Computer-Controlled Machines for Pathology Slide Sorting and Cataloguing System

Final report for Team 11 of ME450, Fall 2008 semesterThe objective of these projects is to develop an opto-mechatronic system with optical scanning of bar codes and sample shapes as well as servomotors to automate the sorting and cataloguing of a collection of pathology glass slides and paraffin blocks. These machines are related to the reduction of human error using automation in healthcare. The UM hospital generates thousand of slides and hundreds of blocks per day, which must be correctly catalogued and filed away for future retrieval and reference. This manual process is very tedious and prone to errors due to its long duration and repetitive nature. Once a slide or block is incorrectly catalogued, it is virtually impossible to locate it again. Patients may need to provide additional tissue samples or errors may result with specimens from other patients. To realize this automation an embedded computer control and monitoring system will be used to drive a series of servo motors to move slides through the mechanical system, while sensors provide feedback to monitor its progression. Each slide is marked with a 2D-barcode, which must be scanned to determine the correct path through the system. Slides may have the incorrect orientation when entering the system for the barcode to be read and thus the orientation must be automatically corrected by the system. Once the slides have been catalogued, they must be ejected from the machine in a specified order into a specially designed receptacle compatible with a robotic storage system. The embedded system must utilize a connection to a network distributed SQL (Structured Query Language) database to record relevant slide and block information. Two machines, one for slides and another for blocks, have different requirements because the physical size and weight difference of slides and blocks. (This project is the slide sorting machine)Peter Lucas (Anatomic Pathology, U of M Medical School) and Ulysses Balis (Pathology Informatics, U of M Medical School)http://deepblue.lib.umich.edu/bitstream/2027.42/61920/1/ME450 Fall2008 Final Report - Team 11 - Slide Sorter.pd

From minerals to rocks: Toward modeling lithologies with remote sensing

High spectral resolution imaging spectroscopy will play an important role in future planetary missions. Sophisticated approaches will be needed to unravel subtle, super-imposed spectral features typically of natural systems, and to maximize the science return of these instruments. Carefully controlled laboratory investigations using homogeneous mineral separates have demonstrated that variations due to solid solution, changes in modal abundances, and the effects of particle size are well understood from a physical basis. In many cases, these variations can be modeled quantitatively using photometric models, mixing approaches, and deconvolution procedures. However, relative to the spectra of individual mineral components, reflectance spectra of rocks and natural surfaces exhibit a reduced spectral contrast. In addition, soils or regolith, which are likely to dominate any natural planetary surface, exhibit spectral properties that have some similarities to the parent materials, but due to weathering and alteration, differences remain that cannot yet be fully recreated in the laboratory or through mixture modeling. A significant challenge is therefore to integrate modeling approaches to derive both lithologic determinations and include the effects of alteration. We are currently conducting laboratory investigations in lithologic modeling to expand upon the basic results of previous analyses with our initial goal to more closely match physical state of natural systems. The effects of alteration are to be considered separately

Composition of the L5 Mars Trojans: Neighbors, not Siblings

Mars is the only terrestrial planet known to have Tro jan (co-orbiting) asteroids, with a confirmed population of at least 4 objects. The origin of these objects is not known; while several have orbits that are stable on solar-system timescales, work by Rivkin et al. (2003) showed they have compositions that suggest separate origins from one another. We have obtained infrared (0.8-2.5 micron) spectroscopy of the two largest L5 Mars Tro jans, and confirm and extend the results of Rivkin et al. (2003). We suggest that the differentiated angrite meteorites are good spectral analogs for 5261 Eureka, the largest Mars Trojan. Meteorite analogs for 101429 1998 VF31 are more varied and include primitive achondrites and mesosiderites.Comment: 14 manuscript pages, 1 table, 6 figures. To be published in Icarus. See companion paper 0709.1921 by Trilling et a

AVAST Survey 0.4-1.0 {\mu}m Spectroscopy of Igneous Asteroids in the Inner and Middle Main Belt

We present the spectra of 60 asteroids, including 47 V-types observed during the first phase of the Adler V-Type Asteroid (AVAST) Survey. SDSS photometry was used to select candidate V-type asteroids for follow up by nature of their very blue $i-z$ color. 47 of the 61 observed candidates were positively classified as V-type asteroids, while an additional six show indications of a 0.9 $\mu$m feature consistent with V-type spectra, but not sufficient for formal classification. Four asteroids were found to be S-type, all of which had $i-z$ values very near the adopted AVAST selection criteria of $i-z \le -0.2$, including one candidate observed well outside the cut (at a mean $i-z$ of -0.11). Three A-type asteroids were also identified. Six V-type asteroids were observed beyond the 3:1 mean motion resonance with Jupiter, including the identification of two new V-type asteroids (63085 and 105041) at this distance. Six V-type asteroids were observed with low ($<5\deg$) orbital inclination, outside of the normal dynamical range of classic Vestoids, and are suggestive of a non-Vesta origin for at least some of the population.Comment: 1 table, 3 figures, To appear to Icaru

Near to Mid-infrared Spectroscopy of (65803) Didymos as Observed by JWST: Characterization Observations Supporting the Double Asteroid Redirection Test

The Didymos binary asteroid was the target of the Double Asteroid Redirection Test (DART) mission, which intentionally impacted Dimorphos, the smaller member of the binary system. We used the Near-Infrared Spectrograph and Mid-Infrared Instrument instruments on JWST to measure the 0.6–5 and 5–20 μm spectra of Didymos approximately two months after the DART impact. These observations confirm that Didymos belongs to the S asteroid class and is most consistent with LL chondrite composition, as was previously determined from its 0.6–2.5 μm reflectance spectrum. Measurements at wavelengths >2.5 μm show Didymos to have thermal properties typical for an S-complex asteroid of its size and to be lacking absorptions deeper than ∼2% due to OH or H2O. Didymos’ mid-infrared emissivity spectrum is within the range of what has been measured on S-complex asteroids observed with the Spitzer Space Telescope and is most consistent with emission from small (<25 μm) surface particles. We conclude that the observed reflectance and physical properties make the Didymos system a good proxy for the type of ordinary chondrite asteroids that cross near-Earth space, and a good representative of likely future impactors

Burden of injury along the development spectrum : associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017

Background The epidemiological transition of non-communicable diseases replacing infectious diseases as the main contributors to disease burden has been well documented in global health literature. Less focus, however, has been given to the relationship between sociodemographic changes and injury. The aim of this study was to examine the association between disability-adjusted life years (DALYs) from injury for 195 countries and territories at different levels along the development spectrum between 1990 and 2017 based on the Global Burden of Disease (GBD) 2017 estimates. Methods Injury mortality was estimated using the GBD mortality database, corrections for garbage coding and CODEm-the cause of death ensemble modelling tool. Morbidity estimation was based on surveys and inpatient and outpatient data sets for 30 cause-of-injury with 47 nature-of-injury categories each. The Socio-demographic Index (SDI) is a composite indicator that includes lagged income per capita, average educational attainment over age 15 years and total fertility rate. Results For many causes of injury, age-standardised DALY rates declined with increasing SDI, although road injury, interpersonal violence and self-harm did not follow this pattern. Particularly for self-harm opposing patterns were observed in regions with similar SDI levels. For road injuries, this effect was less pronounced. Conclusions The overall global pattern is that of declining injury burden with increasing SDI. However, not all injuries follow this pattern, which suggests multiple underlying mechanisms influencing injury DALYs. There is a need for a detailed understanding of these patterns to help to inform national and global efforts to address injury-related health outcomes across the development spectrum.Peer reviewe

Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

Traumatic brain injury (TBI) and spinal cord injury (SCI) are increasingly recognised as global health priorities in view of the preventability of most injuries and the complex and expensive medical care they necessitate. We aimed to measure the incidence, prevalence, and years of life lived with disability (YLDs) for TBI and SCI from all causes of injury in every country, to describe how these measures have changed between 1990 and 2016, and to estimate the proportion of TBI and SCI cases caused by different types of injury. METHODS: We used results from the Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study 2016 to measure the global, regional, and national burden of TBI and SCI by age and sex. We measured the incidence and prevalence of all causes of injury requiring medical care in inpatient and outpatient records, literature studies, and survey data. By use of clinical record data, we estimated the proportion of each cause of injury that required medical care that would result in TBI or SCI being considered as the nature of injury. We used literature studies to establish standardised mortality ratios and applied differential equations to convert incidence to prevalence of long-term disability. Finally, we applied GBD disability weights to calculate YLDs. We used a Bayesian meta-regression tool for epidemiological modelling, used cause-specific mortality rates for non-fatal estimation, and adjusted our results for disability experienced with comorbid conditions. We also analysed results on the basis of the Socio-demographic Index, a compound measure of income per capita, education, and fertility. FINDINGS: In 2016, there were 27·08 million (95% uncertainty interval [UI] 24·30-30·30 million) new cases of TBI and 0·93 million (0·78-1·16 million) new cases of SCI, with age-standardised incidence rates of 369 (331-412) per 100 000 population for TBI and 13 (11-16) per 100 000 for SCI. In 2016, the number of prevalent cases of TBI was 55·50 million (53·40-57·62 million) and of SCI was 27·04 million (24·98-30·15 million). From 1990 to 2016, the age-standardised prevalence of TBI increased by 8·4% (95% UI 7·7 to 9·2), whereas that of SCI did not change significantly (-0·2% [-2·1 to 2·7]). Age-standardised incidence rates increased by 3·6% (1·8 to 5·5) for TBI, but did not change significantly for SCI (-3·6% [-7·4 to 4·0]). TBI caused 8·1 million (95% UI 6·0-10·4 million) YLDs and SCI caused 9·5 million (6·7-12·4 million) YLDs in 2016, corresponding to age-standardised rates of 111 (82-141) per 100 000 for TBI and 130 (90-170) per 100 000 for SCI. Falls and road injuries were the leading causes of new cases of TBI and SCI in most regions. INTERPRETATION: TBI and SCI constitute a considerable portion of the global injury burden and are caused primarily by falls and road injuries. The increase in incidence of TBI over time might continue in view of increases in population density, population ageing, and increasing use of motor vehicles, motorcycles, and bicycles. The number of individuals living with SCI is expected to increase in view of population growth, which is concerning because of the specialised care that people with SCI can require. Our study was limited by data sparsity in some regions, and it will be important to invest greater resources in collection of data for TBI and SCI to improve the accuracy of future assessments