Aplikasi Metode Analisis Swot Untuk Merumuskan Strategi Bersaing Pada PT Berkat Karya Lestari

Penelitian ini dilakukan dalam rangka merumuskan strategi bersaing pada PT Berkat Karya Lestari. Metode penelitian yang digunakan adalah metode penelitian kualitatif deskriptif serta pengumpulan data melalui wawancara dan observasi. Analisis situasi lingkungan internal menggunakan resource based view dan value chain analysis untuk menganalisis aktivitas primer Perusahaan. Analisis lingkungan eksternal menggunakan five forces Porter ditambah dengan dua aspek tambahan milik Daft. Setelah itu dilakukan analisis SWOT sebagai dasar merumuskan strategi bersaing pada PT Berkat Karya Lestari. Hasil penelitian menunjukkan bahwa strategi yang sesuai adalah strategi fokus dengan peningkatan pelayanan terutama kecepatan pelayanan kepada konsumen. PT Berkat Karya Lestari sebaiknya mengimplementasikan strategi fokus dengan memperbaiki kebijkan pembayaran kepada Perusahaan, sehingga Perusahaan dapat bersaing dengan baik di industry pendistribusian obat-obatan herbal

PENGARUH GAYA KEPEMIMPINAN TERHADAP TURNOVER INTENTION DENGAN AFFECTIVE ORGANIZATIONAL COMMITMENT SEBAGAI VARIABEL MEDIASI DI PT XYZ

Leadership style is one of the most important things in managing a company's human resources. The right leadership style can affect affective organizational commitment which is one dimension of organizational commitment, employees who have high affective organizational commitment will reduce turnover intention. Therefore, the researcher feels it is important to examine the influence of leadership style on turnover intention with affective organizational commitment as a mediating variable, especially in the e-commerce industry in Indonesia. This research was done in March 2018 to July 2018 with PT XYZ workers as people who responded. In this study, researchers used OLS regression Macro Process. Based on the calculations made by the researcher, there is an effect of transactional leadership style on affective organizational commitment, but transformational leadership style and laissez-faire doesn't affect on affective organizational commitment. All leadership styles don't have a direct influence and only transactional leadership style that has an significant indirect effect on turnover intention through mediating affective organizational commitment. Therefore, PT XYZ need to pay attention to use transactional leadership in order to build affective organizational commitment and reduce turnover intention in their company

PENGARUH EFIKASI DIRI SISWA SMA TERHADAP JIWA KEWIRAUSAHAAN (ENTREPRENEURSHIP)

Tujuan dalam penelitian ini adalah untuk mengetahui pengaruh efikasi diri terhadap jiwa kewirausahaan (entrepreneurship) siswa SMA. Metode penelitian yang digunakan adalah metode survey. Populasi adalah siswa SMA Citra Kasih Jakarta. Sampel ditentukan dengan menggunakan rumus Taro Yamane, dengan jumlah responden sebanyak 123 siswa. Analisis data dilakukan menggunakan SPSS analisis regresi sederhana dengan uji T dengan taraf signifikansi α = 0,05. Berdasarkan analisis data, efikasi diri seseorang memberikan pengaruh sebesar 90% terhadap jiwa kewirausahaannya. Sedangkan 10% lainnya dipengaruhi oleh variabel lain. Analisis menggunakan uji T, dapat terlihat bahwa ada pengaruh yang signifikan dari variabel X (efikasi diri) terhadap variabel Y (jiwa kewirausahaan). Hal ini karena nilai t hitung > t tabel, 32,961>1,658 dengan nilai signifikansi 0,000 < 0,05. Maka H0 ditolak dan H1 diterima. Jiwa kewirausahaan bisa ditumbuhkan dengan memperkuat efikasi diri. Efikasi diri siswa ini berasal dari dalam diri dan bisa dikembangkan atau diturukan melalui kombinasi 4 (empat sumber) yaitu: 1) pengalaman penguasaan, 2) pemodelan sosial, 3) persuasi sosial, dan 4) kondisi fisik serta emosi

Pharmacoiunetic profile and comparative bioavailability of pentoxyphylline from two sustained-release pentoxyphylline tablets in indonesian healthy volunteers: Profil farmakokinetik dan ketersediaan hayati komparatif pen

In order to assess the quality of a sustained-release pentoxyphylline tablet formulated and produced by a domestic company (PLTF-400), a comparative bioavailability study was carried out in twelve healthy Indonesian volunteers in two-way crossover design. TRTL-400, innovator\u27s product, was taken as reference product. Plasma sample was used and unchanged pentoxyphylline compound was analyzed using HPLC method. It was found that PLTF-400 was bioequivalent to the reference product (TRTL-400) with 90 % confidence intervals of C, , AUCG., and AUC (Test/Reference) of 93.1%-132.0%, 90.6% - 123.5%, and 84.2% - 116.2%, respectively. The pharmacokinetic parameters (C_, AUC, half-life) of the drug found in this study were comparable to those obtained previously by the other authors in differrent ethnics. Keywords: Pentoxyphylline, sustained-release, bioavailability, pharmacokinetics. ABSTRAK Dalam rangka penilaian mutu sebuah sediaan tablet pentoksifilin yang dihasilkan oleh sebuah industri farmasi nasional (PLTF-400), telah dilakukan uji ketersediaan hayati komparatif pada 12 sukarelawan sehat Indonesia dengan cars silang lengkap. TRTL-400 digunakan sebagai produk pembanding. Sampel yang digunakan adalah plasma dan senyawa yang dianalisis adalah senyawa utuh pentoksifilin, yang ditentukan secarakromatografi cair kined a tinggi. Hasil yang diperoleh menunjukkan bahwa PLTF-400 bioekivalen terhadap sediaan pembanding dengan nilai 90% confidence interval rasio C AUC., dan AUC secara berurutan 93,1% -132,0%, 90,6% - 123,5%, dan 84,2% - 116,2%. Harga parameter-parameter farmakokinetik (C.,â AUC, waktu paro eliminasi) yang dihasilkan dalam penelitian ini berdekatan dengan yang diperoleh pars peneliti lain sebelumnya pada etnik yang berbeda. Kata kunci: pentoksifilin, lepas lambat, ketersediaan hayati, farmakokinetik. Key Word:Pentoksilin, lepas lambat, ketersediaan hayati,Farmakokineti

Abundance and Distribution of Enteric Bacteria and Viruses in Coastal and Estuarine Sediments—a Review

The long term survival of fecal indicator organisms (FIOs) and human pathogenic microorganisms in sediments is important from a water quality, human health and ecological perspective. Typically, both bacteria and viruses strongly associate with particulate matter present in freshwater, estuarine and marine environments. This association tends to be stronger in finer textured sediments and is strongly influenced by the type and quantity of clay minerals and organic matter present. Binding to particle surfaces promotes the persistence of bacteria in the environment by offering physical and chemical protection from biotic and abiotic stresses. How bacterial and viral viability and pathogenicity is influenced by surface attachment requires further study. Typically, long-term association with surfaces including sediments induces bacteria to enter a viable-but-non-culturable (VBNC) state. Inherent methodological challenges of quantifying VBNC bacteria may lead to the frequent under-reporting of their abundance in sediments. The implications of this in a quantitative risk assessment context remain unclear. Similarly, sediments can harbor significant amounts of enteric viruses, however, the factors regulating their persistence remains poorly understood. Quantification of viruses in sediment remains problematic due to our poor ability to recover intact viral particles from sediment surfaces (typically <10%), our inability to distinguish between infective and damaged (non-infective) viral particles, aggregation of viral particles, and inhibition during qPCR. This suggests that the true viral titre in sediments may be being vastly underestimated. In turn, this is limiting our ability to understand the fate and transport of viruses in sediments. Model systems (e.g., human cell culture) are also lacking for some key viruses, preventing our ability to evaluate the infectivity of viruses recovered from sediments (e.g., norovirus). The release of particle-bound bacteria and viruses into the water column during sediment resuspension also represents a risk to water quality. In conclusion, our poor process level understanding of viral/bacterial-sediment interactions combined with methodological challenges is limiting the accurate source apportionment and quantitative microbial risk assessment for pathogenic organisms associated with sediments in aquatic environments

Spaceflight Activates Lipotoxic Pathways in Mouse Liver

Spaceflight affects numerous organ systems in the body, leading to metabolic dysfunction that may have long-term consequences. Microgravity-induced alterations in liver metabolism, particularly with respect to lipids, remain largely unexplored. Here we utilize a novel systems biology approach, combining metabolomics and transcriptomics with advanced Raman microscopy, to investigate altered hepatic lipid metabolism in mice following short duration spaceflight. Mice flown aboard Space Transportation System -135, the last Shuttle mission, lose weight but redistribute lipids, particularly to the liver. Intriguingly, spaceflight mice lose retinol from lipid droplets. Both mRNA and metabolite changes suggest the retinol loss is linked to activation of PPARα-mediated pathways and potentially to hepatic stellate cell activation, both of which may be coincident with increased bile acids and early signs of liver injury. Although the 13-day flight duration is too short for frank fibrosis to develop, the retinol loss plus changes in markers of extracellular matrix remodeling raise the concern that longer duration exposure to the space environment may result in progressive liver damage, increasing the risk for nonalcoholic fatty liver disease