Factores de riesgo para la presencia de Eventos Supuestamente Atribuidos a la Vacunación o Inmunización (ESAVI) en la vacunación con BBIBP-CorV contra COVID-19 en Trabajadores de EsSalud en La Libertad en 2021

La vacuna BBIBP-CorV fue la primera vacuna para COVID-19 que llegó al Perú, sin embargo, generó muchas dudas en la población sobre su seguridad por su aprobación antes de cumplir con todas las fases correspondientes. Objetivo: Determinar factores de riesgo para la presencia de Eventos Supuestamente Atribuidos a la Vacunación o Inmunización (ESAVI) en la vacunación con BBIBP-CorV en trabajadores de EsSalud en La Libertad. Materiales y métodos: Se realizó un estudio censal, observacional de casos y controles de trabajadores de EsSalud vacunados con BBIBP-CorV en 2021 en La Libertad, Perú. Los datos sobre la vacunación fueron recolectados mediante autoreporte sin datos personales (anónimo) y voluntario en la vacunación. Resultados: Se incluyó 467 vacunados donde 199 fueron los casos y 268 los controles. En el análisis multivariado se halló riesgo estadísticamente significativo únicamente para el sexo femenino (OR: 2,4; IC 95%: 1,6-3,6; p=0.000) y para la presencia de 3 o más comorbilidades (OR: 5,7; IC 95%: 1,2-27,7; p=0.031). Los demás factores analizados no alcanzaron significancia estadística. Conclusión: El sexo femenino y la presencia de 3 o más comorbilidades son factores de riesgo para la presencia de ESAVI en la vacunación con BBIBP-CorV. Se requieren investigaciones posteriores para conocer si los factores de riesgo hallados en la presente investigación podrían coincidir con otras vacunas y mejorar el control de ESAVI en la poblaciónThe BBIBP-CorV vaccine was the first vaccine for COVID-19 that arrived in Peru, however, it generated many doubts in the population about its safety due to its approval before complying with all the corresponding phases. Objective: To determine risk factors for the development of Events Supposedly Attributed to Vaccination or Immunization (ESAVI) in vaccination with BBIBP-CorV in EsSalud workers in La Libertad. Material and methods: A census, observational case-control study of EsSalud workers vaccinated with BBIBP-CorV in 2021 was conducted in La Libertad, Peru. Data on vaccination were collected through self-report without personal data (anonymous) and voluntary in vaccination. Results: We included 467 vaccinated workers, 199 cases and 268 controls. In the multivariate analysis, statistically significant risk was found only for females (OR: 2.4; CI 95%: 1.6-3.6; p=0.000) and for the presence of 3 or more comorbidities (OR: 5.7; CI 95%: 1.2-27.7; p=0.031). The other factors analyzed did not reach statistical significance. Conclusion: Female sex and the presence of 3 or more comorbidities are risk factors for the development of ESAVI in BBIBP-CorV vaccination. Further research is required to know if the risk factors found in the present investigation could coincide with other vaccines and improve the control of ESAVI in the population.Tesi

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements