111 research outputs found
The genetic and environmental effects on school grades in late childhood and adolescence
Eifler EF, Starr A, Riemann R. The genetic and environmental effects on school grades in late childhood and adolescence. PLOS ONE. 2019;14(12): e0225946.As academic achievement can have a major impact on the development of social inequalities we set out to explore how performance differences arise. Using data of the German twin study TwinLife, genetic and environmental effects on school grades in mathematics, German and the grade point average in two age cohorts (11 and 17 years old) were identified. Structural equation modelling on the data of 432 monozygotic and 529 dizygotic twin pairs as well as 317 siblings of the twins showed substantial genetic effects (up to 62%) in both cohorts on all three variables. Next to genetic influences, the twin-specific environment as well as non-shared environmental influences were found to explain the interindividual differences in mathematics and German as well as the grade point average. A cohort effect showing itself in higher heritability in the older cohort was found for mathematics and the grade point average but not for German. Moreover, we compared twins who were assigned to the same classroom to those twins who were assigned to different classrooms and found lower effects of the twin-specific shared environment in the latter group. Our study thereby contributes to the understanding of the etiology of interindividual differences in academic achievement in the numeracy and literacy domain in two age cohorts
Survey of Period Variations of Superhumps in SU UMa-Type Dwarf Novae. VIII: The Eighth Year (2015-2016)
Continuing the project described by Kato et al. (2009, arXiv:0905.1757), we
collected times of superhump maxima for 128 SU UMa-type dwarf novae observed
mainly during the 2015-2016 season and characterized these objects. The data
have improved the distribution of orbital periods, the relation between the
orbital period and the variation of superhumps, the relation between period
variations and the rebrightening type in WZ Sge-type objects. Coupled with new
measurements of mass ratios using growing stages of superhumps, we now have a
clearer and statistically greatly improved evolutionary path near the terminal
stage of evolution of cataclysmic variables. Three objects (V452 Cas, KK Tel,
ASASSN-15cl) appear to have slowly growing superhumps, which is proposed to
reflect the slow growth of the 3:1 resonance near the stability border.
ASASSN-15sl, ASASSN-15ux, SDSS J074859.55+312512.6 and CRTS J200331.3-284941
are newly identified eclipsing SU UMa-type (or WZ Sge-type) dwarf novae.
ASASSN-15cy has a short (~0.050 d) superhump period and appears to belong to EI
Psc-type objects with compact secondaries having an evolved core. ASASSN-15gn,
ASASSN-15hn, ASASSN-15kh and ASASSN-16bu are candidate period bouncers with
superhump periods longer than 0.06 d. We have newly obtained superhump periods
for 79 objects and 13 orbital periods, including periods from early superhumps.
In order that the future observations will be more astrophysically beneficial
and rewarding to observers, we propose guidelines how to organize observations
of various superoutbursts.Comment: 123 pages, 162 figures, 119 tables, accepted for publication in PASJ
(including supplementary information
The prevalence of intrusive memories in adult depression: A meta-analysis
Background Intrusive memories have typically been associated with post-traumatic stress disorder (PTSD) but some studies have suggested they can also occur in depression-alone. Objective This meta-analysis aimed to estimate the prevalence of intrusive memories in adult depression and to explore methodological and other factors that may moderate this prevalence. Method The databases PsycINFO, PsycARTICLES, MedLine, PubMed, CINAHL and Embase were searched for relevant articles, published up to and including July 2016. Studies measuring point prevalence of intrusive memories in adults aged 18 years or above with depression were included and assessed for quality. Meta-analysis was completed under a random effects model. Results Seven studies measuring point prevalence of intrusive memories in adult depression were included. The overall pooled prevalence estimate calculated was 76.0% (95% CI 59.4 – 89.4%), reducing to 66.0% (95% CI 51.0 – 79.5%) when restricted to intrusive memories experienced within the week prior to assessment. Heterogeneity was high. Between-groups analyses indicated that adults with depression are as likely to experience intrusive memories as adults with PTSD, and more likely to experience intrusive memories than healthy controls (risk ratio of 2.94, 95% CI 1.53 – 5.67). Limitations The strength of conclusions is limited by the small number of studies included. Consideration of the relationship between depression, intrusive memories and trauma exposure is required. Conclusions Intrusive memories are experienced by a large majority of adults with depression and may therefore be an important target for cognitive intervention. Larger scale measurement of clinical outcome is needed with identification of individual factors predicting treatment response
Data from the German TwinLife Study: Genetic and Social Origins of Educational Predictors, Processes, and Outcomes
The major aim of the German TwinLife study is the investigation of gene-environment interplay driving educational and other inequalities across developmental trajectories from childhood to early adulthood. TwinLife encompasses an 8-year longitudinal, cross-sequential extended twin family design with data from same-sex twins of four age cohorts (5, 11, 17, and 23 years) and their parents, as well as their non-twin siblings, partners, and children, if available, altogether containing N = 4,096 families. As such, TwinLife includes unique and openly accessible data that allows, but is not limited to, genetically informative and environmentally sensitive research on sources of inequalities regarding educational attainment, school achievement, and skill development
A longitudinal twin family study of the life course and individual development (TWINLIFE): Data collection and instruments of wave 1 face-to-face interviews
Brix J, Pupeter M, Rysina A, et al. A longitudinal twin family study of the life course and individual development (TWINLIFE): Data collection and instruments of wave 1 face-to-face interviews. TwinLife Technical Report Series. Vol 05. Bielefeld: Project TwinLife "Genetic and social causes of life chances" (Universität Bielefeld / Universität des Saarlandes); 2017
Copied goods and the informal economy in Brazil and China: outlining a comparison of development models
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to ~192,000 individuals, and used ~155,063 samples for independent replication. We identified 31 novel blood pressure or hypertension associated genetic regions in the general population, including three rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1.5mmHg/allele) than common variants. Multiple rare, nonsense and missense variant associations were found in A2ML1 and a low-frequency nonsense variant in ENPEP was identified. Our data extend the spectrum of allelic variation underlying blood pressure traits and hypertension, provide new insights into the pathophysiology of hypertension and indicate new targets for clinical intervention
The Science Performance of JWST as Characterized in Commissioning
This paper characterizes the actual science performance of the James Webb
Space Telescope (JWST), as determined from the six month commissioning period.
We summarize the performance of the spacecraft, telescope, science instruments,
and ground system, with an emphasis on differences from pre-launch
expectations. Commissioning has made clear that JWST is fully capable of
achieving the discoveries for which it was built. Moreover, almost across the
board, the science performance of JWST is better than expected; in most cases,
JWST will go deeper faster than expected. The telescope and instrument suite
have demonstrated the sensitivity, stability, image quality, and spectral range
that are necessary to transform our understanding of the cosmos through
observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures;
https://iopscience.iop.org/article/10.1088/1538-3873/acb29
Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines
Understanding vaccine-elicited protection against SARS-CoV-2 variants and other sarbecoviruses is
key for guiding public health policies. We show that a clinical stage multivalent SARS-CoV-2 spike
receptor-binding domain nanoparticle vaccine (RBD-NP) protects mice from SARS-CoV-2 challenge
after a single immunization, indicating a potential dose-sparing strategy. We benchmarked serum
neutralizing activity elicited by RBD-NP in non-human primates against a lead prefusion-stabilized
SARS-CoV-2 spike (HexaPro) using a panel of circulating mutants. Polyclonal antibodies elicited by
both vaccines are similarly resilient to many RBD residue substitutions tested although mutations at
and surrounding position 484 have negative consequences for neutralization. Mosaic and cocktail
nanoparticle immunogens displaying multiple sarbecovirus RBDs elicit broad neutralizing activity in
mice and protect mice against SARS-CoV challenge even in the absence of SARS-CoV RBD in the
vaccine. This study provides proof of principle that multivalent sarbecovirus RBD-NPs induce
heterotypic protection and motivates advancing such broadly protective sarbecovirus vaccines to the
clinic
New genetic loci link adipose and insulin biology to body fat distribution.
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
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