Visual and melanopic performance of a tropical daylight-mimicking lighting: a case study in Thailand

This paper designed and developed a tropical daylight-mimicking lighting system based on photometric, radiometric and International Commission on Illumination (CIE) standard melanopic performances from natural lighting cycles in Thailand. Spectral power distribution (SPD) during daylight in summer and winter were recorded to create a dynamic artificial lighting system that best matches the natural daylight characteristics. Two set-ups light emitting diode (LED) (LED-A and LED-B) were screened, developed, validated and compared with different chromaticity layouts of the correlated color temperatures (CCTs) allocated on Planckian locus and later converted to x-y co-ordinates in a chromaticity diagram. Based on CCT and Duv deviations between two developed setups, LED-A could mimick circadian points on the chromaticity diagram better than LED-B did. CCT and Duv values of LED-A (dCCT=3.75% and dDuv=17.36%) can match closer to the daylight than those of LED-B (dCCT=5.0 % and dDuv=56.84%). For CIE-standard melanopic performances (melanopic efficacy of luminous radiation (mELR), melanopic equivalent daylight (D65) illuminance (mEDI) and melanopic daylight efficacy ratio (mDER)), LED-A is suitable to use indoor with averages of 1.16 W×lm-1, 236 lx and 0.84, respectively, while LED-B is good to use outdoor with averages of 1.53 W×lm-1, 266 lx and 1.06, respectively. The proposed design can be used as a guideline to establish a daylight-mimicking LED lighting system from actual measurement data

Thai EFL teachers and learners’ beliefs and readiness for autonomous learning

The emergence of the ASEAN Economic Community has spurred countries in the region to relook their English language teaching approaches to ensure it is in line with regional and global changes. This has resulted in Asian countries seeking to modernise their teaching and learning of the language to promote higher order thinking skills and pave the way for better learner autonomy. This paper examines Thai teacher and learner beliefs about autonomous learning within the Thai culture of learning to determine if both are ready for autonomous learning. Using a qualitative approach employing interviews with teacher and students data was created from 76 English language teachers and 116 lower secondary school students, subdivided into high performing and low performing groups from 41 schools in Bangkok. The overall results indicate that both teachers and students hold positive beliefs about autonomous learning. The findings further reveal that the teachers supported communicative language learning while the students emphasised their needs for mental support, that teachers from large schools have higher academic expectations than those from smaller schools, and that lower performing students struggle for more academic and psychological support than their higher performing peers. The exam system, students’ dependence on teachers, and a lack of understanding from families and surrounding communities make it difficult for both teachers and students to achieve a high degree of autonomy. The study sheds some light on the challenges facing policy makers, particularly the Ministry of Education, with regard to what they can do to promote autonomy in the Thai school system

Interharmonics: Basic concepts and techniques for their detection and measurement

Abstract The term interharmonics refer to those frequencies that are not integral harmonics of the supply fundamental frequency. Although international organizations defined the terminology and proposed measurement guidelines, difficulties still exist in its detection and measurement with acceptable accuracy. When interharmonic components appear in a spectrum, it is still debatable if they really exist and, if the answer is yes, what are the actual frequencies and magnitudes of the components. This paper reviews the mathematical basis of the interharmonics and discusses the difficulties in detecting and measuring interharmonics. A few practical rules are proposed to assist the measurement of interharmonics. Simulations, laboratory experiment and field test results are provided to illustrate the difficulties in interharmonics analysis.

Scaling Laws for Mitotic Chromosomes

During mitosis in higher eukaryotes, each chromosome condenses into a pair of rod-shaped chromatids. This process is co-regulated by the activity of several gene families, and the underlying biophysics remains poorly understood. To better understand the factors regulating chromosome condensation, we compiled a database of mitotic chromosome size and DNA content from the tables and figures of >200 published papers. A comparison across vertebrate species shows that chromosome width, length and volume scale with DNA content to the powers ∼1/4, ∼1/2, and ∼1, respectively. Angiosperms (flowering plants) show a similar length scaling, so this result is not specific to vertebrates. Chromosome shape and size thus satisfy two conditions: (1) DNA content per unit volume is approximately constant and (2) the cross-sectional area increases proportionately with chromosome length. Since viscous drag forces during chromosome movement are expected to scale with length, we hypothesize that the cross-section increase is necessary to limit the occurrence of large chromosome elongations that could slow or stall mitosis. Lastly, we note that individual vertebrate karyotypes typically exhibit a wider range of chromosome lengths as compared with angiosperms

Beyond performance status

Oncologists should recognise the need to move beyond the Eastern Cooperative Oncology Group Performance Status (ECOG PS) score. ECOG PS is a longstanding and ubiquitous feature of oncology. It was evolved 40 years ago as an adaption of the 70-year-old Karnofsky performance score. It is short, easily understood and part of the global language of oncology. The wide prevalence of the ECOG PS attests to its proven utility and worth to help triage patient treatment. The ECOG PS is problematic. It is a unidimensional functional score. It is mostly physician assessed, subjective and therefore open to bias. It fails to account for multimorbidity, frailty or cognition. Too often the PS is recorded only once in wilful ignorance of a patient's changing physical state. As modern oncology offers an ever-widening array of therapies that are ‘personalised’ to tumour genotype, modern oncologists must strive to better define patient phenotype. Using a wider range of scoring and assessment tools, oncologists can identify deficits that may be reversed or steps taken to mitigate detrimental effects of treatment. These tools can function well to identify those patients who would benefit from comprehensive assessment. This overview identifies the strengths of ECOG PS but highlights the weaknesses and where these are supported by other measures. A strong recommendation is made here to move to routine use of the Clinical Frailty Score to start to triage patients and most appropriately design treatments and rehabilitation interventions

Integration of oncology and palliative care : a Lancet Oncology Commission

Full integration of oncology and palliative care relies on the specific knowledge and skills of two modes of care: the tumour-directed approach, the main focus of which is on treating the disease; and the host-directed approach, which focuses on the patient with the disease. This Commission addresses how to combine these two paradigms to achieve the best outcome of patient care. Randomised clinical trials on integration of oncology and palliative care point to health gains: improved survival and symptom control, less anxiety and depression, reduced use of futile chemotherapy at the end of life, improved family satisfaction and quality of life, and improved use of health-care resources. Early delivery of patient-directed care by specialist palliative care teams alongside tumour-directed treatment promotes patient-centred care. Systematic assessment and use of patient-reported outcomes and active patient involvement in the decisions about cancer care result in better symptom control, improved physical and mental health, and better use of health-care resources. The absence of international agreements on the content and standards of the organisation, education, and research of palliative care in oncology are major barriers to successful integration. Other barriers include the common misconception that palliative care is end-of-life care only, stigmatisation of death and dying, and insufficient infrastructure and funding. The absence of established priorities might also hinder integration more widely. This Commission proposes the use of standardised care pathways and multidisciplinary teams to promote integration of oncology and palliative care, and calls for changes at the system level to coordinate the activities of professionals, and for the development and implementation of new and improved education programmes, with the overall goal of improving patient care. Integration raises new research questions, all of which contribute to improved clinical care. When and how should palliative care be delivered? What is the optimal model for integrated care? What is the biological and clinical effect of living with advanced cancer for years after diagnosis? Successful integration must challenge the dualistic perspective of either the tumour or the host, and instead focus on a merged approach that places the patient's perspective at the centre. To succeed, integration must be anchored by management and policy makers at all levels of health care, followed by adequate resource allocation, a willingness to prioritise goals and needs, and sustained enthusiasm to help generate support for better integration. This integrated model must be reflected in international and national cancer plans, and be followed by developments of new care models, education and research programmes, all of which should be adapted to the specific cultural contexts within which they are situated. Patient-centred care should be an integrated part of oncology care independent of patient prognosis and treatment intention. To achieve this goal it must be based on changes in professional cultures and priorities in health care

Senior Thesis Proposal

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