Fingerprinting coal-derived gases from the UK

The large-scale extraction of unconventional hydrocarbons in the United States has led to fears of methane contamination of shallow groundwaters. Differentiating between the deep gas released during extraction (shale gas, coal bed methane and underground coal gasification) and natural shallow-sourced methane is imperative for the monitoring and managing of environmental risks related to the extraction process. Here, for the first time, we present measurements of the major gas, and stable and noble gas isotope composition of coal bed methane (CBM) from central Scotland and coal mine methane (CMM) from central England, UK. The molecular (C1/(C2+C3) = 21 to 120) and stable isotope compositions (δ13CCH4 = -39.5 to -51.1‰; δDCH4 = -163 to -238‰) indicate a thermogenic origin for the methane. They are distinct from the majority of shallow-sourced gases in UK. Both sample suites exhibit high He concentrations (338 to 2980 ppmv) that are considerably above atmospheric and groundwater levels. Simple modelling shows that these high 4He concentrations cannot be solely derived from in situ production since coal deposition, and hence the majority is derived from the surrounding crust. The Scottish CBM contains a resolvable mantle He, Ne and Ar contribution that may originate from melts in the deep crust, demonstrating the UK coals have acted as a store for deep volatiles for 10s of millions of years. The high 4He in the coal-derived gases has the potential to be used as a novel diagnostic fingerprint to track fugitive release of deep methane from future unconventional gas extraction operations in the UK

Methane Clumped Isotopes: Progress and Potential for a New Isotopic Tracer

The isotopic composition of methane is of longstanding geochemical interest, with important implications for understanding petroleum systems, atmospheric greenhouse gas concentrations, the global carbon cycle, and life in extreme environments. Recent analytical developments focusing on multiply substituted isotopologues (‘clumped isotopes’) are opening a valuable new window into methane geochemistry. When methane forms in internal isotopic equilibrium, clumped isotopes can provide a direct record of formation temperature, making this property particularly valuable for identifying different methane origins. However, it has also become clear that in certain settings methane clumped isotope measurements record kinetic rather than equilibrium isotope effects. Here we present a substantially expanded dataset of methane clumped isotope analyses, and provide a synthesis of the current interpretive framework for this parameter. In general, clumped isotope measurements indicate plausible formation temperatures for abiotic, thermogenic, and microbial methane in many geological environments, which is encouraging for the further development of this measurement as a geothermometer, and as a tracer for the source of natural gas reservoirs and emissions. We also highlight, however, instances where clumped isotope derived temperatures are higher than expected, and discuss possible factors that could distort equilibrium formation temperature signals. In microbial methane from freshwater ecosystems, in particular, clumped isotope values appear to be controlled by kinetic effects, and may ultimately be useful to study methanogen metabolism

Tracing injected CO2 in the Cranfield enhanced oil recovery field (MS, USA) using He, Ne and Ar isotopes

The He, Ne and Ar isotopic composition of gases collected in 2009 and 2012 from 13 production wells, injection wells and the CO2 supply pipeline at the Cranfield CO2-enhanced oil recovery field (MS, USA) have been measured in order to determine the extent to which they trace the fate of injected CO2 in the reservoir. In the absence of samples of CO2 pre-injection reservoir gas we use the Ne isotope composition of the production and injection well gases to determine the isotopic composition of the natural gas. The noble gas isotopes display binary mixing trends between the injected CO2 and a CH4-rich natural gas that is characterised by radiogenic He, Ne and Ar isotope ratios. 3He/4He and 40Ar*/4He ratios (where 40Ar* represents the non-atmospheric 40Ar) display coherent relationships with CO2 concentrations that can be used to trace and quantify the injected CO2 in an engineered site over a sustained period of injection. The presence of a small amount of air-derived Ar, from a non-atmospheric source, in many gas samples rules out using 40Ar/36Ar to track the injected CO2. The noble gases identify the loss of a significant proportion of the CO2 from the gas phase sampled by five production wells in 2009. Using 3He/4He and 40Ar*/4He ratios to reconstruct the major gas composition, it appears that between 22% and 96% of the CO2 has been lost in individual wells. This study demonstrates that the naturally occurring noble gases have the potential to trace the fate and quantify the sequestration of CO2 at injection sites

First measurement of muon-neutrino disappearance in NOvA

This paper reports the first measurement using the NOvA detectors of νμ disappearance in a νμ beam. The analysis uses a 14 kton-equivalent exposure of 2.74×1020 protons-on-target from the Fermilab NuMI beam. Assuming the normal neutrino mass hierarchy, we measure Δm232=(2.52+0.20−0.18)×10−3  eV2 and sin2θ23 in the range 0.38–0.65, both at the 68% confidence level, with two statistically degenerate best-fit points at sin2θ23=0.43 and 0.60. Results for the inverted mass hierarchy are also presented

First measurement of electron neutrino appearance in NOvA

We report results from the first search for νμ→νe transitions by the NOvA experiment. In an exposure equivalent to 2.74×1020 protons on target in the upgraded NuMI beam at Fermilab, we observe 6 events in the Far Detector, compared to a background expectation of 0.99±0.11(syst) events based on the Near Detector measurement. A secondary analysis observes 11 events with a background of 1.07±0.14(syst). The 3.3σ excess of events observed in the primary analysis disfavors 0.1π<δCP<0.5π in the inverted mass hierarchy at the 90% C.L

Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.

BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were eligible for PPCI were randomly allocated (1:1, stratified by centre with a permuted block method) to receive standard treatment (including a sham simulated remote ischaemic conditioning intervention at UK sites only) or remote ischaemic conditioning treatment (intermittent ischaemia and reperfusion applied to the arm through four cycles of 5-min inflation and 5-min deflation of an automated cuff device) before PPCI. Investigators responsible for data collection and outcome assessment were masked to treatment allocation. The primary combined endpoint was cardiac death or hospitalisation for heart failure at 12 months in the intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02342522) and is completed. FINDINGS: Between Nov 6, 2013, and March 31, 2018, 5401 patients were randomly allocated to either the control group (n=2701) or the remote ischaemic conditioning group (n=2700). After exclusion of patients upon hospital arrival or loss to follow-up, 2569 patients in the control group and 2546 in the intervention group were included in the intention-to-treat analysis. At 12 months post-PPCI, the Kaplan-Meier-estimated frequencies of cardiac death or hospitalisation for heart failure (the primary endpoint) were 220 (8·6%) patients in the control group and 239 (9·4%) in the remote ischaemic conditioning group (hazard ratio 1·10 [95% CI 0·91-1·32], p=0·32 for intervention versus control). No important unexpected adverse events or side effects of remote ischaemic conditioning were observed. INTERPRETATION: Remote ischaemic conditioning does not improve clinical outcomes (cardiac death or hospitalisation for heart failure) at 12 months in patients with STEMI undergoing PPCI. FUNDING: British Heart Foundation, University College London Hospitals/University College London Biomedical Research Centre, Danish Innovation Foundation, Novo Nordisk Foundation, TrygFonden

AN EMPIRICALLY SUPPORTED PSYCHOANALYSIS The Case of Giovanna

Psychoanalysts have long relied on the case study method to support the validity of their theoretical hypotheses and clinical techniques and the efficacy of their treatments. However, limitations of the case study method have become increasingly salient as the medical-scientific community and policymakers have increasingly emphasized the need for empirical data. This article describes the progression of an analysis from the perspective of both the treating analyst and an independent research team using empirical methods to study verbatim session transcripts. Empirical measures include the Shedler-Westen Assessment Procedure-200 (Westen & Shedler, 1999a, b; Shedler & Westen, 2006), the Defense Mechanism Rating Scale (Perry, 1990a) and the Analytic Process Scales (Waldron, Scharf, Crouse, Firestein, & Burton, 2004, and Waldron, Scharf, Hurst, et al., 2004). The article illustrates one way in which clinical and empirical methods can complement each other synergistically and lead to a deeper and more precise understanding of analytic process and psychological change

An empirical investigation of analytic process: Contrasting a good and poor outcome case

The aim of this article is to assess the difference in the analytic processes between two patients with similar personality profiles, who were in analysis during the same time, by two analysts with similar training and working in a similar setting. We explored patients' personality and changes with the Global Assessment of Functioning Scale (GAF; APA, 2000) and the Shedler-Westen Assessment Procedure-200 (SWAP-200; Westen & Shedler, 1999a, 1999b) applied by two pairs of independent raters in 16 sessions. In addition, we assessed therapeutic processes with the Analytic Process Scales (APS; Waldron, Scharf, Hurst, Firestein, & Burton, 2004b) and the Dynamic Interaction Scales (DIS; Waldron, Gazzillo, Genova, Lingiardi, 2013) applied by three independent raters to 20 sessions, as well as the Helping Alliance Rating Scale (HAR; Luborsky, Crits-Cristoph, Alexander, Margolis, & Cohen, 1983) applied to eight sessions from the beginning of each therapy. Our results showed striking differences between the outcomes of these two psychoanalyses that are paralleled by differences in their therapeutic process. We provide verbatim clinical interactions to illustrate these differences and explore the potential implications of these findings. © 2014 American Psychological Association

THE EMPIRICAL DIMENSIONS OF ANALYTIC PROCESS: AN EMPIRICAL INVESTIGATION

The aim of this study was to empirically identify the dimensions of the therapist’s, patient’s and interaction contributions to the analytic process. We performed an Exploratory Factor Analysis of patients’ contributions, therapists’ contributions and interaction dimensions, as assessed with the Analytic Process Scales (APS; Waldron et al., 2004) and Dynamic Interaction Scales (DIS; Waldron, Gazzillo et al., 2013) of 540 sessions from 27 analytic therapies. The EFA identified three dimensions of patients’ contributions (the patient reflects about her/his life and problems; the patient reflects about her/his relationship with the therapist; the patient dynamic competence); these factors explain 84.9% of the variance of patients’ contributions. We identified also three dimensions of the therapists’ contributions (therapist relational attitude, therapist dynamic competence, therapist confrontativeness), which explain 65.7% of the variance of therapists’ contributions; and one overall interaction factor explaining 59% of the variance of the APS and DIS interaction scales. Generalized Estimating Equations and partial correlation analyses enabled us to explore the interactions among these dimensions during the therapeutic process. In particular, we explored how the patient dynamic competence and the therapist dynamic competence and relational attitude contribute to the interaction, and how the interaction may strengthen the patient dynamic competence, i.e. the patients’ ability to participate productively to the analytic process and to oscillate between experiencing and reflecting on their experiences