b-jet, identified by its displaced vertex, with transverse momentum p(T) > 25 GeV and rapidity vertical bar y vertical bar < 2.1. After subtraction of background processes, the yield is extracted from the vertex mass distribution of the candidate b-jets. The ratio of this cross-section to the inclusive Z cross-section (the average number of b-jets per Z event) is also measured. Both results are found to be in good agreement with perturbative QCD predictions at next-to-leading order
Autophagy: Regulation and role in disease
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Recommended from our members
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
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- Wickramasinghe K
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- Yiallouros PK
- Yngve A
- Yoosefi M
- Yoshihara A
- Yotov Y
- You QS
- You S-L
- Younger-Coleman NO
- Yu Y
- Yu Y-L
- Yusof SM
- Yusoff AF
- Yusoff MFM
- Zaccagni L
- Zafiropulos V
- Zainuddin AA
- Zakavi SR
- Zamani F
- Zambon S
- Zampelas A
- Zamrazilova H
- Zapata ME
- Zargar AH
- Zaw KK
- Zayed AA
- Zdrojewski T
- Zeglen M
- Zejglicova K
- Zeng Y
- Zentai A
- Zhang B
- Zhang L
- Zhang Z-Y
- Zhao D
- Zhao M-H
- Zhao W
- Zhecheva YV
- Zhen S
- Zheng W
- Zheng Y
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- Zhou B
- Zhou M
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- Zimmet P
- Zins M
- Zitt E
- Zocalo Y
- Zoghlami N
- Zuziak M
- Publication venue
- Elsevier
- Publication date
- 14/03/2024
- Field of study
Background
Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories.
Methods
We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI 2 SD above the median).
Findings
From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining underweight or thinness.
Interpretation
The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesity.
Funding
UK Medical Research Council, UK Research and Innovation (Research England), UK Research and Innovation (Innovate UK), and European Union
Search for the standard model Higgs boson in the diphoton decay channel with 4.9fb -1 of pp collision data at √s=7TeV with atlas
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- Åkesson TPA
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- Publication venue
- Publication date
- 01/01/2012
- Field of study
A search for the standard model Higgs boson is performed in the diphoton decay channel. The data used correspond to an integrated luminosity of 4.9 fb-1 collected with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of √s=7 TeV. In the diphoton mass range 110–150 GeV, the largest excess with respect to the background-only hypothesis is observed at 126.5 GeV, with a local significance of 2.8 standard deviations. Taking the look-elsewhere effect into account in the range 110–150 GeV, this significance becomes 1.5 standard deviations. The standard model Higgs boson is excluded at 95% confidence level in the mass ranges of 113–115 GeV and 134.5–136 GeV
Search for the standard model Higgs boson in the diphoton decay channel with 4.9fb -1 of pp collision data at √s=7TeV with atlas
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- Abdallah J
- Abdel Khalek S
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- Zutshi V
- Zwalinski L
- Åkesson TPA
- Åsman B
- Publication venue
- Publication date
- 01/01/2012
- Field of study
A search for the standard model Higgs boson is performed in the diphoton decay channel. The data used correspond to an integrated luminosity of 4.9 fb-1 collected with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of √s=7 TeV. In the diphoton mass range 110–150 GeV, the largest excess with respect to the background-only hypothesis is observed at 126.5 GeV, with a local significance of 2.8 standard deviations. Taking the look-elsewhere effect into account in the range 110–150 GeV, this significance becomes 1.5 standard deviations. The standard model Higgs boson is excluded at 95% confidence level in the mass ranges of 113–115 GeV and 134.5–136 GeV
Diminishing benefits of urban living for children and adolescents’ growth and development
- Author
- Abarca-Gómez L
- Abdeen ZA
- Abdrakhmanova S
- Abdul Rahim HF
- Abdurrahmonova Z
- Abril GL
- Abu-Rmeileh NM
- Acosta-Cazares B
- Adam I
- Adamczyk M
- Adams RJ
- Adu-Afarwuah S
- Aekplakorn W
- Afsana K
- Afzal S
- Agbor VN
- Agdeppa IA
- Aghazadeh-Attari J
- Aguenaou H
- Aguilar-Salinas CA
- Agyemang C
- Ahmad MH
- Ahmad NA
- Ahmadi A
- Ahmadi N
- Ahmadi N
- Ahmed I
- Ahmed SH
- Ahrens W
- Aitmurzaeva G
- Ajlouni K
- Al Hourani HM
- Al Qaoud NM
- Al-Hazzaa HM
- Al-Lahou B
- Al-Raddadi R
- Alarouj M
- AlBuhairan F
- AlDhukair S
- Aldwairji MA
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- Łuszczki E
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
AbstractOptimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.</jats:p
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