10 research outputs found
Mathematical Modelling of Cell-Fate Decision in Response to Death Receptor Engagement
- Author
- A Degterev
- A Jurewicz
- A Kawahara
- A Krikos
- A Lissat
- A Naldi
- A Naldi
- A Zinovyev
- AJ Kowaltowski
- Andrei Zinovyev
- AY Andreyev
- B Zhivotovsky
- BB Aldridge
- Boris Zhivotovsky
- BP Eckelman
- C Du
- C Kitanaka
- CG Pham
- CM Croce
- CY Wang
- D Hanahan
- Denis Thieffry
- DJ Turner
- DV Krysko
- E Varfolomeev
- E Varfolomeev
- E Varfolomeev
- EA Slee
- EE Varfolomeev
- Emmanuel Barillot
- G Kroemer
- G Kroemer
- GM Fimia
- H Harlin
- H Kamata
- H LeBlanc
- H Yoshida
- I Imoto
- I Imoto
- IN Lavrik
- J Hitomi
- J Zhang
- JE Chipuk
- JE Vince
- L Tournier
- L Tournier
- L Yu
- Laurence Calzone
- Laurent Tournier
- M Bentele
- M Fussenegger
- M Karin
- M Karin
- M Li
- M Rehm
- MA Kelliher
- MJ Morgan
- N Harper
- N Holler
- N Rampino
- N Shivapurkar
- P Li
- P Vandenabeele
- PH Krammer
- R Thomas
- R Zhang
- Rama Ranganathan
- RS Moubarak
- RW Johnstone
- S Daniel
- S Kreuz
- S Kreuz
- S Legewie
- S Orrenius
- S Sakon
- SA Kauffman
- SD Catz
- Simon Fourquet
- T Eissing
- T Teitz
- T Vanden Berghe
- V Cowling
- W Fiers
- WC Yeh
- WC Yeh
- Y Kouroku
- Y Xu
- Z Dai
- ZG Liu
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Cytokines such as TNF and FASL can trigger death or survival depending on cell lines and cellular conditions. The mechanistic details of how a cell chooses among these cell fates are still unclear. The understanding of these processes is important since they are altered in many diseases, including cancer and AIDS. Using a discrete modelling formalism, we present a mathematical model of cell fate decision recapitulating and integrating the most consistent facts extracted from the literature. This model provides a generic high-level view of the interplays between NFκB pro-survival pathway, RIP1-dependent necrosis, and the apoptosis pathway in response to death receptor-mediated signals. Wild type simulations demonstrate robust segregation of cellular responses to receptor engagement. Model simulations recapitulate documented phenotypes of protein knockdowns and enable the prediction of the effects of novel knockdowns. In silico experiments simulate the outcomes following ligand removal at different stages, and suggest experimental approaches to further validate and specialise the model for particular cell types. We also propose a reduced conceptual model implementing the logic of the decision process. This analysis gives specific predictions regarding cross-talks between the three pathways, as well as the transient role of RIP1 protein in necrosis, and confirms the phenotypes of novel perturbations. Our wild type and mutant simulations provide novel insights to restore apoptosis in defective cells. The model analysis expands our understanding of how cell fate decision is made. Moreover, our current model can be used to assess contradictory or controversial data from the literature. Ultimately, it constitutes a valuable reasoning tool to delineate novel experiments
Relapsing and Remitting Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Association With Infection and Vaccination: A Case Report
- Publication venue
- 'Elsevier BV'
- Publication date
- 18/11/2022
- Field of study
Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is the second most common monoclonal gammopathy of renal significance. Rates of progression to kidney failure as well as rates of recurrence after kidney transplantation are high, especially in the absence of treatment. Treatment is usually targeted toward the abnormal clone, but even in the absence of an identifiable clone, empiric treatment is still recommended to avoid worsening prognosis. In this report, we present an unusual course of a PGNMID case with a relapsing and remitting pattern of illness, likely triggered by infection and vaccination. The patient in this case showed subsequent improvement after each episode, with stable kidney function over the years. This case report highlights the importance of investigating possible recent infectious exposures or vaccinations as potential triggers for this disease. This association should be considered for future patients with PGNMID, especially when there is no identifiable clone to help guide therapy
FAIM-L regulation of XIAP degradation modulates Synaptic Long-Term Depression and Axon Degeneration
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The Role of Excitotoxic Programmed Necrosis in Acute Brain Injury
- Author
- Aarts
- Andrabi
- Ang
- Araújo
- Artus
- Auer
- Auer
- Bano
- Baritaud
- Blenn
- Brophy
- Brown
- Cao
- Cao
- Chen
- Choi
- Choi
- Clark
- Clarke
- Colbourne
- Cook
- Cook
- David
- Fujikawa
- Fujikawa
- Fujikawa
- Fujikawa
- Fujikawa
- Gao
- Gavrielli
- Gill
- Griffiths
- Griffiths
- Hara
- Hardingham
- Henshall
- Hu
- Ikonomidou
- Ishihara
- Kahles
- Kondratyev
- Liu
- MacDermott
- Mandic
- Mattiasson
- McGinn
- Mondello
- Moubarak
- Narkilahti
- Nicholls
- Nur-E-Kamal
- Olney
- Olney
- Olney
- Polster
- Rothman
- Sahara
- Sattler
- Saver
- Schindler
- Siman
- Simon
- Singh
- Takano
- Tang
- Tsukada
- Tu
- Uchiyama
- Vosler
- Wajant
- Wang
- Wang
- Wroge
- Wyllie
- Yamashima
- Yu
- Yu
- Zhao
- Zhou
- Zhu
- Zou
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
Invited Grand Rounds Article—Up Close But Not Too Personal: Establishing Appropriate Boundaries with Individuals Following Spinal Cord Injury
- Author
- A Ginory
- Ann Marie Warren
- CA Galletly
- CB Fisher
- CL Bradbury
- D Linklater
- G Moubarak
- GO Gabbard
- GO Gabbard
- J Peluchette
- JM Farnan
- JM Farnan
- JS Guseh
- Kenleigh Roden-Foreman
- KM Driscoll
- L Emerich
- L Snyder
- MJ DeVivo
- MJ Hess
- NJ Farber
- P Fronek
- PM Miller
- PM Miller
- R Hansen
- R Shore
- RI Simon
- Rita Hamilton
- S Ghuloum
- SJ Knapp
- SS Kurpad
- W Seymour
- Z Ayyoub
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Fas apoptosis inhibitory molecules: more than death-receptor antagonists in the nervous system
- Author
- Aebischer
- Ashkenazi
- Beier
- Bhaskar
- Boehning
- Brenner
- Bucan
- Bucan
- Bucan
- Cai
- Carriba
- Carriba
- Chae
- Chang
- Cohen
- Cusack
- Dastagir
- Debatin
- Deppmann
- Desbarats
- Eckelman
- Felderhoff-Mueser
- Fernandez
- French
- Fulda
- Gavalda
- Gehler
- Gibon
- Guicciardi
- Gumy
- Gutierrez
- Gutierrez
- Hemond
- Heppner
- Hitoshi
- Huo
- Huo
- Hurtado de Mendoza
- Jiang
- Jost
- Keppler
- Kim
- Kischkel
- Kisiswa
- Kong
- Lang
- Li
- Li
- Lisak
- Marchetti
- Marques-Fernandez
- Martin-Villalba
- McKelvey
- Merianda
- Mignotte
- Minter
- Moubarak
- Murakami
- Nguyen
- Nguyen
- Nolan
- Ofengeim
- Pallasch
- Pallasch
- Patron
- Pickering
- Planells-Ferrer
- Ponten
- Proto-Siqueira
- Raj
- Reich
- Reimers
- Richards
- Rojas-Rivera
- Sano
- Schneider
- Schweitzer
- Schweitzer
- Segura
- Sigruener
- Simon
- Slee
- Sole
- Somia
- Song
- Song
- Srinivasula
- Tauber
- Unsain
- Urresti
- Vila
- Vizard
- Wang
- Wheeler
- White
- Willis
- Wozniak
- Yang
- Yu
- Zhong
- Zuliani
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Excitotoxicity*
- Author
- Aarts
- Aarts
- Abele
- Albers
- Albin
- Albin
- Alexi
- Baker
- Bano
- Bath
- Beal
- Beal
- Beal
- Beal
- Beal
- Beal
- Beal
- Beal
- Beal
- Beal
- Beal
- Behrens
- Benveniste
- Besancon
- Bizat
- Boireau
- Bondy
- Bonfoco
- Bridges
- Brorson
- Brouillet
- Brouillet
- Browne
- Bruno
- Bruno
- Buchan
- Buchan
- Buisson
- Bullock
- Cao
- Cao
- Carney
- Carreau
- Chan
- Chan
- Chatterton
- Cheramy
- Chinopoulos
- Choi
- Choi
- Chow
- Clausen
- Clough-Helfman
- Copani
- Coyle
- Czyz
- Dawson
- Dawson
- Dawson
- de Pina-Benabou
- Difazio
- Du
- Dugan
- Dure
- Dykens
- Dykens
- Egebjerg
- Eimerl
- Enari
- Escott
- Faddis
- Faden
- Farahani
- Favit
- Ferrante
- Fink
- Frantseva
- Gao
- Gaspary
- Gill
- Gill
- Golding
- Gotti
- Graham
- Graham
- Grant
- Greenamyre
- Greenamyre
- Greenamyre
- Greenamyre
- Greene
- Greene
- Grotta
- Guttmann
- Hall
- Hall
- Hamada
- Hamada
- Hamilton
- Hara
- Hara
- Hara
- Hara
- Hartley
- Henshaw
- Heyes
- Hicks
- Hollmann
- Hollmann
- Hume
- Ikonomidou
- Immke
- Jenkins
- Jia
- Jones-Humble
- Kampfl
- Kaneko
- Kano
- Keinanen
- Keller
- Kiedrowski
- Kingston
- Klockgether
- Koh
- Koura
- Kowall
- Kumar
- Kuroda
- Kuroda
- Kutsuwada
- Lafon-Cazal
- Lagrue
- Laine
- Lange
- Lankiewicz
- Lazebnik
- Lees
- Lees
- Li
- Lin
- Lucas
- Ludolph
- Ludolph
- Majewska
- Malessa
- Malgouris
- Massieu
- Masu
- Matsuda
- Mattson
- McDonald
- McGeer
- McGeer
- McIntosh
- Meguro
- Merino
- Michetti
- Miller
- Mohr
- Monaghan
- Monyer
- Monyer
- Moore
- Moriyoshi
- Moubarak
- Moudy
- Muir
- Nadler
- Nishikawa
- Novelli
- Nowicki
- Oguro
- Olney
- Ozyurt
- Palfi
- Park
- Park
- Patten
- Pearson
- Pellegrini-Giampietro
- Perraud
- Pignataro
- Pignataro
- Pitsikas
- Plaitakis
- Polster
- Portera-Cailliau
- Pulsinelli
- Puttfarcken
- Radi
- Radi
- Randall
- Reisberg
- Reynolds
- Riepe
- Rogers
- Rothman
- Rothstein
- Rothstein
- Rothstein
- Roussel
- Runnels
- Sattler
- Sattler
- Schulz
- Schulz
- Schulz
- Schulz
- Schulz
- Shaw
- Shaw
- Sheardown
- Shuaib
- Simon
- Singleton
- Siniscalchi
- Smith
- Smith
- Snider
- Sommer
- Sommer
- Sonsalla
- Sonsalla
- Spencer
- Spencer
- Stamler
- Steinberg
- Sun
- Sun
- Susin
- Tanabe
- Teitelbaum
- Tenneti
- Tenneti
- Thayer
- Thompson
- Traynelis
- Turski
- Tymianski
- Tymianski
- Verdoorn
- Volbracht
- Wada
- Wahl
- Waldvogel
- Warner
- Wehage
- Weller
- Werner
- Wu
- Wullner
- Xiong
- Yakovlev
- Young
- Young
- Yu
- Yu
- Yue
- Zeevalk
- Zeevalk
- Zhang
- Zhang
- Zhang
- Zhao
- Zhou
- Zuddas
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2010
- Field of study
Antibacterial Envelope to Prevent Cardiac Implantable Device Infection
- Author
- Ali Al-Mugamgha
- Allan Katz
- Allan Nichols
- Andrew Rubin
- Andrzej Kutarski
- Anthony Chu
- Antoine Da Costa
- António Cãndido de Freitas Fernandes Hipólito Reis
- Arun Kolli
- Attila Mihalcz
- Berit Thornvig Philbert
- Berman Brett
- Biffi Mauro
- Brett Berman
- Brian Ramza
- Byron Lee
- Calum Redpath
- Camille Frazier-Mills
- Carlo De Asmundis
- Cecilia Rorsman
- Chad Brodt
- Chanta Chakrabarti
- Charles Henrikson
- Charles Kennergren
- Charles Love
- Cheng Alan
- Chetan Gangireddy
- Christina Murray
- Christopher Cole
- Collier Jack
- Corey Ralph
- Cronin Edmond
- Daniel Anderson
- Daniel Frisch
- Daniel Gras
- Daniel Lustgarten
- Darius Sholevar
- Darren Traub
- Darryl Wells
- David Juang
- David Justin Wright
- David Rhine
- David Riggio
- David Sandler
- Denise Sorrentino
- Douglas Hodgkin
- Edmond Cronin
- Edward Schloss
- Eldadah Zayd
- Emad Aziz
- Emmanuel Simantirakis
- Eric Johnson
- Eric Putz
- Ethan Fruechte
- Etienne Pruvot
- Evan Adelstein
- Evonich Rudolph
- Fozia Ahmed
- François Philippon
- Frederic Anselme
- Frederick Ehlert
- Gabriela Kaliska
- Gallastegui Jose
- Gautham Kalahasty
- George N Theodorakis
- George Thomas
- Gery Tomassoni
- Girish Nair
- Glenn Meininger
- Grant Simons
- Gregory Golovchiner
- Hafiza Khan
- Hamid Ghanbari
- Harish Manyam
- Havard Keilegavlen
- Heath Saltzman
- Hüseyin Ince
- Ignasi Anguera
- Igor Diemberger
- Ilana Kutinsky
- Imra Zainal Abidin
- Ismaile Abdalla
- Jack Collier
- James Merrill
- James Sandberg
- Janet McComb
- Javier Banchs
- Javier Moreno
- Jay Franklin
- Jean Moubarak
- Jean-Claude Deharo
- Jean-Manuel Herzet
- Jeff Healey
- Jeffrey Luebbert
- Jerome Kuhnlein
- Joaquin Martinez-Arraras
- Jodie Hurwitz
- JoEllyn Moore
- John Bailey
- John Chenarides
- John Douglas Pappas
- John Love
- John McAnulty
- John Schoenhard
- Jonas Hörnsten
- Jorge Massare
- Jorge Silvestre
- Jose Gallastegui
- Joshua Cooper
- João Manuel Frazão
- Juan José Olalla
- Judith Mackall
- Kah Leng Ho
- Kamel Addo
- Katherine Fan
- Kelly Kim
- Kennergren Charles
- Kenneth Civello
- Kevin Boran
- Khaldoun Tarakji
- Khan Hafiza
- Lande Jeff D
- Larry Chinitz
- Laurence Marie-Pierre Guedon-Moreau
- Lexcen Daniel R
- Luca Bontempi
- Lucas V A Boersma
- Malini Madhavan
- Marc Silver
- Maria Grazia Bongiorni
- Mark Castellani
- Mark John Mason
- Mark Kremers
- Mark Mitchell
- Martin Emert
- Marye Gleva
- Matthew Smelley
- Mauro Biffi
- McComb Janet M
- Michael Osayamen
- Michael Pelini
- Michael Springer
- Mittal Suneet
- Mohammad Jazayeri
- Nagib Chalfoun
- Ngai-Yin Chan
- Panagiotis Korantzopoulos
- Paresh Shah
- Paul Wang
- Peter Ammann
- Peter Margitfalvi
- Peter Santucci
- Philippon François
- Pickett Robert A
- Pierce Vatterott
- Poole Jeanne E
- Przemyslaw Mitkowski
- Pugazhendhi Vijayaraman
- R Chris Jones
- Rajesh Venaktaraman
- Rajiv Handa
- Ralph Augostini
- Ramesh Hariharan
- Randel Smith
- Randy Jones
- Riggio David
- Riple Hansalia
- Roark Steven F
- Robert Andrew Drew Pickett
- Robert Sangrigoli
- Robert Schaller
- Robert Schweikert
- Robert Winslow
- Rodrigues de Sousa
- Rubén Aguayo
- Rudolph Evonich
- Saeed Bandar Al Ghamdi
- Sami Pakarinen
- Samir Saba
- Saravanan Krishinan
- Schloss Edward
- Scott Burke
- Scott Wiggins
- Sei Iwai
- Senthil Tambidorai
- Serge David Bar-Lev
- Shabbar Jamaly
- Shang-Chiun Lee
- Sholevar Darius
- Siddarth Mukerji
- Silver Marc T
- Silvia Misikova
- Simon Milstein
- Sluja Amardeep
- Sorrentino Denise
- Stefano Pedretti
- Stephen Keim
- Steven Compton
- Steven Roark
- Stuart Mendenhall
- Suneet Mittal
- Surinder Kaur Khelea
- Svein Faerestrand
- Tan Vern Hsen
- Tarakji Khaldoun G
- Theofanie Mela
- Thomas Blum
- Thomas Burkart
- Timothy Alexander Simmers
- Timothy Lessmeier
- Tina Salo
- Tiziano Moccetti
- Tony Simmons
- Ulrika Maria Birgersdotter-Green
- Vinay Mehta
- Vladimir Rankovic
- Walter Chien
- Wayne Adkisson
- Westby Fisher
- Wilfried Mullens
- Wilkoff Bruce L
- William Kostis
- Wright David J
- Zayd Eldadah
- Ziad Issa
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
Background Infections after placement of cardiac implantable electronic devices (CIEDs) are associated with substantial morbidity and mortality. There is limited evidence on prophylactic strategies, other than the use of preoperative antibiotics, to prevent such infections. Methods We conducted a randomized, controlled clinical trial to assess the safety and efficacy of an absorbable, antibiotic-eluting envelope in reducing the incidence of infection associated with CIED implantations. Patients who were undergoing a CIED pocket revision, generator replacement, or system upgrade or an initial implantation of a cardiac resynchronization therapy defibrillator were randomly assigned, in a 1:1 ratio, to receive the envelope or not. Standard-of-care strategies to prevent infection were used in all patients. The primary end point was infection resulting in system extraction or revision, long-term antibiotic therapy with infection recurrence, or death, within 12 months after the CIED implantation procedure. The secondary end point for safety was procedure-related or system-related complications within 12 months. Results A total of 6983 patients underwent randomization: 3495 to the envelope group and 3488 to the control group. The primary end point occurred in 25 patients in the envelope group and 42 patients in the control group (12-month Kaplan-Meier estimated event rate, 0.7% and 1.2%, respectively; hazard ratio, 0.60; 95% confidence interval [CI], 0.36 to 0.98; P=0.04). The safety end point occurred in 201 patients in the envelope group and 236 patients in the control group (12-month Kaplan-Meier estimated event rate, 6.0% and 6.9%, respectively; hazard ratio, 0.87; 95% CI, 0.72 to 1.06; P<0.001 for noninferiority). The mean (+/- SD) duration of follow-up was 20.7 +/- 8.5 months. Major CIED-related infections through the entire follow-up period occurred in 32 patients in the envelope group and 51 patients in the control group (hazard ratio, 0.63; 95% CI, 0.40 to 0.98). Conclusions Adjunctive use of an antibacterial envelope resulted in a significantly lower incidence of major CIED infections than standard-of-care infection-prevention strategies alone, without a higher incidence of complications
Descriptive epidemiology of 30,223 histopathologically confirmed meningiomas in France: 2006–2015
- Author
- Aboukais R.
- Achim V.
- Adam C.
- Adetchessi T.
- Adle-Biassette H.
- Aesch B.
- Afo B.
- Agha M.
- Aghakhani N.
- Al Hallak R.
- Alami-Thomas W. El
- Albert A.
- Aldea S.
- Ale P
- Algros M. P.
- Ali Y.
- Allano V.
- Allaoui M.
- Alliez J. R.
- Almairac F.
- Am N.
- Amat C.
- Andraud M.
- Andreiuolo F.
- Ange F. Vincentelli
- Ansart F.
- Aouad N.
- Appourchaux D.
- Arbez-Gindre F.
- Arbion F.
- Arrivets P.
- Arthuis F.
- Ashraf A.
- Assaker R.
- Atta M.
- Attencourt C.
- Aubert S.
- Augros M. P
- Auque J.
- Autricque A.
- Averous G.
- Aziza J.
- Badsi B. P.
- Baglin A. C.
- Baldet P.
- Balossier A.
- Bar X.
- Baras Virginie
- Barat J. L.
- Barbey C.
- Baroncini M.
- Barral-Clavel F.
- Barrey C.
- Bataille B.
- Bauchet Fabienne
- Bauchet Luc
- Baujat X.
- Baussart B.
- Bay A.
- Bayram M.
- Bazin A.
- Beaudic Y.
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- Bekaert O.
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- Bernard C.
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- Bernat A. L.
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- Bertocchi C.
- Besson G.
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- Ziyadeh J.
- Zolo D. Memia
- Zouaoui Sonia
- Publication venue
- Publication date
- 14/05/2024
- Field of study
ABSTRACTS
- Author
- E
- S
- Abbate R
- Abbey S
- Abdelaal A
- Abdelwahab A
- Abdollah H
- Abe H
- Abecasis J
- Aboelhoda A
- Abraham P
- Abreu A
- Accadia M
- Achille F
- Adachi M
- Adams D
- Adamyan K
- Adgey A
- Adragao P
- Adrianov A
- Adsett M
- Agarwal S
- Aggio S
- Aghamohammadzadeh R
- Agladze R
- Aguilar P
- Ahmed S
- Ahn M
- Aihara N
- Aime E
- Airaksinen J
- Al-Shawabkeh N
- Alasti M
- Albacete-Moreno C
- Albenque J
- Albertsen A
- Albinni S
- Alboni P
- Aldhoon B
- Aleksic I
- Alessandrini F
- Alexandru R
- Alexopoulos D
- Algalarrondo V
- Alhous H
- Ali M
- Ali N
- Aliot E
- Alizadeh A
- Allaart C
- Allen J
- Allocca G
- Almeida A
- Almeida M
- Almeida S
- Almendral J
- Almendro M
- Almor J
- Alonso A
- Alonso J
- Altaba C
- Alvarenda C
- Alvarenga C
- Alvarez J
- Alves L
- Alves S
- Aly R
- Alzueta J
- Amati F
- Ambrose M
- Amellone C
- Amikam S
- Amlie J
- Ammann P
- Ammar R
- Ammar S
- Andersen K
- Anderson J
- Andersson F
- Ando K
- Andraos A
- Andresen D
- Andreu D
- Andronache M
- Anelli-Monti M
- Angeloni G
- Anger Z
- Angheben C
- Anichkov D
- Anjos R
- Anker S
- Anselme F
- Anselmino M
- Antolini M
- Antoni D
- Antoniadis A
- Antonio N
- Antoniou A
- Antzelevitch C
- Aonuma K
- Apiyasawat S
- Arad M
- Aragoncillo P
- Arana E
- Araujo I
- Arbelo E
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- Arenal A
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- Arkolaki E
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- Arnar D
- Arribas F
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- Arroja I
- Arsenos P
- Artemenko S
- Artuza C
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- Asano T
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- Ashrafpoor G
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