Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice

Although airway hyperresponsiveness (AHR) is a prominent feature of asthma, how it is regulated remains incompletely understood. Allergin-1, an inhibitory immunoglobulin-like receptor containing an immunoreceptor tyrosine-based inhibitory motif (ITIM), is expressed on human and mouse mast cells (MCs) and inhibits high-affinity receptor for IgE (FcεRI)-mediated signaling. Using MC-deficient KitW-sh/W-sh mice and Mas-TRECK mice, which carries a diphtheria toxin (DT)-induced MC deletion system based on il4 enhancer elements, we demonstrate here that MCs are involved in the induction of house dust mite (HDM)-induced AHR. Further, we show that MCs deficient in Allergin-1 exacerbated HDM-induced AHR, but had no effect on airway inflammation. In vitro analysis demonstrated that Allergin-1 inhibited anti-HDM allergen antibody-dependent HDM allergen-mediated degranulation by MCs. Thus, Allergin-1 on MCs plays an important role in the regulation of HDM-induced AHR

The immunoreceptor adapter protein DAP12 suppresses B lymphocyte–driven adaptive immune responses

Human and mouse B cells lacking functional DAP12 are hyperresponsive, and DAP12 works with MAIR-II (CD300d) to negatively regulate B cell activity

First Data Release of the Hyper Suprime-Cam Subaru Strategic Program

The Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) is a three-layered imaging survey aimed at addressing some of the most outstanding questions in astronomy today, including the nature of dark matter and dark energy. The survey has been awarded 300 nights of observing time at the Subaru Telescope and it started in March 2014. This paper presents the first public data release of HSC-SSP. This release includes data taken in the first 1.7 years of observations (61.5 nights) and each of the Wide, Deep, and UltraDeep layers covers about 108, 26, and 4 square degrees down to depths of i~26.4, ~26.5, and ~27.0 mag, respectively (5sigma for point sources). All the layers are observed in five broad bands (grizy), and the Deep and UltraDeep layers are observed in narrow bands as well. We achieve an impressive image quality of 0.6 arcsec in the i-band in the Wide layer. We show that we achieve 1-2 per cent PSF photometry (rms) both internally and externally (against Pan-STARRS1), and ~10 mas and 40 mas internal and external astrometric accuracy, respectively. Both the calibrated images and catalogs are made available to the community through dedicated user interfaces and database servers. In addition to the pipeline products, we also provide value-added products such as photometric redshifts and a collection of public spectroscopic redshifts. Detailed descriptions of all the data can be found online. The data release website is https://hsc-release.mtk.nao.ac.jp/.Comment: 34 pages, 20 figures, 7 tables, moderate revision, accepted for publication in PAS

A study of trends among alumni of Nayoro City College Nursing Department

本研究の目的は,市立名寄短期大学看護学科卒業生の動向と卒業生が社会で果たしている役割を明らかにすることにより,今後の名寄市立大学のあり方やその果たす役割について検討することである。市立名寄短期大学看護学科卒業生1期生〜10期生(1997年〜2006年卒)約500人を調査対象とし,2006年に自記式質問紙による留め置き調査を実施した。回答が得られた123人(回収率24.9%)について分析した。その結果,卒業時には札幌の200床以上の病院に就業していた卒業生たちが調査時点では札幌から道内各地へと広がり,都市部のみならず広く地域の保健福祉医療に従事していることがわかった。また,名寄市を含む道北地域に従事する者も卒業時点より増加していること,とりわけ名寄市内に卒業時就業した者と,調査時点で就業している者の数が等しく,名寄市に就職した後市外に転職した卒業生がいる一方で,他の地域で就業した後に名寄市内に就業する者がいることがわかった。卒業生の看護実践力の自己評価は必ずしも高くはないが,修得したい看護実践内容や自己研鑽の意欲は高く,前向きな姿勢であることが明らかとなった。卒業生がそれぞれの職場で担っている役割や,卒業生が感じている看護職としての前進・進歩の促進要因および阻害要因を分析し,教育機関としてどのような情報提供や協力体制が必要であるかについて考察した。本研究により,卒業生を輩出した地方小都市に位置する教育機関がどのような支援をしたらよいのかが今後の課題となった。This paper reviews results of a survey undertaken to clarify post-graduation trends over a 10-year period among alumini of the Nayoro City College Nursing program. Around 500 questionnaires were mailed out to graduates. Of the 123 respondents, roughly 80% were either working or studying in nursing-related fields. Immediately after graduation, the largest number of respondents found employment in Sapporo, the major centre of Hokkaido, while at the time of this survey, working alumni were spread more evenly throughout the various regions of Hokkaido. Also at graduation, respondents tended to find employment at larger institutions (>200 beds) while this percentage had decreased at the time of this survey. The number of alumni working in Nayoro has remained constant over time with some graduates moving away and others returning. Alumni did not rate their nursing skills highly, although their desire to brush up and advance their careers was high. This study reveals that graduates of Nayoro City College Nursing Department are active throughout Hokkaido

The Physics of the B Factories

This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C

The Hyper Suprime-Cam SSP survey: Overview and survey design

Hyper Suprime-Cam (HSC) is a wide-field imaging camera on the prime focus of the 8.2-m Subaru telescope on the summit of Mauna Kea in Hawaii. A team of scientists from Japan, Taiwan, and Princeton University is using HSC to carry out a 300-night multi-band imaging survey of the high-latitude sky. The survey includes three layers: the Wide layer will cover 1400 deg2 in five broad bands (grizy), with a 5 σ point-source depth of r ≈ 26. The Deep layer covers a total of 26 deg2 in four fields, going roughly a magnitude fainter, while the UltraDeep layer goes almost a magnitude fainter still in two pointings of HSC (a total of 3.5 deg2). Here we describe the instrument, the science goals of the survey, and the survey strategy and data processing. This paper serves as an introduction to a special issue of the Publications of the Astronomical Society of Japan, which includes a large number of technical and scientific papers describing results from the early phases of this survey