68 research outputs found
Simple Models for Turbulent Self-Regulation in Galaxy Disks
We propose that turbulent heating, wave pressure and gas exchanges between
different regions of disks play a dominant role in determining the preferred,
quasi-equilibrium, self-similar states of gas disks on large-scales. We present
simple families of analytic, thermohydrodynamic models for these global states,
which include terms for turbulent pressure and Reynolds stresses. Star
formation rates, phase balances, and hydrodynamic forces are all tightly
coupled and balanced. The models have stratified radial flows, with the cold
gas slowly flowing inward in the midplane of the disk, and with the warm/hot
phases that surround the midplane flowing outward.
The models suggest a number of results that are in accord with observation,
as well as some novel predictions, including the following. 1) The large-scale
gas density and thermal phase distributions in galaxy disks can be explained as
the result of turbulent heating and spatial couplings. 2) The turbulent
pressures and stresses that drive radial outflows in the warm gas also allow a
reduced circular velocity there. This effect was observed by Swaters, Sancisi
and van der Hulst in NGC 891, a particularly turbulent edge-on disk. The models
predict that the effect should be universal in such disks. 3) They suggest that
a star formation rate like the phenomenological Schmidt Law is the natural
result of global thermohydrodynamical balance, and may not obtain in disks far
from equilibrium. (Abridged)Comment: 37 pages, 1 gif figure, accepted for publication in the Astrophysical
Journa
Interacting Galaxies in the A901/902 Supercluster with STAGES
We present a study of galaxy mergers and the influence of environment in the
Abell 901/902 supercluster at z~0.165. We use HST ACS F606W data from the
STAGES survey, COMBO-17, Spitzer 24um, and XMM-Newton X-ray data. Our analysis
utilizes both a visual classification system, and quantitative CAS parameters
to identify systems which show evidence of a recent or ongoing merger of mass
ratio >1/10. Our results are: (1) After visual classification and minimizing
the contamination from false projection pairs, we find that the merger fraction
f_merge is 0.023+/-0.007. The estimated fractions of likely major mergers,
likely minor mergers, and ambiguous cases are 0.01+/-0.004, 0.006+/-0.003, and
0.007+/-0.003, respectively. (2) The mergers lie outside the cluster core of
radius R < 0.25 Mpc: the lack of mergers in the core is likely due to the large
galaxy velocity dispersion in the core. Mergers populate the region (0.25 Mpc <
R <= 2 Mpc) between the core and outskirt. In this region, the estimated
frequency of mergers is similar to those seen at typical group overdensities.
This suggests ongoing growth of the clusters via accretion of group and field
galaxies. (3) We compare our observed merger fraction with those reported in
other clusters and groups out to z~0.4. Existing data points on the merger
fraction for L<= L* galaxies in clusters allow for a range of evolutionary
scenarios. (4) The fraction of mergers, which lie on the blue cloud is
80%+/-18% versus 34%+/-7% for non-interacting galaxies, implying that
interacting galaxies are preferentially blue. (5) The average SFR, based on UV
or UV+IR data, is enhanced by a factor of ~1.5 to 2 in mergers compared to
non-interacting galaxies. However, mergers in the clusters contribute only a
small fraction (between 10% and 15%) of the total SFR density.(Abridged)Comment: Accepted for publication in ApJ. 34 pages, 16 figures. Version with
full resolution figures available at: http://www.as.utexas.edu/~alh/apj/int/
; updated abridged abstrac
History of Galaxy Interactions and their Impact on Star Formation over the Last 7 Gyr from GEMS
We perform a comprehensive estimate of the frequency of galaxy mergers and
their impact on star formation over z~0.24--0.80 (lookback time T_b~3--7 Gyr)
using 3698 (M*>=1e9 Msun) galaxies with GEMS HST, COMBO-17, and Spitzer data.
Our results are: (1) Among 790 high mass (M*>=2.5e10 Msun) galaxies, the
visually-based merger fraction over z~0.24--0.80, ranges from 9%+-5% to 8%+-2%.
Lower limits on the major and minor merger fractions over this interval range
from 1.1% to 3.5%, and 3.6% to 7.5%, respectively. This is the first
approximate empirical estimate of the frequency of minor mergers at z<1. For a
visibility timescale of ~0.5 Gyr, it follows that over T_b~3--7 Gyr, ~68% of
high mass systems have undergone a merger of mass ratio >1/10, with ~16%, 45%,
and 7% of these corresponding respectively to major, minor, and ambiguous
`major or minor' mergers. The mean merger rate is a few x 1e-4 Gyr-1 Mpc-3. (2)
We compare the empirical merger fraction and rate for high mass galaxies to a
suite of Lambda CDM-based models: halo occupation distribution models,
semi-analytic models, and hydrodynamic SPH simulations. We find qualitative
agreement between observations and models such that the (major+minor) merger
fraction or rate from different models bracket the observations, and show a
factor of five dispersion. Near-future improvements can now start to rule out
certain merger scenarios. (3) Among ~3698 M*>=1e9 Msun galaxies, we find that
the mean SFR of visibly merging systems is only modestly enhanced compared to
non-interacting galaxies over z~0.24--0.80. Visibly merging systems only
account for less than 30% of the cosmic SFR density over T_b~3--7 Gyr. This
suggests that the behavior of the cosmic SFR density over the last 7 Gyr is
predominantly shaped by non-interacting galaxies.Comment: Accepted for Publication in the Astrophysical Journal. 17 pages of
text, 21 figures, 3 tables. Uses emulateapj5.st
Patterns of transmitted HIV drug resistance in Europe vary by risk group
Background: In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the risk behaviour reported. Methods: HIV-1 patients newly diagnosed in 27 countries from 2002 through 2007 were included. Inclusion was representative for risk group and geographical distribution in the participating countries in Europe. Trends over time were calculated by logistic regression. Results: From the 4317 patients included, the majority was men-having-sex-with-men -MSM (2084, 48%), followed by heterosexuals (1501, 35%) and injection drug users (IDU) (355, 8%). MSM were more often from Western Europe origin, infected with subtype B virus, and recently infected (<1 year) (p<0.001). The prevalence of TDRM was highest in MSM (prevalence of 11.1%), followed by heterosexuals (6.6%) and IDU (5.1%, p<0.001). TDRM was predominantly ascribed to nucleoside reverse transcriptase inhibitors (NRTI) with a prevalence of 6.6% in MSM, 3.3% in heterosexuals and 2.0% in IDU (p = 0.001). A significant increase in resistance to non- nucleoside reverse transcriptase inhibitors (NNRTIs) and a decrease in resistance to protease inhibitors was observed in MSM (p = 0.008 and p = 0.006, respectively), but not in heterosexual patients (p = 0.68 and p = 0.14, respectively). Conclusions: MSM showed to have significantly higher TDRM prevalence compared to heterosexuals and IDU. The increasing NNRTI resistance in MSM is likely to negatively influence the therapy response of first-line therapy, as most include NNRTI drugs
Increase in transmitted resistance to non-nucleoside reverse transcriptase inhibitors among newly diagnosed HIV-1 infections in Europe
Background: One out of ten newly diagnosed patients in Europe was infected with a virus carrying a drug resistant mutation. We analysed the patterns over time for transmitted drug resistance mutations (TDRM) using data from the European Spread program.Methods: Clinical, epidemiological and virological data from 4317 patients newly diagnosed with HIV-1 infection between 2002 and 2007 were analysed. Patients were enrolled using a pre-defined sampling strategy.Results: The overall prevalence of TDRM in this period was 8.9% (95% CI: 8.1-9.8). Interestingly, significant changes over time in TDRM caused by the different drug classes were found. Whereas nucleoside resistance mutations remained constant at 5%, a significant decline in protease inhibitors resistance mutations was observed, from 3.9% in 2002 to 1.6% in 2007 (p = 0.001). In contrast, resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) doubled from 2.0% in 2002 to 4.1% in 2007 (p = 0.004) with 58% of viral strains carrying a K103N mutation. Phylogenetic analysis showed that these temporal changes could not be explained by large clusters of TDRM.Conclusion: During the years 2002 to 2007 transmitted resistance to NNRTI has doubled to 4% in Europe. The frequent use of NNRTI in first-line regimens and the clinical impact of NNRTI mutations warrants continued monitoring
A community-maintained standard library of population genetic models
The explosion in population genomic data demands ever more complex modes of analysis, and increasingly, these analyses depend on sophisticated simulations. Recent advances in population genetic simulation have made it possible to simulate large and complex models, but specifying such models for a particular simulation engine remains a difficult and error-prone task. Computational genetics researchers currently re-implement simulation models independently, leading to inconsistency and duplication of effort. This situation presents a major barrier to empirical researchers seeking to use simulations for power analyses of upcoming studies or sanity checks on existing genomic data. Population genetics, as a field, also lacks standard benchmarks by which new tools for inference might be measured. Here, we describe a new resource, stdpopsim, that attempts to rectify this situation. Stdpopsim is a community-driven open source project, which provides easy access to a growing catalog of published simulation models from a range of organisms and supports multiple simulation engine backends. This resource is available as a well-documented python library with a simple command-line interface. We share some examples demonstrating how stdpopsim can be used to systematically compare demographic inference methods, and we encourage a broader community of developers to contribute to this growing resource.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach
<p>Abstract</p> <p>Background</p> <p>The prevalence and the origin of HIV-1 subtype B, the most prevalent circulating clade among the long-term residents in Europe, have been studied extensively. However the spatial diffusion of the epidemic from the perspective of the virus has not previously been traced.</p> <p>Results</p> <p>In the current study we inferred the migration history of HIV-1 subtype B by way of a phylogeography of viral sequences sampled from 16 European countries and Israel. Migration events were inferred from viral phylogenies by character reconstruction using parsimony. With regard to the spatial dispersal of the HIV subtype B sequences across viral phylogenies, in most of the countries in Europe the epidemic was introduced by multiple sources and subsequently spread within local networks. Poland provides an exception where most of the infections were the result of a single point introduction. According to the significant migratory pathways, we show that there are considerable differences across Europe. Specifically, Greece, Portugal, Serbia and Spain, provide sources shedding HIV-1; Austria, Belgium and Luxembourg, on the other hand, are migratory targets, while for Denmark, Germany, Italy, Israel, Norway, the Netherlands, Sweden, Switzerland and the UK we inferred significant bidirectional migration. For Poland no significant migratory pathways were inferred.</p> <p>Conclusion</p> <p>Subtype B phylogeographies provide a new insight about the geographical distribution of viral lineages, as well as the significant pathways of virus dispersal across Europe, suggesting that intervention strategies should also address tourists, travellers and migrants.</p
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine
[This corrects the article DOI: 10.1186/s13054-016-1208-6.]
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