The column densities of molecular gas across cosmic time: bridging observations and simulations

International audienceObservations of the cosmic evolution of different gas phases across time indicate a marked increase in the molecular gas mass density towards z ~ 2-3. Such a transformation implies an accompanied change in the global distribution of molecular hydrogen column densities ($N_{\rm {H_2}}$). Using observations by PHANGS-ALMA/SDSS and simulations by GRIFFIN/IllustrisTNG we explore the evolution of this H2 column density distribution function [$f(N_{\rm {H}_2})$]. The H2 (and H I) column density maps for TNG50 and TNG100 are derived in post-processing and are made available through the IllustrisTNG online API. The shape and normalization of $f(N_{\rm {H}_2})$ of individual main-sequence star-forming galaxies are correlated with the star formation rate (SFR), stellar mass (M*), and H2 mass ($M_{\rm {H}_2}$) in both observations and simulations. TNG100, combined with H2 post-processing models, broadly reproduces observations, albeit with differences in slope and normalization. Also, an analytically modelled f(N), based on exponential gas discs, matches well with the simulations. The GRIFFIN simulation gives first indications that the slope of $f(N_{\rm {H}_2})$ might not majorly differ when including non-equilibrium chemistry in simulations. The $f(N_{\rm {H}_2})$ by TNG100 implies that higher molecular gas column densities are reached at z = 3 than at z = 0. Further, denser regions contribute more to the molecular mass density at z = 3. Finally, H2 starts dominating compared to H I only at column densities above log($N_{\rm {H}_2} / \rm {cm}^{-2}) \sim 21.8\!-\!22$ at both redshifts. These results imply that neutral atomic gas is an important contributor to the overall cold gas mass found in the ISM of galaxies including at densities typical for molecular clouds at z = 0 and 3

Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells <i>in Vivo</i>

Gold nanorods are excellent contrast agents for imaging technologies which rely on near-infrared absorption such as photoacoustic imaging. For cell tracking applications, the cells of interest are labeled with the contrast agent prior to injection. However, after uptake into cells by endocytosis, the confinement and high concentration in endosomes leads to plasmon band broadening and reduced absorbance. This would limit the potential of multispectral optoacoustic tomography in terms of spectral processing and, consequently, sensitivity. Here, we show that steric hindrance provided by silica coating of the nanorods leads to the preservation of their spectral properties and improved photoacoustic sensitivity. This strategy allowed the detection and monitoring of as few as 2 × 10⁴ mesenchymal stem cells in mice over a period of 15 days with a high spatial resolution. Importantly, the silica-coated nanorods did not affect the viability or differentiation potential of the transplanted mesenchymal stem cells