42 research outputs found
Mannose-binding lectin deficiency with eosinophilic meningoencephalitis due to Angiostrongylus cantonensis in children: a case series
- Author
- AJ Dorta-Contreras
- AJ Dorta-Contreras
- AJ Dorta-Contreras
- AJ Dorta-Contreras
- Alberto J Dorta-Contreras
- B Padilla-Docal
- B Padilla-Docal
- Bárbara Padilla-Docal
- FN Frakking
- Hansotto Reiber
- Jens Christian Jensenius
- Olga Susana de Paula-Almeida
- PJ Foley
- R Sørensen
- Raisa Bu-Coifiu-Fanego
- René H Martínez-Alderete
- S Lv
- S Thiel
- S Thiel
- SL MacDonald
- V Marsán Suárez
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Introduction</p> <p>Eosinophilic meningitis, a potentially fatal disease caused by <it>Angiostrongylus cantonensis</it>, is considered an emerging infectious disease.</p> <p>Case presentation</p> <p>Three Caucasian boys (aged five-years-old, 10-years-old and six-years-old) with a diagnosis of eosinophilic meningoencephalitis caused by <it>Angiostrongylus cantonensis </it>were studied. Serum immunoglobulin A (IgA), IgM, IgG, and complements C3c and C4 levels were quantified by using an immunodiffusion technique. Immunoglobulin E in serum was quantified by nephelometry and mannose-binding lectin by time-resolved fluorometry. Mannose-binding lectin deficiency was observed in the three patients. The first patient showed a reduction in the levels of IgA and IgM and an increase in the values of IgE and C4. The second patient showed a reduction in mannose-binding lectin level with increased IgG, C4 and IgE levels, and the third patient showed a decrease in mannose-binding lectin level and increased levels of IgM and complement C3c as well as a low level of C4.</p> <p>Conclusions</p> <p>To the best of our knowledge, this is the first report of mannose-binding lectin deficiency associated with <it>Angiostrongylus cantonensis </it>meningoencephalitis in children, and it may contribute to the understanding of the participation of this component of the lectin pathway in the development of the disease.</p
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
- Author
- Abellán Javier
- Acosta-isaac René
- Aguado Jose María
- Aguilar Carlos
- Aguilera-albesa Sergio
- Ahmadi Sabbagh Abdolah
- Alba Jorge
- Albu Sergiu
- Alcalá-gallardo Karla A. M.
- Alcoba-florez Julia
- Alcolea Batres Sergio
- Algarin-lara Holmes Rafael
- Almadana Virginia
- Almeida Julia
- Almoguera Berta
- Alonso María R.
- Andreu-bernabeu Álvaro
- Antonijoan Maria Rosa
- Arana-arri Eunate
- Aranda Carlos
- Arango Celso
- Araque Carolina
- Araujo Izabel M. T.
- Araujo Nathalia K.
- Arcanjo Ana C.
- Arnaiz Ana
- Arnalich Fernández Francisco
- Arranz María J.
- Arribas López José Ramón
- Artiga Maria-jesús
- Avello-malaver Yubelly
- Ayuso Carmen
- Balagué-dobón Laura
- Baldion Ana María
- Ballina Martín Belén
- Baptista-rosas Raúl C.
- Barranco-díaz Andrea
- Barreda-sánchez María
- Barrera-penagos Viviana
- Belhassen-garcia Moncef
- Bernal Enrique
- Bernal-bello David
- Bezerra Joao F.
- Bezerra Marcos A. C.
- Blanca-lópez Natalia
- Blancas Rafael
- Boix-palop Lucía
- Borobia Alberto
- Bravo Elsa
- Brion María
- Brochado-kith Óscar
- Brugada Ramón
- Bustos Matilde
- Cabello Alfonso
- Calbo Esther
- Calderón Enrique J.
- Camacho Shirley
- Campos Marcela C.
- Carbonell Cristina
- Cardona-huerta Servando
- Carioca Antonio Augusto F.
- Carpio Segura Carlos
- Carracedo Ángel
- Carratto Thássia M. T.
- Carrillo-avila José Antonio
- Carvalho Maria C. C.
- Casasnovas Carlos
- Castaño Carlos F.
- Castaño Luis
- Castelao Jose E.
- Castellano Candalija Aranzazu
- Castillo María A.
- Cañadas Yolanda
- Ceballos Francisco C.
- Chaux Jessica G.
- Chaves-santiago Walter G.
- Chiquillo-gómez Sylena
- Cid-lópez Marco A.
- Cienfuegos-jiménez Óscar
- Conde-vicente Rosa
- Cordero-lorenzana M. Lourdes
- Corella Dolores
- Corrales Almudena
- Corton Marta
- Cortés-sánchez Jose L.
- Costa Tatiana X.
- Cruz Marina S.
- Cruz Raquel
- Cuesta Luisa
- Cunha Gabriela C. R.
- Cáceres Alejandro
- Cáceres-agra Juan J.
- Dalmau David
- Dantas-komatsu Raquel C. S.
- Darnaude M. Teresa
- De Andrés Raimundo
- De Araújo Jéssica N. G.
- De Juan Carmen
- De La Cruz Troca Juan J.
- De La Horra Carmen
- De La Hoz Ana B.
- De Martino-rodríguez Alba
- De Sousa Alves Neri Julianna Lys
- Del Campo-pérez Victor
- Delgado-cuesta Juan
- Diaz De Bustamante Aranzazu
- Dietl Beatriz
- Diz-de Almeida Silvia
- Do Monte Alves Manoella
- Domínguez-garrido Elena
- Dos Santos Katiusse A.
- Duarte Alice L.
- Díaz-caneja Covadonga M.
- Díaz-pérez Anderson
- Echave-sustaeta Jose
- Eiros Rocío
- Enciso-olivera César O.
- Escudero Gabriela
- Esko Tonu
- España Pedro Pablo
- Estigarribia Sanabria Gladys
- Fariñas María Carmen
- Fernandes Marianne R.
- Fernandez-nestosa María J.
- Fernández Martínez Yolanda
- Fernández Ramón
- Fernández Ruth
- Fernández-caballero Lidia
- Fernández-capitán Carmen
- Fernández-cruz Ana
- Fernández-ferrero Silvia
- Fernández-robelo Uxía
- Fernández-rodríguez Amanda
- Fernández-sampedro Marta
- Fernández-villa Tania
- Flores Carlos
- Flores-pérez Patricia
- Friaza Vicente
- Fuenmayor-hernández Lácides
- Fuertes-núñez Marta
- Fumadó Victoria
- Gadea Ignacio
- Gagliardi Lidia
- Gago-domínguez Manuela
- Gallego Natalia
- Galoppo Cristina
- Garcia-garcía Josefina
- García Torrejón María Carmen
- García Inés
- García Leticia
- García Mercedes
- García-cerrada Carlos
- García-de-vicuña Aitor
- García-garcía Irene
- García-ibarbia Carmen
- García-montero Andrés C.
- García-soidán Ana
- García-vázquez Elisa
- Garza-frias Emiliano
- Gentile Angela
- Gil-fournier Belén
- Gonzalez-sagrado Manuel
- Gonzalo-benito Hugo
- González Bernaldo De Quirós Fernán
- González Álvarez Beatriz
- González Juan R.
- González Juan R.
- González-montelongo Rafaela
- González-neira Anna
- González-peñas Javier
- Gorgojo-galindo Oscar
- Guaragna Florencia
- Guegel Genilson P.
- Guillén-guío Beatriz
- Guillén-navarro Encarna
- Guisado-vasco Pablo
- Gutiérrez-bautista Juan F.
- Gutiérrez-castañeda Luz D.
- Gómez Carrera Luis
- Gómez García María
- Gómez Sacristán Ángela
- Gómez-arrue Javier
- Gómez-duque Mario
- Górgolas Miguel
- Heili-frades Sara
- Hernández Estefania
- Hernández-moro Cristina
- Hernández-ortega Luis D.
- Hernández-pérez Guillermo
- Hernández-vaquero Rebeca
- Herranz M. Teresa
- Herrera María
- Herrero María José
- Herrero-gonzález Antonio
- Herráez Belén
- Horcajada Juan P.
- Imaz-ayo Natale
- Intxausti-urrutibeaskoa Maider
- Jacomo Rafael H.
- Jara Rubén
- Jiménez Pilar
- Jiménez Ángel
- Jiménez-alfaro Ignacio
- Jiménez-sousa María A.
- Jordan Iolanda
- Laguna-goya Rocío
- Laorden Daniel
- Lapunzina Pablo
- Lasa-lázaro María
- Lattig María Claudia
- Lauriente Ailen
- Liger Borja Anabel
- Llanos Lucía
- Lopez-garcia Esther
- Lopez-rodriguez Rosario
- Lorente Leonardo
- Lorenzo-salazar José M.
- Lozano José E.
- Lozano-espinosa María
- Luchessi Andre D.
- López De Heredia Miguel
- López De Heredia Miguel
- López-bernús Amparo
- López-granados Eduardo
- López-ruz Miguel A.
- Mahillo Ignacio
- Mancebo Esther
- Mar Carmen
- Marcelo Calvo Cristina
- Marcos Miguel
- Marcos-delgado Alba
- Mariscal-aguilar Pablo
- Martin-fernandez Marta
- Martin-pedraza Laura
- Martinez Amalia
- Martinez-paz Pedro
- Martín María Dolores
- Martín María M.
- Martín Vicente
- Martín-lópez Caridad
- Martín-oterino José-Ángel
- Martín-vicente María
- Martínez Juan José
- Martínez Ricardo
- Martínez Silvia
- Martínez-aquino Eleno
- Martínez-gonzález Óscar
- Martínez-lópez Iciar
- Martínez-nieto Óscar
- Martínez-pérez Ángel
- Martínez-ramas Andrea
- Martínez-reséndez Michel F.
- Martínez-robles Violeta
- Marzal Laura
- Marín-candón Alicia
- Maya Belén Rodríguez
- Mazzeu Juliana F.
- Medeiros Jeane F. P.
- Medeiros Kelliane A.
- Medrano Francisco J.
- Meijome Xose M.
- Mejuto-montero Natalia
- Mendes Ingrid
- Mendoza Charris Humberto
- Merayo Macías Eleuterio
- Mercadillo Fátima
- Mercado-sesma Arieh R.
- Molina Antonio J. J.
- Molina-roldán Elena
- Montoya Juan José
- Moraes Vitor M. S.
- Moreira-escriche Patricia
- Morelos-arnedo Xenia
- Moreno Cuerda Víctor
- Moreno Fernández Alberto
- Moreno Rocío
- Moreno-docón Antonio
- Moreno-escalante Junior
- Morilla Rubén
- Muñoz García Patricia
- Méndez-echevarría Ana
- Mínguez Pablo
- Neira Pablo
- Nevado Julián
- Nieto-gañán Israel
- Nunes Joana F. R.
- Nuñez-torres Rocío
- Obrador-hevia Antònia
- Ocejo-vinyals J. Gonzalo
- Olivar Virginia
- Oliveira Silviene F.
- Olivera María Rubio
- Ondo Lorena
- Orfao Alberto
- Ortega Luis
- Ortega-paino Eva
- Ortiz-flores Fernando
- Ortiz-lópez Rocío
- Oteo José A.
- Pacheco Manuel
- Pacheco-miranda Fredy Javier
- Padilla-conejo Irene
- Panadero-fajardo Sonia
- Parellada Mara
- Pariente-rodríguez Roberto
- Paz-artal Estela
- Peces-barba Germán
- Pedromingo Kus Miguel S.
- Perales Celia
- Perucho Teresa
- Pichardo Lisbeth A.
- Pinho Susana M. T.
- Pinsach-abuin Mel·lina
- Pinzón Luz Adriana
- Pita Guillermo
- Pla-juncà Francesc
- Planas-serra Laura
- Pompa-mera Ericka N.
- Porras-hurtado Gloria L.
- Pujol Aurora
- Pérez Alexandra
- Pérez César
- Pérez María Jazmín
- Pérez Patricia
- Pérez-de-nanclares Gustavo
- Pérez-garcía Felipe
- Pérez-jurado Luis A.
- Pérez-matute Patricia
- Pérez-tomás M. Elena
- Quevedo-chávez María Eugenia
- Quijada Maria Angeles
- Quintela Inés
- Quintela Inés
- Ramiro-león Soraya
- Rascado Sedes Pedro
- Recalde Delia
- Recio-fernández Emma
- Resino Salvador
- Riancho José A.
- Ribeiro Adriana P.
- Rivadeneira-chamorro Carlos S.
- Roa-agudelo Diana
- Robelo Pardo Montserrat
- Rodriguez Marilyn Johanna
- Rodriguez-nicolas Antonio
- Rodriguez-palmero Agustí
- Rodriguez-urrego Paula A.
- Rodríguez-artalejo Fernando
- Rodríguez-ferrer Marena
- Rodríguez-gallego Carlos
- Rodríguez-garcía José A.
- Rodríguez-hernández María A.
- Rodríguez-novoa German Ezequiel
- Rodríguez-ruiz Emilio
- Rojas-martinez Augusto
- Rojo Federico
- Romero-coronado Andrea
- Rondón-garcía Filomeno
- Rosa Lidia S.
- Rosales-castillo Antonio
- Rubio Cladelis
- Ruiz Montserrat
- Ruiz-cabello Francisco
- Ruiz-casares Eva
- Ruiz-cubillan Juan J.
- Ruiz-hornillos Javier
- Ryan Pablo
- Salamanca Hector D.
- Salazar-garcía Lorena
- Salgueiro-origlia Giorgina Gabriela
- Sancho-sainz Cristina
- Sande Esther
- Sangil Anna
- Santos Arnoldo
- Santos Ney P. C.
- Schlüter Agatha
- Scourge Cohort Group
- Segovia Sonia
- Serra-llovich Alex
- Sevil-puras Fernando
- Sevilla-porras Marta
- Sicolo Miguel A.
- Silbiger Vivian N.
- Silva Fabiola T. C.
- Silva Gabriela V.
- Silva Nayara S.
- Silván-fuentes Cristina
- Solé-violán Jordi
- Soria José Manuel
- Sorlí Jose V.
- Sousa Renata R.
- Souto Juan Carlos
- Souza Karla S. C.
- Souza Vanessa S.
- Sprockel John J.
- Suárez-rama José Javier
- Suárez-zamora David A.
- Sánchez López Antonio J.
- Sánchez Pedro-luis
- Sánchez-carpintero Abad María
- Sánchez-pablo Clara
- Sánchez-pernaute Olga
- Sánchez-prados María Concepción
- Sánchez-real Javier
- Sánchez-redondo Jorge
- Taboada-fraga Xiana
- Tamayo Eduardo
- Tamayo-velasco Alvaro
- Taracido-fernández Juan Carlos
- Tavares Nathali A. C.
- Tellería Carlos
- Tenorio-castaño Jair Antonio
- Teper Alejandro
- Torres-gutiérrez Ronald P.
- Torres-macho Juan
- Torres-tobar Lilian
- Troya Jesús
- Urioste Miguel
- Valencia-ramos Juan
- Valido Agustín
- Vargas-gallo Juan Pablo
- Varón Belén
- Vasconcelos Romero H. T.
- Vega Tomas
- Velasco-quirce Santiago
- Vidán-estévez Julia
- Vieitez-santiago Miriam
- Vilches Carlos
- Villalobos Lavinia
- Villar Felipe
- Villar-garcia Judit
- Villaverde Cristina
- Villoslada-blanco Pablo
- Virseda-berdices Ana
- Vélez-santamaría Valentina
- Víctor Virginia
- Yáñez Zuleima
- Zapatero-gaviria Antonio
- Zarate Ruth
- Zazo Sandra
- Álvarez Nuria
- Álvarez-benítez Yady
- Álvarez-navia Felipe
- Álvarez-sala Walther Rodolfo
- Íñigo-campos Antonio
- Íñiguez María
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 08/05/2024
- Field of study
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality
Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19
- Author
- Abdul Latiff Amir Hamzah
- Abdullah Baharudin
- Aberer Werner
- Abusada Nancy
- Adcock Ian
- Afani Alejandro
- Agache Ioana
- Aggelidis Xenofon
- Agustin Jenifer
- Akdis Cezmi A.
- Akdis Cezmi A.
- Akdis Mubeccel
- Al-Ahmad Mona
- Al-Zahab Bassam Abou
- Alburdan Hussam
- Aldrey-Palacios Oscar
- Alvarez Cuesta Emilio
- Alwan Salman Hiba
- Alzaabi Ashraf
- Amade Salma
- Ambrocio Gene
- Angles Rosana
- Annesi-Maesano Isabella
- Ansotegui Ignacio J.
- Anto Josep M.
- Anto Josep M.
- Ara Bardajo Paula
- Arasi Stefania
- Arrais Margarete
- Arshad Hasan
- Artesani Maria-Cristina
- Asayag Estrella
- Avolio Francesca
- Azhari Khuzama
- Bachert Claus
- Bagnasco Diego
- Baiardini Ilaria
- Bajrovic Nissera
- Bakakos Petros
- Bakeyala Mongono Sergio
- Balotro-Torres Christine
- Barba Sergio
- Barbara Cristina
- Barbosa Elsa
- Barreto Bruno
- Bartra Joan
- Basagana Xavier
- Bateman Eric D.
- Battur Lkhagvaa
- Bedbrook Anna
- Bedolla Barajas Martin
- Beghe Bianca
- Bekere Antra
- Bel Elizabeth
- Ben Kheder Ali
- Bennoor Kazi S.
- Benson Mikael
- Berghea Elena-Camelia
- Bergmann Karl-Christian
- Bernardini Roberto
- Bernstein David
- Bewick Mike
- Bialek Slawomir
- Bialoszewski Artur
- Bieber Thomas
- Billo Nils E.
- Bilo Maria-Beatrice
- Bindslev-Jensen Carsten
- Bjermer Leif
- Blain Hubert
- Blain Hubert
- Bobolea Irina
- Bochenska Marciniak Malgorzata
- Bond Christine
- Boner Attilio
- Bonini Matteo
- Bonini Sergio
- Bosnic-Anticevich Sinthia
- Bosse Isabelle
- Botskariova Sofia
- Bouchard Jacques
- Boulet Louis-Philippe
- Bourret Rodolphe
- Bousquet Jean
- Bousquet Philippe
- Braido Fulvio
- Briggs Andrew
- Brightling Christopher E.
- Brozek Jan
- Brussino Luisa
- Buhl Roland
- Bumbacea Roxana
- Buquicchio Rosalva
- Burguete Cabanas Maria-Teresa
- Bush Andrew
- Busse William W.
- Buters Jeroen
- Caballero-Fonseca Fernan
- Calderon Moises A.
- Calvo Mario
- Camargos Paulo
- Camuzat Thierry
- Canevari F. R.
- Cano Antonio
- Canonica G. Walter
- Capriles-Hulett Arnaldo
- Caraballo Luis
- Cardona Vicky
- Carlsen Kai-Hakon
- Carmona Pirez Jonas
- Caro Jorge
- Carr Warner
- Carreiro-Martins Pedro
- Carreon-Asuncion Fredelita
- Carriazo Ana-Maria
- Carrion y Ribas Carme
- Casale Thomas
- Castor Mary-Ann
- Castro Elizabeth
- Caviglia A. G.
- Cecchi Lorenzo
- Cepeda Sarabia Alfonso
- Chalubinski Maciej
- Chandrasekharan Ramanathan
- Chang Yoon-Seok
- Chato-Andeza Victoria
- Chatzi Lida
- Chatzidaki Christina
- Chavannes Niels H.
- Chaves Loureiro Claudia
- Chavez Garcia Aurora-Alejandra
- Chelninska Marta
- Chen Yuzhi
- Cheng Lei
- Chinthrajah Sharon
- Chivato Tomas
- Chkhartishvili Ekaterine
- Christoff George
- Chrystyn Henry
- Chu Derek K.
- Chua Antonio
- Chuchalin Alexander
- Chung Kian Fan
- Ciceran Alberto
- Cingi Cemal
- Ciprandi Giorgio
- Cirule Ieva
- Coelho Ana-Carla
- Compalati Enrico
- Constantinidis Jannis
- Correia de Sousa Jaime
- Costa David
- Costa Elisio Manuel
- Coste Andre
- Cottini M.
- Cox Linda
- Crisci Carlos
- Crivellaro Maria Angiola
- Cruz Alvaro A.
- Cullen John
- Custovic Adnan
- Cvetkovski Biljana
- Czarlewski Wienczyslawa
- Czarlewski Wienczyslawa
- D'Amato Gennaro
- da Silva Jane
- Dahl Ronald
- Dahlen Sven-Erik
- Daniilidis Vasilis
- Darjazini Nahhas Louei
- Darsow Ulf
- Davies Janet
- de Blay Frederic
- De Feo Giulia
- De Guia Eloisa
- de la Luz Hortensia Garcia Cruz Maria
- de la Torre Navarrete Jose-Ricardo
- de los Santos Chato
- De Manuel Keenoy Esteban
- De Vries Govert
- De Wang Yun
- del Carmen Costa Dominguez Maria
- Deleanu Diana
- Demoly Pascal
- Denburg Judah
- Devillier Philippe
- Didier Alain
- Dimic Janjic Sanja
- Dimou Maria
- Dinh-Xuan Anh Tuan
- Djukanovic Ratko
- Do Ceu Texeira Maria
- Dokic Dejan
- Dominguez Silva Margarita Gabriela
- Douagui Habib
- Douladiris Nikolaos
- Doulaptsi Maria
- Dray Gerard
- Dubakiene Ruta
- Dupas Eve
- Durham Stephen
- Duse Marzia
- Dykewicz Mark
- Ebo Didier
- Edelbaher Natalija
- Eiwegger Thomas
- Eklund Patrik
- El-Gamal Yehia
- El-Sayed Shereen S.
- El-Sayed Zeinab A.
- El-Seify Magda
- Emuzyte Regina
- Enecilla Lourdes
- Erhola Marina
- Espinoza Contreras Jesus Guillermo
- Espinoza Heidilita
- Farrell John
- Fernandez Lenora
- Fimbres Jimenez Paola
- Fink Wagner Antje
- Fiocchi Alessandro
- Fokkens Wytske J.
- Folletti Lenia
- Fonseca Joao A.
- Fonseca Susana C.
- Fontaine Jean-Francois
- Forastiere Francesco
- Fuentes Perez Jose Miguel
- Gaerlan-Resureccion Emily
- Gaga Mina
- Galvez Romero Jose Luis
- Gamkrelidze Amiran
- Garcia Cobas Cecilia Yvonne
- Garcia Alexis
- Gayraud Jacques
- Gelardi Matteo
- Gemicioglu Bilun
- Gennimata Dimitra
- Genova Sonya
- Gereda Jose
- Gerth van Wijk Roy
- Giuliano Antonio
- Gomez Rene-Maximiliano
- Gonzalez Ballester Miguel-Ange
- Gonzalez Diaz Sandra
- Gotua Maia
- Grigoreas Christos
- Grisle Ineta
- Guidacci Marta
- Guldemond Nick
- Gutter Zdenek
- Guzman Antonieta
- Haahtela Tari
- Haahtela Tari
- Halloum Ramsa
- Halpin David
- Hamelmann Eckard
- Hammadi Suleiman
- Harvey Richard
- Heffler Enrico
- Heinrich Joachim
- Hejjaoui Adnan
- Hellquist-Dahl Birthe
- Hernandez Velazquez Luiana
- Hew Mark
- Hossny Elham
- Howarth Peter
- Hrubisko Martin
- Huerta Villalobos Yunuen Rocio
- Humbert Marc
- Husain Salina
- Hyland Michael
- Iaccarino Guido
- Iaccarino Guido
- Ibrahim Moustafa
- Ilina Nataliya
- Illario Maddalena
- Incorvaia Cristoforo
- Infantino Antonio
- Irani Carla
- Ispayeva Zhanat
- Ivancevich Juan Carlos
- Jares Edgardo E. J.
- Jarvis Deborah
- Jassem Ewa
- Jenko Klemen
- Jimeneracruz Uscanga Ruben Dario
- Johnston Sebastian L.
- Joos Guy
- Jost Maja
- Julge Kaja
- Jung Ki-Suck
- Just Jocelyne
- Jutel Marek
- Kaidashev Igor
- Kalayci Omer
- Kalyoncu Fuat
- Kapsali Jeni
- Kardas Przemyslaw
- Karjalainen Jussi
- Kasala Carmela A.
- Katotomichelakis Michael
- Kavaliukaite Loreta
- Keil Thomas
- Keith Paul
- Khaitov Musa
- Khaltaev Nikolai
- Kim You-Young
- Kirenga Bruce
- Kleine-Tebbe Jorg
- Klimek Ludger
- Ko Fanny W.
- Koffi N'Goran Bernard
- Kompoti Evangelia
- Kopac Peter
- Koppelman Gerard
- Koren Jeverica Anja
- Koskinen Seppo
- Kosnik Mitja
- Kostka Tomasz
- Kostov Kosta V.
- Kowalski Marek L.
- Kralimarkova Tanya
- Kramer Vrscaj Karmen
- Kraxner Helga
- Kreft Samo
- Kritikos Vicky
- Kudlay Dmitry
- Kuitunen Mikael
- Kull Inger
- Kuna Piotr
- Kupczyk Maciej
- Kvedariene Violeta
- Kyriakakou Marialena
- Lalek Nika
- Landi Massimo
- Lane Stephen
- Larenas-Linnemann Desiree E.
- Lau Susanne
- Laune Daniel
- Lavrut Jorge
- Le Lan
- Lenzenhuber Martina
- Leo Gualtiero
- Lessa Marcus
- Levin Michael
- Li Jing
- Lieberman Philip
- Liotta Giuseppe
- Lipworth Brian
- Liu Xuandao
- Lobo Rommel
- Lodrup Carlsen Karin C.
- Lombardi Carlo
- Louis Renaud
- Loukidis Stelios
- Lourenco Olga
- Luna Pech Jorge A.
- Madjar Bojan
- Maggi Enrico
- Magnan Antoine
- Mahboub Bassam
- Mair Alpana
- Maitland van der Zee Anke-Hilse
- Makela Mika
- Makris Michael
- Malling Hans-Jorgen
- Mandajieva Mariana
- Manning Patrick
- Manousakis Manolis
- Maragoudakis Pavlos
- Marseglia Gianluigi
- Marshall Gailen
- Masjedi Mohammad Reza
- Maspero Jorge F.
- Matta Campos Juan Jose
- Maurer Marcus
- Mavale-Manuel Sandra
- Meco Cem
- Melen Erik
- Melioli Giovanni
- Melo-Gomes Elisabete
- Meltzer Eli O.
- Menditto Enrica
- Menzies-Gow Andrew
- Merk Hans
- Michel Jean-Pierre
- Micheli Yann
- Miculinic Neven
- Midao Luis
- Mihaltan Florin
- Mikos Nikolaos
- Milanese Manlio
- Milenkovic Branislava
- Mitsias Dimitrios
- Moalla Bassem
- Moda Giuliana
- Mogica Martinez Maria Dolores
- Mohammad Yousser
- Moharra Frances-Montserrat
- Moin Mostafa
- Molimard Mathieu
- Momas Isabelle
- Mommers Monique
- Monaco Alessandro
- Montefort Stephen
- Montenegro Lucia-Elvira
- Monti Riccardo
- Mora Dory
- Morais-Almeida Mario
- Mosges Ralph
- Mostafa Badr Eldin
- Mullol Joaquim
- Munter Lars
- Muraro Antonella
- Murray Ruth
- Musarra Antonio
- Mustakov Tihomir
- Naclerio Robert
- Nadeau Kari C.
- Nadif Rachel
- Nakonechna Alla
- Namazova-Baranova Leyla
- Navarro-Locsin Gretchen
- Neffen Hugo
- Nekam Kristof
- Neou Angelos
- Nettis Eustachio
- Neuberger Daniel
- Nicod Laurent
- Nicola Stefania
- Niederberger-Leppin Verena
- Niedoszytko Marek
- Nieto Antonio
- Novellino Ettore
- Nunes Elizabete
- Nyembue Dieudonne
- O'Hehir Robyn E.
- Odjakova Cvetanka
- Ohta Ken
- Okamoto Yoshitaka
- Okubo Kimi
- Oliver Brian
- Onorato Gabrielle L.
- Orru Maria Pia
- Ortiz Valeria Garcia
- Ouedraogo Solange
- Ouoba Kampadilemba
- Padilla Francisco-Javier
- Paggiaro Pier Luigi
- Pagkalos Aris
- Pajno Giovanni
- Pala Gianni
- Palaniappan S. P.
- Pali-Scholl Isabella
- Palkonen Susanna
- Palmer Stephen
- Panaitescu Bunu Carmen
- Panzner Petr
- Papadopoulos Nikos G.
- Papanikolaou Vasilis
- Papi Alberto
- Paralchev Bojidar
- Paraskevopoulos Giannis
- Park Hae-Sim
- Passalacqua Giovanni
- Patella Vincenzo
- Pavord Ian
- Pawankar Ruby
- Pedersen Soren
- Peleve Susete
- Pellegino Simona
- Pereira Ana
- Pereira Mariana
- Perez Tamara
- Perna Andrea
- Peroni Diego
- Pfaar Oliver
- Pham-Thi Nhan
- Pigearias Bernard
- Pin Isabelle
- Pinto Barnaro Sousa
- Piskou Konstantina
- Pitsios Constantinos
- Plavec Davor
- Poethig Dagmar
- Pohl Wolfgang
- Poplas Susic Antonija
- Popov Todor A.
- Portejoie Fabienne
- Potter Paul
- Poulsen Lars
- Prados-Torres Alexandra
- Prarros Fotis
- Price David
- Prokopakis Emmanuel
- Puggioni Francesca
- Puig-Domenech Elisa
- Puy Robert
- Rabe Klaus
- Rabotti Silvia
- Raciborski Filip
- Ramos Josephine
- Recalcati Cristina
- Recto Marysia T.
- Reda Shereen M.
- Regateiro Frederico S.
- Reider Norbert
- Reitsma Sietze
- Repka-Ramirez Susana
- Ridolo Erminia
- Rimmer Janet
- Rivero Yeverino Daniela
- Rizzo Jose Angelo
- Robalo-Cordeiro Carlos
- Roberts Graham
- Robles Karen
- Roche Nicolas
- Rodriguez Gonzalez Monica
- Rodriguez Zagal Erendira
- Rolla Giovanni
- Rolland Christine
- Roller-Wirnsberger Regina
- Roman Rodriguez Miguel
- Romano Antonino
- Romantowski Jan
- Rombaux Philippe
- Romualdez Joel
- Rosado-Pinto Jose
- Rosario Nelson
- Rosenwasser Lanny
- Rossi Oliviero
- Rottem Menachem
- Rouadi Philip W.
- Rovina Nikoleta
- Rozman Sinur Irma
- Ruiz Segura Lucy Tania
- Ruiz Mauricio
- Ryan Dermot
- Sagara Hironori
- Sakai Daiki
- Sakurai Daiju
- Saleh Wafaa
- Salimaki Johanna
- Samitas Konstantinos
- Samolinski Boleslaw
- Sanchez Coronel Maria Guadalupe
- Sanchez-Borges Mario
- Sanchez-Lopez Jaime
- Sansonna Melissa
- Sarafoleanu Codrut
- Sarquis Serpa Faradiba
- Sastre Joaquin
- Savi Eleonora
- Savonyte Agne
- Sawaf Bisher
- Scadding Glenis K.
- Scheire Sophie
- Schmid-Grendelmeier Peter
- Schuhl Juan Francisco
- Schunemann Holger
- Schvalbova Maria
- Schwarze Jorgen
- Scichilone Nicola
- Senna Gianenrico
- Sepulveda Cecilia
- Serrano Elie
- Shamai Sara
- Sheikh Aziz
- Sheikh Aziz
- Shields Mike
- Shishkov Vasil
- Siafakas Nikos
- Simeonov Alexander
- Simons Estelle F. E. R.
- Sisul Juan Carlos
- Sitkauskiene Brigita
- Skrindo Ingelbjorg
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- Wehner Katrin
- Wickman Magnus
- Williams Dennis
- Williams Sian
- Wilson Nicola
- Wong Gary
- Woo Kent
- Wozniak Lucyna
- Wright John
- Wroczynski Piotr
- Xepapadaki Paraskevi
- Yakovliev Plamen
- Yamaguchi Masao
- Yan Kwok
- Yap Yoke Yeow
- Yassin Mais
- Yawn Barbara
- Yiallouros Panayiotis
- Yorgancioglu Arzu
- Yoshihara Shigemi
- Young Ian
- Yusuf Osman B.
- Zaidi Asghar
- Zaitoun Fares
- Zalud Petra
- Zar Heather
- Zedda M. T.
- Zernotti Mario E.
- Zhang Luo
- Zhong Nanshan
- Zidarn Mihaela
- Zuberbier Torsten
- Zuberbier Torsten
- Zubrinich Celia
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe
Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies
- Author
- Abdul Latiff Amir Hamzah
- Abdullah Baharudin
- Aberer Werner
- Abusada Nancy
- Adcock Ian
- Afani Alejandro
- Agache Ioana
- Aggelidis Xenofon
- Agustin Jenifer
- Akdis Cezmi A.
- Akdis Cezmi A.
- Akdis Mubeccel
- Al-Ahmad Mona
- Al-Zahab Bassam Abou
- Alburdan Hussam
- Aldrey-Palacios Oscar
- Alvarez Cuesta Emilio
- Alwan Salman Hiba
- Alzaabi Ashraf
- Amade Salma
- Ambrocio Gene
- Angles Rosana
- Annesi-Maesano Isabella
- Ansotegui Ignacio J.
- Anto Josep M.
- Anto Josep M.
- Ara Bardajo Paula
- Arasi Stefania
- Arrais Margarete
- Arshad Hasan
- Artesani Maria-Cristina
- Asayag Estrella
- Avolio Francesca
- Azhari Khuzama
- Bachert Claus
- Bagnasco Diego
- Baiardini Ilaria
- Bajrovic Nissera
- Bakakos Petros
- Bakeyala Mongono Sergio
- Balotro-Torres Christine
- Barba Sergio
- Barbara Cristina
- Barbosa Elsa
- Barreto Bruno
- Bartra Joan
- Basagana Xavier
- Bateman Eric D.
- Battur Lkhagvaa
- Bedbrook Anna
- Bedolla Barajas Martin
- Beghe Bianca
- Bekere Antra
- Bel Elizabeth
- Ben Kheder Ali
- Bennoor Kazi S.
- Benson Mikael
- Berghea Elena-Camelia
- Bergmann Karl-Christian
- Bernardini Roberto
- Bernstein David
- Bewick Mike
- Bialek Slawomir
- Bialoszewski Artur
- Bieber Thomas
- Billo Nils E.
- Bilo Maria-Beatrice
- Bindslev-Jensen Carsten
- Bjermer Leif
- Blain Hubert
- Blain Hubert
- Bobolea Irina
- Bochenska Marciniak Malgorzata
- Bond Christine
- Boner Attilio
- Bonini Matteo
- Bonini Sergio
- Bosnic-Anticevich Sinthia
- Bosse Isabelle
- Botskariova Sofia
- Bouchard Jacques
- Boulet Louis-Philippe
- Bourret Rodolphe
- Bousquet Jean
- Bousquet Philippe
- Braido Fulvio
- Briggs Andrew
- Brightling Christopher E.
- Brozek Jan
- Brussino Luisa
- Buhl Roland
- Bumbacea Roxana
- Buquicchio Rosalva
- Burguete Cabanas Maria-Teresa
- Bush Andrew
- Busse William W.
- Buters Jeroen
- Caballero-Fonseca Fernan
- Calderon Moises A.
- Calvo Mario
- Camargos Paulo
- Camuzat Thierry
- Canevari F. R.
- Cano Antonio
- Canonica G. Walter
- Canonica G. Walter
- Capriles-Hulett Arnaldo
- Caraballo Luis
- Cardona Vicky
- Carlsen Kai-Hakon
- Carmona Pirez Jonas
- Caro Jorge
- Carr Warner
- Carreiro-Martins Pedro
- Carreon-Asuncion Fredelita
- Carriazo Ana-Maria
- Carrion y Ribas Carme
- Casale Thomas
- Castor Mary-Ann
- Castro Elizabeth
- Caviglia A. G.
- Cecchi Lorenzo
- Cepeda Sarabia Alfonso
- Chalubinski Maciej
- Chandrasekharan Ramanathan
- Chang Yoon-Seok
- Chato-Andeza Victoria
- Chatzi Lida
- Chatzidaki Christina
- Chavannes Niels H.
- Chaves Loureiro Claudia
- Chavez Garcia Aurora-Alejandra
- Chelninska Marta
- Chen Yuzhi
- Cheng Lei
- Chinthrajah Sharon
- Chivato Tomas
- Chkhartishvili Ekaterine
- Choi Hak-Jong
- Christoff George
- Chrystyn Henry
- Chu Derek K.
- Chua Antonio
- Chuchalin Alexander
- Chung Kian Fan
- Ciceran Alberto
- Cingi Cemal
- Ciprandi Giorgio
- Cirule Ieva
- Coelho Ana-Carla
- Compalati Enrico
- Constantinidis Jannis
- Correia de Sousa Jaime
- Costa David
- Costa Elisio Manuel
- Coste Andre
- Cottini M.
- Cox Linda
- Crisci Carlos
- Cristol Jean-Paul
- Crivellaro Maria Angiola
- Cruz Alvaro A.
- Cullen John
- Custovic Adnan
- Cvetkovski Biljana
- Czarlewski Wienczyslawa
- Czarlewski Wienczyslawa
- D'Amato Gennaro
- da Silva Jane
- Dahl Ronald
- Dahlen Sven-Erik
- Daniilidis Vasilis
- Darjazini Nahhas Louei
- Darsow Ulf
- Davies Janet
- de Blay Frederic
- De Feo Giulia
- De Guia Eloisa
- de la Luz Hortensia Garcia Cruz Maria
- de la Torre Navarrete Jose-Ricardo
- de los Santos Chato
- De Manuel Keenoy Esteban
- De Vries Govert
- De Wang Yun
- del Carmen Costa Dominguez Maria
- Deleanu Diana
- Demoly Pascal
- Denburg Judah
- Devillier Philippe
- Didier Alain
- Dimic Janjic Sanja
- Dimou Maria
- Dinh-Xuan Anh Tuan
- Djukanovic Ratko
- Do Ceu Texeira Maria
- Dokic Dejan
- Dominguez Silva Margarita Gabriela
- Douagui Habib
- Douladiris Nikolaos
- Doulaptsi Maria
- Dray Gerard
- Dubakiene Ruta
- Dupas Eve
- Durham Stephen
- Duse Marzia
- Dykewicz Mark
- Ebo Didier
- Edelbaher Natalija
- Eiwegger Thomas
- Eklund Patrik
- El-Gamal Yehia
- El-Sayed Shereen S.
- El-Sayed Zeinab A.
- El-Seify Magda
- Emuzyte Regina
- Enecilla Lourdes
- Erhola Marina
- Espinoza Contreras Jesus Guillermo
- Espinoza Heidilita
- Farrell John
- Fernandez Lenora
- Fimbres Jimenez Paola
- Fink Wagner Antje
- Fiocchi Alessandro
- Fiocchi Alessandro
- Fokkens Wytske J.
- Folletti Lenia
- Fonseca Joao A.
- Fonseca Joao A.
- Fonseca Susana C.
- Fontaine Jean-Francois
- Forastiere Francesco
- Fuentes Perez Jose Miguel
- Gaerlan-Resureccion Emily
- Gaga Mina
- Galvez Romero Jose Luis
- Gamkrelidze Amiran
- Garcia Cobas Cecilia Yvonne
- Garcia Alexis
- Gayraud Jacques
- Gelardi Matteo
- Gemicioglu Bilun
- Gennimata Dimitra
- Genova Sonya
- Gereda Jose
- Gerth van Wijk Roy
- Giuliano Antonio
- Gomez Rene-Maximiliano
- Gonzalez Ballester Miguel-Ange
- Gonzalez Diaz Sandra
- Gotua Maia
- Grigoreas Christos
- Grisle Ineta
- Guidacci Marta
- Guldemond Nick
- Gutter Zdenek
- Guzman Antonieta
- Haahtela Tari
- Haahtela Tari
- Halloum Ramsa
- Halpin David
- Hamelmann Eckard
- Hammadi Suleiman
- Harvey Richard
- Heffler Enrico
- Heinrich Joachim
- Hejjaoui Adnan
- Hellquist-Dahl Birthe
- Hernandez Velazquez Luiana
- Hew Mark
- Hossny Elham
- Howarth Peter
- Hrubisko Martin
- Huerta Villalobos Yunuen Rocio
- Humbert Marc
- Husain Salina
- Hyland Michael
- Iaccarino Guido
- Iaccarino Guido
- Ibrahim Moustafa
- Ilina Nataliya
- Illario Maddalena
- Incorvaia Cristoforo
- Infantino Antonio
- Irani Carla
- Ispayeva Zhanat
- Ivancevich Juan Carlos
- Jares Edgardo E. J.
- Jarvis Deborah
- Jassem Ewa
- Jenko Klemen
- Jimeneracruz Uscanga Ruben Dario
- Johnston Sebastian L.
- Joos Guy
- Jost Maja
- Julge Kaja
- Jung Ki-Suck
- Just Jocelyne
- Jutel Marek
- Kaidashev Igor
- Kalayci Omer
- Kalyoncu Fuat
- Kapsali Jeni
- Kardas Przemyslaw
- Karjalainen Jussi
- Kasala Carmela A.
- Katotomichelakis Michael
- Kavaliukaite Loreta
- Keil Thomas
- Keith Paul
- Khaitov Musa
- Khaltaev Nikolai
- Kim Hyun Ju
- Kim You-Young
- Kirenga Bruce
- Kleine-Tebbe Jorg
- Klimek Ludger
- Ko Fanny W.
- Koffi N'Goran Bernard
- Kompoti Evangelia
- Kopac Peter
- Koppelman Gerard
- Koren Jeverica Anja
- Koskinen Seppo
- Kosnik Mitja
- Kostka Tomasz
- Kostov Kosta V.
- Kowalski Marek L.
- Kralimarkova Tanya
- Kramer Vrscaj Karmen
- Kraxner Helga
- Kreft Samo
- Kritikos Vicky
- Kudlay Dmitry
- Kuitunen Mikael
- Kull Inger
- Kuna Piotr
- Kupczyk Maciej
- Kvedariene Violeta
- Kyriakakou Marialena
- Lalek Nika
- Landi Massimo
- Lane Stephen
- Larenas-Linnemann Desiree E.
- Lau Susanne
- Laune Daniel
- Lavrut Jorge
- Le Moing Vincent
- Le Lan
- Lenzenhuber Martina
- Leo Gualtiero
- Lessa Marcus
- Levin Michael
- Li Jing
- Lieberman Philip
- Liotta Giuseppe
- Lipworth Brian
- Liu Xuandao
- Lobo Rommel
- Lodrup Carlsen Karin C.
- Lombardi Carlo
- Louis Renaud
- Loukidis Stelios
- Lourenco Olga
- Luna Pech Jorge A.
- Madjar Bojan
- Maggi Enrico
- Magnan Antoine
- Mahboub Bassam
- Mair Alpana
- Maitland van der Zee Anke-Hilse
- Makela Mika
- Makris Michael
- Malling Hans-Jorgen
- Mandajieva Mariana
- Manning Patrick
- Manousakis Manolis
- Maragoudakis Pavlos
- Marseglia Gianluigi
- Marshall Gailen
- Martineau Adrian
- Masjedi Mohammad Reza
- Maspero Jorge F.
- Matta Campos Juan Jose
- Maurer Marcus
- Mavale-Manuel Sandra
- Meco Cem
- Melen Erik
- Melioli Giovanni
- Melo-Gomes Elisabete
- Meltzer Eli O.
- Menditto Enrica
- Menzies-Gow Andrew
- Merk Hans
- Michel Jean-Pierre
- Micheli Yann
- Miculinic Neven
- Midao Luis
- Mihaltan Florin
- Mikos Nikolaos
- Milanese Manlio
- Milenkovic Branislava
- Mitsias Dimitrios
- Moalla Bassem
- Moda Giuliana
- Mogica Martinez Maria Dolores
- Mohammad Yousser
- Moharra Frances-Montserrat
- Moin Mostafa
- Molimard Mathieu
- Momas Isabelle
- Mommers Monique
- Monaco Alessandro
- Montefort Stephen
- Montenegro Lucia-Elvira
- Monti Riccardo
- Mora Dory
- Morais-Almeida Mario
- Mosges Ralph
- Mostafa Badr Eldin
- Mullol Joaquim
- Munter Lars
- Muraro Antonella
- Murray Ruth
- Musarra Antonio
- Mustakov Tihomir
- Naclerio Robert
- Nadeau Kari C.
- Nadif Rachel
- Nakonechna Alla
- Namazova-Baranova Leyla
- Navarro-Locsin Gretchen
- Neffen Hugo
- Nekam Kristof
- Neou Angelos
- Nettis Eustachio
- Neuberger Daniel
- Nicod Laurent
- Nicola Stefania
- Niederberger-Leppin Verena
- Niedoszytko Marek
- Nieto Antonio
- Novellino Ettore
- Nunes Elizabete
- Nyembue Dieudonne
- O'Hehir Robyn E.
- Odjakova Cvetanka
- Ohta Ken
- Okamoto Yoshitaka
- Okubo Kimi
- Oliver Brian
- Onorato Gabrielle L.
- Orru Maria Pia
- Ortiz Valeria Garcia
- Ouedraogo Solange
- Ouoba Kampadilemba
- Padilla Francisco-Javier
- Paggiaro Pier Luigi
- Pagkalos Aris
- Pajno Giovanni
- Pala Gianni
- Palaniappan S. P.
- Pali-Scholl Isabella
- Palkonen Susanna
- Palmer Stephen
- Panaitescu Bunu Carmen
- Panzner Petr
- Papadopoulos Nikos G.
- Papanikolaou Vasilis
- Papi Alberto
- Paralchev Bojidar
- Paraskevopoulos Giannis
- Park Hae-Sim
- Passalacqua Giovanni
- Patella Vincenzo
- Pavord Ian
- Pawankar Ruby
- Pedersen Soren
- Peleve Susete
- Pellegino Simona
- Pereira Ana
- Pereira Mariana
- Perez Tamara
- Perna Andrea
- Peroni Diego
- Pfaar Oliver
- Pham-Thi Nhan
- Pigearias Bernard
- Pin Isabelle
- Pinto Barnaro Sousa
- Piskou Konstantina
- Pitsios Constantinos
- Plavec Davor
- Poethig Dagmar
- Pohl Wolfgang
- Poplas Susic Antonija
- Popov Todor A.
- Portejoie Fabienne
- Potter Paul
- Poulsen Lars
- Prados-Torres Alexandra
- Prarros Fotis
- Price David
- Prokopakis Emmanuel
- Puggioni Francesca
- Puig-Domenech Elisa
- Puy Robert
- Rabe Klaus
- Rabotti Silvia
- Raciborski Filip
- Ramos Josephine
- Recalcati Cristina
- Recto Marysia T.
- Reda Shereen M.
- Regateiro Frederico S.
- Reider Norbert
- Reitsma Sietze
- Repka-Ramirez Susana
- Reynes Jacques
- Ridolo Erminia
- Rimmer Janet
- Rivero Yeverino Daniela
- Rizzo Jose Angelo
- Robalo-Cordeiro Carlos
- Roberts Graham
- Robles Karen
- Roche Nicolas
- Rodriguez Gonzalez Monica
- Rodriguez Zagal Erendira
- Rolla Giovanni
- Rolland Christine
- Roller-Wirnsberger Regina
- Roman Rodriguez Miguel
- Romano Antonino
- Romantowski Jan
- Rombaux Philippe
- Romualdez Joel
- Rosado-Pinto Jose
- Rosario Nelson
- Rosenwasser Lanny
- Rossi Oliviero
- Rottem Menachem
- Rouadi Philip W.
- Rovina Nikoleta
- Rozman Sinur Irma
- Ruiz Segura Lucy Tania
- Ruiz Mauricio
- Ryan Dermot
- Sagara Hironori
- Sakai Daiki
- Sakurai Daiju
- Saleh Wafaa
- Salimaki Johanna
- Samitas Konstantinos
- Samolinski Boleslaw
- Sanchez Coronel Maria Guadalupe
- Sanchez-Borges Mario
- Sanchez-Lopez Jaime
- Sansonna Melissa
- Sarafoleanu Codrut
- Sarquis Serpa Faradiba
- Sastre Joaquin
- Savi Eleonora
- Savonyte Agne
- Sawaf Bisher
- Scadding Glenis K.
- Scheire Sophie
- Schmid-Grendelmeier Peter
- Schuhl Juan Francisco
- Schunemann Holger
- Schvalbova Maria
- Schwarze Jorgen
- Scichilone Nicola
- Senna Gianenrico
- Sepulveda Cecilia
- Serrano Elie
- Shamai Sara
- Sheikh Aziz
- Sheikh Aziz
- Shields Mike
- Shishkov Vasil
- Siafakas Nikos
- Simeonov Alexander
- Simons Estelle F. E. R.
- Sisul Juan Carlos
- Sitkauskiene Brigita
- Skrindo Ingelbjorg
- Soklic Kosak Tanja
- Sole Dirceu
- Sondermann Martin
- Sooronbaev Talant
- Soto-Martinez Manuel
- Soto-Quiros Manuel
- Sova Milan
- Soyka Michael
- Specjalski Krzysztof
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- Torres Jaen Maria-Jose
- Toskala Elina
- Tran Thien Quan Vu
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- Triller Katja
- Triller Nadja
- Tsiligianni Ioanna
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- Ulmeanu Ruxandra
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- Urrutia Pereira Marilyn
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- Valenta Rudolf
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- Van Eerd Michiel
- Van Ganse Eric
- van Hage Marianne
- Vandenplas Olivier
- Vasankari Tuula
- Vassileva Dafina
- Velasco Munoz Cesar
- Ventura Maria Teresa
- Vera-Munoz Cecilia
- Viart Frederic
- Vicheva Dilyana
- Vichyanond Pakit
- Vidal Alain
- Vidgren Petra
- Viegi Giovanni
- Vogelmeier Claus
- Von Hertzen Leena
- Vontetsianos Theodoros
- Vourdas Dimitris
- Wagenmann Martin
- Walker Samantha
- Wallace Dana
- Waserman Susan
- Wehner Katrin
- Wickman Magnus
- Williams Dennis
- Williams Sian
- Wilson Nicola
- Wong Gary
- Woo Kent
- Wozniak Lucyna
- Wright John
- Wroczynski Piotr
- Xepapadaki Paraskevi
- Yakovliev Plamen
- Yamaguchi Masao
- Yan Kwok
- Yap Yoke Yeow
- Yassin Mais
- Yawn Barbara
- Yiallouros Panayiotis
- Yorgancioglu Arzu
- Yoshihara Shigemi
- Young Ian
- Yusuf Osman B.
- Zaidi Asghar
- Zaitoun Fares
- Zalud Petra
- Zar Heather
- Zedda M. T.
- Zernotti Mario E.
- Zhang Luo
- Zhong Nanshan
- Zidarn Mihaela
- Zuberbier Torsten
- Zuberbier Torsten
- Zubrinich Celia
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity
Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world
- Author
- Abad Pedro
- Abbara Suhny
- Abbasi Taimur
- Abbott Brian
- Abdel Aziz Islam Shawky
- Abdulla Jawdat
- Abikhzer Gad
- Abohashem Shady
- Abougabal Mahasen
- Abramson Sandra
- Abrihan Paz
- Acuña Arturo Romero
- Affandi Erwin
- Afzal Muhammad Shehzad
- Agolti Mariela
- Agranovich Svetlana
- Aguadé-Bruix Santiago
- Aguero Roberto Nicolas
- Ahmed Hassan Mohamed Ismail
- Ahmed Taghreed
- Akhter Afroza
- Al Dhuhli Humoud
- Al Kindi Faiza
- Al-Abboud Tarek
- Al-Bulushi Naeema
- Al-Mallah Mouaz
- Alak Maria del Carmen
- Alam Edison
- Alaoui Nadia Ismaili
- Alasnag Mirvat
- Albadr Amjed
- Albalooshi Batool
- Albano Domenico
- Alberguina Lucia Graciela
- Albernaz Siqueira Maria Helena
- Alexanderson-Rosas Erick
- Alfaro Ana
- Ali Mohamed Mandour
- Alkadhi Hatem
- Alkandari Faridah
- Allam Adel
- Allarakha Mohammad Aaftaab
- Almeida Augusto
- Almousalli Omar
- Alongi Pierpaolo
- Alonso Omar
- Alves Togni Paulo Henrique
- Alves Wilson Furlan
- Ananthasubramaniam Karthikeyan
- Anderson Jill
- Andrade Jose Henrique
- Andrade Luciana
- Angelidis George
- Anselmi Carlos
- Ansheles Alexey
- Araújo Roberta
- Archontaki Aikaterini
- Arnone Gaspare
- Arnous Samer
- Arnson Yoav
- Arroñada Guillermo
- Arturo Harold
- Asano Hiroshi
- Ascani Sebastian Perez
- Asfour Ahmed
- Askew Jeffrey
- Assadi Majid
- Astesiano Alfredo
- Astesiano Andrea
- Attanasio Lea
- Atyani Said
- Ayala Sandra
- Ayetey Harold
- Ayodele Tolulope
- Azevedo Guilherme
- Bagatin Elisa
- Bailly Matthieu
- Baldari Sergio
- Balmer-Swain Mallory
- Bang Ji-In
- Banthia Nilesh
- Bar-Shalom Rachel
- Barette Rene
- Baric Ana
- Barneveld Peter
- Barragan Adriana Puente
- Barragan Erika
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- Baugh Dainia
- Bayer Richard R.
- Bedi Punit
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- Pospelov Viktor
- Possetti Priscila
- Poulter Rohan
- Prawiro Djoko
- Preciado-Anaya Andrés
- Preciado-Gutiérrez Óscar Ulises
- Premaratne Manuja
- Premprabha Teerapon
- Prentice Ryan
- Prior David
- Prior John O.
- Probst Stephan
- Proffit Franck
- Prpic Marina
- Pubul-Nuñez Virginia
- Pugliese Francesca
- Pujol Maria Paula
- Pulizzi Sabina
- Punda Ante
- Pursnani Amit
- Pynda Yaroslav
- Pynda Yaroslav
- Quartuccio Natale
- Quinon Alvin
- Quinta Mayra
- Rabbat Mark
- Radzinschi Alejandro
- Raggi Paolo
- Raggi Paolo
- Raimondi Gustavo
- Rajbanshi Bijoy
- Rajvong Sonexay
- Ramamurti Suresh
- Ramkumar Prasad Guntur
- Rampin Lucia
- Ramírez Nelsy Gonzalez
- Randazzo Michael
- Randazzo Michael J.
- Ranser Sara
- Rawashdeh Mohammad
- Rayo Madrid Juan Ignacio
- Redruello Marcela
- Regaieg Hamza
- Reichmuth Luise
- Repasos Evangelos
- Rey Cristina Rodríguez
- Riaz Musab
- Ricci Fabrizio
- Rich Florence
- Ridley Lloyd
- Robinson Austin
- Robles Kim
- Rocha Ricardo
- Rochela Luis
- Rodrigues Alfredo
- Rodrigues Carlos
- Rodriguez Daniel Calderon
- Rodríguez Cesar
- Rodríguez Marina
- Rodríguez Matías
- Roelants Veronique
- Rofe Christopher
- Roifman Idan
- Rojas Juan Carlos
- Romantini Leila
- Romero Romina Lorena
- Rominger Axel
- Roque Vanegas Hector Bladimir
- Rorie Mark
- Rosales Uvera Sandra Graciela
- Rossini Pierluigi
- Rostami Maryam Tajik
- Rovaletti Federico
- Rozikhodjaeva Gulnora
- Rubini Giuseppe
- Ruiz Diego
- Ruiz Joaquín
- Rumberger John
- Russell Raymond
- Russo Vincenzo
- Rutherford Natalie
- Ryzhkova Daria
- Ríos Raúl Araujo
- Rønnow Sand Niels Peter
- Saadullah Mohammad
- Sabharwal Nikant
- Sabra Philip
- Sacchetti Gian Mauro
- Sadler Diego
- Saifullina Guzaliya
- Saito Masaki
- Sakanyan Mari
- Sakata Sakata Yasushi
- Salehi Hamid
- Salobir Barbara Gužic
- Sambuceti Gianmario
- Samuel Anthony
- San Miguel Lucas
- Sanches Adelina
- Sandoval Sigelinda
- Santana Sara
- Sara da Silva Leonardo
- Sarai Masayoshi
- Saranovic Dragana Sobic
- Sarda-Mantel Laure
- Sasse Alexander
- Sato Daisuke
- Satyr Maryna
- Saunders Connor
- Saxena Sudhir
- Sayman Haluk
- Sazonova Svetlana
- Scarano Massimo
- Scarlett Luke
- Schemmer Mary
- Schmidt Erzsébet
- Schneider Roman P.
- Schoepf U. Joseph
- Schofield Rebecca
- Scholte Arthur
- Scholtens Asbjørn
- Scholtz Leonie
- Schvartzman Paulo
- Sciagrà Roberto
- Sebikali Mugisha Julius
- Sekar Ramkumar
- Sellem Ali
- Semple Thomas
- Seneviratne Sujith
- Sengupta Shantanu
- Senra Tiago
- Sereegotov Erdenechimeg
- Sergienko Vladimir
- Sergienko Vladimir
- Sevilla Ana
- Shaaban Mahmoud
- Shah Nishant
- Shah Nishant R.
- Shah Samir
- Shalev Aryeh
- Shanbhag Sujata
- Sharma Gaurav
- Sharma Naveen
- Shaw Leslee J.
- Shaw Leslee J.
- Shayani Steven
- Shetty Deepa
- Shiozaki Afonso
- Shiraishi Shinya
- Shirani Jamshid
- Shirka Ervina
- Shivaram Pushpa
- Shrestha Ganesh
- Shulman Jonathan
- Shurupova Irina
- Sierra-Galan Lilia M.
- Sierra-Galan Lilia M.
- Sigman Steven
- Silva Fábio Martins
- Simanek Milan
- Simon Mitch
- Simonsson Magnus
- Singh Bhanupriya
- Singh Santosh
- Sinitsyn Valentin
- Siqueira Cristiano
- Siu Silvia
- Slart Riemer
- Slim Ahmad
- Small Gary
- Smanio Paola
- Smith Alexandra
- Smith David
- So Young
- Soares Carlos Eduardo
- Soeriadi Erwin Affandi
- Solanki Vijay
- Solari Lucrecia
- Soldat-Stankovic Valentina
- Soli Idrissa Adamou
- Soman Prem
- Sood Aditya
- Sood Ashwani
- Sperandio Massimiliano
- Spiro Bernardo
- Srichai-Parsia Monvadi Barbara
- Stan Claudiu Adrian
- Stankovic Sinisa
- Stanton Tony
- Stavrou Petros
- Stefanelli Antonella
- Steffensen Rolf
- Strada Bruno
- Streeter James
- Strouhal Peter
- Stuart Murch
- Stubbs Michael
- Subedi Deepak
- Sueldo Claudio Pereyra
- Sun Kai
- Suwa Yoshinobu
- Swainson Ian
- Syawaluddin Hilman
- Syed Ghulam
- Szilveszter Balint
- T Albert
- Tacher Vania
- Tag Naima
- Takanami Kentaro
- Takehana Kazuya
- Taki Junichi
- Taleb Sara
- Tamaki Nagara
- Tandon Vikas
- Tang Gongshun
- Tang Jeanelle Margareth
- Taniguchi Yasuyo
- Taubman Kim
- Tawakol Ahmed
- Taylor Andrew
- Tecson Bettina
- Teragawa Hiroki
- Theng Youdaline
- Thientunyakit Tanyaluck
- Thimister Paul
- Thomas Dustin
- Thomas Paul
- Thomassen Anders
- Thompson Randall
- Thu Phyo Si
- To Andrew
- Tomas Miguel Santaularia
- Tomizawa Nobuo
- Topping William
- Torbet Tara
- Torreao Jorge
- Torres Rafael
- Traverso Sonia
- Traverzo Sonia Simona
- Trifonova Tatjana
- Trinidad Desiree
- Trivedi Adwait
- Tsujita Kenichi
- Tweed Katharine
- Udugama Chandraguptha
- Uellendahl Marly
- Ullery Shawn
- Umeji Kyoko
- Unger Steven
- Unzek Samuel
- Upton Anthony
- Uretsky Seth
- Uson Kristine Joy
- Ussov Wladimir Yurievich
- Uusitalo Valtteri
- Uy Mila
- Vajauskas Donatas
- Vakhromeeva Margarita
- Valiullina Nailya
- Vallejo Enrique
- Valles Mario
- Vallurupalli Srikanth
- Vallée Jean-Paul
- Valsamaki Pipitsa
- Vamadevan Shankar
- Van Asperen Erik-Jan
- Van De Heyning Caroline M.
- Van Gaal William
- Van Pelt Niels
- Vangu Mboyo
- Vargas Luis Salazar
- Vasquez Andres
- Vavlukis Marija
- Velez Mayra Sanchez
- Veltman Niels
- Ventroni Guido
- Vergel Damiana
- Verjans Johan
- Verma Atul
- Verma Vikas
- Verschure Derk
- Veríssimo Otávia
- Villines Todd C.
- Villines Todd C.
- Vitola Joao V.
- Vitola Joao V.
- Vondrak Andrej
- Voutnis Demetrius
- Vuuren Magritha Jv
- Várady Edit
- Vázquez Manuel Castillo
- Wagenaar Nils
- Wakabayashi Yasushi
- Waller Alfonso
- Waltrick Roberto
- Wang Ellen
- Wang Jian
- Wang Ximing
- Wang Yifan
- Wang Yining
- Wang Zhao-Qian
- Ward Parker
- Wayne Victor
- Weihmuller Juan Sebastian
- Weir-Mccall Jonathan
- Weiss Konrad
- Weissman Gaby
- Wesbey George
- White James
- White Kelly
- Williams Michelle C.
- Williams Michelle C.
- Wilson Peter
- Winchester David
- Winchester David
- Wolcan Juan
- Wolinsky David
- Won Kyoung Sook
- Wong David
- Wong Kirby
- Wu Jiang
- Wu Zhifang
- Xia Liming
- Xiao Jiangxi
- Xu Lei
- Xu Zhuoran
- Yamada Shinichiro
- Yamazaki Shinya
- Yang Youyou
- Yew Min Sen
- Yin Wu
- Yoneyama Tatsuya
- Yost Sandra
- Young Calum
- Younger John
- Younis Muhammad Numair
- Yu Jianqun
- Yuan Li
- Zaid Eed Abu
- Zakavi Seyed Rasoul
- Zapparoli Marcello
- Zavadovsky Konstantin
- Zeffiro Susana
- Zeidán Nahla
- Zerahn Bo
- Zgaljardic Michael
- Zhang Longjiang
- Zhang Tong
- Zhang Xiaoli
- Zhang Yong-Gao
- Zhu Li
- Zhuravlev Kirill
- Zoboli Stefania
- Zukotynski Katherine
- Zuluaga Alejandro
- Øvrehus Kristian Altern
- Štalc Monika
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic.
Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality.
Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States.
Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis.
Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection
Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial
- Author
- Abdel-Rahman Emaad
- Abhayaratna Walter
- Abramof Ness Rosane
- Acosta Idalia
- Adams Atoya
- Adawi Faiad
- Adler Sharon
- Ahmed Fayzal
- Aizenberg Diego
- Ajani Dilawar
- Al-Karadsheh Amer
- Albota Adrian
- Alferi Dino
- Alicic Radica
- Alla Sreedhara
- Allison D
- Almeida Edgar
- Alpizar Salazar Melchor
- Amer Joseph
- Amod Aslam
- Andrawis Nabil
- Antonio Bossi Carlo
- Antsiferov Mikhail
- Antunes Daniela
- Araki Hideo
- Arango Clara
- Arcos Edgar
- Arif Ahmed
- Arif Imrozia
- Arkhipov Mikhail
- Armaly Zaher
- Aroca Gustavo
- Asprusten Emil
- Atar Shaul
- Avila Pardo Sandro
- Awad Ahmed
- Axthelm Christoph
- Azizad Masoud
- Azizah Aziz Nor
- B Brouwer C
- Babikova Jana
- Babkin Andrey
- Badak Ozer
- Bahrami Michael
- Bajcsi Dora
- Baker John
- Bala Cornelia
- Ballesteros Rosa
- Bansal Shweta
- Barag Steven
- Barakzoy Ahmad
- Baranov Vitaliy
- Barbarash Olga
- Barbonta Hortensia
- Barney Mark
- Barre Paul
- Barrera Sandra
- Barreto Carlos
- Barreto Germ\ue1n
- Bartolacci In\ue9s
- Bashir Khalid
- Bashkin Amir
- Bastidas Adrian Miriam
- Bautista Albert
- Bautista Jose
- Bech Jesper
- Beddhu Srinivasan
- Beltr\ue1n L\uf3pez Nelly
- Ben Chetrit Sydney
- Benitez Diego
- Benjamin Sabrina
- Berar Yanay Noa
- Berenji Ramin
- Bertram Pitt
- Bertsch John
- Besada Diego
- Bhana Sindeep
- Bhargava Anuj
- Bilz Stefan
- Birkenfeld Andreas
- Birriel Jose
- Bittar Julio
- Blanco Guillermo
- Bleich David
- Boletis Ioannis
- Bondarets Iryna
- Bonora Enzo
- Bornfreund Jonathan
- Boshnyashka Radostina
- Botelho Roberto
- Botero Rodrigo
- Botsyurko Volodymyr
- Bouarich Hanane
- Brada Michal
- Brandao Ilidio
- Brar Harjeet
- Braun Hermann
- Brezina Jiri
- Brian Susan
- Brietzke Stephen
- Brito Claudia
- Bruchfeld Annette
- Bruno Giorda Carlo
- Brusco Osvaldo
- Bu Ruifang
- Bucek Petr
- Buganova Ingrid
- Burgner Anna
- Busch Klaus
- Busch Robert
- Butrymowicz Patrycja
- C Bakker R
- C\ue1rdenas Tatiana
- Caceaune Elena
- Cai Hanqing
- Calabr\uf2 Paolo
- Calero Francesca
- Canadas Rafael
- Canani Luis
- Caramori Maria
- Cardona Jose
- Cariou Bertrand
- Carlo Maggi Davide
- Carlos Palma Juan
- Carlos Prieto Juan
- Carlson Brian
- Carpio Jose
- Carvalho Rui
- Case Christopher
- Castro Cristina
- Catindig Elizabeth
- Catrinoiu Doina
- Cayli Murat
- Cereto Castro Fernando
- Cerqueira Maria
- Chahin Mariano
- Chang Chiz-Tzung
- Chantrel Fran\ue7ois
- Chen Dejun
- Chen Nan
- Chen Qinkai
- Cheng Jinluo
- Chernikova Viktoriia
- Chernin Gil
- Chernyavskaya Elena
- Chew Wong Alfredo
- Christina Nowack
- Chuang Lee-Ming
- Chung ChoonHee
- Ciechanowski Kazimierz
- Cieslik Grazyna
- Cigarr\ue1n Guldris Secundino
- Cimino Roberto
- Clavel Sylvaine
- Clodi Martin
- Cobos Jorge
- Colman Peter
- Colquhoun David
- Constantin Ciprian
- Contzen Christel
- Conway James
- Coronel Julian
- Cortes-Maisonet Gregorio
- Cortes-Maisonet Gregorio
- Cournoyer Serge
- Crawford Veronica
- Cristina Gregorini Maria
- Cruz Humberto
- Cruzado Garrit Josep
- Cure Carlos
- Curiac Dan
- Cutfield Rick
- Dandillaya Ramprasad
- Dang Cuong
- Danos Peter
- Darawsha Mahmud
- de \uc1lvaro Fernando
- de Paula Rogerio
- Deerochanawong Chaicharn
- Degenhardt Stefan
- Demko Arkadiy
- Derwahl Karl
- Dhanireddy Soni
- Din Zia
- Distiller Larry
- Dixon Bradley
- Dolores Mart\uednez Esteban M\uaa
- Donath Marc
- Donets Oleksandra
- Dong Junwu
- Dong Youping
- Doshi Ankur
- Doubel Peter
- Dreval Alexander
- Drexel Heinz
- Du Yuming
- Dumas Richard
- Dumitrescu Adriana
- Dunn Peter
- Dur\ue1n Carlos
- Duyck Francis
- Dzupina Andrej
- E Costa Fernando Teixeira
- Ebenbichler Christoph
- Ebisui Osamu
- Edelsberger Tomas
- Edin Anton
- Eduardo Figueiredo Carlos
- Eduardo Salles Joao
- Efrati Shai
- Ekinci Elif
- El Shahawy Mahfouz
- El-Shahawy Mohammed
- Elbert Alicia
- Elias Mazen
- Eliaschewitz Freddy
- Eliasson Ken
- Emdin Michele
- Engelen Wendy
- Eren Necmi
- Eriksen Erik
- Ermakova Polina
- Escalada San Mart\uedn Javier
- Escobedo de la Pe\uf1a Jorge
- Esteves Cesar
- Eugenia Canziani Maria
- Eustace Joe
- Evans John
- Faber Jens
- Fadda George
- Fang Sum Chee
- Fang Yi
- Fangh\ue4nel Salm\uf3n Guillermo
- Farah Ghassan
- Farber Evgeny
- Farooq Umar
- Fauvel Jean-Pierre
- Fernando Roland
- Fiaccadori Enrico
- Fikry Sameh
- Fink Raymond
- Finnes Trine
- Fiorina Paolo
- First Brian
- Fitz-Patrick David
- Flack John
- Fliesser-G\uf6rzer Evelyn
- Fluck Patrick
- Fogelfeld Leon
- Fonseca Vivian
- Forti Adriana
- Franek Edward
- Frank Malin
- Frias Juan
- Fujita Naruhiro
- Furuya Ryuichi
- Fushtey Ivan
- G Lieverse A
- Galcer\ue1n Josep
- Gallouj Karim
- Galphin Claude
- Galyavich Albert
- Gansevoort Ron
- Garc\ueda Hern\ue1ndez Pedro
- Garc\ueda Luis
- Garcia-Mayol Luis
- Gaysina Leyla
- Gelersztein Elizabeth
- George L Bakris
- Georgiev Dimitar
- Gerasimos Filippatos
- Giebel Thomas
- Gillard Pieter
- Giorgio Battaglia Giovanni
- Gislason Gunnar
- Glandt Mariela
- Goldstein Gary
- Goluch Richard
- Gonz\ue1lez Albarr\ue1n Olga
- Gonz\ue1lez G\ue1lvez Guillermo
- Gonz\ue1lez Gonz\ue1lez Jos\ue9
- Gonz\ue1lez Fernando
- Gonzalez Edgar
- Gonzalez-Abreu Francisco
- Gordeev Ivan
- Gore Ashwini
- Gouet Didier
- Grachova Mariia
- Grant David
- Grossman Ehud
- Guan Tianjun
- Guerci Bruno
- Guerrot Dominique
- Guia Jose
- Gul Ibrahim
- Gulakova Drahomira
- Gumprecht Janusz
- Guo Weiying
- Guron Gregor
- Gushterova Valentina
- Guti\ue9rrez Ochoa Ramiro
- Guzm\ue1n Gustavo
- H Boonstra A
- H\uf8ivik Hans
- Habwe Violet
- Hagemeier Robert
- Hagenow Andreas
- Halabi Majdi
- Haller Hermann
- Halpern Stephen
- Hamamoto Yoshiyuki
- Hamasaki Akihiro
- Hamet Pavel
- Hamilton Maxine
- Hammoud Jamal
- Handelsman Stuart
- Hangaard J\uf8rgen
- Hanna Fahmy
- Hanusch Ursula
- Hao Chuanming
- Harcsa Eleonora
- Hart Randolph
- Hartman Israel
- Hasalova Zapletalova Jitka
- Hasnul Halimi Bin Wan Hasan Wan
- Hasslacher Christoph
- Hatazaki Masahiro
- Hatunic Mensud
- Hatziagelaki Erifili
- Hayashi Terumasa
- Heigerick Glenn
- Heitor Susana
- Hellberg Olof
- Hellgren Margareta
- Henein Sam
- Hern\ue1ndez Jaras Julio
- Hern\ue1ndez Eric
- Hernandez German
- Hernandez-Cassis Carlos
- Herrera Carlos
- Higashi Takayuki
- Hirohata Yoshihide
- Hissa Miguel
- Hoffmann Michal
- Hola Olga
- Holian John
- Honkasalo Mikko
- Honkasalo Mikko
- Horacek Thomas
- Horinouchi Shuji
- Hornova Lucie
- Houdova Jana
- Hougardy Jean-Michel
- Hrmova Helena
- Humaloja Kari
- Hung Cheng-Chieh
- Hwang YouCheol
- Ibarra Jaime
- Ibern\uf3n Meritxell
- Imoto Hirofumi
- Inagaki Akemi
- Inagaki Masayuki
- Ioannidis Ioannis
- Ipatko Irina
- Iranmanesh Ali
- Irizar Santana Sa\ufal
- Isayeva Anna
- Ishii Masao
- Ishiko Tamayo
- Jackson Timothy
- Jain Mahendra
- Jamerson Kenneth
- Jansen van Rensburg Dirkie
- Jaramillo Carlos
- Jaramillo Nicol\ue1s
- Jaroslaw Pacyk Grzegorz
- Jiang Fangfang
- Jiang Ju-Ying
- Jiang Sheng
- Jinnouchi Hideaki
- Johnson Karen
- Joshi Mukesh
- Joshi Shaifali
- Juhl Claus
- Juli\ue1n Segura de la Morena Jos\ue9
- Jungmair Wolfgang
- Kahal Hassan
- Kalashnikova Marina
- Kalathil Dhanya
- Kalina Akos
- Kanai Hidetoshi
- Kananen Kristiina
- Kanda Daisuke
- Kanehara Hideo
- Kang JunGoo
- Kantola Ilkka
- Karasek David
- Karlsson Thomas
- Kashima Masayuki
- Kato Kiyoe
- Katsuki Takeshi
- Kattah William
- Kawamitsu Katsunori
- Kawasaki Satsuki
- Kayali Zeid
- Kaye William
- Kazup Szilvia
- Kelly Allan
- Keltai Katalin
- Khalimov Yuriy
- Khan Bobby
- Khan Muhammad
- Khanh Tran
- Kharait Sourabh
- Kikuchi Fumi
- Kikuchi Hidetoshi
- Kilvert Anne
- Kim HyeSoon
- Kim InJoo
- Kim JaeHyeon
- Kim SinGon
- Kirschner Robert
- Kiss Julianna
- Klein Alexandre
- Klimontov Vadim
- Kloos Christof
- Klyuchkova Neli
- Kobalava Zhanna
- Kobayashi Kunihisa
- Koch Stanley
- Koch Thorsten
- Kocyigit Ismail
- Kogut Dmytro
- Koide Junko
- Koistinen Arvo
- Komisarenko Julia
- Kooy Adriaan
- Kopecka Sarka
- Kopyt Nelson
- Korff Gary
- Korsoff Pirkko
- Kosachunhanan Natapong
- Kosmacheva Elena
- Kotzker Wayne
- Kounadi Theodora
- Kovacs Laszlo
- Kovar Richard
- Kovesdy Csaba
- Koziolova Natalya
- Kr\ufcger Thilo
- Krarup Thure
- Kravchun Nonna
- Krcova Eva
- Krebs Jeremy
- Kreit Camil
- Krekels Marielle
- Kriauciuniene Dovile
- Krishna Arvind
- Kronfli Saeed
- Krzykowska Jolanta
- Kuang Jian
- Kubota Miyuki
- Kuchar Jiri
- Kumbasar Abdulbaki
- Kurnatowska Ilona
- Kusano Yoshiro
- Kutejova Vlasta
- Kvitkova Lyudmila
- Kyriakidou Christina
- L Penne E
- L\uf3pez M\uf3nica
- L\uf6ndahl Magnus
- La Manna Gaetano
- Lahtela Jorma
- Laimer Markus
- Lakha Deepak
- Lamboy Beata
- Landa Katarzyna
- Larnefeldt Hans
- Lasiene Jurate
- Lazcano Soto Jos\ue9
- LE Meur Yannick
- Lee ByungWan
- Lee Chien-Te
- Lee Keung
- Lee Paul
- Lee WooJe
- Lei Minxiang
- Leite Jr Maurilo
- LeJeune Derek
- Lemus Brenda
- Lerman Sam
- Levashov Sergey
- Li Dongmei
- Li Hongmei
- Li Jingmei
- Li Ling
- Li Yan
- Li Yuxiu
- Li Zhonghe
- Li\ue9vano Manuel
- Liberman Alberto
- Liberty Idit
- Libis Roman
- Lim Soo
- Lindhardt Morten
- Lindholm Carl-Johan
- Linfert Douglas
- Literati-Nagy Botond
- Liu Fang
- Liu Jian
- Liu Yinghong
- Liu Yuantao
- Liu Zhihong
- Liutkus Joanne
- Long Gang
- Loong Loh Chek
- Lora Henry
- Lu Guoyuan
- Lu Weiping
- Lu Yibing
- Lubanda Hana
- Lucheva Mariya
- Ludvik Bernhard
- Luigi Cavalot Franco
- Luis M Ruilope
- Lurie Alexander
- M Barendregt J N
- M van Leendert Ruud J
- M\ue9ndez Machado Gustavo
- M\ufcller Joachim
- Ma Jianhua
- MacIsaac Richard
- Maddukuri Geetha
- Madero Rovalo Magdalena
- Madore Francois
- Madrzejewski Adam
- Madsbad Sten
- Madziarska Katarzyna
- Maeda Hajime
- Maffei Laura
- Magno Alexander
- Maia Lilia
- Makriniotou Ioanna
- Maletz Louis
- Malyar Kateryna
- Malykh Natalia
- Malyutina Sofya
- Mandayam Sreedhar
- Mandviwala Mustafa
- Mankovsky Borys
- Mann Mah Peak
- Manova Petya
- Mar\ueda Pascual Izuel Jos\ue9
- Marasaev Vyacheslav
- Mareev Vyacheslav
- Maria Veronelli Anna
- Markell Mariana
- Mart\uednez Deben Francisco
- Martin Earl
- Martinho Valdemar
- Martins Judith
- Martynenko Vladimir
- Martynyuk Liliya
- Maslyanko Vitaliy
- Matos Pedro
- Matsubayashi Sunao
- Matsumoto Kazunari
- Matsuo Yasuto
- Matsuoka Naoki
- Matyasek Ivo
- Mayfield Ronald
- Mazur Stanislaw
- Mazza Giuseppe
- Mbogua Caroline
- McCafferty Kieran
- McFarlane Philip
- McMullen Dierdre
- Mediavilla Juan
- Medina Marcelo
- Meisner Carl
- Melo Pedro
- Merai Imad
- Mesbah Rafik
- Meyer Jill
- Mich\ue1n Alfredo
- Mileder Margit
- Min Cho Young
- Mindrescu Nicoleta
- Minh Nui Nguyen
- Minkova Dotska
- Minton Stephen
- Mirasol Roberto
- Mistodie Cristina
- Mitha Essack
- Miyaoka Hiroaki
- Mkrtumyan Ashot
- Mo Zhaohui
- Mocherla Bharat
- Mohamad Masni
- Mohd Ali Norhaliza
- Mohd Izani Wan Mohamed Wan
- Mokrejsova Magdalena
- Molina Dora
- Mong Bee Yong
- Monier Arnaud
- Montero Manuel
- Moranne Olivier
- Morita Takeshi
- Mosenzon Ofri
- Moustafa Moustafa
- Murao Satoshi
- Myshanych Halyna
- Myung Yu Jae
- Nadkarni Salil
- Nagy Laszlo
- Najme Khir Rizmy
- Nakayama Mikihiro
- Nakazawa Jun
- Nakhle Samer
- Napora Piotr
- Navarro Jesus
- Navickas Antanas
- Nechaeva Galina
- Negrisanu Gabriela
- Nelson Craig
- Neudorfer Peter
- Nevarez Ruiz Luis
- Neyra Nilda
- Ngoc Nguyen Boi
- Nguyen Son Pham
- Nica Romanita
- Nicol Philip
- Nicole Mentenich
- Nielsen Joan
- Nieminen Sakari
- Nieminen Tuomo
- Nikolaev Konstantin
- Nimer Assy
- Nina Petunina
- Nirmalaraj Kingsley
- Nischik Ruth
- Niu Jianying
- Nolasco Fernando
- Nomiyama Takashi
- Nonchev Boyan
- Noori Ebrahim
- Noritake Masayuki
- Noronha Irene
- Norwood Paul
- Nowicki Michal
- Numrungroad Visal
- Nur Fatnoon Nik Ahmad Nik
- Nyirati Gabor
- O Donovan Richard
- O Keefe Dennis
- O Meara Yvonne
- Ochodnicka Zuzana
- Ocicka-Kozakiewicz Anna
- Odugbesan A
- Ogiwara Takayuki
- Oguz Aytekin
- Ohashi Hiroshi
- Okamoto Hideki
- Okenka Libor
- Oliver David
- Onaca Adriana
- Oparil Suzanne
- Osonoi Takeshi
- Ozdogan Oner
- P\ue9rez Manghi Federico
- Packham David
- Palyutin Shamil
- Pamugas Glenda
- Pang Ip Tai
- Pani Antonello
- Paoli-Bruno Jorge
- Paolino Bruno
- Papadopoulou Dorothea
- Papagianni Aikaterini
- Pape Alexia
- Paschoalin Nathalia
- Paschoalin Raphael
- Pascual Santos Julio
- Passadakis Ploumis
- Patel Rajesh
- Patel Rakesh
- Paulweber Bernhard
- Paveliu Silvia
- Pech\ue8re-Bertschi Antoinette
- Pecoits Filho Roberto
- Pedersen-Bjergaard Pedersen-Bjergaard Ulrik
- Peixoto Aldo
- Peng Ai
- Pereira Amalia
- Pereira Marcio
- Pererva Larysa
- Pergola Pablo
- Perico Norberto
- Pertseva Nataliia
- Peter Kolkhof
- Peterson Sean
- Petro Gizella
- Pettis Karlton
- Pf\ufctzner Andreas
- Phi Kon Sui
- Phuong Tran Lan
- Piatti PierMarco
- Pichmanova Mariyana
- Pimenov Leonid
- Pintilei Ella
- Pisani Antonio
- Pisoni Roberto
- Pistrosch Frank
- Poch Esteban
- Podgorski Gracjan
- Polaina Rusillo Manuel
- Ponduchi Mirela
- Pongchaiyakul Chatlert
- Ponzani Paola
- Pop Lavinia
- Popa Amorin
- Popeil Larry
- Popescu Alexandrina
- Portes Evandro
- Posada Jorge
- Poulsen Per
- Prabhakar Sharma
- Prager Rudolf
- Prakova Zhulieta
- Prazny Martin
- Precoma Dalton
- Prei f Wolfgang
- Prischl Friedrich
- Pumprla Jiri
- R Winkelmann Bernhard
- Radulian Gabriela
- Radzeviciene Lina
- Raina Rupesh
- Rajiv Agarwal
- Ramanathan Kodangudi
- Ramos L\uf3pez Gabriel
- Ramos-Gonez Luis
- Rangelov Rangel
- Ranjith Naresh
- Rashkov Rosen
- Rasmussen Ole
- Rastogi Anjay
- Ratnasingam Jeyakantha
- Rayner Brian
- Rea Rosangela
- Rechkova Elena
- Red\uf3n Josep
- Reddan Donal
- Rein-Hedin Erik
- Reisin Efrain
- Rendell Marc
- Rewerska Barbara
- Reyes Eliana
- Rheeder Paul
- Ricardo Colomar Javier
- Rice Sam
- Riella Miguel
- Rinke Andrea
- Risberg Knut
- Rocco Michael
- Rocke Jan
- Rodionova Tatyana
- Roger Simon
- Roman-Miranda Amaury
- Romero Carmen
- Romeu Hugo
- Roque Cristina
- Rosario Francisco
- Rosas Sylvia
- Rose Ludger
- Ross Dennis
- Rossing Peter
- Rothman Jeffrey
- Roussel Ronan
- Roy-Chaudhury Prabir
- Rudofsky Gottfried
- Rudolph Lance
- Ruhullah Yusuf
- Rump Lars
- Ruoff Gary
- Rusicka Teresa
- Ruxer Jan
- Rymar Oksana
- Ryu Jeffrey
- S\ue1nchez Juan Carlos
- S\ue1nchez Gregorio
- Saavedra Victor
- Sadeharju Karita
- Sahani Mandeep
- Sahin Idris
- Salda\uf1a Mendoza Arturo
- Samuels Garfield
- San Tan Ru
- Sanabria Hugo
- Sanchez William
- Santamar\ueda Olmo Rafael
- Santorelli Gennaro
- Santoro Domenico
- Sardinov Ruslan
- Sari Ramazan
- Sarvan Mohamed
- Sasaki Nobuhiro
- Satirapoj Bancha
- Sauque Reyna Leobardo
- Saxena Sanjeev
- Sch\uf6ll Norbert
- Sch\uf6nherr Hans-Robert
- Sch\ufcrholz Thomas
- Scheen Andr\ue9
- Schernthaner Gerit-Holger
- Schettler Volker
- Schiefke Ingolf
- Schlichthaar Heike
- Schneider Karoly
- Schousboe Karoline
- Schr\uf6ppel Bernd
- Schwartz Daniel
- Schwartz Doron
- Scott David
- Scott Russell
- Seco Gilberto
- Seeber Mary
- Sekigami Taiji
- Sels\ue5s Hilde
- Semenova Olga
- Serhiyenko Oleksandr
- Seron Daniel
- Serota Harvey
- Serusclat Pierre
- Shafi Tariq
- Shahid Nauman
- Shanik Michael
- Sharma Santosh
- Shen Feixia
- Shen Jiansong
- Sherenkov Alexander
- Shi Bingyin
- Shibasaki Taro
- Shibata Hirotaka
- Shinoda Junji
- Shu Daniel
- Siebert Heidi
- Sigal Helena
- Silva Ana
- Silva Gil
- Simon Judit
- Sinha Arjun
- Skokowska Ewa
- Smelser James
- Smirnov Ivan
- Smith Mark
- Smolyarchuk Elena
- Smuts Nine
- Sobajima Hiroshi
- Soe Kyaw
- Sokolova Liubov
- Solache Ortiz Gustavo
- Soln\uf8r Leidulv
- Solomon Richard
- Solovev Oleg
- Soroka Eugene
- Sosovec Dalibor
- Soto Alfonso
- Soufer Joseph
- Sourij Harald
- Soveri Inga
- Spaak Jonas
- Speeckaert Marijn
- Spodniakova Denisa
- Sritara Piyamitr
- Stanchev Pavel
- Stankiewicz Andrzej
- Stas Koen
- Steele Andrew
- Stefan D Anker
- Stefanidis Ioannis
- Stemler Lutz
- Stephenson Hugo
- Stompor Tomasz
- Stoyanovska-Elencheva Bilyana
- Strack Georg
- Strand Jorma
- Strey Christopher
- Strongin Leonid
- Stryzhak Vasyl
- Su Qing
- Suarez Rosa
- Subramanian Bala
- Sue Kirkman M
- Sugitatsu Kazuya
- Sugiura Toshiyuki
- Sugiyama Toru
- Sulosaari Sakari
- Sun Zhuxing
- Suranyi Michael
- Suzuki Daisuke
- Suzuki Masaaki
- Swift Pauline
- Szerlip Harold
- Szilagyi Iosif
- Szocs Albert
- T Luik P
- T\ue4schner Heidrun
- Tagarev Zhivko
- Tamirisa Aparna
- Tanaka Asami
- Tanaka Seiichi
- Tang Shuifu
- Tanque Maribel
- Tarng Der-Cherng
- Tavli Talat
- Tayob Mohammed
- Teitelbaum Ivor
- Tellier Guy
- Temelkova-Kurktschieva Theodora
- Temizhan Ahmet
- Tengmark Bengt-Olov
- Tennankore Karthik
- Terront M\uf3nica
- Thomson Stephen
- Thorup Frode
- Tigen Mustafa
- Tirador Louie
- Tiuryn-Petrulewicz Agnieszka
- Tobe Sheldon
- Tomanek Pavel
- Tong Nanwei
- Tonolo Giancarlo
- Topliss Duncan
- Toursarkissian Nicole
- Tran Tuan-Huy
- Treger Richard
- Trevisan Roberto
- Trokis J
- Troya Maribel
- Trujillo Freddy
- Trullenque Gretel
- Tsch\uf6pe Diethelm
- Tsoukas George
- Tsunematsu Izumi
- Tu Shih-Te
- Turcu Liana
- Turk Thomas
- Tytus Richard
- Ujihara Makoto
- Ukhanova Olga
- Ulmer Achim
- Umpierrez Guillermo
- Urbach Daniel
- Urbach Dorothea
- Urbanaviciene Egle
- Urbonas Gediminas
- Urina Miguel
- Ustundag Sedat
- Vacaru Georgeta
- Valdes Martin
- Valdez Ortiz Rafael
- Valika Shujauddin
- Vallejos Augusto
- van Buren M
- van den Born Bert-Jan
- van der Giet Markus
- VAN Gaal Luc
- VAN Hoang Lam
- van Zyl Louis
- Vanbelleghem Hilde
- Vandeleur James
- Varleta Paola
- Vasas Szilard
- Vasconcellos Eduardo
- Vasileva Svetla
- Vega Damaris
- Velaviciene Audrone
- Vencio Sergio
- Verges Bruno
- Verlan Nadezhda
- Vi\uf1es Gloria
- Vijayaraman Arutchelvam
- Vila Lobos Ana
- Villagordoa Mesa Juan
- Villegas Iv\ue1n
- Vitou Louise
- Vlad Adrian
- Vlasenko Maryna
- Vorokhobina Natalya
- Wainstein Julio
- Wainstein Julio
- Walsh Michael
- Wan Ronald Ma Ching
- Wang Hao
- Wang Jianqin
- Wang Li
- Wang Lihua
- Wang Xinjun
- Wanner Christoph
- Wasilewska Katarzyna
- Wassermann Alfredo
- Wei Jiali
- Weisnagel Stanley
- Weissman Peter
- Whaley-Connell Adam
- Wierusz-Wysocka Bogna
- Wilderman Igor
- Winston Jonathan
- Wise Jonathan
- Wittert Gary
- Wnetrzak-Michalska Renata
- Wong Yuk-Ki
- Wu Chaoqing
- Wu Mai-Szu
- Wu Ming-Ju
- Wu Tianfeng
- Wudi Krisztina
- Wuerzner Gregoire
- Wynne Katie-Jane
- Xing Changying
- Xiong Fei
- Xu Ning
- Xu Xudong
- Yagil Yoram
- Yajima Ken
- Yakhontov Davyd
- Yale Jean-Francois
- Yamada Daishiro
- Yamada Masayo
- Yamagata Kazuo
- Yamakawa Fumiko
- Yamakawa Ken
- Yamasaki Yoshimitsu
- Yambe Yuko
- Yanai Hidekatsu
- Yang Jinkui
- Yasuda Tetsuyuki
- Yenicerioglu Yavuz
- Yeung Vincent
- Yilmaz Huseyin
- Yin Aiping
- Yoncheva-Mihaylova Mariana
- Young Park Cheol
- Yuan Lee Li
- Yupanqui Hern\ue1n
- Yuryev Michael
- Zakharova Elena
- Zalevskaya Alsu
- Zanozina Olga
- Zaoui Philippe
- Zeig Steven
- Zeng Longyi
- Zhang Hao
- Zhang Yanlin
- Zhang Ying
- Zhao Zhiquan
- Zhdanova Elena
- Zheng Hongguang
- Zhong Ling
- Zhong Liyong
- Zhu Dalong
- Zhukova Larisa
- Zilahi Zsolt
- Zsom Marianna
- Zukermann Robert
- Zykova Tatyana
- Publication venue
- 'S. Karger AG'
- Publication date
- 01/01/2019
- Field of study
Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials.
Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure.
Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen.
Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049
Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study
- Author
- Liza
- - AP-HP) Bertrand Dousset (H\uf4pital Cochin
- - APHP) Anne Thomin (H\uf4pital Trousseau
- - ASST Rhodense) Carlo Corbellin (Ospedale Di Rho
- - NYU Winthrop Hospital) Amir H Sohail (NYU Langone Health
- - Xarxa Assistencial Universit\ue0ria de Manresa) Pablo Collera Ormazabal (Fundaci\uf3 Althaia
- / Columbia University Medical Center) Miriam Callahan (NewYork-Presbyterian
- 3 University Hospital) Bridget Egan (Tallaght
- 4 Lapolla Pierfrancesco
- 5 Spain: Eduardo E Rubio Susana Henriques (Hospital Garcia de Orta).
- 6 G\uf3mez Marcos
- \u2013 IRCCS Francesca Gaino (Humanitas Clinical and Research Center
- \u2013 Italy) 20089 Rozzano (MI)
- \uc1ngel Hern\ue1ndez Bartolom\ue9 Miguel
- A Aaraj Mahmoud
- A Ayeni Funbi
- A Bass Gary
- A Benson Ruth
- A Bozkurt Mehmet
- A Breen Kerry
- A Breen Kerry
- A Breen Kerry
- A Callcut Rachael
- A Chung Eric
- A Coughlin Patrick
- A de Gheldere Charles
- A De Marchi Joshua
- A Elliott Jessie
- A Fahey Brian
- A Griffiths Ewen
- A Griffiths Ewen
- A Griffiths Ewen
- A Guariglia Claudio
- A Hirji Sameer
- A Khalefa Mohamed
- A Marra (Fondazione Policlinico Universitario Agostino Gemelli) Angelo
- A Nguyen (Frankfurt University Hospital Truong
- A Olson (Duke University Medical Center) Steven
- A Raptis Dimitri
- A Rollett Rebecca
- A Saeed Samerah
- A Salama Hiba
- A Salamah Abdulrauf
- A Schnitzbauer Andreas
- A Schnitzbauer Andreas
- A Singh Aminder
- A Stevens Kent
- A Stylianides Nicholas
- A Thaha Mohamed
- A Vega (12 de Octubre University Hospital) Viviana
- A Vivas Alfredo
- A Zappa Marco
- Abate Emmanuele
- Abdalaziz (Gloucestershire Royal Hospital) Hossam
- Abdelkarim Mostafa
- Abdou Hossam
- Aboelkassem-Ibrahim Ahmad
- Abuown Ala
- Acebes-Garcia Fernando
- Acharya Metesh
- Adamina Michel
- Addae-Boateng Emmanuel
- Adolfo Pisanu (Cagliari University Hospital) Mauro Podda
- Aftab Raiyyan
- AG Moir John
- Agarwal Arnav
- AH Ibrahim Mohamed
- Aitken (Queen Elizabeth University Hospital) Emma
- Al-Azzawi Marwa
- Al-Embideen Somya
- Al-Sukaini Ahmad
- Alakaloko Felix
- Alam (Heartlands Hospital) Ruhina
- Alameer Ehab
- Alderson Derek
- Ali Mohamed Ali (Queen Elizabeth Hospital King's Lynn) Inthekab
- Aliyeva (Acibadem Mehmet Ali Aydinlar University Zumrud
- Aljanadi Firas
- Almasri Murad
- Alonso Poza (Hospital Universitario del Sureste) Alfredo
- Alonso-Ortu\uf1o Paula
- Alser Osaid
- Alser Osaid
- Alser Osaid
- Altintoprak (Sakarya University Faculty of Medicine) Fatih
- Amalina Che Bakri Nur
- Amjad Rabbia
- Anania Gabriele
- and Westminster Hospital NHS FT and Imperial College London) Chelsea
- Andabaka Tatjana
- Andrea Pisani Ceretti (ASST Santi Paolo e Carlo) Nicol\uf2 M Mariani
- Angelou Dimitrios
- Anita Volpe (New York Presbyterian Queens) Stephen Merola
- Annamalai Seethalakshmi
- Annessi Valerio
- Anthoney James
- Anuradha R Bhama (Rush University Medical Center) Alfonso Torquati
- Anwar Sibtain
- Aragon-Chamizo Juan
- Ardito Antonella
- Arigoni Michele
- Armao Teodora
- Arminio (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia) Armando
- Armstrong Lara
- Asaad Peter
- Ashcroft James
- Ashmore Christopher
- Asqalan Ahmad
- Asti (IRCCS Policlinico San Donato Emanuele
- Aubry Emmanuelle
- Aytac Erman
- Ayuso-Herrera Esther
- Azerbaijan:Elgun Samadov Joana FF Simoes (Chair). 2 Collaborators: (denotes Local Principal Investigator) Algeria: Faraj S Almaadany (\uc9tablissement Hospitalier Sp\ue9cialis\ue9 en Canc\ue9rologie - Centre Pierre-et- Marie-Curie).
- B Avellana Rocio
- B Catton Andrew
- B Fonsi Giovanni
- B Hing Caroline
- B O'Meara Lindsay
- B Schaffer Kathryn
- B Yousuf (Tobruk Medical Center) Farhat
- B\ue0mbina (Fabrizio Spaziani Hospital Fabrizio
- Bailon-Cuadrado (Hospital Universitario R\uedo Hortega) Martin
- Baldi Caterina
- Baldini Edoardo
- Baldo (Ospedale Santa Corona Stefano
- Ballabio Michele
- Baloyiannis Ioannis
- Baltazar Gerard
- Bandiera Alessandro
- Barlow Emma
- Barmasse (Ospedale Regionale Umberto Parini) Roberto
- Barmpagianni Christina
- Baronio (Policlinico San Pietro) Gianluca
- Barra Fabio
- Bartholomew's Hospital) St
- Bartsch Anne-Marie
- Basgaran Amedra
- Basha Amr
- Bashkirova (North Middlesex University Hospital) Varvara
- Bastazza Marco
- BB Sullivan (The Royal London Hospital) Tom
- Beak Philip
- Belcher Elizabeth
- Belgium: Gabrielle H van Ramshorst Sevda Jafarova (Leyla Medical Center).
- Beltr\ue1n de Heredia Juan
- Belvedere Angela
- Ben\uedtez-Linero Inmaculada
- Benjamin Franklin) Campus
- Bergeat Damien
- Bernasconi Matteo
- Bhalla Ashish
- Bhangu Aneel
- Bianco Federica
- Bisagni Pietro
- BJ Borgstein Alexander
- Blake (Southport and Formby District General Hospital) Iain
- Blanco-Colino Ruth
- Blazquez-Martin (Hospital Principe De Asturias) Alma
- Boal Matthew
- Bologna) Ausl
- Bonavina Giulia
- Bonavina Luigi
- Bond-Smith Giles
- Booth (Freeman Hospital) Karen
- Borges Filipe
- Borghi Felice
- Borja De Lacy (Hospital Clinic Barcelona) F
- Bourke Grainne
- Boyle Emily
- Brachini Gioia
- Brain Jessie
- Brar Amanpreet
- Breckles Lisa
- Brendan L Skelly (Altnagelvin Area Hospital) Catherine Rossborough
- Brianza) Carate
- Brixton Genevieve
- Bruzzaniti Placido
- Bueser Teofila
- Burnside Nathan
- C Bosanquet David
- C Brown (Manchester University NHS Foundation Trust Benjamin
- C De Souza Anthony
- C Glasbey James
- C Glasbey James
- C Hopkins James
- C Lauscher Johannes
- C McIntyre Robert
- C Mckay Siobhan
- C Neary Paul
- C Nugent III William
- C Rodriguez-Sanjuan (Marqu\ue9s de Valdecilla University Hospital) Juan
- C Roslani April
- C Tucker Sarah
- C Velmahos (Massachusetts General Hospital) George
- C Winter Stuart
- Caballero Albert
- Cairo University) Mahmoud MA Elfiky (Kasr Alainy Faculty of Medicine
- Calcerrada-Alises Enrique
- Camacho Fern\ue1ndez-Pacheco (Complejo Hospitalario Universitario Insular-Materno Infantil) Borja
- Camarero Enrique
- Campagnaro Tommaso
- Campanelli Michela
- Candiani Massimo
- Cannoletta (Royal Brompton Hospital) Marina
- Cantalejo-Diaz (Hospital Universitario Miguel Servet) Miguel
- Cao Han
- Capizzi Vita
- Carcano (Ospedale di Circolo Giulio
- Carissimi Francesca
- Carlini Massimo
- Carlos Bernal-Sprekelsen Juan
- Carlos Catal\ue1 Bauset (Consorcio Hospital General Universitario) Juan
- Carlucci Michele
- Carmela Giuffrida Maria
- Carmichael Heather
- Carrasco Milagros
- Carrillo Mariana
- Carvello Michele
- Casati Massimiliano
- Castoro Carlo
- Castro Ruiz Carolina
- Catalan Vanesa
- Catriona R Luney (Nuffield Orthopaedic Centre) Benjamin JF Dean
- Cavaleiro Salom\ue9
- Cellerino Paola
- Center Amsterdam) Cancer
- Centinaio (Ospedale Maggiore di Lodi) Giovanna
- Cernei Cristina
- Cervellera Maurizio
- Chakrabortee Sohini
- Chamberlain Stephanie
- Chan Jeffrey
- Chang Grace
- Chaudhry Daoud
- Chebaro Alexandre
- Chen (Jamaica Hospital) David
- Chetty Govind
- Chia (Royal Derby Hospital) Zoe
- Chiappini Ambra
- Chiarugi (Azienda Ospedaliero Universitaria Pisana) Massimo
- Chidambaram Swathikan
- Chiozza Matteo
- Cholewa Hanna
- Chong (Evelina London Children's Hospital) Clara
- Choolani-Bhojwani Ekta
- Christian Cotsoglou (ASST Vimercate) Stefano Granieri
- Chui Karen
- Chung Choyin
- Cirillo Bruno
- Citterio Davide
- Clermidi Pauline
- Coccolini Federico
- Colletti Gaia
- Compagnoni Bruno
- Concepci\uf3n-Mart\uedn Vanesa
- Confalonieri Marco
- Connolly Hannah
- Conso Christel
- Conti Luigi
- Cooper Zara
- Corral Javier
- Costa Marta
- Costanzi Andrea
- Cox Daniel
- Cozza Valerio
- CR Wormald Justin
- Croatia: Jakov Mihanovic Nicolas Duchateau (Heilig Hart Ziekenhuis Lier).
- CS Clough Ethan
- Cuming Tamzin
- Cuneo)
- Curtis Miles
- Cuschieri Joseph
- D Baron Ryan
- D Bosch Karen
- D Brown Oliver
- D Bueno-Ca\uf1ones Alejandro
- D Cato Liam
- D Drake Thomas
- D Jenkinson Michael
- D Jenkinson Michael
- D Liyanage Aloka S
- D Pinkney Thomas
- D Rajgor Amarkumar
- D Stewart Grant
- D Tebala Giovanni
- D'Agruma Michele
- D'Andrea Giancarlo
- D\uedaz P\ue9rez David
- D\uedaz-Garc\ueda (Hospital Universitario Nuestra Se\uf1ora de Candelaria) Alberto
- Da Roit Anna
- da Saliceto\u201d Patrizio Capelli (Ospedale \u201cG.
- Dare Oliver
- Darko Ebenezer
- Data Monitoring and Ethics Committee: Deborah S Keller H. Hunt Batjer (University of Texas Southwestern).
- Day Andrew
- De Andr\ue9s-Asenjo Beatriz
- de Medicina Facultad
- De Miguel-Ardevines Maria-Carmen
- De Nardi Paola
- De Simone Veronica
- De Toma Giorgio
- Deepti Sinha (University College London Hospital) Nicholas Kalavrezos
- Dehal (Kaiser Permanente Panorama City Medical Center) Ahmed
- Dehart Dustin
- Del Giudice Roberto
- Delgado-Oliver Eduardo
- Denmark: Henry G Smith Bernarda Bakmaz (Zadar General Hospital).
- Denning Max
- Desai Anant
- Desender (Ghent University Hospital) Liesbeth
- Dester (ASST Valcamonica Ospedale di Esine) Sara
- Di Candido Francesca
- Di Chiara Francesco
- Di Franco Gregorio
- Di Giuseppe (Ente Ospedaliero Cantonale del Canton Ticino) Matteo
- Di Saverio Salomone
- Di Saverio Salomone
- Di Saverio Salomone
- Di Saverio Salomone
- Diaz-Pe\uf1a Patricia
- Dieguez Fernandez Beatriz
- Dissemination Committee: Michel Adamina Aneel Bhangu.
- Dolores Del Toro M
- Domodossola
- Doussot Alexandre
- Duff Sarah
- Dunning Joel
- Dunstan Matt
- Duque-Mallen Victoria
- Dziakova Jana
- E Canova Michaela
- e Carle Hospital Chiara Peluso (Santa Croce
- e Carlo ASST Santi Paolo
- E Dawson Brett
- E Dickson Kathryn
- E Hudson Victoria
- E Jenny (Johns Hopkins Hospital) Hillary
- E Lewis Sophia
- E Nita George
- e Oftalmico) Giulio Iacob (Ospedale Fatebenefratelli
- E P\ue9rez-S\ue1nchez Luis
- E Rice Henry
- E Ssentongo Anna
- e Universit\ue1rio de Coimbra) Ana C Almeida (Centro Hospitalar
- E Xyda Souzana
- Edward Fitzgerald J
- EF Abbott Tom
- EF Abbott Tom
- Egan Richard
- Egypt: Mohamed El Kassas University of Copenhagen).
- El Youzouri Hanan
- El-Ali (Queen's Hospital Abess
- Elaine YL Leung (The Pan Birmingham Gynaecological Cancer Centre) Sudha Sundar
- Elfeki Hossam
- Elhadi Muhammed
- Eljareh (Aljalaa Hospital) Mohammed
- Elkadi Hannah
- Elkady Ramy
- Elkhafeefi Fatimah
- Elmore Ugo
- Elmoslemany (The Walton Centre NHS Foundation Trust) Tarek
- EM Bouhuwaish Ahmad
- EM Brathwaite Collin
- Emmerson (North Manchester General Hospital) Oliver
- Enemosah Ibrahim
- English Camilla
- English William
- Ereidge Simon
- Escartin Jorge
- Estaire-Gomez Mercedes
- EuroSurg
- Evans (Queen Elizabeth the Queen Mother Hospital Margate) Jessica
- Exley Rebecca
- F Bath Michael
- F Cunha Miguel
- F Cunha Miguel
- F Davis Niall
- F Ridgway Paul
- Fabbri Nicol\uf3
- Falco Giuseppe
- Familiari Pietro
- Fancellu (Cliniche San Pietro Alessandro
- Fanjul G\uf3mez Mar\ueda
- Farik Shebani
- Farr\ue9 Font Roser
- Farrell Tony
- Fehervari Matyas
- Fell Adam
- Fern\ue1ndez- Mart\uednez Mar\ueda
- Fern\ue1ndez-Gomez Cruzado (Hospital Urduliz) Laura
- Fern\ue1ndez-Mar\uedn Reyes
- Fernandez-Camu\uf1as Angel
- Ferrara)
- Ferrara Francesco
- Ferrari Guglielmo
- Ferrero Simone
- FF Simoes Joana
- FF Simoes Joana
- Findlay Laura
- Fiore Marco
- Fiore Marco
- Fiori Enrico
- FJ Dunne Declan
- Flatman Michael
- Flindall Ian
- Fontana (Vittorio Emanuele Tommaso
- Ford (The Robert Jones and Agnes Hunt Orthopaedic Hospital) David
- Ford Samuel
- Forlani Stefano
- Fr\ue9d\ue9ric Bretagnol (H\uf4pital Louis-Mourier - GHU AP-HP. Nord - Universit\ue9 de Paris) David Moszkowicz
- France: Zaher Lakkis Mohamed Sherief (MISR Cancer Center/MISR International Hospital).
- Francisco de Vitoria Universidad
- Francone Elisa
- Frattaruolo Colomba
- Frio (Institute of Neurological Sciences of Bologna Federico
- Frosinone)
- G Aoun Salah
- G Barranquero Alberto
- G Blazer III Dan
- G Collins Chris
- G Edwards John
- G Edwards John
- G Morton Dion
- G Povey Meical
- G Velopulos Catherine
- G Wade Ryckie
- Gabriel Kinnaman (IU Health Methodist Hospital) Ashley D Meagher
- Gagliano Annalisa
- Gagliardi Filippo
- Gahunia Sukhpreet
- Gala Tanzeela
- Galfrascoli Elisa
- Galimberti Luca
- Galindo Jara (Hospital Universitario de Torrej\uf3n Pablo
- Gallagher Phoebe
- Galleano Raffaele
- Gallo Gaetano
- Gallo Gaetano
- Gallo Gaetano
- Galv\ue1n-P\ue9rez Armando
- Gamal Amira Ibrahim Sallam
- Gammeri Emanuele
- Ganau Mario
- Garc\ue9s-Garc\ueda Ra\ufal
- Garcia Fernandez Andres
- Garcia-Conde Delgado Maria
- Garulli (Ospedale Infermi di Rimini) Gianluca
- Gascon-Ferrer Isabel
- Gattolin (Regina Montis Regalis Hospital Andrea
- Gaujoux Sebastien
- Gentilli Sergio
- Georgiades Fanourios
- Germany: Carsten Kamphues Didier Ollat (Institut Mutualiste Montsouris).
- Gerogiannis (Kingston Hospital NHS Foundation Trust) Ioannis
- Ghanbari (Homerton University Hospital) Amir
- Ghosh Dhruv
- Giacometti Marco
- Giblin Anna-Victoria
- Gilbert (Surrey and Sussex Healthcare NHS Trust) Catherine
- Gim\ue9nez Clara
- Giorgakis Emmanouil
- Gipponi Manuel
- Glen Paul
- GlobalPaedSurg GlobalSurg
- Goatly Giles
- Gobatti (San Carlo Borromeo Hospital Davide
- Godbole Chintamani
- Gohil Kajal
- Gomez-Rosado Juan-Carlos
- Gonullu Emre
- Gonzalez-De Miguel Melania
- Gonzalez-Gonzalez Enrique
- Gordini Luca
- Gracia Isabel
- Gracia-Roche Carlos
- Greece: Konstantinos Bouchagier Markus W L\uf6ffler (University Hospital Tu\u308bingen).
- Green Susanna
- Grivon Manuela
- Grove (Department of Colorectal Surgery Thomas
- Guaglio Marcello
- Guaitoli (Perrino) Eleonora
- Guglielmi Alfredo
- Guha Soumya
- Gustavino (Unit of Obstetrics and Gynecology IRCCS Ospedale Policlinico San Martino Genoa) Claudio
- Guti\ue9rrez Samaniego Mar\ueda
- H Babu Bheemanakone
- H Chowdhury Abeed
- H Davidson Giana
- H Davidson Giana
- H Davidson Giana
- H Elfallal Ahmed
- H Emile Sameh
- H Kirmani Bilal
- H Liu Helen
- H Murphy Suzanne
- H van Ramshorst Gabrielle
- H\uf6lzle Frank
- Habeeb Amir
- Hagger Robert
- Hakmi Hazim
- Halkias Constantine
- Halkias Constantine
- Hampton (Rotherham District General Hospital) Matthew
- Handa Siddhartha
- Haq Iram
- Harky (Liverpool Heart and Chest Hospital) Amer
- Harries (Morriston Hospital Rhiannon
- Harrison Joseph
- Hasan Raashad
- Hawari Mohammad
- Hawkin Paul
- Hebblethwaite Bethany
- Helier University Hospitals NHS Trust) St
- Heritage Emily
- Hernandez Garcia Miguel
- Hernandez-Juara Pilar
- Herrero-Lopez Maria
- Hervieux Erik
- Heyd Bruno
- Higgs Simon
- Hitchman (Hull University Teaching Hospitals NHS Trust) Louise
- Ho Beatrice
- Hogan Aisling
- Hospital of Varese University
- Hospital Universitario del Henares) Miguel Angel Garcia-Ure\uf1a (Universidad Francisco de Vitoria
- Hospital) Atakent
- Hospital) Wythenshawe
- Hossain Tanvir
- Houston Roy
- Hurt Libor
- HV Byrne Matthew
- i Pujol) Alba Zarate (Hospital Germans Trias
- I Roxo (Brigham and Women's Hospital) Vanessa
- I van Berge Henegouwen (Amsterdam UMC Mark
- I Alessandro Di Bartolomeo (Policlinico Umberto
- Iannone Immacolata
- Ibrahim Sherif
- Iovino Domenico
- Ireland: Arnold DK Hill Paraskevi Tourountzi (Kavala General Hospital).
- Isik Arda
- Israel: Oded Zmora Thomas M Aherne (Galway University Hospital).
- Italy: Maurizio Zizzo Nadav Kugler (Shamir Medical Center).
- J Abbott Sarah
- J Baker Olivia
- J Baldwin Alexander
- J Beamish Andrew
- J Carlos William
- J Caruana Edward
- J Caruana Edward
- J Davies Emma
- J Diaz Jose
- J Doe Matthew
- J Eardley Nicola
- J Fern\ue1ndez Antonio
- J G\uf3mez D\uedaz Carlos
- J Hainsworth Alison
- J Hall Bria
- J Holme Thomas
- J Hutchinson Peter
- J Hutchinson Peter
- J Kalkwarf Kyle
- J Lin Daniel
- J Lowery Aoife
- J McCluney Simon
- J Mehigan Brian
- J Mills Sarah
- J Pachl (Birmingham Children's Hospital) Max
- J Rogers Luke
- J Ryan \uc9anna
- J Scurrah Rachel
- J Shackcloth Michael
- J Smart Neil
- J Steinkamp Pieter
- J Tejero-Pintor Francisco
- J Thomas Amy
- J Torres Antonio
- J Warren Oliver
- J Warren Oliver
- J Williams Katherine
- James RW Hall (Stepping Hill Hospital) Claire Hall
- James's Hospital) Conor P Barry (St.
- Jamil Tahir
- Jayaraju (University Hospital of Wales) Ullas
- Jenner Edward
- JG Chase Thomas
- Jha Shane Lester (James Cook University Hospital) Madan
- Jimenez-Higuera Elisa
- Jimeno Jaime
- JM Dunne Naomi
- JM Ferguson Henry
- Jo\ue3o Lima Maria
- Johnstone Jack
- Jones Mark
- Jordan: Mahmoud Al-Masri Gela).
- JS Wall Joshua
- Judkins Nicholas
- JW Wilkin Richard
- K Abou Chaar Mohamad
- K Ambler Graeme
- K Bankhead-Kendall Brittany
- K Bankhead-Kendall Brittany
- K Bankhead-Kendall Brittany
- K Brown Allison
- K Fusai Giuseppe
- K Gill Charn
- K Kamarajah Sivesh
- K Patel Panna
- K Ubhi Harmony
- K Weerasinghe Chamindri
- K\uf6nigsrainer Alfred
- Kalidindi Venugopala
- Kamal Mona
- Kang Chong
- Kara Yasin
- Karam Edward
- Karim Ahmed
- Kashora Florence
- KC Jonker (University Medical Center Groningen (University of Groningen) Pascal
- Kearney (Beaumont Hospital) David
- Khajuria Apoorva
- Khan Azam
- Khan Umul
- Khatri Chetan
- Kinross James
- Kler Aaron
- Klimopoulos (Evangelismos General Hospital) Serafeim
- Kocata\u15f (Kanuni Sultan Suleyman Training and Research Hospital) Ali
- Kolias Angelos
- Kolias Angelos
- Kontovounisios Christos
- Kourdouli (Leicester Royal Infirmary) Amar
- Krishnan Emily
- Kristinsson Sverrir
- Kruijff Schelto
- KS Viswanath Yirupaiahgari
- Kudsk-Iversen S\uf8ren
- Kufeji Dorothy
- Kulkarni Rugved
- Kurihara Hayato
- L Biffl Walter
- L Coleman Natasha
- L Collins Michelle
- L Engel (Temple University Hospital) Jamie
- L Fowler Amy
- L Garcia Galocha Jose
- L Hughes Jane
- L J\uf6nsson (Bispebjerg Hospital Maria
- L Labib Peter
- L Marsh (Scripps Memorial Hospital) Christopher
- L McKevitt Kevin
- L Osorio Alexander
- L Romera Jose
- L Serevina Olivia
- L Venn Mary
- L Venn Mary
- L Venn Mary
- L Wright Franklin
- L Young Alastair
- L\ue1zaro Andr\ue9
- La Torre Filippo
- Laface (Ospedale Vittorio Emanuele III Letizia
- Lami Mariam
- Landaluce-Olavarria Aitor
- Laura Hansen 9
- Lawani Ismail
- Lawday (Southmead Hospital) Samuel
- Lawday Samuel
- Le Roy Bertrand
- Lecco) Asst
- Lecolle Katia
- Lederhuber Hans
- Lederhuber Hans
- Leeds)
- Leicester)
- Leventoglu Sezai
- Li Elizabeth
- Li Elizabeth
- Li Zoe
- Libya: Ghadah Z Alkadeeki Hani Al-Najjar (King Hussein Cancer Center).
- Liew Ignatius
- Ligure (SV) Pietra
- Lima Buarque Igor
- Lisi Giorgio
- Lizzi Vincenzo
- Lo Terence
- Lombardia) Regione
- Lomiento Daniele
- Longhi Marco
- Lopez Antonanzas (Hospital Clinico San Carlos Leyre
- Losada Ruiz Manuel
- Lostis Emilie
- Lostoridis Eftychios
- Loubani Mahmoud
- Lowy- Benoliel Alejandro
- Lucianetti (Papa Giovanni XXIII Hospital) Alessandro
- Luigi MP Marino Cosentino (PO San Filippo Neri - ASL ROMA 1) Andrea Sagnotta
- luis Blas Laina Juan
- Luke Evans (Norfolk and Norwich University Hospital) Mina MG Youssef
- Luke Louis
- Lunevicius Raimundas
- Luraghi Marco
- Lye George
- M Alrahawy (Menofiya University Hospital) Mahmoud
- M Andreani Stefano
- M Ashoush Fouad
- M Bajomo Oreoluwa
- M Blundell Chris
- M Cicerchia Pierfranco
- M Connolly Tara
- M Diez-Alonso Manuel
- M Dur\ue1n-Mu\uf1oz-Cruzado (Hospital Universitario Virgen del Rocio) Virginia
- M Emslie Katy
- M Harrison Ewen
- M Holbrook Charlotte
- M Isolani Simone
- M Keatley James
- M Leite-Moreira Andr\ue9
- M Mithany Reda H
- M Mohan Helen
- M Mohan Helen
- M Monteiro Joana
- M Morgom (Tripoli Central Hospital) Marwa
- M Muguerza Jose
- M Nunes Quentin
- M Nygaard Rachel
- M Omar Aneel Bhangu Omar
- M Philp Matthew
- M Pollok Joerg
- M Rooney Siobhan
- M Sampietro Gianluca
- M Sewards Joseph
- M Tang Alethea
- M Trout Isobel
- M Walters (Harborview Medical Center Andrew
- MA Kaafarani Haytham
- MA Kaafarani Haytham
- MA Kaafarani Haytham
- Maarten van Heinsbergen (VieCuri Medisch Centrum) Joop Konsten
- Mabrouk Islam
- Macchi Alberto
- MacDonald Luisa
- Machairas (Royal Free Hospital) Nikolaos
- Madonini Marco
- Madrid)
- Madrid)
- Magalh\ue3es Maia Mariana
- Magne Augestad Knut
- Magowan Drew
- Maha H Haqqani (Boston Medical Center) Frederick T Drake
- Maisonneuve Emeline
- Majkowska Agata
- Majkowski (Northern General Hospital Lawrence
- Mak (Queen Elizabeth Hospital Birmingham) Jason
- Malabarba Stefano
- Malerba Michele
- Maninder Kalkat 7
- Mannan Syed
- Manson Joanna
- Mansuri Ahmer
- Mantoglu (Sakarya University Research and Educational Hospital) Baris
- Manu Nichola
- Manzoni 56 Via
- Maqsood Afnan
- Marano Alessandra
- Marchbank Adrian
- Marcos-Santos Pablo
- Marinos Kouris (Buckinghamshire Healthcare NHS Trust) Spyros
- Marqueta De Salas Maria
- Marrano Enrico
- Mart\uedn-Rom\ue1n Lorena
- Mart\uednez P\ue9rez Carolina
- Mart\uednez-dePaz Fernando
- Martel Lozano Saida
- Martin (St Mary's Hospital) Guy
- Martin Emmeline
- Martin Janet
- Martin-Albo Lorena
- Martine Uittenbogaart (M\ue1xima Medical Center) Wouter KG Leclercq
- Martinelli Fabio
- Martinez-German Antonio
- Martinez-Pinedo Carlos
- Martins Ricardo
- Marwan Hisham
- Marzi Federica
- MAS Baig Mirza
- Mateos-Sierra (Hospital General Universitario Gregorio Mara\uf1\uf3n) Olga
- Mater Studiorum University of Bologna) Alma
- Mathieu (CHU Besan\ue7on) Pierre
- Matute-Najarro Maria-Soledad
- Maw Andrew
- Mazingi Dennis
- Mazzaferro (Fondazione IRCCS Istituto Nazionale dei Tumori Vincenzo
- McCanny (Antrim Area Hospital) Andrew
- McKenzie Katherine
- McLarty (Northumbria NHS Hospital Trust) Nicola
- McPherson Iain
- Medina Esther
- Mediratta Saniya
- Medone Marzia
- Mehra (Guy's and St Thomas\u2019 NHS Foundation Trust) Gautam
- Mele Simone
- Melero-Cort\ue9s Lidia
- Melody Baeza (Morales Meseguer University Hospital) Jos\ue9 Aguilar
- Mendon\ue7a Ata\uedde Gomes Gustavo
- Mendoza-Moreno Fernando
- Meneghini Simona
- Merate
- Mercante Giuseppe
- Merdrignac (Rennes University Hospital) Aude
- Metallidis Symeon
- Michel (Pinderfields Hospital) Martin
- Migliore Marco
- Milan)
- Milan)
- Milan)
- Miller Douglas
- Minaya- Bravo Ana
- Minaya-Bravo Ana
- Minaya-Bravo Ana
- Minaya-Bravo Ana
- Mingoli Andrea
- Minto Gary
- Mirabella Antonello
- Misra Nikhil
- Mitrasinovic Stefan
- Miu Victor
- Moawad (Royal Victoria Hospital) Nader
- Mochet Sylvie
- Modabber Ali
- Mohammad Adam
- Mohan Midhun
- Moliner-S\ue1nchez Carmen
- Mondov\uec)
- Mongelli Francesco
- Monteleone (Ospedale San Leopoldo Mandic Michela
- Montuori Mauro
- Moore Rachel
- Mora-Guzm\ue1n (Hospital Santa B\ue1rbara) Ismael
- Morales Dieter
- Morales Xavier
- Morelli Luca
- Morelli Lucia
- Morgan Richard
- Morris Chris
- Mortini Pietro
- Mosca Angelo
- Moszkowicz David
- Moszkowicz David
- Motter Dema
- Moug Susan
- Mukherjee Samrat
- Munoz Rivas Ana
- Murcia)
- N Bence Matthew
- N Hopkinson David
- N Mashbari Hassan
- N Mashbari Hassan
- N Mashbari Hassan
- N Naumann David
- N Rao Jagan
- N Townshend David
- N\ufa\uf1ez Jordi
- Najdy Manhal
- Nakas (Glenfield Hospital Apostolos
- Namazov Ilgar
- Naredla Pradyumna
- Nasef Emmhamed
- Nassa Heeam
- Nath Rahul
- Navarro-S\ue1nchez Antonio
- Nazarian (Bupa Cromwell Hospital) Scarlet
- Neal Bhutiani (University of Louisville Hospital and Norton Hospital) Robert CG Martin
- Negri Giampiero
- Nehra Deepika
- Neil-Dwyer Jason
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Neri Jacopo
- Netherlands: Suzanne S Gisbertz Mustafa R Bulugma (Zawia Teaching Hospital). Mexico: Fernando Cordera (ABC Medical Center).
- Newton (Manchester Royal Infirmary) Katy
- Nikaj (Azienda Ospedaliero Universitaria Maggiore della Carit\ue0 Herald
- Niquen Milagros
- Nobile (Azienda Ospedaliera Universitaria Integrata di Verona) Sara
- Nogueiro Jorge
- Nogues Pevidal (Royo Villanova) Ana
- Novara)
- Ntirenganya Faustin
- Nugent Michael
- O Ademuyiwa Adesoji
- O Kavanagh Dara
- O Larkin John
- Oca\uf1a Juan
- of Amsterdam University
- of Ferrara) University
- of Insubria University
- of Milan) University
- of Surgeons in Training (ASiT) Association
- of Surgery) Department
- of Washington) University
- Okafor Barbara U.
- Okechukwu Valentine
- Oliva-Mompean (Hospital Universitario Virgen Macarena) Fernando
- Oliveira Ana
- OM Abdalla Mutwakil
- Omar M Omar
- OO Ayorinde John
- Osagie-Clouard (Epsom &
- Osman (Walsall Manor Hospital) Khabab
- Ottolina Jessica
- Ourieff (Mount Sinai Hospital) Jared
- Outani Oumaima
- Oyewole Bankole
- P Arnaud Alexis
- P Arnaud Alexis
- P Arnaud Alexis
- P Baker Markus
- P Belgaumkar Ajay
- P Boddy Alexander
- P Duffy (Nottingham City Hospital) John
- P Evans Jonathan
- P Hazelton Joshua
- P Jones Andrew
- P Jones Robert
- P Joyce Doireann
- P Kisiel Aaron
- P Pezzuto Anna
- P Singh Rabindra
- P\ue9rez-Gonz\ue1lez Marta
- P\ue9rez-Saborido Baltasar
- Pacheco-Sanchez David
- Padilla-Valverde (Hospital General Universitario De Ciudad Real) David
- Pai (Hammersmith Hospital) Madhava
- Paiella Salvatore
- Paisley (Brighton and Sussex NHS Trust Samuel
- Palermo)
- Palini Gianmarco
- Palmeri Matteo
- Parente Alessandro
- Parlanti Daniele
- Parmar Chetan
- Pascual Angela
- Pata Francesco
- Pata Francesco
- Patel Mahul
- Pathak Abhijit
- Patil Sangram
- Pattyn Piet
- Peckham- Cooper Adam
- Pedram Panahi (University Hospitals Plymouth NHS Trust) Mariam Rela
- Pedrazzani Corrado
- Pellino Gianluca
- Pereira Andr\ue9
- Pereira-Neves Ant\uf3nio
- Perez-Diaz Md
- Perivoliotis (General University Hospital of Larissa) Konstantinos
- Perkins Clare
- Perotto (CHU Saint Etienne) Ornella
- Perra Teresa
- Petrone Patrizio
- Phenix George
- Piacenza)
- Picazo Sara
- Picon-Rodriguez Rafael
- Piloni Martina
- Pingarr\uf3n-Mart\uedn Lorena
- Pinotti Enrico
- Pizzini Paolo
- PM de Vries Jean-Paul
- Pockney Peter
- Podolsky Dina
- Poggioli Gilberto
- Pompili Cecilia
- Pontari Michael
- Porcu Alberto
- Portugal: Hugo Santos-Sousa Pakistan: Mariyah Anwer (Jinnah postgraduate medical center).
- Potter (Royal Bournemouth Hospital) Ryan
- Price Claire
- Prita Daliya 8
- Pruvot (Lille University Hospital) Fran\ue7ois-Ren\ue9
- PTSurg ItSURG
- Pujol-Muncunill Roger
- Puppo Andrea
- Q Mehdi (University of Texas Medical Branch) Mohammad
- Quante Markus
- Quintana-Villamandos Bego\uf1a
- Qureshi Ali
- R Burke Joshua
- R Davidson Brian
- R Dixon Jan
- R Fretwell Kenneth
- R Gujjuri Rohan
- R Gujjuri Rohan
- R Kowal Mikolaj
- R O\u2019Neill John
- R Sarma Diwakar
- R Spalding Duncan
- R Springford Laurie
- Rachel Baumber (Royal National Orthopaedic Hospital) James T Parry
- Radenkovic Dejan
- Rahman Saad (Medway Maritime Hospital) Abdel
- Rakvin Ivan
- Ramallo-Sol\ueds Irene
- Ramcharan Sean
- Ramos Diego
- Ramos-Bonilla Antonio
- Ramos-De la Medina Antonio
- Ramzi Joussi
- Rathinam Sridhar
- Rausa Emanuele
- Ravaioli Matteo
- Ravindran Sharanya
- Raymond (Royal Lancaster Infirmary) Thomas
- Razik Aisha
- Redfern (Furness General Hospital) Jennifer
- Reguera-Rosal Julio
- Rey-Biel Juan
- Rey-Valcarcel Cristina
- RG Sheel Andrea
- Ribolla Marta
- Richards Tomos
- Richmond (University of Maryland Medical Center) Michael
- Righini (Ospedale del Delta Erminio
- Rio-Gomez Javier
- Riuniti Villa Sofia-Cervello Ospedali
- Riyat Harjoat
- Rizvi Sana
- Roberts Keith
- Roberts Matthew
- Robertson (University Hospitals Coventry and Warwickshire) Stuart
- Robertson (University of Arkansas for Medical Sciences) Ronald
- Robin-Valle Alvaro
- Rochon Melissa
- Rojo Mikel
- Rolli Luigi
- Romano Silvio
- Rome)
- Romford)
- Ross Elizabeth
- Ross Howard
- Rottoli Matteo
- Royal Hospital) Princess
- Ruiz (Hospital General Universitario Reina Sof\ueda Miguel
- Ruiz- Grande Fernando
- Ruiz-Martin (Rey Juan Carlos University Hospital) Irene
- Ruiz-Soriano (Hospital Cl\uednico Universitario de Valladolid) Mar\ueda
- Ruzzenente Andrea
- Ryska Ondrej
- S Abdelaal (Alexandria Main University Hospital) Ahmed
- S Al Maadany Faraj
- S Faria Carlos
- S Hammond John
- S Hossain Fahad
- S Jeyaretna Deva
- S Jones Conor
- S Khan (Queen Alexandra Hospital) Jim
- S Moura Francisco
- S Ng-Kamstra Joshua
- S Sica Giuseppe
- S Tamimy Muhammad
- S Wadley Martin
- S\ue1nchez- Arteaga Alejandro
- SA Taher Ahmed
- Saez Carlos
- Sahnan Kapil
- Sahni Arun
- Salim Ali
- Salvia Roberto
- Sammarco Giuseppe
- Sampaio-Alves Mafalda
- San Miguel-Mendez Carlos
- Sanchez del Pueblo Cristina
- Sanchez-Fuentes Maria-Nieves
- Sanchez-Pelaez Daniel
- Sanchez-Perez Coral
- Sanchez-Rubio Maria
- Sancho-Muriel Jorge
- Sanchon Fructuoso Lorena
- Sanders Julie
- Santero-Ramirez Maria-Pilar
- Santora Thomas
- Santoro Antonio
- Santos Irene
- Sapienza Paolo
- Sartarelli (Sant\u2019Orsola Hospital Lodovico
- Sarveswaran Janahan
- Sasia Diego
- Sassari) A. O. U.
- Saudemont Alain
- Saudi-Moro Sef
- Saxena Dolly
- Saxena Shobhit
- Sayasneh Ahmad
- Scalabre Aurelien
- Schache Andrew
- Schiavina Riccardo
- Schineis (Charit\ue9 University Medicine Christian
- Schreckenbach Teresa
- Scorza Antonella
- Scott Lucy
- Seegert (ProMedica Toledo Hospital) Sara
- Seguin-Givelet Agathe
- Senent-Boza Ana
- Serrano Gonz\ue1lez Javier
- Sette Laghi Asst
- Seymour Keith
- Shabana Amanda
- Shah (The Whittington Hospital) Sujay
- Shah Jigar
- Shah Karishma
- Shah Preena
- Shakir Taner
- Shalaby (Mansoura University Hospital) Mostafa
- Shankar (Oxford University Hospitals NHS Foundation Trust Sushma
- Shaw Richard
- Sheffield)
- Shehata Sameh
- Shelley Hwang E.
- Shen Ban Vin
- Shenfine Amy
- Sheridan Kelda
- Sherief Ahmed
- Sherif Mohamed
- Shinkwin Michael
- Shu Sebastian
- Siaw-Acheampong Kwabena
- Sileri (San Raffaele Scientific Institute Pierpaolo
- Singh Abhinav
- Singh Shailendra
- Sinha Sanjay
- Siragusa (Policlinico Tor Vergata Hospital Leandro
- Sivaprakasam Rajesh
- Sivayoganathan Sriharan
- SJ Ledesma Frances
- Smillie Robert
- Smith (Countess of Chester Hospital) Claire
- Smith Andrew
- Smith Christopher
- Sochorova (Royal Liverpool University Hospital) Dana
- Society of Coloproctology (ESCP) European
- Society of Colorectal Surgery (SICCR) Italian
- Soggiu Fiammetta
- Sohrabi (St Bartholomew's Hospital) Catrin
- Sohrabi (Whipps Cross University Hospital) Catrin
- Sohrabi Catrin
- Solari (Royal Gwent Hospital) Francesca
- Solli Piergiorgio
- Soreide Kjetil
- Soto Montesinos Cristina
- SpainSurg
- Spinelli Antonino
- Spinelli Antonino
- Spoletini (Sant'Eugenio Hospital) Domenico
- Spriano Giuseppe
- Sravanam Sanskrithi
- Ssentongo (Pennsylvania State University) Paddy
- Stanger Sophie
- Stavroulias Dionisios
- Steel (Sunderland Royal Hospital) Ben
- Stella Marco
- Stewart Robbie
- Stringer Sally
- Sudan: Osman M Ali Elima P Cagigal- Ortega (Hospital Universitario Severo Ochoa).
- Sulen Nina
- Sundar Sudha
- Sundhu (Aintree University Hospital) Matthew
- Surgical Research Collaborative (ISRC) Irish
- Suri (University of California Davis Health Avni
- Swansea)
- Switzerland: Dimitri Christoforidis Ali A Ali karar (Al-rajhi).
- Syed Arooj
- Szatmary Peter
- T Colonna Emily
- T Enjuto Diego
- T Montella (Azienda Unit\ue0 Sanitaria Locale-IRCCS di Reggio Emilia) Maria
- TA Neely David
- Tabiri Stephen
- Tadross Daniel
- Taglietti Lucio
- Tansey (Princess Alexandra Hospital) Rosamond
- Tartaglia Dario
- Tawheed (Endemic Medicine Department Ahmed
- Tayeh Salim
- Testa Valentina
- Tewari Nilanjana
- Thoenissen Philipp
- Thomas (Worcestershire Acute Hospitals NHS Trust) Kane
- Thrush Jessica
- Tierney Sean
- Tiwari Abhinav
- Tobias Teles (Hospital de Cascais - Dr. Jos\ue9 de Almeida) Pedro A Serralheiro
- Toledo Enrique
- Tonini Valeria
- Torkington Jared
- Torzilli Guido
- Totty Joshua
- Tousidonis Manuel
- Townend Philip
- Townsend Catherine
- Trompeter (St George's Hospital) Alex
- Trotta Francesco
- Truant St\ue9phanie
- Trujillo-D\uedaz Jeancarlos
- Tsoulfas George
- Tsoulfas Georgios
- Turco Celia
- Turkey: Volkan Ozben Georgios Peros (Kantonsspital Winterthur).
- Turrado- Rodriguez Victor
- Turri Giulia
- Tustin (Cumberland Infirmary) Harry
- Tyler Jayne
- Tzedakis Stylianos
- Tzovaras George
- Ullah Ramzan
- Unit\ue0 Sanitaria Locale di Ferrara Azienda
- United Kingdom: Richard J Davies Alp Yildiz (Yildirim Beyazit University Yenimahalle Training and Research Hospital).
- United States: John RT Monson (AdventHealth Orlando) Lavinia Onos (York Teaching Hospitals NHS Trust).
- University Hospitals NHS Trust) Nottingham
- University of Rome) Sapienza
- University) Goethe
- University) Helwan
- Urban (University of Colorado Hospital) Shane
- Urbani (Azienda Ospedaliero Universitaria San'Anna Alessia
- Usai Antonella
- V Bhavaraju Avi
- V Comini Lara
- V Feo Carlo
- V Marino Marco
- V Shaw Abigail
- V\ue1zquez- Fern\ue1ndez Andrea
- Vaccarella (Azienda Ospedaliera Gianpaolo
- Valdes- Hernandez Javier
- Valsecchi Luca
- Vashisht Rajiv
- VCO) Asl
- Venkatesan (Glan Clwyd Hospital) Gowtham
- Vera-Mansilla Cristina
- Vergari (Ospedali Riuniti di Ancona) Roberto
- Vescio (University 'Magna Graecia' of Catanzaro) Giuseppina
- Vidya Raghavan
- Vieira (Centro Hospital Universit\ue1rio S\ue3oJo\ue3o) Paula
- Vijay Vardhini
- Vimalachandran Dale
- Vimalachandran Dale
- Violante Tommaso
- Vovola Fernanda
- Vulliamy Paul
- W Endorf (Hennepin Healthcare) Frederick
- W Etchill Eric
- W L\uf6ffler Markus
- W L\uf6ffler Markus
- Wall Rosemary
- Wallwork Kate
- Ward Alex
- Warwick (University Hospital Southampton) David
- Waseem Saima
- Weaver Helen
- Wells Fiona
- Wen Jiaxin
- West Raha
- Whitehall Emma
- Wild Laura
- Wilkins Alex
- Williams Gethin
- Williams Matthew
- Winnand (University Hospital Aachen) Philipp
- Wong (Addenbrooke's Hospital) Ken
- Worku (Queen\u2019s Medical Centre Dawit
- Wright Naomi
- WS Ho (Leeds Teaching Hospitals NHS Trust Michael
- WT Ngu Albert
- y Cajal) Cristina Cerro (Hospital Universitario Ram\uf3n
- Y Oo (Department of Cardiothoracic Surgery Aung
- y Polit\ue9cnico La Fe) Blas Flor (Hospital Universitario
- Y van der Plas Willemijn
- Yalamanchili Seema
- Yershov (South Warwickshire NHS Foundation Trust) Danylo
- Young Richard
- Yousra Ahmed (Portsmouth Hospital NHS Trust) Simon Toh
- Yurttas Can
- Zadegan Frederic
- Zafar (Northwick Park Hospital) Noman
- Zakaria Rasheed
- Zambon Martina
- Zanini Nicola
- ZE Durst Alexander
- Zerbib Philippe
- Zonta (Ospedale San Biagio Sandro
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research
Abstracts from the Food Allergy and Anaphylaxis Meeting 2016
- Author
- A. Wesley Burks
- Abdulhadi Al-Qahtani
- Abdullah Alfhaid
- Abir Haddi
- Adam T. Fox
- Adam Wawrzeńczyk
- Adnan Custovic
- Adriana Machinena
- Adriana Muntean
- Adriano Mari
- Aeilko Zwinderman
- Afke M. M. Schins
- Agata Michalska
- Agata Szymkiewicz
- Agha Rehan Khaliq
- Agnieszka Lipiec
- Agurtzane Bilbao
- Agustin Madroñero
- Aida del Campo García
- Aida Semic-Jusufagic
- Aideen Byrne
- Aimee Lou Nano
- Aimée Dorkenoo
- Aine Adams
- Akanksha Sharma
- Akila Rekima
- Alba Pablos-Tanarro
- Alejandro Joral
- Aleksandar Bulog
- Alena Berger
- Alessandro Fiocchi
- Alessandro Travaglini
- Alexander Rohrbach
- Alexandra Rodrigues
- Alf Weimann
- Ali Almontasheri
- Alice Coimbra
- Alina Zbróg
- Aline Sprikkelman
- Alkerta Ibranji
- Amaranta Traversa
- Amena Warner
- Amyra Ali Azamar Jácome
- Ana Célia Costa
- Ana Fiandor
- Ana María Plaza
- Ana Miranda
- Ana Molina
- Ana Paula Moschione Castro
- Ana Pereira
- Ana Prieto
- Ana Prieto del Prado
- Ana Reis Ferreira
- Ana Rodolfo
- Ana Rodriguez-Fernandez
- Anastasia Cirisano
- Anastasia Papadopoulou
- Anders Blom Jensen
- Andre Knulst
- Andrea Costanzi
- Andrea Di Rienzo Businco
- Andrea Keiko Gushken
- Andrea Mikkelsen
- Andrea Vereda
- Andrea Wangorsch
- Andreas Frey
- Andreia Forno
- André C. Knulst
- André Moreira
- André Wolterbeek
- Aneta Tomaszewska
- Angela Simpson
- Angelica Ehrenberg
- Ania Carsin
- Anja Jeverica
- Anja Koren Jeverica
- Anna G. Vidarsdottir
- Anna Iliopoulou
- Anna Kaarina Kukkonen
- Anna Kuklinska-Pijanka
- Anna Pelkonen
- Anna Selby
- Anna Sokolova
- Anna Szyc
- Anna Wawrzeńczyk
- Anna-Lena Bramstång Björk
- Anna-Maija Hanni
- Annabelle Capt
- Annamaria Bianchi
- Anne Miles
- Anne Moneret-Vautrin
- Anne-Fleur Schoemaker
- Anne-Marie Kochuyt
- Anne-Marie Oomkes-Pilon
- Anne-Sofie Ballegaard
- Annette Jamin
- Annick Bastiaensen
- Annick Mercenier
- Anouska D. Michelsen-Huisman
- Anthony Dubois
- Anthony E. J. Dubois
- Antima Banerjee
- Antoine Deschildre
- Antoine Magnan
- Anton A. Shekhetov
- Anton Hartmann
- Antonia Rojas
- Antonino Romano
- Antonio Amoroso
- Antonio Carlos Pastorino
- Antonio Fernandez
- Antonio Pastorino
- António Jorge Cabral
- Arianna Dondi
- Arnaldo Porto
- Arne Homann
- Artur Walkiewicz
- Assad M. Butt
- Astrid G. Kruizinga
- Astrid Kruizinga
- Astrid Versluis
- Athina van Gasse
- Attilio Francesco Speciani
- Audrey Dunn Galvin
- Ayelet Rimon
- Barbara Ballmer
- Barbara Ballmer-Weber
- Barbara Majkowska-Wojciechowska
- Barbara Pfitzner
- Barbara Wróblewska
- Beatriz Secades Barbado
- Ben Remington
- Benoît Sterling
- Berber Vlieg-Boerstra
- Bernard Mahon
- Bert Popping
- Bertine M. J. Flokstra-de Blok
- Bertrand Evrard
- Bettina Brix
- Bianca Balbino
- Birgit Kalb
- Birgit Quinting
- Bjorn R. Ludviksson
- Bo Pontoppidan
- Bodo Niggemann
- Boleslaw Samolinski
- Borja Bartalomé
- Borja Bartolomé
- Boudewjin J. Kollen
- Bruna Aquilante
- Bruno Pereira
- Bryan M. Harvey
- Bushra Javed
- Carina Kelleher
- Carl Hamsten
- Carla Camerotto
- Carla Jones
- Carla Mastrorilli
- Carlo Caffarelli
- Carlotta Povesi Dascola
- Carmen Di Scala
- Carmen D’Amelio
- Carmen Ponce
- Carmen Riggioni
- Carmen Saviana Ganea
- Carolina Aranda
- Carolina S. Aranda
- Caroline Klingebiel
- Caroline Thumerelle
- Caroline Zimmermann
- Carsten Bindslev-Jensen
- Catherine Bertholet
- Catherine Nock
- Chantal Agabriel
- Chantal Brossard
- Charlotte Eisenmann
- Charlotte Hands Plovdiv
- Charlotte Madsen
- Charlotte Mortz
- Chia-Chi Wang
- Chiara Fiamingo
- Chiara Pistoletti
- Chiara Rafaiani
- Chris H. Bridts
- Christian Harwanegg
- Christian Radauer
- Christian Schwager
- Christine Breynaert
- Christopher Munro
- Chrystyna Kalicinsky
- Chun-Wei Tung
- Chung-Hsiung Huang
- Claire Claverie
- Claire Mills
- Clara Ippolito
- Claudia Alessandri
- Claudia Pföhler
- Cleonir Lui de Moraes Beck
- Clémence Mordacq
- Colette Larré
- Colin Barber
- Cono Casale
- Constantinos Pitsios
- Corinne Herouet-Guicheney
- Cornelia Bergmayr
- Cornelia Jansen
- Cornelis K. van der Ent
- Cristiane Nunes dos Santos
- Cristiano Caruso
- Cristina Arêde
- Cristina Bueno
- Cristina Deaconu
- Cristina Ornelas
- Cristobalina Mayorga
- Daniel Corbacho
- Daniel Lozano-Ojalvo
- Daniel Sampaio
- Daniela Adriano
- Daniela Manila Bianchi
- Danijela Apostolovic
- Danila Zennaro
- Danilo Villalta
- Dasha Roa-Medellín
- David Alejandro Mendoza Hernández
- David C. A. Candy
- David Endesfelder
- David Gillick
- David Luyt
- Deirdre Galloway
- Denise Borges
- Diana Deleanu
- Diana Pérez Alzate
- Diana Silva
- Dianne Campbell
- Didier Ebo
- Diego Faggian
- Diego G. Peroni
- Diego Peroni
- Dikla Pivko Levy
- Dimitris Mitsias
- Dirceu Solé
- Dirk Verhoeven
- Djamel Saidi
- Djordje Filipovic
- Domingo Barber
- Donatella Bignardi
- Dorien Van Ginkle
- Duncan Brown
- E. N. Clare Mills
- Edward F. Knol
- Edyta Krzych
- Ekaterina Khaleva
- Ekaterini Goudouris
- Ekaterini Papadopoulou
- Elena D. Kuvshinova
- Elena Molina
- Elena Varin
- Eleonora Savi
- Elida Nikolla
- Elin Lustig
- Elisa Gritti
- Elisa Haroun
- Elizabeth Griffiths
- Elodie Drumez
- Elodie Michaud
- Eman Madbouly
- Emanuel Sarinho
- Emiliano De Dominicis
- Emmanouil Manousakis
- Erik Wambre
- Erika Jensen-Jarolim
- Erna Van Hoeyveld
- Esben Eller
- Esozia Arroabarren
- Esther Barrionuevo
- Esther van Twuijver
- Etienne Beaudouin
- Etienne Cavalier
- Eugénia Matos
- Eun Ha Jang
- Eunice Dias de Castro
- Eva Batanero
- Eva Corbet
- Eva Lasa
- Eva Untersmayr
- Evangelia Kompoti
- Evelyne Mangodt
- Evgen Benedik
- Ewa Gawronska-Ukleja
- Ewa Ternesten Hasseus
- Ewout W. Steyerberg
- Fabricia Carolino
- Fabrícia Carolino
- Faisal R. Bakhsh
- Farrukh Sheikh
- Fernando Bandrés Sánchez-Cruz
- Filip Raciborski
- Filipe Benito-Garcia
- Fiona Kenna
- Fiona Ward
- Flavio Sano
- Florence Pineau
- Florin-Adrian Secureanu
- Florin-Dan Popescu
- Frances Smith
- Francesca Cipriani
- Francesco Macrì
- Francesco Zinno
- Francine C. van Erp
- Francisca Gomez
- Francisca Palomares
- Francisco Cabrera-Chavez
- Francisco Javier Monteseirin
- Francisco Javier Ruano
- Frans Timmermans
- Franziska Ruëff
- Frauke Schocker
- Frieke Kuper
- Frits Koning
- Frédéric de Blay
- Fátima Duarte
- Gabriel Gastaminza
- Gabriela Canto
- Gabriele Piuri
- Gabriele Schulz
- Gador Bogas
- Gador Gomez
- Gary Stiefel
- Geert F. Houben
- Geert Houben
- Georg Mitterer
- George Du Toit
- Georgios Rentzos
- Gerard H. Koppelman
- Gert van Duijn
- Geunwoong Noh
- Giampaolo Ricci
- Gian Lodovico Rapaccini
- Giorgio Bedogni
- Giovanni Pajno
- Giuseppe Crisafulli
- Giuseppe Pingitore
- Gjustina Loloci
- Glauce Yonamine
- Graham King
- Graham Roberts
- Grzegorz Sergiejko
- Grégory Bouchaud
- Guillaume Pouessel
- Gustavo Soldateli
- H. Kim A. Brand
- H. Mary-Lene de Zeeuw-Brouwer
- Hajime Karasuyama
- Hanan Sharif
- Hanane Kaddouri
- Hannah M. Kansen
- Hanneke van der Kleij
- Hans de Groot
- Hans-Jørgen Malling
- Harmieke van Os-Medendorp
- Harry J. Wichers
- Harry Wichers
- Hassan Al-Dhekri
- Heinz Fehrenbach
- Helen Brown
- Helen Lindqvist
- Helena Larramona
- Helga Magnusdottir
- Henk van Loveren
- Henny Otten
- Henrik Fomsgaard Kjaer
- Hervé Bernard
- Hilde Cnossen
- Huan Rao
- Hub P. J. M. Noteborn
- Hulya Ercan Sarıcoban
- Huub F. J. Savelkoul
- Ifigenia Sfika
- Ignacio García Núñez
- Ileana-Maria Ghiordanescu
- Ilya Vorozhko
- Indre Butiene
- Ine Decuyper
- Ines Mrakovcic-Sutic
- Ines Padua
- Ingo Marenholz
- Ingrid Sutic
- Inmaculada Doña
- Inmaculada Sánchez-Machín
- Inna A. Larkova
- Ioana Maris
- Ioanna Manolaraki
- Irena Nedelea
- Irene Berends
- Iride Dello Iacono
- Isabella Annesi-Maesano
- Isabella Pali-Schöll
- Isabelle Cleach
- Isidor Hutteger
- Italo De Vitis
- Ivana Filipovic
- Ivana Giangrieco
- Ivana Sutic
- Ivona Barcievic-Jones
- Ivona Baricevic-Jones
- Iztok Devetak
- J. L. van der Velde
- Jaakko Yrjänä
- Jaap Akkerdaas
- Jacek Borowicz
- Jackeline F. Motta
- Jacqueline J. M. Castenmiller
- Jaime Lozano
- James Hindley
- Jan Knol
- Javier Cuesta-Herranz
- Javier Moreno
- Jean Tratt
- Jean-Louis Mège
- Jean-Luc Fauquert
- Jean-Marie Renaudin
- Jean-Michel Wal
- Jeanette Fisker Trandbohus
- Jelena Mihailovic
- Jennette Higgs
- Jennifer Hammond
- Jennifer Santos
- Jenny Badas
- Jenny van Odijk
- Jia Yin
- Jim Langridge
- Jlenia Fresta
- Joan Bartra
- Joana Caiado
- Joana Vitte
- Joaquín Navarro
- Jochen Behrends
- Joe Baumert
- Johan Garssen
- Johanna P. M. van der Valk
- Johanna Rost
- Johanna van der Valk
- Jolanda van Bilsen
- Jonas Lidholm
- Jonas Östling
- Jonathan Hourihane
- Jonathan O’B. Hourihane
- Joost Westerhout
- Jordi Roca-Ferrer
- Jorge Alvarez
- Jorge Esparza-Gordillo
- Jorge Kalil
- Joris Mens
- Jose Ignacio Larco
- Josefina Cernadas
- Josefina R. Cernadas
- Joseph Baumert
- Jossie Garthoff
- Josué Alejandro Huertas Guzmán
- José Antonio Bácter Martos
- José María Ignacio García
- José Pedro Moreira Silva
- José Plácido
- José Ramón Fernández Lorenzo
- Joyce A. M. Emons
- Joyce Emons
- João Marcelino
- Juan Carlos Daza
- Juan Carlos Julia
- Juan Carlos López-Rodríguez
- Juan Heber Castellanos
- Juan Miguel Garcia
- Juliane Gregersen
- Juliane Schulz
- Julie C. Locklear
- Julie Galand
- Julie Locklear
- Julien Labreuche
- Justine Courtois
- Júlio Oliveira
- Kamel Eddine El Mecherfi
- Karen English
- Karin Hoffman-Sommergruber
- Karin Hoffmann-Sommergruber
- Karine Adel-Patient
- Karine Patient
- Karla Leversia Borjas Aguilar
- Katarzyna Pyrz
- Kate Grimshaw
- Katharina Blümchen
- Kathrin Scherer
- Kati Palosuo
- Katia Basello
- Katrine L. Bøgh
- Katrine Lindholm Bøgh
- Kayoko Matsunaga
- Kerrie Kirk
- Khaled Messaoudi
- Kirsten Beyer
- Kirsten Mehlig
- Kirsten Skamstrup Hansen
- Koen Smit
- Kok Loong Ue
- Kollen Boudewijn
- Konrad Furmanczyk
- Kristian Bravin
- Kristin Verbeke
- Kriti Gupta
- Laetitia Sellam
- Lali Saginadze
- Lars Kjaergaard Poulsen
- Lars Verschuren
- Lau Fabricius Larsen
- Laura Martín-Pedraza
- Laura Santos-Diez
- Laura Valdesoiro Navarrete
- Laure Castan
- Lauren Lissner
- Laurent L. Reber
- Laurian Jongejan
- Lee Gethings
- Leire Dopazo
- Lene Heise Garvey
- Leonieke N. van Veen
- Leonor Carneiro-Leão
- Lesya Besh
- Leticia Pérez-Rodríguez
- Liana Jorjoliani
- Lidia Ilènko
- Lidia Markiewicz
- Lieve Coorevits
- Lilian Moraes
- Linda Cosenza
- Linda Verrill
- Linus Grabenhenrich
- Lisa Tuppo
- Lizalet Oosthuizen
- Loredana Chini
- Lorella Paparo
- Louise J. Michaelis
- Luc S. De Clerck
- Lucia Caminiti
- Lucia Decastelli
- Lucien F. Harthoorn
- Lucy Walker
- Luis Amaral
- Luis F. Ensina
- Luisa Galindo
- Lukasz Sokolowski
- Luís Câmara Pestana
- Lynne Regent
- Lénaïck Dupuis
- Léon Knippels
- M. Eleonore Pettersson
- Magdalena Zbikowska-Gotz
- Magna Correia
- Maja Krstic
- Malika Guendouz
- Mandy Ziegert
- Manon M. Oude Nijhuis
- Manuel Branco Ferreira
- Manuel Pereira-Barbosa
- Manzoor Ahmed
- Marcia C. Mallozi
- Mareen Datema
- Mareike Price
- Marek Kowalski
- Margareta Brandt Gertmo
- Margaretha A. Faber
- Margherita Di Costanzo
- Margherita Varini
- Margitta Worm
- Margo M. Hagendorens
- Maria Antonetta Ciardiello
- Maria Auxiliadora Guerrero
- Maria Basagaña
- Maria Carmen Verga
- Maria de Lurdes Torre
- Maria del Mar Folqué
- Maria Francesca Patria
- Maria Isabel Garcimartín
- Maria Jose Goikoetxea
- Maria Jose Rodriguez
- Maria Jose Torres
- Maria Konstantakopoulou
- Maria Livia Bernardi
- Maria Luisa Somoza
- Maria Nassiri
- Maria Pasioti
- Maria Passioti
- Maria Petrodimopoulou
- Maria Salas
- Maria Starkhammar
- Maria Teresa Costantino
- Maria Teresa Giner
- Maria Teresa Guerra Perez
- Maria Vázquez de la Torre
- Mariam Tskhakaia
- Mariana Vieru
- Marianna Murdjeva
- Marianne van Hage
- Marie Bodinier
- Marina A. Kiseleva
- Marina Peredelskaya
- Marina Suárez Vergara
- Marina Themisb
- Mario Plebani
- Mariola Dietrich
- Mariona Pascal
- Marit Reitsma
- Mariya Ivanovska
- Marjeta Sedmak
- Mark Blankestijn
- Marleen T. J. Van Ampting
- Marta Anda
- Marta Goñi Esarte
- Marta Lomikovska
- Marta Neto
- Marta Vazquez-Ortiz
- Martin D. Chapman
- Martin Karjalainen
- Martinus Lovik
- Marysia Recto
- María José Barasona Villarejo
- María Luisa Baeza
- María Teresa Villalba
- María Ángeles Algaba Mármol
- Mashary Altamimi
- Mathilde Claude
- Mathilde Turfkruyer
- Matt Sperrin
- Matteo Moretti
- Maurits van Maaren
- Maurizio Mennini
- Maurizio Tamburrini
- Mauro Calvani
- Mayra Coutinho Andrade
- Mayra de Barros Dorna
- Melanie Cap
- Melina Makatsori
- Meltem Ugras
- Mercedes Escarrer Jaume
- Merima Bublin
- Meropi Kontogianni
- Meta Accetto
- Michael Clausen
- Michał Przybyszewski
- Michel Neunlist
- Michela Carola Speciani
- Michela Ciancamerla
- Michele Miraglia del Giudice
- Michelle Epstein
- Miguel García Domínguez
- Miguel Vieira
- Mihaela Popescu
- Mika Mäkelä
- Mikael Kuitunen
- Mindy Tsai
- Mira Šilar
- Mireille Eb
- Miren Arteaga
- Miriam Palacios
- Mirjana Zupančič
- Mohammad Al Bahkali
- Moira Austin
- Monica Bronkowska
- Monica Maćków
- Monica Piquer
- Montserrat Alvaro
- Montserrat Bosque García
- Montserrat De Prada
- Montserrat Fernandez-Rivas
- Montserrat López Onieva
- Montserrat Álvaro
- Morten Christensen
- Moshe Ben-Shoshan
- Mukul Das
- Muriel Totis
- Mário Morais-Almeida
- Mònica Piquer
- Nandinee Patel
- Nanju Alice Lee
- Nanna Juel-Berg
- Natalia Blanca López
- Natalia Nenasheva
- Natalia Ukleja-Sokolowska
- Nehad Gomaa
- Nelly Gourdon-Dubois
- Nelson Rosario
- Nerea Sarmiento Carrera
- Nesrine Zaabat
- Network for Online Registration of Anaphylaxis (NORA)
- Neusa F. Wandalsen
- Niamh Brosnan
- Nicolas Gaudenzio
- Nicolette Arends
- Nicolette de Jong
- Nicolette J. T. Arends
- Nicolette W. de Jong
- Nicolette W. de Jong
- Niels Röckendorf
- Nikki Edelbroek
- Nikolaos A. Kitsioulis
- Nikolaos Douladiris
- Nikolaos G. Papadopoulos
- Nikolaos Mikos
- Nikolaos Papadopoulos
- Nikos Papadopoulos
- Nino Adamia
- Noe Ontiveros
- Nour Baiz
- Nunzia Maiello
- Oksana Matsyura
- Olga Chernyak
- Olga Dominguez
- Olga Pakholchuk
- Olivier Tranquet
- Omar Kheroua
- Oona Mustonen
- Oscar Asensio
- Pablo Mérida
- Pablo San Segundo-Acosta
- Paloma Campo
- Paloma Poza-Guedes
- Paola Dignetti
- Paola Minale
- Paolo Giordani
- Paolo Maria Matricardi
- Paraskevi Xepapadaki
- Pasquale Comberiati
- Patricia Macchiaverni
- Patricia Padrao
- Patrizia Polverino de Laureto
- Paul J. Turner
- Paul Turner
- Pawel Dubiela
- Pedro Giavina Bianchi
- Pedro Moreira
- Pernille Winther
- Peter Korošec
- Peter Meyer
- Petri Kulmala
- Phil Couch
- Phil Padfield
- Philip Couch
- Philipp Starkl
- Philippe Aubert
- Philippe Delahaut
- Philippe Egenmann
- Pierre Bruhns
- Pierre Lukas
- Pieter-Jan de Kam
- Pilar Hernandez
- Piotr Humeniuk
- Piotr Samel-Kowalik
- Premendra Dwivedi
- Prescilla Jeurink
- Päivi Vähäsarja
- Rabea Reinert
- Raditsa Sokolova
- Rand Arnaout
- Rand K. Arnaout
- Raquel Perez
- Rashid Amin
- Rebeca Lopez
- Rebecca Knibb
- Rebekah Sayers
- Regina Selb
- Regina Treudler
- Reiko Teshima
- Renata Barros
- Renata R. Cocco
- Reyna Simon
- Ricardo Prata
- Riccardo Asero
- Riccardo Sibilano
- Richard Cooke
- Rik Schrijvers
- Rinkesh Kumar Gupta
- Rita Nocerino
- Rob Klemans
- Robbert Sutorius
- Robert Elfont
- Robert Voyksner
- Robert Zacniewski
- Roberta Aina
- Roberta Lupi
- Roberta Olcese
- Roberto Bernardini
- Roberto Berni Canani
- Rodrigo Barderas
- Romy Gadisseur
- Ronald van Ree
- Rosa Jimenez
- Rosa Jimenez-Feijoo
- Rosa Muñoz-Cano
- Rosana Camara Agondi
- Rosella De Poi
- Rosetta Ferrara
- Rosina López-Fandiño
- Rosita Aitoro
- Ross Yarham
- Roxana Silvia Bumbacea
- Roy Gerth van Wijk
- Rumyana Yankova
- Rupert Schlags
- Ruperto González-Pérez
- Rusudan Karseladze
- Ruta Dubakiene
- Rute Gonçalves
- Sabina Bijlsma
- Sabine Dölle
- Sabine Pfeifer
- Sabine Schnadt
- Sahar Elshorbagi
- Salvatore Tripodi
- Sam Mehr
- Sandra Brandhoff
- Sandra Denery
- Sandra Denery-Papini
- Sandra Lucarelli
- Sara Abián
- Sara Martínez
- Sara Pereiro Fernández
- Sarah Grosche
- Sarah Kuntz
- Sarah Lindsley
- Saskia Albroscheit
- Sean Bennett
- Sebastian Tschirner
- Sebastien Holvoet
- Serena Perna
- Shan Deng
- Shinobu Sakai
- Shira Benor
- Sigrun Lund
- Sigurveig Sigurdardottir
- Silvia Gallina
- Silvia Peveri
- Simon Rosenberg
- Simone Frediani
- Sira Miquel
- Skadi Kull
- Sofia Kostoudi
- Songül Yürek
- Sonia Ricò
- Sonja Posega Devetak
- Sonsoles Intente-Herrero
- Sophia Watts
- Sophie Nutten
- Soraya Ainad Tabet
- Soren Wille
- Srdan Banac
- Sridevi Muralidharan
- Stefan Kabasser
- Stefan Vieths
- Stefania Arasi
- Stefanie Rohwer
- Stefano Luccioli
- Stefano Pattini
- Stephan Scheurer
- Stephane Leteurtre
- Stephanie Claus
- Stephen J. Galli
- Stephen Till
- Steve Taylor
- Stéphanie Lejeune
- Susana Piedade
- Susana Rodrigues
- Susanne Diesner
- Susanne Lau
- Susanne Schwarz
- Svetlan Dermendzhiev
- Svetlana Denisova
- Svitlana Nedelska
- Svitlana Zubchenko
- Sylke Rietz
- Sylvia Osscini
- Tadej Avčin
- Tanja Cirkovic Velickovic
- Tanja Rouhani Rankouhi
- Tatyana Popova
- Tatyana Sentsova
- Teija Dunder
- Teodoríkez Jiménez-Rodríguez
- The Anaphylaxis Working Group of the French Allergology SocietyThe Anaphylaxis Working Group of the French Allergology Society
- Thomas Eiwegger
- Thomas Keil
- Thomas Marichal
- Tiina Kauppila
- Timothy Watts
- Tina Vesel
- Tomaž Poredoš
- Tong-Rong Jan
- Tullio Frediani
- Tushar Banerjee
- Ulf Bengtsson
- Ulrike Lehnigk
- Umberto Pelosi
- Urszula Samolinska-Zawisza
- Uta Jappe
- Valentino Pavisic
- Valery Muhortnich
- Valérie Liabeuf
- Valérie Trendelenburg
- Valérie Verhasselt
- Vasti Iancu
- Vera A. Revyakina
- Vera Elisabeth Assmann
- Vicente Albendiz
- Victor Matheu-Delgado
- Vito Sabato
- Viviana Moschese
- Vladimir Micovic
- Vladyslava Barzylovych
- Véronique Nève
- W. Marty Blom
- Waltraud Suer
- Wentong Xue
- Winfried Leeman
- Wolf-Meinhard Becker
- Xavier Domingo Miró
- Yanne Boloh
- Yin-Hua Cheng
- Yolanda Meijer
- Yolanda Puente
- Youcef Bouferkas
- Younes Belabbas
- Young-Ae Lee
- Yvonne Vergouwe
- Zbigniew Bartuzi
- Zdenka Baricev-Novakovic
- Zerrin Yalvac
- Zizi Cojocariu
- Zorica Zivkovic
- Zsolt Szepfalusi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2017
- Field of study
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.
- Author
- Aban Marites
- Abayomi Fatola
- Abeyskera Kushala
- Aboagye Jeremy
- Adam Matthew
- Adams Kirsty
- Adamson James
- Adelaja Yemi A.
- Adlou Syed
- Ahmed Khatija
- Akhalwaya Saajida
- Akhalwaya Yasmeen
- Alcock Andrew
- Aley Parvinder K.
- Ali Aabidah
- Allen Elizabeth R.
- Allen Lauren
- Almeida Thamires C. D. S. C
- Alves Mariana P.S.
- Amorim Fabio
- Andritsou Foteini
- Angus Brian
- Anslow Rachel
- Appleby Matthew
- Arbe-Barnes Edward H.
- Ariaans Mark P.
- Arns Beatriz
- Arruda Laiana
- Awedetan Gbadebo
- Azi Lorena
- Azi Paula
- Babbage Gavin
- Bailey Catherine
- Baillie Vicky L.
- Baker Kenneth F.
- Baker Megan
- Baker Natalie
- Baker Philip
- Baldwin Lisa
- Baleanu Ioana
- Bandeira Danieli
- Bara Anna
- Barbosa Marcella A.S.
- Barker Debbie
- Barlow Gavin D.
- Barnabas Shaun L.
- Barnes Eleanor
- Barr Andrew S.
- Barrett Jessica
- Barrett Jordan R.
- Bates Louise
- Batten Alexander
- Beadon Kirsten
- Beales Emily
- Beckley Rebecca
- Belij-Rammerstorfer Sandra
- Bell Jonathan
- Bellamy Duncan
- Bellei Nancy
- Belton Sue
- Berg Adam
- Bermejo Laura
- Berrie Eleanor
- Berry Lisa
- Berzenyi Daniella
- Beveridge Amy
- Bewley Kevin R.
- Bexhell Helen
- Bhikha Sutika
- Bhorat Asad E.
- Bhorat Qasim E.
- Bhorat Zaheda E.
- Bibi Sagida
- Bijker Else
- Birch Geeta
- Birch Sarah
- Bird Adam
- Bird Olivia
- Bisnauthsing Karen
- Bittaye Mustapha
- Blackstone Katherine
- Blackwell Luke
- Bletchly Heather
- Blundell Caitlin L.
- Blundell Susannah R.
- Bodalia Pritesh
- Boettger Bruno C.
- Bolam Emma
- Boland Elena
- Bormans Daan
- Borthwick Nicola
- Bowring Francesca
- Boyd Amy
- Bradley Penny
- Brenner Tanja
- Briner Carmen
- Brown Claire
- Brown Phillip
- Brown-O'Sullivan Charlie
- Bruce Scott
- Brunt Emily
- Buchan Ruaridh
- Budd William
- Bulbulia Yusuf A.
- Bull Melanie
- Burbage Jamie
- Burhan Hassan
- Burn Aileen
- Buttigieg Karen R.
- Byard Nicholas
- Cabera Puig Ingrid
- Calderon Gloria
- Calvert Anna
- Camara Susana
- Cao Michelangelo
- Cappuccini Federica
- Cardoso João R.
- Carr Melanie
- Carroll Miles W.
- Carson-Stevens Andrew
- Carvalho José A.M.
- Carvalho Yasmin de M.
- Casey Helen R.
- Cashen Paul
- Castro Lucia Carratala
- Castro Thais
- Cathie Katrina
- Cavey Ana
- Cerbino-Neto José
- Chadwick Jim
- Chapman David
- Charlton Sue
- Chelysheva Irina
- Chester Oliver
- Chita Sunder
- Cho Jee-Sun
- Cicconi Paola
- Cifuentes Liliana
- Clark Elizabeth
- Clark Matthew
- Clarke Andrea
- Clemens Sue Ann Costa
- Clutterbuck Elizabeth A.
- Colin-Jones Rachel
- Collins Andrea M.
- Collins Sarah L.K.
- Conlon Christopher P.
- Connarty Sean
- Coombes Naomi
- Cooper Cushla
- Cooper Rachel
- Cornelissen Lynne
- Corrah Tumena
- Cosgrove Catherine
- Cox Tony
- Crocker Wendy E.M.
- Crosbie Sarah
- Cullen Dan
- Cullen Lorraine
- Cunha Debora R.M.F.
- Cunningham Christina
- Cuthbertson Fiona C.
- Cutland Clare L.
- Da Guarda Suzete N. Farias
- da Silva Moraes Antonio Carlos
- da Silva Larissa P.
- Damratoski Brad E.
- Danos Zsofia
- Dantas Maria T.D.C.
- Darroch Paula
- Darton Thomas C.
- Datoo Mehreen S.
- Datta Chandrabali
- Davids Malika
- Davies Hannah
- Davies Sarah L.
- Davis Elizabeth
- Davis John
- Davis Judith
- De Jager Jeanne
- De Nobrega Maristela M.D.
- De Oliveira Kalid Lis Moreno
- Dearlove David
- Demissie Tesfaye
- Desai Amisha
- Dheda Keertan
- Di Marco Stefania
- Di Maso Claudio
- Dinelli Maria I.S.
- Dinesh Tanya
- Docksey Claire
- Dold Christina
- Dong Tao
- Donnellan Francesca R.
- Dos Santos Erika Pachecho
- Dos Santos Tannyth
- dos Santos Thainá G.
- Douglas Alexander D.
- Douglas Naomi
- Downing Charlotte
- Drake Jonathan
- Drake-Brockman Rachael
- Driver Kimberley
- Drury Ruth
- Du Plessis Joan
- Dunachie Susanna J.
- Duncan Christopher J. A.
- Durham Benjamin S.
- Dutra Lidiana
- Easom Nicholas J.W.
- Edwards Mandy
- Edwards Nick J.
- El Muhanna Omar M.
- Elias Sean C.
- Elmore Mike
- Emary Katherine R. W.
- English Marcus
- Esmail Alisgair
- Essack Yakub Moosa
- Ewer Katie J.
- Fairlie Lee
- Farmer Eoghan
- Farooq Mutjaba
- Farrar Madi
- Farrugia Leonard
- Faulkner Beverley
- Faust Saul N.
- Fedosyuk Sofiya
- Felle Sally
- Feng Shuo
- Feng Shuo
- Ferreira Da Silva Carla
- Ferreira Daniela M.
- Field Samantha
- Finn Adam
- Fisher Richard
- Flaxman Amy
- Fletcher James
- Fofie Hazel
- Fok Henry
- Folegatti Pedro M.
- Ford Karen J.
- Fowler Jamie
- Fraiman Pedro H.A.
- Francis Emma
- Franco Marilia M.
- Frater John
- Freire Marilúcia S.M.
- Fry Samantha H.
- Fudge Sabrina
- Furze Julie
- Fuskova Michelle
- Galian-Rubio Pablo
- Galiza Eva
- Garlant Harriet
- Gavrila Madita
- Geddes Ailsa
- Gibbons Karyna A.
- Gilbert Sarah C
- Gilbride Ciaran
- Gill Hardeep
- Glynn Sharon
- Godwin Kerry
- Gokani Karishma
- Goldoni Ursula Carvalho
- Goncalves Maria
- Gonzalez Isabela G.S.
- Goodman Anna L.
- Goodwin Jayne
- Goondiwala Amina
- Gordon-Quayle Katherine
- Gorini Giacomo
- Grab Janet
- Gracie Lara
- Green Catherine M.
- Green Christopher A.
- Greenland Melanie
- Greenwood Nicola
- Greffrath Johann
- Groenewald Marisa M.
- Grossi Leonardo
- Gupta Gaurav
- Hackett Mark
- Hallis Bassam
- Hamaluba Mainga
- Hamilton Elizabeth
- Hammersley Daniel
- Hanrath Aidan T.
- Hanumunthadu Brama
- Harris Clair
- Harris Stephanie A.
- Harris Tara
- Harrison Daisy
- Harrison Thomas D.
- Hart Thomas C.
- Hartnell Birgit
- Hassan Shadin
- Haughney John
- Hawkins Sophia
- Hay Jodie
- Head Ian
- Heath Paul T.
- Henry John
- Hermosin Herrera Macarena
- Hettle David B.
- Hill Adrian V. S.
- Hill Catherine
- Hill Helen
- Hill Jennifer
- Hirsch Ian
- Hodges Gina
- Hodgson Susanne H. C.
- Horne Elizea
- Hou Mimi M.
- Houlihan Catherine
- Howe Elizabeth
- Howell Nicola
- Humphreys Jonathan
- Humphries Holly E.
- Hurley Katrina
- Huson Claire
- Hyamns Catherine
- Hyder-Wright Angela
- Ikram Sabina
- Ishwarbhai Alka
- Ivan Monica
- Iveson Poppy
- Iyer Vidyashankara
- Izu Alane
- Jackson Frederic
- Jackson Susan
- Jaumdally Shameem
- Jeffers Helen
- Jenkin Daniel
- Jesudason Natasha
- Joe Carina C. D.
- Jones Bryony
- Jones Christopher
- Jones Elizabeth
- Jones Kathryn
- Jorge Marianna Rocha
- Jose Aylin
- Joshi Amar
- Júnior Eduardo A.M.S.
- Kadziola Joanne
- Kailath Reshma
- Kana Faeeza
- Karampatsas Konstantinos
- Kasanyinga Mwila
- Keen Jade
- Kelly Dearbhla M.
- Kelly Debbie
- Kelly Elizabeth J.
- Kelly Sarah
- Kerr David
- Kerridge Simon
- Kfouri Renato de Ávila
- Khan Liaquat
- Khozoee Baktash
- Kidd Sarah
- Killen Annabel
- Kinch Jasmin
- Kinch Patrick
- King Lloyd D.W.
- King Thomas B.
- Kingham Lucy
- Klenerman Paul
- Knapper Francesca
- Knight Julian C.
- Knott Daniel
- Koen Anthonet
- Koleva Stanislava
- Kwatra Gaurav
- Lambe Teresa
- Lang Gail
- Lang Matilda
- Larkworthy Colin W.
- Larwood Jessica P.J.
- Law Rebecca
- Lawrie Alison M.
- Lazarus Erica M.
- Lazarus Rajeka
- Leach Amanda
- Lees Emily A.
- Lelliott Alice
- Lemm Nana-Marie
- Lessa Alvaro
- Leung Stephanie
- Li Yuanyuan
- Lias Amelia M.
- Liatsikos Kostas
- Libri Vincenzo
- Lillie Patrick J.
- Linder Aline
- Lipworth Samuel
- Liu Shuchang
- Liu Xinxue
- Lloyd Adam
- Lloyd Stephanie
- Loew Lisa
- Lopez Ramon Raquel
- Lora Leandro
- Lowthorpe Vicki
- Luz Kleber
- MacDonald Jonathan C.
- MacGregor Gordon
- Madhavan Meera
- Madhi Shabir A.
- Mainwaring David O.
- Makambwa Edson
- Makinson Rebecca
- Malahleha Mookho
- Malamatsho Ross
- Mallett Garry
- Mallory Raburn
- Mansatta Kushal
- Maoko Takalani
- Mapetla Katlego
- Marchevsky Natalie G.
- Marinou Spyridoula
- Marlow Emma
- Marques Gabriela N.
- Marriott Paula
- Marshall Julia L.
- Marshall Richard P.
- Martins Flávia J.
- Masenya Masebole
- Masilela Mduduzi
- Masters Shauna K.
- Mathew Moncy
- Matlebjane Hosea
- Matshidiso Kedidimetse
- Mazur Olga
- Mazzella Andrea
- McCaughan Hugh
- McEwan Joanne
- McGlashan Joanna
- McGregor Alastair
- McInroy Lorna
- McIntyre Zoe
- McLenaghan Daniela
- McRobert Nicky
- McSwiggan Steve
- Megson Clare
- Mehdipour Savviz
- Meijs Wilma
- Mendes Ana V .A.
- Mendonça Renata N.Á.
- Mentzer Alexander J.
- Milan Eveline P.
- Minassian Angela M.
- Mirtorabi Neginsadat
- Mitton Celia
- Mnyakeni Sibusiso
- Moghaddas Fiona
- Molapo Kgaogelo
- Moloi Mapule
- Moore Maria
- Moraes-Pinto M. Isabel
- Moran Marni
- Morey Ella
- Morgans Róisín
- Morris Helen C.
- Morris Sheila
- Morris Susan
- Morrison Hazel
- Morselli Franca
- Morshead Gertraud
- Morter Richard
- Mottal Lynelle
- Moultrie Andrew
- Moya Nathifa
- Mpelembue Mushiya
- Msomi Sibekezelo
- Mugodi Yvonne
- Mujadidi Yama F.
- Mukhopadhyay Ekta
- Muller Jilly
- Munro Alasdair
- Munro Claire
- Murphy Sarah
- Mweu Philomena
- Myasaki Celia Hatsuko
- Naik Gurudutt
- Naker Kush
- Nana Anusha
- Nastouli Eleni
- Nazir Abida
- Ndlovu Bongani
- Neffa Fabio
- Njenga Cecilia
- Noal Helena
- Novaes Gabrielle
- Noé Andrés
- Nugent Fay L.
- Nunes Géssika
- O'Brien Katie
- O'Connor Daniel
- O'Reilly Paula
- O'Reilly Peter J.
- Odam Miranda
- Oelofse Suzette
- Oguti Blanche
- Olchawski Victoria
- Oldfield Neil J.
- Oliveira Catarina
- Oliveira Marianne G.
- Oosthuizen Angela
- Osborne Piper
- Owen David R.J.
- Owen Lydia
- Owens Daniel
- Owino Nelly
- Pacurar Mihaela
- Padayachee Sherman D.
- Paiva Brenda V.B.
- Palhares Edna M.F.
- Palmer Susan
- Parkinson Sivapriyai
- Parracho Helena M.R.T.
- Parsons Karen
- Patel Bhumika
- Patel Dipak
- Patel Faeezah
- Patel Kelly
- Patrick-Smith Maia
- Payne Ruth O.
- Peng Yanchun
- Penn Elizabeth J.
- Pennington Anna
- Peralta Alvarez Marco Polo
- Perring James
- Perry Nicola
- Perumal Rubeshan
- Petkar Sahir
- Philip Tricia
- Phillips Daniel J.
- Phillips Jennifer
- Phohu Mary Kgomotso
- Pickup Lorinda
- Pieterse Sonja
- Piper Jo
- Pipini Dimitra
- Pittella Ana
- Plank Mary
- Plested Emma
- Pollard Andrew J
- Pollard Samuel
- Pollock Katrina M.
- Pooley Jennifer
- Pooran Anil
- Poulton Ian
- Powers Claire
- Presa Fernando B.
- Price David A.
- Price Vivien
- Primeira Marcelo
- Proud Pamela C.
- Provstgaard-Morys Samuel
- Pueschel Sophie
- Pulido David
- Quaid Sheena
- Rabara Ria
- Radford Alexandra
- Radia Kajal
- Rajapaska Durga
- Rajeswaran Thurkka
- Ramasamy Maheshi N.
- Ramos Lopez Fernando
- Ramos Alberto San Francisco
- Rampling Tommy
- Rand Jade
- Ratcliffe Helen
- Rawlinson Tom
- Rea David
- Rees Byron
- Reiné Jesús
- Resuello-Dauti Mila
- Reyes Pabon Emilia
- Rhead Sarah
- Ribiero Carla M.
- Ricamara Marivic
- Richter Alex
- Ritchie Adam J.
- Ritchie Neil
- Robbins Alexander J.
- Roberts Hannah
- Robinson Hannah
- Robinson Ryan E.
- Rocchetti Talita T.
- Rocha Beatriz Pinho
- Roche Sophie
- Rollier Christine
- Rose Louisa
- Ross Russell Amy L.
- Rossouw Lindie
- Royal Simon
- Rudiansyah Indra
- Ruiz Sarah
- Saich Stephen
- Sala Claudia
- Sale Jessica
- Salman Ahmed M.
- Salvador Natalia
- Salvador Stephannie
- Sampaio Milla
- Samson Annette D.
- Sanchez-Gonzalez Amada
- Sanders Helen
- Sanders Katherine
- Santos Guerra Mayara F.S.
- Santos Erika
- Satti Iman
- Saunders Caroline
- Saunders Jack E.
- Sayed Aakifah
- Schim van der Loeff Ina
- Schmid Annina B.
- Schofield Ella
- Schwarzbold Alexandre V.
- Screaton Gavin
- Seddiqi Samiullah
- Segireddy Rameswara R.
- Senger Roberta
- Serrano Sonia
- Shah Rajiv
- Shaik Imam
- Sharpe Hannah E.
- Sharrocks Katherine
- Shaw Robert
- Shea Adam
- Shepherd Amy
- Shepherd James G.
- Shiham Farah
- Sidhom Emad
- Silk Sarah E.
- Silva-Junior Gilberto
- Silva-Reyes Laura
- Silveira Anderson D.
- Silveira Mariana B.V.
- Singh Nisha
- Sinha Jaisi
- Skelly Donal T.
- Smith Andrew
- Smith Catherine C.
- Smith Daniel C.
- Smith David J.
- Smith Holly E.
- Smith Nick
- Snape Matthew D.
- Soares Airanuédida
- Soares Tiago
- Solórzano Carla
- Song Rinn
- Sorio Guilherme L.
- Sorley Kim
- Sosa-Rodriguez Tiffany
- Souza Alessandra R.
- Souza Bruno S.D.F.
- Souza Cinthia M.C.D.L.
- Spencer Alexandra J.
- Spina Fernanda
- Spoors Louise
- Sprinz Eduardo
- Stafford Lizzie
- Stamford Imogen
- Starinskij Igor
- Stein Ricardo
- Steven Jill
- Stockdale Lisa
- Stockwell Lisa V.
- Strickland Louise H.
- Stuart Arabella C.
- Sturdy Ann
- Sutherland Rebecca K.
- Sutton Natalina
- Szigeti Anna
- Tahiri-Alaoui Abdessamad
- Tanner Rachel
- Taoushanis Carol
- Tarr Alexander W.
- Tarrant Richard
- Taylor Iona Jennifer
- Taylor Justin
- Taylor Keja
- Taylor Ursula
- te Water Naude Rebecca
- Themistocleous Andreas
- Themistocleous Yrene
- Thomas Kelly
- Thomas Merin
- Thomas Tonia M.
- Thombrayil Asha
- Thompson Amber
- Thompson Ameeka
- Thompson Fawziyah
- Thompson Kevin
- Thomson Emma C.
- Thomson Julia
- Thornton-Jones Viv
- Tighe Patrick J.
- Tinoco Lygia Accioly
- Tiongson Gerlynn
- Tladinyane Bonolo
- Tomasicchio Michele
- Tomic Adriana
- Tonks Susan
- Toshner Mark
- Tran Nguyen
- Tree Julia
- Trillana Gerry
- Trinham Charlotte
- Trivett Rose
- Truby Adam
- Tsheko Betty Lebogang
- Turabi Aadil
- Turner Cheryl
- Turner David P. J.
- Turner Richard
- Török M Estée
- Ulaszewska Marta
- Underwood Benjamin R.
- van Eck Samual
- Varughese Rachel
- Vekemans Johan
- Verbart Dennis
- Verheul Marije
- Vichos Iason
- Vieira Taiane
- Villafana Tonya L.
- Voysey Merryn
- Waddington Claire S.
- Walker Laura
- Wallis Erica
- Wand Matthew
- Warbick Deborah
- Wardell Theresa
- Warimwe George
- Warren Sarah C.
- Watkins Bridget
- Watson Ekaterina
- Watson Marion E. E.
- Webb Stewart
- Webb-Bridges Alice
- Webster Angela
- Weckx Lily Y.
- Welch Jessica
- Wells Jeanette
- West Alison
- White Caroline
- White Rachel
- Williams Christopher J.
- Williams Paul
- Williams Rachel L.
- Winslow Rebecca
- Woodyer Mark
- Worth Andrew T.
- Wright Danny
- Wroblewska Marzena
- Yao Andy
- Zimmer Rafael
- Zizi Dalila
- Zuidewind Peter
- Publication venue
- 'Elsevier BV'
- Publication date
- 03/12/2020
- Field of study
BACKGROUND: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. METHODS: This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. FINDINGS: Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0-75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4-97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8-80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3-4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. INTERPRETATION: ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials. FUNDING: UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, Rede D'Or, Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
- Author
- Aban Marites
- Abayomi Fatola
- Abeyskera Kushala
- Aboagye Jeremy
- Adam Matthew
- Adams Kirsty
- Adamson James
- Adelaja Yemi A.
- Adlou Syed
- Ahmed Khatija
- Akhalwaya Saajida
- Akhalwaya Yasmeen
- Alcock Andrew
- Aley Parvinder K.
- Ali Aabidah
- Allen Elizabeth R.
- Allen Lauren
- Almeida Thamires C. D. S. C
- Alves Mariana P.S.
- Amorim Fabio
- Andritsou Foteini
- Angus Brian
- Anslow Rachel
- Appleby Matthew
- Arbe-Barnes Edward H.
- Ariaans Mark P.
- Arns Beatriz
- Arruda Laiana
- Awedetan Gbadebo
- Azi Lorena
- Azi Paula
- Babbage Gavin
- Bailey Catherine
- Baillie Vicky L.
- Baker Kenneth F.
- Baker Megan
- Baker Natalie
- Baker Philip
- Baldwin Lisa
- Baleanu Ioana
- Bandeira Danieli
- Bara Anna
- Barbosa Marcella A.S.
- Barker Debbie
- Barlow Gavin D.
- Barnabas Shaun L.
- Barnes Eleanor
- Barr Andrew S.
- Barrett Jessica
- Barrett Jordan R.
- Bates Louise
- Batten Alexander
- Beadon Kirsten
- Beales Emily
- Beckley Rebecca
- Belij-Rammerstorfer Sandra
- Bell Jonathan
- Bellamy Duncan
- Bellei Nancy
- Belton Sue
- Berg Adam
- Bermejo Laura
- Berrie Eleanor
- Berry Lisa
- Berzenyi Daniella
- Beveridge Amy
- Bewley Kevin R.
- Bexhell Helen
- Bhikha Sutika
- Bhorat Asad E.
- Bhorat Qasim E.
- Bhorat Zaheda E.
- Bibi Sagida
- Bijker Else
- Birch Geeta
- Birch Sarah
- Bird Adam
- Bird Olivia
- Bisnauthsing Karen
- Bittaye Mustapha
- Blackstone Katherine
- Blackwell Luke
- Bletchly Heather
- Blundell Caitlin L.
- Blundell Susannah R.
- Bodalia Pritesh
- Boettger Bruno C.
- Bolam Emma
- Boland Elena
- Bormans Daan
- Borthwick Nicola
- Bowring Francesca
- Boyd Amy
- Bradley Penny
- Brenner Tanja
- Briner Carmen
- Brown Claire
- Brown Phillip
- Brown-O'Sullivan Charlie
- Bruce Scott
- Brunt Emily
- Buchan Ruaridh
- Budd William
- Bulbulia Yusuf A.
- Bull Melanie
- Burbage Jamie
- Burhan Hassan
- Burn Aileen
- Buttigieg Karen R.
- Byard Nicholas
- Cabera Puig Ingrid
- Calderon Gloria
- Calvert Anna
- Camara Susana
- Cao Michelangelo
- Cappuccini Federica
- Cardoso João R.
- Carr Melanie
- Carroll Miles W.
- Carson-Stevens Andrew
- Carvalho José A.M.
- Carvalho Yasmin de M.
- Casey Helen R.
- Cashen Paul
- Castro Lucia Carratala
- Castro Thais
- Cathie Katrina
- Cavey Ana
- Cerbino-Neto José
- Chadwick Jim
- Chapman David
- Charlton Sue
- Chelysheva Irina
- Chester Oliver
- Chita Sunder
- Cho Jee-Sun
- Cicconi Paola
- Cifuentes Liliana
- Clark Elizabeth
- Clark Matthew
- Clarke Andrea
- Clemens Sue Ann Costa
- Clutterbuck Elizabeth A.
- Colin-Jones Rachel
- Collins Andrea M.
- Collins Sarah L.K.
- Conlon Christopher P.
- Connarty Sean
- Coombes Naomi
- Cooper Cushla
- Cooper Rachel
- Cornelissen Lynne
- Corrah Tumena
- Cosgrove Catherine
- Cox Tony
- Crocker Wendy E.M.
- Crosbie Sarah
- Cullen Dan
- Cullen Lorraine
- Cunha Debora R.M.F.
- Cunningham Christina
- Cuthbertson Fiona C.
- Cutland Clare L.
- Da Guarda Suzete N. Farias
- da Silva Moraes Antonio Carlos
- da Silva Larissa P.
- Damratoski Brad E.
- Danos Zsofia
- Dantas Maria T.D.C.
- Darroch Paula
- Darton Thomas C.
- Datoo Mehreen S.
- Datta Chandrabali
- Davids Malika
- Davies Hannah
- Davies Sarah L.
- Davis Elizabeth
- Davis John
- Davis Judith
- De Jager Jeanne
- De Nobrega Maristela M.D.
- De Oliveira Kalid Lis Moreno
- Dearlove David
- Demissie Tesfaye
- Desai Amisha
- Dheda Keertan
- Di Marco Stefania
- Di Maso Claudio
- Dinelli Maria I.S.
- Dinesh Tanya
- Docksey Claire
- Dold Christina
- Dong Tao
- Donnellan Francesca R.
- Dos Santos Erika Pachecho
- Dos Santos Tannyth
- dos Santos Thainá G.
- Douglas Alexander D.
- Douglas Naomi
- Downing Charlotte
- Drake Jonathan
- Drake-Brockman Rachael
- Driver Kimberley
- Drury Ruth
- Du Plessis Joan
- Dunachie Susanna J.
- Duncan Christopher J. A.
- Durham Benjamin S.
- Dutra Lidiana
- Easom Nicholas J.W.
- Edwards Mandy
- Edwards Nick J.
- El Muhanna Omar M.
- Elias Sean C.
- Elmore Mike
- Emary Katherine R. W.
- English Marcus
- Esmail Alisgair
- Essack Yakub Moosa
- Ewer Katie J.
- Fairlie Lee
- Farmer Eoghan
- Farooq Mutjaba
- Farrar Madi
- Farrugia Leonard
- Faulkner Beverley
- Faust Saul N.
- Fedosyuk Sofiya
- Felle Sally
- Feng Shuo
- Feng Shuo
- Ferreira Da Silva Carla
- Ferreira Daniela M.
- Field Samantha
- Finn Adam
- Fisher Richard
- Flaxman Amy
- Fletcher James
- Fofie Hazel
- Fok Henry
- Folegatti Pedro M.
- Ford Karen J.
- Fowler Jamie
- Fraiman Pedro H.A.
- Francis Emma
- Franco Marilia M.
- Frater John
- Freire Marilúcia S.M.
- Fry Samantha H.
- Fudge Sabrina
- Furze Julie
- Fuskova Michelle
- Galian-Rubio Pablo
- Galiza Eva
- Garlant Harriet
- Gavrila Madita
- Geddes Ailsa
- Gibbons Karyna A.
- Gilbert Sarah C
- Gilbride Ciaran
- Gill Hardeep
- Glynn Sharon
- Godwin Kerry
- Gokani Karishma
- Goldoni Ursula Carvalho
- Goncalves Maria
- Gonzalez Isabela G.S.
- Goodman Anna L.
- Goodwin Jayne
- Goondiwala Amina
- Gordon-Quayle Katherine
- Gorini Giacomo
- Grab Janet
- Gracie Lara
- Green Catherine M.
- Green Christopher A.
- Greenland Melanie
- Greenwood Nicola
- Greffrath Johann
- Groenewald Marisa M.
- Grossi Leonardo
- Gupta Gaurav
- Hackett Mark
- Hallis Bassam
- Hamaluba Mainga
- Hamilton Elizabeth
- Hammersley Daniel
- Hanrath Aidan T.
- Hanumunthadu Brama
- Harris Clair
- Harris Stephanie A.
- Harris Tara
- Harrison Daisy
- Harrison Thomas D.
- Hart Thomas C.
- Hartnell Birgit
- Hassan Shadin
- Haughney John
- Hawkins Sophia
- Hay Jodie
- Head Ian
- Heath Paul T.
- Henry John
- Hermosin Herrera Macarena
- Hettle David B.
- Hill Adrian V. S.
- Hill Catherine
- Hill Helen
- Hill Jennifer
- Hirsch Ian
- Hodges Gina
- Hodgson Susanne H. C.
- Horne Elizea
- Hou Mimi M.
- Houlihan Catherine
- Howe Elizabeth
- Howell Nicola
- Humphreys Jonathan
- Humphries Holly E.
- Hurley Katrina
- Huson Claire
- Hyamns Catherine
- Hyder-Wright Angela
- Ikram Sabina
- Ishwarbhai Alka
- Ivan Monica
- Iveson Poppy
- Iyer Vidyashankara
- Izu Alane
- Jackson Frederic
- Jackson Susan
- Jaumdally Shameem
- Jeffers Helen
- Jenkin Daniel
- Jesudason Natasha
- Joe Carina C. D.
- Jones Bryony
- Jones Christopher
- Jones Elizabeth
- Jones Kathryn
- Jorge Marianna Rocha
- Jose Aylin
- Joshi Amar
- Júnior Eduardo A.M.S.
- Kadziola Joanne
- Kailath Reshma
- Kana Faeeza
- Karampatsas Konstantinos
- Kasanyinga Mwila
- Keen Jade
- Kelly Dearbhla M.
- Kelly Debbie
- Kelly Elizabeth J.
- Kelly Sarah
- Kerr David
- Kerridge Simon
- Kfouri Renato de Ávila
- Khan Liaquat
- Khozoee Baktash
- Kidd Sarah
- Killen Annabel
- Kinch Jasmin
- Kinch Patrick
- King Lloyd D.W.
- King Thomas B.
- Kingham Lucy
- Klenerman Paul
- Knapper Francesca
- Knight Julian C.
- Knott Daniel
- Koen Anthonet
- Koleva Stanislava
- Kwatra Gaurav
- Lambe Teresa
- Lang Gail
- Lang Matilda
- Larkworthy Colin W.
- Larwood Jessica P.J.
- Law Rebecca
- Lawrie Alison M.
- Lazarus Erica M.
- Lazarus Rajeka
- Leach Amanda
- Lees Emily A.
- Lelliott Alice
- Lemm Nana-Marie
- Lessa Alvaro
- Leung Stephanie
- Li Yuanyuan
- Lias Amelia M.
- Liatsikos Kostas
- Libri Vincenzo
- Lillie Patrick J.
- Linder Aline
- Lipworth Samuel
- Liu Shuchang
- Liu Xinxue
- Lloyd Adam
- Lloyd Stephanie
- Loew Lisa
- Lopez Ramon Raquel
- Lora Leandro
- Lowthorpe Vicki
- Luz Kleber
- MacDonald Jonathan C.
- MacGregor Gordon
- Madhavan Meera
- Madhi Shabir A.
- Mainwaring David O.
- Makambwa Edson
- Makinson Rebecca
- Malahleha Mookho
- Malamatsho Ross
- Mallett Garry
- Mallory Raburn
- Mansatta Kushal
- Maoko Takalani
- Mapetla Katlego
- Marchevsky Natalie G.
- Marinou Spyridoula
- Marlow Emma
- Marques Gabriela N.
- Marriott Paula
- Marshall Julia L.
- Marshall Richard P.
- Martins Flávia J.
- Masenya Masebole
- Masilela Mduduzi
- Masters Shauna K.
- Mathew Moncy
- Matlebjane Hosea
- Matshidiso Kedidimetse
- Mazur Olga
- Mazzella Andrea
- McCaughan Hugh
- McEwan Joanne
- McGlashan Joanna
- McGregor Alastair
- McInroy Lorna
- McIntyre Zoe
- McLenaghan Daniela
- McRobert Nicky
- McSwiggan Steve
- Megson Clare
- Mehdipour Savviz
- Meijs Wilma
- Mendes Ana V .A.
- Mendonça Renata N.Á.
- Mentzer Alexander J.
- Milan Eveline P.
- Minassian Angela M.
- Mirtorabi Neginsadat
- Mitton Celia
- Mnyakeni Sibusiso
- Moghaddas Fiona
- Molapo Kgaogelo
- Moloi Mapule
- Moore Maria
- Moraes-Pinto M. Isabel
- Moran Marni
- Morey Ella
- Morgans Róisín
- Morris Helen C.
- Morris Sheila
- Morris Susan
- Morrison Hazel
- Morselli Franca
- Morshead Gertraud
- Morter Richard
- Mottal Lynelle
- Moultrie Andrew
- Moya Nathifa
- Mpelembue Mushiya
- Msomi Sibekezelo
- Mugodi Yvonne
- Mujadidi Yama F.
- Mukhopadhyay Ekta
- Muller Jilly
- Munro Alasdair
- Munro Claire
- Murphy Sarah
- Mweu Philomena
- Myasaki Celia Hatsuko
- Naik Gurudutt
- Naker Kush
- Nana Anusha
- Nastouli Eleni
- Nazir Abida
- Ndlovu Bongani
- Neffa Fabio
- Njenga Cecilia
- Noal Helena
- Novaes Gabrielle
- Noé Andrés
- Nugent Fay L.
- Nunes Géssika
- O'Brien Katie
- O'Connor Daniel
- O'Reilly Paula
- O'Reilly Peter J.
- Odam Miranda
- Oelofse Suzette
- Oguti Blanche
- Olchawski Victoria
- Oldfield Neil J.
- Oliveira Catarina
- Oliveira Marianne G.
- Oosthuizen Angela
- Osborne Piper
- Owen David R.J.
- Owen Lydia
- Owens Daniel
- Owino Nelly
- Pacurar Mihaela
- Padayachee Sherman D.
- Paiva Brenda V.B.
- Palhares Edna M.F.
- Palmer Susan
- Parkinson Sivapriyai
- Parracho Helena M.R.T.
- Parsons Karen
- Patel Bhumika
- Patel Dipak
- Patel Faeezah
- Patel Kelly
- Patrick-Smith Maia
- Payne Ruth O.
- Peng Yanchun
- Penn Elizabeth J.
- Pennington Anna
- Peralta Alvarez Marco Polo
- Perring James
- Perry Nicola
- Perumal Rubeshan
- Petkar Sahir
- Philip Tricia
- Phillips Daniel J.
- Phillips Jennifer
- Phohu Mary Kgomotso
- Pickup Lorinda
- Pieterse Sonja
- Piper Jo
- Pipini Dimitra
- Pittella Ana
- Plank Mary
- Plested Emma
- Pollard Andrew J
- Pollard Samuel
- Pollock Katrina M.
- Pooley Jennifer
- Pooran Anil
- Poulton Ian
- Powers Claire
- Presa Fernando B.
- Price David A.
- Price Vivien
- Primeira Marcelo
- Proud Pamela C.
- Provstgaard-Morys Samuel
- Pueschel Sophie
- Pulido David
- Quaid Sheena
- Rabara Ria
- Radford Alexandra
- Radia Kajal
- Rajapaska Durga
- Rajeswaran Thurkka
- Ramasamy Maheshi N.
- Ramos Lopez Fernando
- Ramos Alberto San Francisco
- Rampling Tommy
- Rand Jade
- Ratcliffe Helen
- Rawlinson Tom
- Rea David
- Rees Byron
- Reiné Jesús
- Resuello-Dauti Mila
- Reyes Pabon Emilia
- Rhead Sarah
- Ribiero Carla M.
- Ricamara Marivic
- Richter Alex
- Ritchie Adam J.
- Ritchie Neil
- Robbins Alexander J.
- Roberts Hannah
- Robinson Hannah
- Robinson Ryan E.
- Rocchetti Talita T.
- Rocha Beatriz Pinho
- Roche Sophie
- Rollier Christine
- Rose Louisa
- Ross Russell Amy L.
- Rossouw Lindie
- Royal Simon
- Rudiansyah Indra
- Ruiz Sarah
- Saich Stephen
- Sala Claudia
- Sale Jessica
- Salman Ahmed M.
- Salvador Natalia
- Salvador Stephannie
- Sampaio Milla
- Samson Annette D.
- Sanchez-Gonzalez Amada
- Sanders Helen
- Sanders Katherine
- Santos Guerra Mayara F.S.
- Santos Erika
- Satti Iman
- Saunders Caroline
- Saunders Jack E.
- Sayed Aakifah
- Schim van der Loeff Ina
- Schmid Annina B.
- Schofield Ella
- Schwarzbold Alexandre V.
- Screaton Gavin
- Seddiqi Samiullah
- Segireddy Rameswara R.
- Senger Roberta
- Serrano Sonia
- Shah Rajiv
- Shaik Imam
- Sharpe Hannah E.
- Sharrocks Katherine
- Shaw Robert
- Shea Adam
- Shepherd Amy
- Shepherd James G.
- Shiham Farah
- Sidhom Emad
- Silk Sarah E.
- Silva-Junior Gilberto
- Silva-Reyes Laura
- Silveira Anderson D.
- Silveira Mariana B.V.
- Singh Nisha
- Sinha Jaisi
- Skelly Donal T.
- Smith Andrew
- Smith Catherine C.
- Smith Daniel C.
- Smith David J.
- Smith Holly E.
- Smith Nick
- Snape Matthew D.
- Soares Airanuédida
- Soares Tiago
- Solórzano Carla
- Song Rinn
- Sorio Guilherme L.
- Sorley Kim
- Sosa-Rodriguez Tiffany
- Souza Alessandra R.
- Souza Bruno S.D.F.
- Souza Cinthia M.C.D.L.
- Spencer Alexandra J.
- Spina Fernanda
- Spoors Louise
- Sprinz Eduardo
- Stafford Lizzie
- Stamford Imogen
- Starinskij Igor
- Stein Ricardo
- Steven Jill
- Stockdale Lisa
- Stockwell Lisa V.
- Strickland Louise H.
- Stuart Arabella C.
- Sturdy Ann
- Sutherland Rebecca K.
- Sutton Natalina
- Szigeti Anna
- Tahiri-Alaoui Abdessamad
- Tanner Rachel
- Taoushanis Carol
- Tarr Alexander W.
- Tarrant Richard
- Taylor Iona Jennifer
- Taylor Justin
- Taylor Keja
- Taylor Ursula
- te Water Naude Rebecca
- Themistocleous Andreas
- Themistocleous Yrene
- Thomas Kelly
- Thomas Merin
- Thomas Tonia M.
- Thombrayil Asha
- Thompson Amber
- Thompson Ameeka
- Thompson Fawziyah
- Thompson Kevin
- Thomson Emma C.
- Thomson Julia
- Thornton-Jones Viv
- Tighe Patrick J.
- Tinoco Lygia Accioly
- Tiongson Gerlynn
- Tladinyane Bonolo
- Tomasicchio Michele
- Tomic Adriana
- Tonks Susan
- Toshner Mark
- Tran Nguyen
- Tree Julia
- Trillana Gerry
- Trinham Charlotte
- Trivett Rose
- Truby Adam
- Tsheko Betty Lebogang
- Turabi Aadil
- Turner Cheryl
- Turner David P. J.
- Turner Richard
- Török M Estée
- Ulaszewska Marta
- Underwood Benjamin R.
- van Eck Samual
- Varughese Rachel
- Vekemans Johan
- Verbart Dennis
- Verheul Marije
- Vichos Iason
- Vieira Taiane
- Villafana Tonya L.
- Voysey Merryn
- Waddington Claire S.
- Walker Laura
- Wallis Erica
- Wand Matthew
- Warbick Deborah
- Wardell Theresa
- Warimwe George
- Warren Sarah C.
- Watkins Bridget
- Watson Ekaterina
- Watson Marion E. E.
- Webb Stewart
- Webb-Bridges Alice
- Webster Angela
- Weckx Lily Y.
- Welch Jessica
- Wells Jeanette
- West Alison
- White Caroline
- White Rachel
- Williams Christopher J.
- Williams Paul
- Williams Rachel L.
- Winslow Rebecca
- Woodyer Mark
- Worth Andrew T.
- Wright Danny
- Wroblewska Marzena
- Yao Andy
- Zimmer Rafael
- Zizi Dalila
- Zuidewind Peter
- Publication venue
- 'Elsevier BV'
- Publication date
- 09/01/2021
- Field of study
Background
A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials.
Methods
This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674.
Findings
Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0–75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4–97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8–80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3–4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation.
Interpretation
ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials