47 research outputs found
Double Secret Protection: Bridging Federal and State Law To Protect Privacy Rights for Telemental and Mobile Health Users
Mental health care in the United States is plagued by stigma, cost, and access issues that prevent many people from seeking and continuing treatment for mental health conditions. Emergent technology, however, may offer a solution. Through telemental health, patients can connect with providers remotelyâavoiding stigmatizing situations that can arise from traditional healthcare delivery, receiving more affordable care, and reaching providers across geographic boundaries. And with mobile health technology, people can use smart phone applications both to self-monitor their mental health and to communicate with their doctors. But people do not want to take advantage of telemental and mobile health unless their privacy is protected. After evaluating the applicability of current health information privacy law to these new forms of treatment, this Note proposes changes to the federal regime to protect privacy rights for telemental and mobile health users
The Lantern, 2009-2010
âą I\u27m Pregnant. It\u27s Yours âą The Nightmare âą What Death Became After Cyparissus âą Substances âą Ain\u27t That a Man? âą Portrait âą The 100th Chemo âą Looking into Her Toy Box with a Lover âą They Used to Talk About Burning Cities âą MESSAGE: Absence for Allen Ginsberg âą Lunch with Candide âą Behold! Man of Unbelief! Behold! âą Dream #1 Final Strophe âą Patience (Things You Will Discover) âą Four Years âą He Falls Like Leaves âą The Quilt âą Ariel (Turning Tricks at Fisherman\u27s Wharf, Monterey, California) âą Extranjera âą The Taste of Morning âą Fear of Glory âą The Rum Bottle\u27s Fortune âą While Thinking of What to Write âą Dying in Spring âą Tutte le Eta di Firenze âą Token âą A House Grows Into Itself âą Gravity âą Father with the Skyy âą He Says He Dreams of Me âą Myth âą Sun-Veins and Wishbones âą Attempts at Bravery âą One Boy in Four Parts âą Blacktop Rollin\u27 âą Getting My Feet Wet âą The Long Ride After Ending âą Wet Tongues and Sweaty Cotton âą Norman Bates is My Mother âą Sims Trek âą Tomorrow Comes Today âą The Writer\u27s Process âą This Too Was Real âą Venus from the Waves âą Shark âą Monday\u27s Expectations âą Recognition âą The Black Shoes âą Climax âą Andrew âą Bottles âą Calle de Cusco âą God in the Machine âą The 26th of December âą Lollipop Lollipop âą When Dinosaurs Roamed the Earth âą Meaning âą Jeffrey âą Looking âą Jagged Edges âą Fading Storm âą Shoes âą Cover Image: Death by Chocolatehttps://digitalcommons.ursinus.edu/lantern/1175/thumbnail.jp
The Lantern, 2010-2011
âą The Graterford Department of Corrections âą Visiting Room: Lewis Considers the Space & Time Continuum âą String âą The Tale of Lad Wadley âą The Devout âą One Moment in the Garden âą Water, Focused and Tumbling âą Bomber âą Another âą I Walked Home âą Perhe âą I Describe the Last Time My Parents Had Sex âą Butterflies âą Ship Without Fools âą The Interview âą Cyane âą An Imaginary Portrait of Stella as a Young Girl âą At the Farm Market in Early Autumn âą Victor Jorgenson\u27s Photograph of the V-J Day Kiss âą Lightning âą The Citadel âą Whenever You Come Home From School âą It Came in a Dream âą What I Know About Fission âą Please Don\u27t Fire Me for Saying Such Things âą Femina Irata âą Thank You For Shopping âą Sunday, November 27th âą An Introduction to The Lifestyle âą Laid-Off Perception âą Good-Night, Sweet Prince âą Requiem for a Marriage âą Gertrude\u27s Book âą Passing âą Elk Run II âą Shady Tides âą A Quiet House âą Tell Him. A Manual âą Silence âą Google This âą The Dinner Table Dance âą The Inevitable Extinction of Filing Cabinets âą Chateau d\u27If âą Man Smoking in Charcoal âą Inside Auschwitz âą Bark Glow âą Anticipation âą Look Up âą Major News Networks âą Others Wage War âą Insert Bible Verse Here âą The Empress âą Candy Castle âą Venice, Italy âą Quebec âą Bhutanese Child âą Jumper âą Pomegranates âą Cover Image: Octopus Hathttps://digitalcommons.ursinus.edu/lantern/1176/thumbnail.jp
A Multisite Preregistered Paradigmatic Test of the Ego-Depletion Effect
We conducted a preregistered multilaboratory project (k = 36; N = 3,531) to assess the size and robustness of ego-depletion effects using a novel replication method, termed the paradigmatic replication approach. Each laboratory implemented one of two procedures that was intended to manipulate self-control and tested performance on a subsequent measure of self-control. Confirmatory tests found a nonsignificant result (d = 0.06). Confirmatory Bayesian meta-analyses using an informed-prior hypothesis (ÎŽ = 0.30, SD = 0.15) found that the data were 4 times more likely under the null than the alternative hypothesis. Hence, preregistered analyses did not find evidence for a depletion effect. Exploratory analyses on the full sample (i.e., ignoring exclusion criteria) found a statistically significant effect (d = 0.08); Bayesian analyses showed that the data were about equally likely under the null and informed-prior hypotheses. Exploratory moderator tests suggested that the depletion effect was larger for participants who reported more fatigue but was not moderated by trait self-control, willpower beliefs, or action orientation.</p
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Comprehensive molecular characterization of gastric adenocarcinoma
Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project. We propose a molecular classification dividing gastric cancer into four subtypes: tumours positive for EpsteinâBarr virus, which display recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, CD274 (also known as PD-L1) and PDCD1LG2 (also knownasPD-L2); microsatellite unstable tumours, which show elevated mutation rates, including mutations of genes encoding targetable oncogenic signalling proteins; genomically stable tumours, which are enriched for the diffuse histological variant and mutations of RHOA or fusions involving RHO-family GTPase-activating proteins; and tumours with chromosomal instability, which show marked aneuploidy and focal amplification of receptor tyrosine kinases. Identification of these subtypes provides a roadmap for patient stratification and trials of targeted therapies
Search for dark matter produced in association with bottom or top quarks in âs = 13 TeV pp collisions with the ATLAS detector
A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fbâ1 of protonâproton collision data recorded by the ATLAS experiment at âs = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements
Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743
In many macroorganisms, the ultimate source of potent biologically active natural products has remained elusive due to an inability to identify and culture the producing symbiotic microorganisms. As a model system for developing a meta-omic approach to identify and characterize natural product pathways from invertebrate-derived microbial consortia, we chose to investigate the ET-743 (Yondelis) biosynthetic pathway. This molecule is an approved anticancer agent obtained in low abundance (10â4â10â5 % w/w) from the tunicate Ecteinascidia turbinata and is generated in suitable quantities for clinical use by a lengthy semisynthetic process. On the basis of structural similarities to three bacterial secondary metabolites, we hypothesized that ET-743 is the product of a marine bacterial symbiont. Using metagenomic sequencing of total DNA from the tunicate/microbial consortium, we targeted and assembled a 35 kb contig containing 25 genes that comprise the core of the NRPS biosynthetic pathway for this valuable anticancer agent. Rigorous sequence analysis based on codon usage of two large unlinked contigs suggests that Candidatus Endoecteinascidia frumentensis produces the ET-743 metabolite. Subsequent metaproteomic analysis confirmed expression of three key biosynthetic proteins. Moreover, the predicted activity of an enzyme for assembly of the tetrahydroisoquinoline core of ET-743 was verified in vitro. This work provides a foundation for direct production of the drug and new analogues through metabolic engineering. We expect that the interdisciplinary approach described is applicable to diverse hostâsymbiont systems that generate valuable natural products for drug discovery and development