12 research outputs found
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
- Author
- Abad Capa Jorge
- Abel L.
- Abela L.
- Abelb L.
- Abelc L.
- Abers M.S.
- Agra J.J.C.
- Aguilera-Albesa S.
- Aiuti A.
- Akcan O.M.
- Al-Mulla F.
- Alarcon M.G.
- Alavoine L.
- Albert M.L.
- Alcover A.
- Aldave J.C.
- Algera A.G.
- Alkan G.
- Allardet-Servent J.
- Allende L.M.
- Alsina L.
- Alvarez J.T.
- Alyanakian M.A.
- Amador-Borrero B.
- Amat K.K.A.
- Amoura Z.
- Anderson M.S.
- Andrejak C.
- Angoulvant F.
- Antolí A.
- Arias A.A.
- Arias A.A.
- Arquero M.F.
- Arranz M.J.
- Arslan S.
- Aschard H.
- Assant S.
- Astrom K.
- Auguet T.
- Aytekin S.E.
- Azot A.
- Bachelet D.
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- Universitat Autònoma de Barcelona
- Ursini M.V.
- Ursini M.V.
- Uzunhan Y.
- Vabres P.
- Valencia-Ramos J.
- Valsecchi M.G.
- van Agtmael M.
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- van der Poll T.
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- Visseaux B.
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- Vlaar A.P.J.
- Vladikine N.
- Vogt G.
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- von Bernuth H.
- Vuotto F.
- Vélez-Santamaria V.
- Wang Q.
- Washington N.
- Wiedemann A.
- Woollett M.
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- Yazdanpanah Y.
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- Yucel F.
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- Zwinderman A.H.
- Íñigo-Campos A.
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
Get PDFInterindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men
Prevalence of viral infection markers by polymerase chain reaction amplification and interferon-alpha measurements among patients undergoing lumbar puncture in an emergency department
- Author
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2004
- Field of study
No full textTransdisciplinary Bioblitz: Rapid biotic and abiotic inventory allows studying environmental changes over 60 years at the Biological Field Station of Paimpont (Brittany, France) and opens new interdisciplinary research opportunities
- Author
- Ayati Khaoula
- Balbi Manon
- Barbe Lou
- Bellido Alain
- Benezeth Elora
- Blémus Jérémie
- Bormans Myriam
- Bouger Guillaume
- Briand Valérie
- Butet Alain
- Bütof Astrid
- Carnet Mathurin
- Caudal Jean-Pierre
- Chambet Audrey
- Charrier Maryvonne
- Chedanne Hughes
- Cluzeau Daniel
- Collias Eric
- Cylly Daniel
- Dahirel Maxime
- Devogel Pierre
- Dubois Glenn
- Dubos Thomas
- Dugravot Sébastien
- Esnault Joël
- Farcy Jacques-Olivier
- Froger Benoît
- Garrin Maël
- Gouraud Clément
- Guernion Muriel
- Guillocheau Sarah
- Hervé Morgane
- Hoeffner Kevin
- Hotte Hoël
- Humbert Guillaume
- Jung Vincent
- Le Gouar Pascaline
- Le Lann Cécile
- LOIS Grégoire
- Mai Barbara
- Marguerie Dominique
- Marie-Réau Odile
- Monard Cécile
- Ménard Nelly
- Nicolai Annegret
- Norvez Olivier
- Ouisse Tiphaine
- Pannard Alexandrine
- Perez Grégoire
- Petillon Julien
- Piscart Christophe
- Potthoff Martin
- Poupelin Maxime
- RANTIER Yann
- Richard Gaëlle
- Rissel Alain
- Rochais Céline
- Santonja Mathieu
- Sene Lina
- Supper Régis
- Tougeron Kevin
- Vallet Dominique
- Vernon Philippe
- Welk Erik
- Wiegand Claudia
- Publication venue
- Pensoft Publishers
- Publication date
- 01/01/2020
- Field of study
No full textTransdisciplinary Bioblitz: Rapid biotic and abiotic inventory allows studying environmental changes over 60 years at the Biological Field Station of Paimpont (Brittany, France) and opens new interdisciplinary research opportunities
- Author
- Ayati Khaoula
- Balbi Manon
- Barbe Lou
- Bellido Alain
- Benezeth Elora
- Blémus Jérémie
- Bormans Myriam
- Bouger Guillaume
- Briand Valérie
- Butet Alain
- Bütof Astrid
- Carnet Mathurin
- Caudal Jean-Pierre
- Chambet Audrey
- Charrier Maryvonne
- Chedanne Hughes
- Cluzeau Daniel
- Collias Eric
- Cylly Daniel
- Dahirel Maxime
- Devogel Pierre
- Dubois Glenn
- Dubos Thomas
- Dugravot Sébastien
- Esnault Joël
- Farcy Jacques-Olivier
- Froger Benoît
- Garrin Mael
- Gouraud Clément
- Guernion Muriel
- Guillocheau Sarah
- Hervé Morgane
- Hoeffner Kevin
- Hotte Hoël
- Humbert Guillaume
- Jung Vincent
- Le Gouar P.
- Le Lann Cécile
- Lois Grégoire
- Mai Barbara
- Marguerie Dominique
- Marie-Réau Odile
- Monard Cécile
- Ménard Nelly
- Nicolai Annegret
- Norvez Olivier
- Ouisse Tiphaine
- Pannard A.
- Perez Grégoire
- Petillon Julien
- Piscart Christophe
- Potthoff Martin
- Poupelin Maxime
- Rantier Yann
- Richard Gaëlle
- Rissel Alain
- Rochais Céline
- Santonja Mathieu
- Sene Lina
- Supper Régis
- Tougeron Kévin
- Vallet Dominique
- Vernon Philippe
- Welk Erik
- Wiegand Claudia
- Publication venue
- Pensoft
- Publication date
- 01/01/2020
- Field of study
No full textInternational audienceBackground - The Biological Field Station of Paimpont (Station Biologique de Paimpont, SBP), owned by the University of Rennes and located in the Brocéliande Forest of Brittany (France), has been hosting student scientific research and field trips during the last 60 years. The study area of the SBP is a landscape mosaic of 17 ha composed of gorse moors, forests, prairies, ponds and creeks. Land use has evolved over time. Historical surveys by students and researchers focused on insects and birds. With this study, we aimed to increase the range of taxa observations, document changes in species composition and landscape and provide a basis for interdisciplinary research perspectives. We gathered historical data, implemented an all-taxon biodiversity inventory (ATBI) in different habitats of the SBP study area, measured abiotic factors in the air, water and soil and performed a photographical landscape observation during the BioBlitz held in July 2017. New information - During the 24 h BioBlitz, organised by the SBP and the EcoBio lab from the University of Rennes and the French National Center of Scientific Research (CNRS), different habitats were individually sampled. Seventy-seven experts, accompanied by 120 citizens and 12 young people participating in the European Volunteer Service, observed, identified and databased 660 species covering 5 kingdoms, 8 phyla, 21 classes, 90 orders and 247 families. In total, there were 1819 occurrences including records identified to higher taxon ranks, thereby adding one more kingdom and four more phyla. Historical data collection resulted in 1176 species and 4270 occurrences databased. We also recorded 13 climatic parameters, 10 soil parameters and 18 water parameters during the BioBlitz. Current habitats were mapped and socio-ecological landscape changes were assessed with a diachronic approach using 32 historical photographs and historical maps. The coupling of historical biodiversity data with new biotic and abiotic data and a photographic comparison of landscape changes allows an integrative understanding of how the SBP changed from agriculturally-used land to a managed natural area within the last 60 years. Hence, this BioBlitz represents an important holistic sampling of biodiversity for studies on trophic webs or on trophic interactions or on very diverse, but connected, habitats. The integration of social, biotic and abiotic data opens innovative research opportunities on the evolution of socio-ecosystems and landscapes
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
- Publication venue
- Publication date
- 01/01/2021
- Field of study
No full textCirculating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or IFN-ω (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected individuals from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or IFN-ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases. © 2021 The Authors, some rights reserved
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cáceres
- Aguilera-Albesa Sergio
- Aguiló-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Özge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Andrés Ana De
- Anglicheau Dany
- Angoulvant François
- Annereau Jean-Philippe
- Antolí Arnau
- Appelman Brent
- Arias Andrés
- Arias Andrés Augusto
- Arkin Lisa
- Arquero Miguel Fernandez
- Arranz María Jesús
- Arrestier Romain
- Arrestier Romain
- Asano Takaki
- Aschard Hugues
- Aubart Mélodie
- Auguet Teresa
- Avramenko Iryna
- Aytekin Gökhan
- Aytekin Selma Erol
- Azot Axelle
- Azoulay Cecile
- Bachelet Delphine
- Bahram Seiamak
- Bajolle Fanny
- Baldanti Fausto
- Baldolli Aurélie
- Ballester Maite
- Baris-Feldman Hagit
- Barreiros Lucila
- Barrou Benoit
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Batten Isabella
- Bauters Fré
- Bax Diane
- Bayhan Gulsum Iclal
- Behillil Sylvie
- Behillill Sylvie
- Bellani Giacomo
- Belot Alexandre
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Beretta Ilaria
- Bergin Colm
- Bertholon Frédérique
- Bettini Laura Rachele
- Beudel Martijn
- Bezrodnik Liliana
- Bhavsar Krishna
- Biggs Catherine
- Biggs Catherine
- Bilbao Agurtzane
- Bilguvar Kaya
- Biondi Andrea
- Bitker Laurent
- Bizien Lucy
- Blanchard-Rohner Geraldine
- Blanco Ignacio
- Blandinières Adeline
- Bleibtreu Alexandre
- Bloomfield Marketa
- Blázquez-Gamero Daniel
- Bogaard Harm Jan
- Bogunovic Dusan
- Boisson Bertrand
- Bolivar-Prados Mireia
- Bolze Alexandre
- Bomers Marije
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bonfanti Paolo
- Bonneaudeau Brigitte
- Bonta Peter
- Borghesi Alessandro
- Borie Raphael
- Borrero Blanca Amador
- Bos Lieuwe
- Bosteels Cédric
- Botdhlo-Nevers Elisabeth
- Botelho-Nevers Elisabeth
- Botta Michela
- Bouadma Lila
- Bouadma Lila
- Boucherit Soraya
- Boudhabhay Idris
- Bouiller Kévin
- Boulanger Cécile
- Bourgeois Fleur Le
- Bourgeon Marilou
- Bourke Nollaig
- Bourke Nollaig
- Bourke Nollaig
- Bouscambert-Duchamp Maude
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousquet Aurore
- Bousso Philippe
- Boutolleau David
- Bouvattier Claire
- Boyarchuk Oksana
- Boyarchuk Oksana
- Bozdemir Şefika Elmas
- Bravais Juliette
- Briones M. Luisa
- Briseño-Roa Luis
- Brodin Petter
- Brodin Petter
- Brouwer Matthijs
- Bruhns Pierre
- Bruneau Léa
- Brunner Marie-Eve
- Bruno Raffaele
- Bryceson Yenan
- Bueno Maria Rita P.
- Bugiani Marianna
- Buis David
- Bukhari Huda
- Bulle Esther
- Burdet Charles
- Burdet Charles
- Burrel Sonia
- Bustamante Carlos
- Bustamante Jacinta
- Butte Manish
- Béziat Vivien
- Cannet Dorothée
- Capra Ruggero
- Carapito Raphael
- Carrabba Maria
- Carrillo Jorge
- Casanova Jean-Laurent
- Casanova Jean-Laurent
- Casari Giorgio
- Casari Giorgio
- Casari Giorgio
- Casasnovas Carlos
- Caseris Marion
- Cassaniti Irene
- Castagnoli Riccardo
- Castelle Martin
- Castelli Francesco
- Castro Mateus
- Catherinot Emilie
- Cazzaniga Marina
- Celik Jale Bengi
- Cerf-Bensussan Nadine
- Cervantes-Gonzalez Minerva
- Ceschi Alessandro
- Chahine Abir
- Chair Anissa
- Chakravorty Samya
- Chalumeau Martin
- Charbit Bruno
- Charpentier Charlotte
- Chauvineau-Grenier Angélique
- Chen Jie
- Cheng Matthew
- Chirouze Catherine
- Chirouze Catherine
- Chouchane Osoul
- Chrabieh Maya
- Christodoulou John
- Ciceri Fabio
- Citerio Giuseppe
- Clavé Pere
- Clercq Jozefien De
- Cloherty Alex
- Clotet Bonaventura
- Cobat Aurélie
- Codina Anna
- Coelho Alexandra
- Coeuret-Pellicer Mireille
- Cognasse Fabrice
- Cognasse Fabrice
- Cohen Yves
- Colobran Roger
- Colobran Roger
- Comarmond Cloé
- Combes Alain
- Comoli Patrizia
- Condino-Neto Antonio
- Condino-Neto Antonio
- Conlon Niall
- Connolly Emma
- Constantinescu Stefan
- Conti Francesca
- Contro Ernesto
- Cooper Megan
- Cordel Hugues
- Correales Luisa Paola Duarte
- Corsico Angelo
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Couffin-Cadiergues Sandrine
- Coulongeat Matthieu
- Coşkuner Taner
- Cruz Inés Marín
- Cuadros Esmeralda Nuñez
- Cumano Ana
- Cvetkovski Aleksandar
- Cyrus Cyril
- Daganou Maria
- Dalgard Clifton
- Dalgard Clifton
- Dalmau David
- Dalmau David
- Danielson Jeffrey
- Danion François
- Darazam Ilad Alavi
- Darley David Ross
- Das Vincent
- Dauby Nicolas
- Dauger Stéphane
- de Brabander Justin
- de Bree Godelieve
- de Bruin Sanne
- de Chambrun Marc Pineton
- de Diego Rebeca Perez
- de Jong Menno
- de la Chapelle Aliénor
- de Lamballerie Xavier
- de Montmollin Etienne
- de Munter Paul
- de Pontual Loic
- de Prost Nicolas
- de Rotte Maurits
- de Vera Martín Castillo
- de Vries Heder
- Debard Alexa
- Debette Stéphanie
- Debette Stéphanie
- Debray Marie-Pierre
- Dechanet Aline
- Dehban Amin
- Delmonte Ottavia
- Delplancq Geoffroy
- Demar Magalie
- Demirkol Yasemin Kendir
- Demoule Alexandre
- Deplanque Dominique
- Deplanque Dominique
- Deriano Ludovic
- Desai Murkesh
- Descamps Diane
- Descamps Diane
- Desguerre Isabelle
- Desille-Dugast Mireille
- Desmarets Maxime
- Desvallée Mathilde
- Di Sabatino Antonio
- Di Santo James
- Diallo Alpha
- Diego Rebeca Pérez De
- Diehl Jean-Luc
- Diehl Jean-Luc
- Dijkstra Mirjam
- Dillies Marie-Agnès
- Ding Li
- Dinh Khoa Manh
- Diouf Alphonsine
- Djossou Félix
- Dobbelaere Stephanie
- Dobbs Kerry
- Dominguez-Garrido Elena
- Domínguez-Garrido Elena
- Dongelmans Dave
- Dorgham Karim
- Dorival Céline
- Drolet Beth
- Dromer Françoise
- Dubos François
- Dubost Clément
- Duffy Darragh
- Duffy Darragh
- Dufouil Carole
- Dujardin Romein
- Dunne Jean
- Dupont Annabelle
- Duval Xavier
- Duval Xavier
- Duvlis Sotirija
- Dyer Adam
- D’angio Mariella
- D’enfert Christophe
- D’ortenzio Eric
- Eberl Gérard
- Ecobichon Jean-Luc
- Ekwall Olov
- El Baghdadi Jamila
- El Bakkouri Jalila
- Elbers Paul
- Elnagdy Marwa
- Eloy Philippine
- Emiroglu Melike
- Endo Akifumi
- Enninga Jost
- Enouf Vincent
- Enouf Vincent
- Epaulard Olivier
- Erdeniz Emine Hafize
- Erikstrup Christian
- Erikstrup Christian
- Esperou Hélène
- Espinosa-Padilla Sara
- Esposito-Farase Marina
- Espérou Hélène
- Etienne Manuel
- Eto Shohei
- Euvrard Romain
- Fabio Giovanna
- Faivre Laurence
- Falck Antonin
- Fallon Aoife
- Fartoukh Muriel
- Faure Morgane
- Fekkar Arnaud
- Feldman Hagit Baris
- Feldman Hagit Baris
- Fellay Jacques
- Fellay Jacques
- Fellay Jacques
- Ferrer Ricard
- Ferreres Jose
- Fievet Nathalie
- Flaig Amandine
- Fleuren Lucas
- Flores Carlos
- Flores Carlos
- Florkin Benoit
- Fontes Magnus
- Foti Giuseppe
- Fouchard Julie
- Franco José Luis
- Franco José Luis
- Francois Bruno
- Frezouls Wahiba
- Froidure Antoine
- Fumadó Victoria
- Fung Kitty
- Fusco Francesca
- Gagneux-Brunon Amandine
- Gagro Alenka
- Gallian Pierre
- Garcia-Prat Marina
- García Paula Andrea Gaviria
- Garot Denis
- Garçon Pierre
- Gatineau Audrey Giraud
- Gaudet Alexandre
- Gault Nathalie
- Gaussem Pascale
- Gaymard Alexandre
- Gayretli Zeynep
- Geerlings Suzanne
- Geijtenbeek Theo
- Gentile Stéphanie
- Gervais Adrian
- Ghirardello Stefano
- Ghosn Jade
- Gigante Tristan
- Gil-Herrera Juana
- Gilardin Laurent
- Gilardin Laurent
- Gilg Morgane
- Girbes Armand
- Girona-Alarcón Mònica
- Gissot Valérie
- Godínez Karen Alejandra Cifuentes
- Goehringer François
- Goffard Jean-Christophe
- Goldberg Marcel
- Gomperts-Boneca Ivo
- Gonzales Nacho
- Gonzalez-Granado Luis
- González-Montelongo Rafaela
- Goorhuis Bram
- Gorochov Guy
- Got Stéphane Le
- Gregersen Peter
- Gregersen Peter
- Gribouval Olivier
- Grimbacher Bodo
- Grobusch Martin
- Guaqueta Jeser Santiago Grass
- Guedj Jérémie
- Guerder Antoine
- Gumucio Victor Daniel
- Gunst Jan
- Gut Marta
- Gálvez-Romero José Luis
- Gérardin Patrick
- Gómez Oscar
- Gülhan Belgin
- Hadjadj Jérôme
- Haerynck Filomeen
- Haerynck Filomeen
- Haerynck Filomeen
- Hafkamp Florianne
- Hagens Laura
- Hagin David
- Hagin David
- Haljasmägi Liis
- Halwani Rabih
- Halwani Rabih
- Halwani Rabih
- Hamann Jorg
- Hammarström Lennart
- Hammarström Lennart
- Hammarström Lennart
- Hamzeh-Cognasse Hind
- Hancerli Selda
- Hanitsch Leif Gunnar
- Hansen Morten Bagge
- Hariyan Tetyana
- Harris Vanessa
- Hasan Milena
- Hatipoglu Nevin
- Heath James
- Heath James
- Hedestam Gunilla Karlsson
- Heijmans Cathérine
- Hemke Robert
- Hendou Samia
- Henny Joseph
- Henrickson Sarah
- Heppekcan Deniz
- Hercberg Serge
- Hermans Sabine
- Hermine Olivier
- Hernandez-Brito Elisa
- Heunks Leo
- Ho Po-Ki
- Hoctin Alexandre
- Hoffmann Hans-Heinrich
- Hoffmann Isabelle
- Holanda-Peña María Soledad
- Holland Steven
- Hollmann Markus
- Horcajada Juan
- Horn Janneke
- Hoste Eric
- Hoste Levi
- Houas Ikram
- Houhou Nadhira
- Hovius Joppe
- Hraiech Sami
- Hsieh Elena
- Hulot Jean-Sébastien
- Humbert Linda
- Hung Ivan
- Husebye Eystein
- Iglesias Alejandro
- Imai Kohsuke
- Imberti Luisa
- Ingersoll Molly
- Itan Yuval
- Jaafoura Salma
- Jamme Matthieu
- Jarvis Erich
- Jaïs Jean-Philippe
- Jeanne Michel
- Jeulin Hélène
- Jimeno Marie-Thérèse
- Jordan Iolanda
- Jouanguy Emmanuelle
- Jørgensen Sofie
- Kafif Ouifiya
- Kafif Ouifiya
- Kaguelidou Florentia
- Kali Sabrina
- Kanık-Yüksek Saliha
- Kann Nelli
- Kara Yalcin Burak
- Karahan Aydın
- Karamitros Timokratis
- Karbuz Adem
- Kasapcopur Ozgur
- Kashimada Kenichi
- Kashyap Anuj
- Keles Sevgi
- Keles Sevgi
- Kennelly Sean
- Kenny Rose Anne
- Kerroumi Younes
- Khalil Antoine
- Khan Coralie
- Khan Taj Ali
- Kido Yasutoshi
- Kılıç Ahmet Osman
- Kimmoun Antoine
- Kisand Kai
- Kisand Kai
- Kizil Can
- Klocperk Adam
- Klocperk Adam
- Koning Rutger
- Koning Rutger
- Kouakam Christelle
- Koukaki Evangelia
- Koutsoukou Antonia
- Król Zbigniew
- Ksouri Hatem
- Ku Cheng-Lung
- Kuentz Paul
- Kurolap Alina
- Kwan Arthur
- Kwan Yat Wah M.
- Kwok Janette
- Lachaize Morgane
- Lagier Jean-Christophe
- Lagier Jean-Christophe
- Laine Fabrice
- Laine Fabrice
- Lam David
- Lambrecht Bart
- Lampasona Vito
- Lampropoulou Vicky
- Landinez Lina Marcela Acevedo
- Landinez Sandra
- Lanternier Fanny
- Lantz Olivier
- Laouénan Cédric
- Laribi Samira
- Larsen Margit Anita Hørup
- Lasa Maria Pilar Etxart
- Lau Yu-Lung
- Lau Yu-Lung
- Lau Yu-Lung
- Laviolle Bruno
- Le Bris Cyril
- Le Gac Sylvie
- Le Goas Carole
- Le Hingrat Quentin
- Le Mestre Soizic
- Le Nagard Hervé
- Le Voyer Tom
- Le Minh
- Lefèvre Benjamin
- Legrand Karine
- Lehacaut Jonathan
- Lemaignen Adrien
- Lemee Véronique
- Lemonnier Sylvie
- Leo Yee-Sin
- Lescure François-Xavier
- Letrou Sophie
- Letrou Sophie
- Leturque Nicolas
- Leung Daniel
- Leung Daniel
- Levin Michael
- Levy Michael
- Levy Yves
- Li Zhi
- Licari Amelia
- Lifton Richard
- Lilleri Daniele
- Lim Endry
- Lima Edson Jose Adrian Bolanos
- Lina Bruno
- Lina Bruno
- Ling Yun
- Lingas Guillaume
- Linglart Agnes
- Liu Dana
- Liu Zhiyong
- Llovich Alex Serra
- Lomazzi Sandra
- Lopez Rafael Leon
- Lorenzo Lazaro
- Lorenzo-Salazar José
- Louapre Céline
- Lubetzki Catherine
- Lucarelli Aude
- Lucas Carrie
- Lucet Jean Christophe
- Lucet Jean-Christophe
- Lung Kwok-Cheung
- Luyt Charles-Edouard
- Luyt Charles-Edouard
- Lye David
- Lyonnet Stanislas
- Lévy Romain
- López Gustavo Andrés Salguero
- López-Collazo Eduardo
- Machado Moïse
- Magnone Cinthia
- Maillot Adrien
- Malvy Denis
- Malvy Denis
- Mambert Marina
- Manchon Pauline
- Mane Shrikant
- Maniatis Tom
- Manry Jérémy
- Mansouri Davood
- Mansouri Davood
- Mantilla Rubén
- Manuel Aldric
- Marchal Astrid
- Marchioni Enrico
- Marioli Carola
- Marjani Majid
- Marlet Julien
- Marques Laura
- Marseglia Gian Luigi
- Martin Fernando
- Martin-Loeches Ignacio
- Martinez Antonio Morales
- Martinez-Picado Javier
- Martinez-Picado Javier
- Martín-Nalda Andrea
- Marzana Iciar
- Maródi László
- Maslovskaja Julia
- Mata-Martínez Carmen
- Materna Marie
- Mateus Yady Nataly
- Mathian Alexis
- Matos Larissa Rb
- Matthews Gail
- Matuozzo Daniela
- Mayaux Julien
- Mcelheron Matt
- Mclaughlin-Garcia Raquel
- Medina Yeray Novoa
- Meersseman Philippe
- Mekontso-Dessap Armand
- Melián Abián Montesdeoca
- Melki Isabelle
- Meloni Federica
- Mentré France
- Mergeay-Fabre Mayka
- Meritet Jean-François
- Merlani Paolo
- Metz Christine
- Meunier Alexandre
- Meyts Isabelle
- Meyts Isabelle
- Meyts Isabelle
- Meziane Amina
- Mezidi Mehdi
- Michailidis Eleftherios
- Michel Frédérique
- Migaud Maria-Claire
- Migaud Mélanie
- Migeotte Isabelle
- Mikkelsen Susan
- Millereux Maude
- Million Matthieu
- Milner Joshua
- Mirault Tristan
- Mircher Clotilde
- Mironska Kristina
- Mirsaeidi Mehdi
- Mizoguchi Yoko
- Modi Bhavi
- Mogensen Trine
- Mogensen Trine
- Mojoli Francesco
- Moncada-Vélez Marcela
- Moncomble Elsa
- Mond James
- Monneret Guillaume
- Monsalve Diana
- Montagna Daniela
- Montagne Samatha
- Morandeira Francisco
- Morandeira Francisco
- Morange Pierre-Emmanuel
- Mordacq Clémence
- Morel Pascal
- Morel Pascal
- Morelle Guillaume
- Morio Tomohiro
- Morio Tomohiro
- Mouly Stéphane
- Mouquet Hugo
- Mouquet Hugo
- Mullaert Jimmy
- Muñoz-Barrera Adrián
- Mège Jean-Louis
- Mégarbane Bruno
- Ménager Mickaël
- Nadif Rachel
- Nadji Seyed Alireza
- Naesens Leslie
- Nafati Cyril
- Nagashima Shintaro
- Nakagama Yu
- Navarro Laura Mancera
- Neant Nadège
- Nellen Jeaninne
- Nemirowskaya Yelena
- Neven Bénédicte
- Neves João Farela
- Ng Lisa
- Ng Lisa
- Ng Yuk-Yung
- Nguyen Duc
- Nguyen Duc
- Ni Cheallaigh Cliona
- Nielly Hubert
- Noonan Claire
- Noret Marion
- Nossent Esther
- Notarangelo Luigi
- Notarangelo Luigi
- Nouroudine Mariama
- Novelli Antonio
- Novelli Giuseppe
- Nukui Yoko
- Nussenzweig Michel
- Ocejo-Vinyals J. Gonzalo
- Okada Satoshi
- Okada Satoshi
- Okamoto Keisuke
- Okamoto Keisuke
- Oriol Roger Colobran
- Ostrowski Sisse Rye
- Oualha Mehdi
- Ouedrani Amani
- Ozcelik Tayfun
- Ozcelik Tayfun
- Ozguler Anna
- Ozkaya-Parlakay Aslinur
- O’farrelly Cliona
- O’farrelly Cliona
- O’farrelly Cliona
- Pagani Michele
- Pan-Hammarström Qiang
- Pan-Hammarström Qiang
- Pan-Hammarström Qiang
- Papadaki Maria
- Papadopoulos Aurélie
- Pape Jean
- Paris Christophe
- Parizot Christophe
- Parola Philippe
- Parra-Martínez Alba
- Pascreau Tiffany
- Patin Etienne
- Paul Christelle
- Paul Stéphane
- Paul Stéphane
- Paulsen Isabella Worlewenut
- Paulus Frederique
- Payet Christine
- Paz Pauline Caraux
- Paz-Artal Estela
- Pedersen Ole Birger
- Pedraza-Sánchez Sigifredo
- Peiffer-Smadja Nathan
- Peigne Vincent
- Pelet Anna
- Pelet Sophie
- Pellecer Nancy Carolina González
- Pellegrini Sandra
- Pellegrini Silvia
- Pereira Jesus Marquez
- Perez-Tur Jordi
- Perlin David
- Perreau Pauline
- Perroquin Magali
- Pesci Alberto
- Pesole Graziano
- Pession Andrea
- Peters Edgar
- Peterson Pärt
- Petrov-Sanchez Ventzislava
- Peytavin Gilles
- Pham Huong
- Philippe Aurélien
- Philippot Quentin
- Philippot Quentin
- Picod Adrien
- Picone Olivier
- Piemonti Lorenzo
- Pina-Fuentes Dan
- Piquard Valentine
- Piquard Valentine
- Piralla Antonio
- Pistone Thierry
- Planas Anna
- Planas Anna
- Planas-Serra Laura
- Ploin Dominique
- Poissy Julien
- Poissy Julien
- Poissy Julien
- Poncelet Géraldine
- Poulakou Garyphallia
- Pouletty Marie
- Pourshahnazari Persia
- Prado Maria Yolanda Ruiz Del
- Prando Carolina
- Prando Carolina
- Preckel Bennedikt
- Prins Jan
- Puel Anne
- Pueyo David Martínez
- Pujol Aurora
- Pujol Aurora
- Puéchal Oriane
- Pérez Cristian Alejandro Ricaurte
- Pérez-Díaz Carlos
- Pérez-Fernández Xosé Luis
- Qiu-Chen Jia Li
- Quaresima Virginia
- Quentric Paul
- Quintana-Murci Lluis
- Quintana-Murci Lluis
- Quintana-Murci Lluis
- Quintin Caroline
- Quiros-Roldan Eugenia
- Raasveld Jorinde
- Ramaswamy Sathishkumar
- Rambaud Thomas
- Ramirez-Santana Carolina
- Ramos Miquel Alfonso
- Raoult Didier
- Raoult Didier
- Raoult Violette
- Rapti Vasiliki
- Rausell Antonio
- Rebillat Anne-Sophie
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- Tancevski Ivan
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- Tangye Stuart
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- Tiberghien Pierre
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- Tolstrup Martin
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- Trouillet-Assant Sophie
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- Tubiana Sarah
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- Uddin K.
- Uddin Mohammed
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- Ursini Matilde Valeria
- Utsumi Takanori
- Uzunhan Yurdagul
- Vabres Pierre
- Valencia-Ramos Juan
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt Michèle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vasse Marc
- Veelo Denise
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Venet Fabienne
- Vergara José Alejandro Daza
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- Vidaur Loreto
- Vidigal Mateus
- Vidigal Mateus
- Viel Sébastien
- Vignali Valérie
- Vilaire-Meunier Marie
- Villain Cédric
- Villar-García Judit
- Vincent Audrey
- Vinh Donald
- Vinh Donald
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Vogt Guillaume
- Voiriot Guillaume
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- von Stemann Jakob Hjorth
- Vught Lonneke
- Vuotto Fanny
- Vélez Verónica Posada
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Wauters Joost
- Wauters Joost
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- Yahşi Aysun
- Yang Rui
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yepes Jairo David Torres
- Yesilbas Osman
- Yildiz Mehmet
- Young Barnaby
- Yükselmiş Ufuk
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Íñigo-Campos Antonio
- Öz Şadiye Kübra Tüter
- Özkan Esra Akyüz
- Özçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
No full textInternational audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cáceres
- Aguilera-Albesa Sergio
- Aguiló-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Özge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Andrés Ana De
- Anglicheau Dany
- Angoulvant François
- Annereau Jean-Philippe
- Antolí Arnau
- Appelman Brent
- Arias Andrés
- Arias Andrés Augusto
- Arkin Lisa
- Arquero Miguel Fernandez
- Arranz María Jesús
- Arrestier Romain
- Arrestier Romain
- Asano Takaki
- Aschard Hugues
- Aubart Mélodie
- Auguet Teresa
- Avramenko Iryna
- Aytekin Gökhan
- Aytekin Selma Erol
- Azot Axelle
- Azoulay Cecile
- Bachelet Delphine
- Bahram Seiamak
- Bajolle Fanny
- Baldanti Fausto
- Baldolli Aurélie
- Ballester Maite
- Baris-Feldman Hagit
- Barreiros Lucila
- Barrou Benoit
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Batten Isabella
- Bauters Fré
- Bax Diane
- Bayhan Gulsum Iclal
- Behillil Sylvie
- Behillill Sylvie
- Bellani Giacomo
- Belot Alexandre
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Beretta Ilaria
- Bergin Colm
- Bertholon Frédérique
- Bettini Laura Rachele
- Beudel Martijn
- Bezrodnik Liliana
- Bhavsar Krishna
- Biggs Catherine
- Biggs Catherine
- Bilbao Agurtzane
- Bilguvar Kaya
- Biondi Andrea
- Bitker Laurent
- Bizien Lucy
- Blanchard-Rohner Geraldine
- Blanco Ignacio
- Blandinières Adeline
- Bleibtreu Alexandre
- Bloomfield Marketa
- Blázquez-Gamero Daniel
- Bogaard Harm Jan
- Bogunovic Dusan
- Boisson Bertrand
- Bolivar-Prados Mireia
- Bolze Alexandre
- Bomers Marije
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bonfanti Paolo
- Bonneaudeau Brigitte
- Bonta Peter
- Borghesi Alessandro
- Borie Raphael
- Borrero Blanca Amador
- Bos Lieuwe
- Bosteels Cédric
- Botdhlo-Nevers Elisabeth
- Botelho-Nevers Elisabeth
- Botta Michela
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- Bouadma Lila
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- Boudhabhay Idris
- Bouiller Kévin
- Boulanger Cécile
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- Bourgeon Marilou
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- Bourke Nollaig
- Bourke Nollaig
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- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousquet Aurore
- Bousso Philippe
- Boutolleau David
- Bouvattier Claire
- Boyarchuk Oksana
- Boyarchuk Oksana
- Bozdemir Şefika Elmas
- Bravais Juliette
- Briones M. Luisa
- Briseño-Roa Luis
- Brodin Petter
- Brodin Petter
- Brouwer Matthijs
- Bruhns Pierre
- Bruneau Léa
- Brunner Marie-Eve
- Bruno Raffaele
- Bryceson Yenan
- Bueno Maria Rita P.
- Bugiani Marianna
- Buis David
- Bukhari Huda
- Bulle Esther
- Burdet Charles
- Burdet Charles
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- Ceschi Alessandro
- Chahine Abir
- Chair Anissa
- Chakravorty Samya
- Chalumeau Martin
- Charbit Bruno
- Charpentier Charlotte
- Chauvineau-Grenier Angélique
- Chen Jie
- Cheng Matthew
- Chirouze Catherine
- Chirouze Catherine
- Chouchane Osoul
- Chrabieh Maya
- Christodoulou John
- Ciceri Fabio
- Citerio Giuseppe
- Clavé Pere
- Clercq Jozefien De
- Cloherty Alex
- Clotet Bonaventura
- Cobat Aurélie
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- Coelho Alexandra
- Coeuret-Pellicer Mireille
- Cognasse Fabrice
- Cognasse Fabrice
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- Comarmond Cloé
- Combes Alain
- Comoli Patrizia
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- Condino-Neto Antonio
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- Connolly Emma
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- Contro Ernesto
- Cooper Megan
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- Corsico Angelo
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- Couffin-Cadiergues Sandrine
- Coulongeat Matthieu
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- Cumano Ana
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- Daganou Maria
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- Das Vincent
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- Dauger Stéphane
- de Brabander Justin
- de Bree Godelieve
- de Bruin Sanne
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- de Jong Menno
- de la Chapelle Aliénor
- de Lamballerie Xavier
- de Montmollin Etienne
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- Debette Stéphanie
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- Demar Magalie
- Demirkol Yasemin Kendir
- Demoule Alexandre
- Deplanque Dominique
- Deplanque Dominique
- Deriano Ludovic
- Desai Murkesh
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- Descamps Diane
- Desguerre Isabelle
- Desille-Dugast Mireille
- Desmarets Maxime
- Desvallée Mathilde
- Di Sabatino Antonio
- Di Santo James
- Diallo Alpha
- Diego Rebeca Pérez De
- Diehl Jean-Luc
- Diehl Jean-Luc
- Dijkstra Mirjam
- Dillies Marie-Agnès
- Ding Li
- Dinh Khoa Manh
- Diouf Alphonsine
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- Dobbelaere Stephanie
- Dobbs Kerry
- Dominguez-Garrido Elena
- Domínguez-Garrido Elena
- Dongelmans Dave
- Dorgham Karim
- Dorival Céline
- Drolet Beth
- Dromer Françoise
- Dubos François
- Dubost Clément
- Duffy Darragh
- Duffy Darragh
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- Dujardin Romein
- Dunne Jean
- Dupont Annabelle
- Duval Xavier
- Duval Xavier
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- D’enfert Christophe
- D’ortenzio Eric
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- Ecobichon Jean-Luc
- Ekwall Olov
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- El Bakkouri Jalila
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- Eloy Philippine
- Emiroglu Melike
- Endo Akifumi
- Enninga Jost
- Enouf Vincent
- Enouf Vincent
- Epaulard Olivier
- Erdeniz Emine Hafize
- Erikstrup Christian
- Erikstrup Christian
- Esperou Hélène
- Espinosa-Padilla Sara
- Esposito-Farase Marina
- Espérou Hélène
- Etienne Manuel
- Eto Shohei
- Euvrard Romain
- Fabio Giovanna
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- Fellay Jacques
- Fellay Jacques
- Ferrer Ricard
- Ferreres Jose
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- Flores Carlos
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- Fontes Magnus
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- Fouchard Julie
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- Franco José Luis
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- Fumadó Victoria
- Fung Kitty
- Fusco Francesca
- Gagneux-Brunon Amandine
- Gagro Alenka
- Gallian Pierre
- Garcia-Prat Marina
- García Paula Andrea Gaviria
- Garot Denis
- Garçon Pierre
- Gatineau Audrey Giraud
- Gaudet Alexandre
- Gault Nathalie
- Gaussem Pascale
- Gaymard Alexandre
- Gayretli Zeynep
- Geerlings Suzanne
- Geijtenbeek Theo
- Gentile Stéphanie
- Gervais Adrian
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- Gil-Herrera Juana
- Gilardin Laurent
- Gilardin Laurent
- Gilg Morgane
- Girbes Armand
- Girona-Alarcón Mònica
- Gissot Valérie
- Godínez Karen Alejandra Cifuentes
- Goehringer François
- Goffard Jean-Christophe
- Goldberg Marcel
- Gomperts-Boneca Ivo
- Gonzales Nacho
- Gonzalez-Granado Luis
- González-Montelongo Rafaela
- Goorhuis Bram
- Gorochov Guy
- Got Stéphane Le
- Gregersen Peter
- Gregersen Peter
- Gribouval Olivier
- Grimbacher Bodo
- Grobusch Martin
- Guaqueta Jeser Santiago Grass
- Guedj Jérémie
- Guerder Antoine
- Gumucio Victor Daniel
- Gunst Jan
- Gut Marta
- Gálvez-Romero José Luis
- Gérardin Patrick
- Gómez Oscar
- Gülhan Belgin
- Hadjadj Jérôme
- Haerynck Filomeen
- Haerynck Filomeen
- Haerynck Filomeen
- Hafkamp Florianne
- Hagens Laura
- Hagin David
- Hagin David
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- Halwani Rabih
- Halwani Rabih
- Halwani Rabih
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- Hammarström Lennart
- Hammarström Lennart
- Hammarström Lennart
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- Hancerli Selda
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- Holland Steven
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- Medina Yeray Novoa
- Meersseman Philippe
- Mekontso-Dessap Armand
- Melián Abián Montesdeoca
- Melki Isabelle
- Meloni Federica
- Mentré France
- Mergeay-Fabre Mayka
- Meritet Jean-François
- Merlani Paolo
- Metz Christine
- Meunier Alexandre
- Meyts Isabelle
- Meyts Isabelle
- Meyts Isabelle
- Meziane Amina
- Mezidi Mehdi
- Michailidis Eleftherios
- Michel Frédérique
- Migaud Maria-Claire
- Migaud Mélanie
- Migeotte Isabelle
- Mikkelsen Susan
- Millereux Maude
- Million Matthieu
- Milner Joshua
- Mirault Tristan
- Mircher Clotilde
- Mironska Kristina
- Mirsaeidi Mehdi
- Mizoguchi Yoko
- Modi Bhavi
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- Mogensen Trine
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- Moncomble Elsa
- Mond James
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- Monsalve Diana
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- Montagne Samatha
- Morandeira Francisco
- Morandeira Francisco
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- Morel Pascal
- Morel Pascal
- Morelle Guillaume
- Morio Tomohiro
- Morio Tomohiro
- Mouly Stéphane
- Mouquet Hugo
- Mouquet Hugo
- Mullaert Jimmy
- Muñoz-Barrera Adrián
- Mège Jean-Louis
- Mégarbane Bruno
- Ménager Mickaël
- Nadif Rachel
- Nadji Seyed Alireza
- Naesens Leslie
- Nafati Cyril
- Nagashima Shintaro
- Nakagama Yu
- Navarro Laura Mancera
- Neant Nadège
- Nellen Jeaninne
- Nemirowskaya Yelena
- Neven Bénédicte
- Neves João Farela
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- Ng Lisa
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- Nguyen Duc
- Ni Cheallaigh Cliona
- Nielly Hubert
- Noonan Claire
- Noret Marion
- Nossent Esther
- Notarangelo Luigi
- Notarangelo Luigi
- Nouroudine Mariama
- Novelli Antonio
- Novelli Giuseppe
- Nukui Yoko
- Nussenzweig Michel
- Ocejo-Vinyals J. Gonzalo
- Okada Satoshi
- Okada Satoshi
- Okamoto Keisuke
- Okamoto Keisuke
- Oriol Roger Colobran
- Ostrowski Sisse Rye
- Oualha Mehdi
- Ouedrani Amani
- Ozcelik Tayfun
- Ozcelik Tayfun
- Ozguler Anna
- Ozkaya-Parlakay Aslinur
- O’farrelly Cliona
- O’farrelly Cliona
- O’farrelly Cliona
- Pagani Michele
- Pan-Hammarström Qiang
- Pan-Hammarström Qiang
- Pan-Hammarström Qiang
- Papadaki Maria
- Papadopoulos Aurélie
- Pape Jean
- Paris Christophe
- Parizot Christophe
- Parola Philippe
- Parra-Martínez Alba
- Pascreau Tiffany
- Patin Etienne
- Paul Christelle
- Paul Stéphane
- Paul Stéphane
- Paulsen Isabella Worlewenut
- Paulus Frederique
- Payet Christine
- Paz Pauline Caraux
- Paz-Artal Estela
- Pedersen Ole Birger
- Pedraza-Sánchez Sigifredo
- Peiffer-Smadja Nathan
- Peigne Vincent
- Pelet Anna
- Pelet Sophie
- Pellecer Nancy Carolina González
- Pellegrini Sandra
- Pellegrini Silvia
- Pereira Jesus Marquez
- Perez-Tur Jordi
- Perlin David
- Perreau Pauline
- Perroquin Magali
- Pesci Alberto
- Pesole Graziano
- Pession Andrea
- Peters Edgar
- Peterson Pärt
- Petrov-Sanchez Ventzislava
- Peytavin Gilles
- Pham Huong
- Philippe Aurélien
- Philippot Quentin
- Philippot Quentin
- Picod Adrien
- Picone Olivier
- Piemonti Lorenzo
- Pina-Fuentes Dan
- Piquard Valentine
- Piquard Valentine
- Piralla Antonio
- Pistone Thierry
- Planas Anna
- Planas Anna
- Planas-Serra Laura
- Ploin Dominique
- Poissy Julien
- Poissy Julien
- Poissy Julien
- Poncelet Géraldine
- Poulakou Garyphallia
- Pouletty Marie
- Pourshahnazari Persia
- Prado Maria Yolanda Ruiz Del
- Prando Carolina
- Prando Carolina
- Preckel Bennedikt
- Prins Jan
- Puel Anne
- Pueyo David Martínez
- Pujol Aurora
- Pujol Aurora
- Puéchal Oriane
- Pérez Cristian Alejandro Ricaurte
- Pérez-Díaz Carlos
- Pérez-Fernández Xosé Luis
- Qiu-Chen Jia Li
- Quaresima Virginia
- Quentric Paul
- Quintana-Murci Lluis
- Quintana-Murci Lluis
- Quintana-Murci Lluis
- Quintin Caroline
- Quiros-Roldan Eugenia
- Raasveld Jorinde
- Ramaswamy Sathishkumar
- Rambaud Thomas
- Ramirez-Santana Carolina
- Ramos Miquel Alfonso
- Raoult Didier
- Raoult Didier
- Raoult Violette
- Rapti Vasiliki
- Rausell Antonio
- Rebillat Anne-Sophie
- Reddy Conor
- Redin Claire
- Reijnders Tom
- Renia Laurent
- Resmini Léa
- Resnick Igor
- Reyes Luis Felipe
- Ricart Pilar
- Ricaurte Oscar Andrés Briceño
- Rice Charles
- Richard Jean-Christophe
- Richard Lucie
- Richard Pascale
- Richard Pascale
- Rieux-Laucat Frédéric
- Rigo-Bonnin Raúl
- Rigo-Bonnin Raúl
- Rivet Nadia
- Rivière Jacques
- Rivière Jacques
- Rocamora-Blanch Gemma
- Rodero Mathieu
- Rodrigo Carlos
- Rodriguez Luis Antonio
- Rodriguez-Gallego Carlos
- Rodriguez-Palmero Agustí
- Rodríguez Yhojan
- Rodríguez-Gallego Carlos
- Rodríguez-Gallego Carlos
- Rogge Lars
- Rojas Manuel
- Rojas-Villaraga Adriana
- Romero Carolina Soledad
- Rosa-Calatrava Manuel
- Rosain Jérémie
- Rosen Lindsey
- Rossi Camillo
- Rossignol Bénédicte
- Rossignol Patrick
- Rothenbuhler Anya
- Roufai Layidé
- Roussel Lucie
- Roux Damien
- Rovina Nikoletta
- Rowen Lee
- Roy Carine
- Rozenberg Flore
- Ruch Yvon
- Ruiz Montse
- Ruiz-Rodriguez Juan Carlos
- Sabater-Riera Joan
- Sahanic Sabina
- Saker Kahina
- Saks Kai
- Sakuntabhai Anavaj
- Salagianni Maria
- Sallette Jérôme
- Sanchez Oliver
- Sancho-Shimizu Vanessa
- Schidlowski Laire
- Schinkel Michiel
- Schluter Agatha
- Schmidt Julien
- Schmidt Matthieu
- Schneider Marion
- Schrauwen Femke
- Schuetz Catharina
- Schultz Marcus
- Schuurman Alex
- Schuurmans Jaap
- Schwartz Olivier
- Schweitzer Cyril
- Schwikowski Benno
- Scolari Francesco
- Sediva Anna
- Sediva Anna
- Sedkaoui Souad Mehlal
- Seeleuthner Yoann
- Seijo Luis
- Seminario Analia Gisela
- Sene Damien
- Sene Damien
- Seng Piseth
- Senoglu Sevtap
- Seppänen Mikko
- Seppänen Mikko R.J.
- Shahrooei Mohammad
- Shahrooei Mohammed
- Sharif-Askari Fatemeh Saheb
- Shaw Elana
- Shcherbina Anna
- Shcherbina Anna
- Shcherbina Anna
- Shorte Spencer
- Sigaloff Kim
- Siguret Virginie
- Siouti Eleni
- Slabbynck Hans
- Slaby Ondrej
- Slim Marleen
- Smadja David
- Smeele Patrick
- Smit Marry
- Smith Nikaia
- Snow Andrew
- Snow Andrew
- Sobh Ali
- Solanich Xavier
- Solanich Xavier
- Soler Catherine
- Soler-Palacin Pere
- Soler-Palacín Pere
- Soler-Palacín Pere
- Solis Blanca Garcia
- Solé-Violán Jordi
- Solé-Violán Jordi
- Sottini Alessandra
- Soumaré Aïcha
- Spaan András
- Spaan András
- Stella Giulia Maria
- Stepanian Alain
- Stepanovskiy Yuriy
- Stepanovskyy Yurii
- Stijnis Cornelis
- Stilma Willemke
- Stoclin Annabelle
- Storgaard Merete
- Su Helen
- Su Helen
- Su Richa
- Susen Sophie
- Syrigos Konstantinos
- Sánchez-Montalvá Adrián
- Sánchez-Ramón Silvia
- Särekannu Karita
- Sözeri Betül
- Sørensen Erik
- Taccone Fabio
- Talouarn Estelle
- Tanaka Junko
- Tancevski Ivan
- Tancevski Ivan
- Tandjaoui-Lambiotte Yacine
- Tandjaoui-Lambiotte Yacine
- Tangy Frédéric
- Tangye Stuart
- Tangye Stuart
- Tardivon Coralie
- Tardy Bernard
- Taupin Jean-Luc
- Tavernier Simon
- Tayoun Ahmad Abou
- Tellier Marie-Capucine
- Terrier Benjamin
- Terrier Olivier
- Teunissen Charlotte
- Tharaux Pierre-Louis
- Thibault Chloé
- Thiery Guillaume
- Thoral Patrick
- Thorball Christian
- Thorn Karolina
- Thumerelle Caroline
- Thy Michael
- Tiberghien Pierre
- Tiberghien Pierre
- Timsit Jean-François
- Tipu Imran
- Tolstrup Martin
- Tolstrup Martin
- Tomasoni Gabriele
- Toubert Antoine
- Toubiana Julie
- Touvier Mathilde
- Townsend Liam
- Triantafyllia Vasiliki
- Trouillet-Assant Sophie
- Trouillet-Assant Sophie
- Troya Jesús
- Troya Jesús
- Tsang Owen
- Tserel Liina
- Tso Eugene
- Tsonas Anissa
- Tsumura Miyuki
- Tual Christelle
- Tubiana Sarah
- Tubiana Sarah
- Tucci Alessandra
- Tuinman Pieter
- Turvey Stuart
- Tzourio Christophe
- Téoulé François
- Uddin K.
- Uddin Mohammed
- Ungeheuer Marie-Noëlle
- Ursini Matilde Valeria
- Utsumi Takanori
- Uzunhan Yurdagul
- Vabres Pierre
- Valencia-Ramos Juan
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt Michèle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vasse Marc
- Veelo Denise
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Venet Fabienne
- Vergara José Alejandro Daza
- Vidaur Loreto
- Vidaur Loreto
- Vidigal Mateus
- Vidigal Mateus
- Viel Sébastien
- Vignali Valérie
- Vilaire-Meunier Marie
- Villain Cédric
- Villar-García Judit
- Vincent Audrey
- Vinh Donald
- Vinh Donald
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Vogt Guillaume
- Voiriot Guillaume
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- von Stemann Jakob Hjorth
- Vught Lonneke
- Vuotto Fanny
- Vélez Verónica Posada
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Wauters Joost
- Wauters Joost
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- Yahşi Aysun
- Yang Rui
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yepes Jairo David Torres
- Yesilbas Osman
- Yildiz Mehmet
- Young Barnaby
- Yükselmiş Ufuk
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Íñigo-Campos Antonio
- Öz Şadiye Kübra Tüter
- Özkan Esra Akyüz
- Özçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
No full textInternational audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
- Author
- Abad Jorge
- Abad Sebastien
- Abassi Radhiya
- Abdelhadi Nour Mekki
- Abdellaoui Abdelrafie
- Abdelmalek Abdelkrim
- Abdoul Hendy
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abergel Helene
- Abeud Fariza
- Abgrall Sophie
- Abisror Noemie
- Abolhassani Hassan
- Abou Tayoun Ahmad
- Accordino Giulia
- Achille Cristian
- Adechian Marylise
- Aderdour Nordine
- Admane Hakeem Farid
- Adnet Frederic
- Afritt Sara
- Agostini Helene
- Agra Juan José Cáceres
- Aguilar Claire
- Aguilera-Albesa Sergio
- Aguiló-Cucurull Aina
- Agut Sophie
- Aiello Tommaso Francesco
- Aiuti Alessandro
- Ajeenthiravasan Gokula
- Akcan Özge Metin
- Al-Muhsen Saleh
- Al-Muhsen Saleh Zaid
- Al-Mulla Fahd
- Alauzy Virginie
- Alavi Darazam Ilad
- Alavoine Loubna
- Alba Camille
- Albisures Jonathan Antonio Roblero
- Alby-Laurent Fanny
- Aldave Juan C.
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- AlKhater Suzan A.
- Allard Lucie
- Allardet-Servent Jerome
- Allende Luis M.
- Alonso-Arias Rebeca
- Alosaimi Mohammed Faraj
- Alshahrani Mohammed S.
- Alsina Laia
- Alsohime Fahad M.
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Alyanakian Marie-Alexandra
- Amam Sabrina
- Amara Yasmina Ould
- Amat Karine
- Amoura Zahir
- Amrouche Lucile
- Amsterdam UMC Covid-19 Biobank [missing]
- Anderson Mark S.
- Andreakos Evangelos
- Andrejak Claire
- Andronikof Marc
- Anglicheau Dany
- Angoulvant François
- Anguel Nadia
- Annane Djillali
- Antolí Arnau
- Aounzou Mohammed
- Aparicio Caroline
- Appelman Brent
- Aratus Gladys
- Arias Andrés A.
- Arias Andrés Augusto
- Arlet Jean-Benoit
- Arquero Miguel Fernandez
- Arranz María Jesús
- Arrestier Romain
- Arzoine Jeremy
- Asano Takaki
- Aslangul Elisabeth
- Assefi Mona
- Aubart Mélodie
- Aubry Adeline
- Audiffred Laetitia
- Audureau Etienne
- Auger Christelle Nathalie
- Auguet Teresa
- Auregan Jean-Charles
- Avramenko Iryna
- Awotar Celine
- Aytekin Gokhan
- Aytekin Gökhan
- Aytekin Selma Erol
- Azan Delphine
- Azemar Laurene
- Azot Axelle
- Azzouguen Billal
- Bachelet Delphine
- Badsi Aïda
- Baghdadi Jamila El
- Bahram Seiamak
- Bajolle Fanny
- Bakouboula Prissile
- Balcerowiak Coline
- Baldanti Fausto
- Balde Fanta
- Baldivia Elodie
- Baldolli Aurélie
- Ballester Maite
- Bangamingo Eliane-Flore
- Baptiste Amandine
- Baran-Marszak Fanny
- Barau Caroline
- Barget Nathalie
- Baris-Feldman Hagit
- Baronnet Flore
- Barrou Benoit
- Barthelemy Romain
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Baudel Jean-Luc
- Baudry Camille
- Baudry Elodie
- Bauters Fre
- Bax Diane
- Bayhan Gulsum Iclal
- Beaugerie Laurent
- Behilill Sylvie
- Behillil Sylvie
- Belamri Adel
- Belaube Nicolas
- Belilita Rhida
- Bellani Giacomo
- Bellassen Pierre
- Belmokhtar Rawan
- Belot Alexandre
- Belot Alexandre
- Beltran Isabel
- Beluze Marine
- Benainous Ruben
- Benallaoua Mourad
- Benamouzig Robert
- Benbara Amélie
- Benhida Jaouad
- Benkerrou Dehbia
- Benkhelouf Anis
- Benlagha Jihene
- Benmostafa Chahinez
- Benothmane Skander
- Bentifraouine Miassa
- Berard Laurence
- Beretta Ilaria
- Bergman Peter
- Berkell Matilda
- Bernier Quentin
- Bertholon Frédérique
- Berti Enora
- Bertier Astrid
- Berton Laure
- Bessis Simon
- Bettini Laura Rachele
- Beudel Martijn
- Beurton Alexandra
- Bezrodnik Liliana
- Bhavsar Krishna
- Bianco Celine
- Bianquis Clara
- Bidar Frank
- Biggs Catherine M.
- Bilbao Agurtzane
- Biondi Andrea
- Bizien Lucy
- Blanchard-Rohner Geraldine
- Blanche Philippe
- Blanco Ignacio
- Blandinières Adeline
- Blayau Clarisse
- Bleibtreu Alexandre
- Bleibtreu Alexandre
- Blin Emmanuelle
- Bloch-Queyrat Coralie
- Bloomfield Marketa
- Blázquez-Gamero Daniel
- Bogaard Harm Jan
- Bogunovic Dusan
- Boissier Marie-Christophe
- Boisson Bertrand
- Boisson-Dupuis Stephanie
- Boland Anne
- Bolivar-Prados Mireia
- Bollens Diane
- Bolze Alexandre
- Bolzoni Marion
- Bomers Marije
- Bompard Rudy pierre
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bondesan Simone
- Bonnet Nicolas
- Bonnouvrier Justine
- Bonta Peter
- Borghesi Alessandro
- Borie Raphael
- Borrero Blanca Amador
- Borrero Blanca Amador
- Bos Lieuwe
- Bosteels Cedric
- Botdhlo-Nevers Elisabeth
- Botelho-Nevers Elisabeth
- Botha Shirmonecrystal
- Botta Michela
- Bouadma Lila
- Boucenna Wissam
- Bouchama Fatiha
- Bouchaud Olivier
- Bouchez Sabelline
- Bouchghoul Hanane
- Boudjebla Taoueslylia
- Boudjema Noel
- Bouffard Catherine
- Bougle Adrien
- Bouguerra Meriem
- Bouiller Kévin
- Boulanger Cécile
- Bouras Leila
- Bourcier Agnes
- Bourgeon Marilou
- Bourrier Anne
- Bouscambert Maude
- Bouscarat Fabrice
- Bousfiha Ahmed A.
- Bousfiha Ahmed A.
- Bousquet Aurore
- Boutolleau David
- Bouvattier Claire
- Bouvry Diane
- Bouziri Nesrine
- Bouzrara Ons
- Boyarchuk Oksana
- Bozdemir Şefika Elmas
- Bravais Juliette
- Bribier Sarah
- Briones M. Luisa
- Brodin Petter
- Brouwer Matthijs C.
- Brugier Delphine
- Bruneau Léa
- Brunel Melanie
- Brunner Marie-Eve
- Bruno Raffaele
- Bryceson Yenan
- Bryceson Yenan T.
- Bueno Maria Rita P.
- Bugiani Marianna
- Bui Eida
- Buis David T. P.
- Buisson Anne
- Bukhari Huda
- Bukreyeva Iryna
- Bulle Esther
- Burdet Charles
- Bureau Côme
- Bureau Serge
- Bustamante Carlos D.
- Bustamante Jacinta
- Bustos Ingrid G.
- Butte Manish J.
- Cabrera-Marante Oscar
- Cadranel Jacques
- Cailhol Johann
- Calin Ruxandra
- Canavaggio Pauline
- Cancella Marta
- Cantin Delphine
- Cao Albert
- Capra Ruggero
- Carapito Raphael
- Carbillon Lionel
- Carcel Sheila
- Carelli Valerio
- Carlier Nicolas
- Carrabba Maria
- Carrera Paola
- Casanova Jean-Laurent
- Casanova Jean-Laurent
- Casari Giorgio
- Casasnovas Carlos
- Caseris Marion
- Cassaniti Irene
- Cassard Clementine
- Castelle Martin
- Castelli Francesco
- Castor Guylaine
- Castro Mateus V.
- Catherinot Emilie
- Cauchy Marion
- Cazzaniga Marina
- Celik Jale Bengi
- Cervantes-Gonzalez Minerva
- Ceschi Alessandro
- Cha Olivier
- Chachoua Abla
- Chahine Abir
- Chaigne Benjamin
- Chair Anissa
- Chakravorty Samya
- Chaldebas Matthieu
- Challal Salima
- Chalumeau Martin
- Chalumeau Nathalie Costedoat
- Champion Karine
- Charbit Bruno
- Chariot Patrick
- Charpentier Charlotte
- Chas Julie
- Chauveau Simon
- Chauvin Anthony
- Chauvin Clement
- Chavarot Nathalie
- Chaïbi Khalil
- Chebbout Kamélia
- Cheng Matthew P.
- Cherai Mustapha
- Cherubini Ilaria
- Chevalier Amelie
- Chiarabini Thibault
- Chinet Thierry
- Chirouze Catherine
- Chirouze Catherine
- Chocron Richard
- Choinier Pascaline
- Chommeloux Juliette
- Choquet Christophe
- Choupeaux Laure
- Chousterman Benjamin
- Christelle Kouakam
- Christodoulou John
- Ciocan Dragosmarius
- Citerio Giuseppe
- Clarke Ada
- Clavere Gaëlle
- Clavier Florian
- Clavé Père
- Clement Karine
- Clerc Sebastien
- Cloherty Osoul Chouchane Alex
- Clotet Bonaventura
- Cobat Aurélie
- Codina Anna
- Coelho Alexandra
- Cohen Adrien
- Cohen Fleur
- Cohen Yves
- Cohen Yves
- Coilly Audrey
- Colboc Hester
- Colin Pauline
- Collet Magalie
- Colobran Roger
- Comarmond Chloé
- Comarmond Cloé
- Combacon Emeline
- Combe Caroline Lascoux
- Combes Alain
- Combes Alain
- Comoli Patrizia
- Comparon Celine
- Condino-Neto Antonio
- Constantin Jean-Michel
- Constantinescu Stefan N.
- Contro Ernesto
- Cooper Megan A.
- Cordel Hugues
- Cordier Anne-Gael
- Corsico Angelo G.
- Costantini Adrien
- Couffignal Camille
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Couffin-Cadiergues Sandrine
- Coupeau Doriane
- CoV-Contact Cohort [missing]
- COVID Clinicians [missing]
- COVID Human Genetic Effort [missing]
- COVID-STORM Clinicians [missing]
- COVIDeF Study Group [missing]
- Covill Laura E.
- Coşkuner Taner
- Creange Alain
- Cuadros Esmeralda Nuñez
- Cvetkovski Aleksandar
- Cyrus Cyril
- Da Silveira Charlène
- Dalgard Clifton L.
- Dalmau David
- Danielson Jeffrey J.
- Danion François
- Darley David Ross
- Das Vincent
- Dauby Nicolas
- Dauger Stéphane
- De Bouille Jeanne Goupil
- de Brabander Justin
- de Bree Godelieve
- de Bruin Sanne
- De Castro Nathalie
- De Chambrun Marc Pineton
- de Chambrun Marc Pineton
- de Diego Rebeca Pérez
- De Farcy Pauline Mary
- de Jong Menno D.
- De Munter Paul
- de Pontual Loic
- de Rotte Maurits C. F. J.
- De Rycke Yann
- de Vera Martín Castillo
- de Vries Heder
- Debray Marie-Pierre
- Dechanet Aline
- Declercq Jozefien
- Deconinck Lauren
- Dehban Amin
- Del Pozo Lucie
- del Prado Maria Yolanda Ruiz
- Delannoy Quentin
- Delay Mathieu
- Deleris Robin
- Deleuze Jean-François
- Delforge Juliette
- Delmonte Ottavia M.
- Delphine Laëtitia
- Delplancq Geoffroy
- Demar Magalie
- Demare Noemie
- Demeret Sophie
- Demerville Lauren
- Demirkol Yasemin Kendir
- Demoule Alexandre
- Demoule Alexandre
- Deniau Aurore
- Deplanque Dominique
- Deplanque Dominique
- Depret François
- Derolez Sophie
- Derradji Ouda
- Derridj Nawal
- Desai Murkesh
- Descamps Diane
- Descamps Diane
- Descamps Vincent
- Deschamps Lydia
- Desconclois Celine
- Desguerre Isabelle
- Desille-Dugast Mireille
- Desmarets Maxime
- Desnos Cyrielle
- Desongins Karine
- Desvallée Mathilde
- Devouge Eglantine Ferrand
- Dhote Robin
- Di Sabatino Antonio
- Diallo Alpha
- Diallo Benjamin
- Didier Morgane
- Diehl Jean-Luc
- Diemer Myriam
- Diez Stephane
- Dijkstra Mirjam
- Diouf Alphonsine
- Djadi-Prat Juliette
- Djebara Siham
- Djebra Naoual
- Djietcheu Minette
- Djillali Hadjer
- Djossou Félix
- Djouadi Nouara
- Dobbelaere Stephanie
- Dobbs Kerry
- Domínguez-Garrido Elena
- Dongelmans Dave A.
- Donneger Severine
- Dorival Céline
- Dos Santos Catarina
- Dournon Nathalie
- Dres Martin
- Droctove Laura
- Drogrey Marie
- Drolet Beth A.
- Dropy Margot
- Drouet Elodie
- Dubos François
- Dubosq Valérie
- Dubost Clément
- Dubreucq Evelyne
- Dubus Estelle
- Duchemann Boris
- Duchenoy Thibault
- Dudoignon Emmanuel
- Dufau Romain
- Dujardin Romein W. G.
- Dumas Florence
- Duran Clara
- Durand Anne Bourgarit
- Duron Emmanuelle
- Durrbach Antoine
- Duval Xavier
- Duval Xavier
- Duvivier Claudine
- D’Angio’ Mariella
- d’Ortenzio Eric
- Ebstein Nathan
- Ecobichon Jean-Luc
- Ekwall Olov
- El Zein Loubna
- Elabbadi Alexandre
- Elbers Paul
- Elharrar Brigitte
- Elie Caroline
- Elnagdy Marwa H.
- Eloy Philippine
- Elrufaai Marwa Bachir
- Emiroglu Melike
- Endo Akifumi
- Enouf Vincent
- Enouf Vincent
- Erdeniz Emine Hafize
- Ernotte Gabriel
- Esling Anne
- Esperou Hélène
- Espinosa-Padilla Sara
- Esposito-Farese Marina
- Espérou Hélène
- Etienne Manuel
- Etienne Martin
- Euvrard Romain
- Eyer Xavier
- Fabio Giovanna
- Faivre Laurence
- Falck Antonin
- Fartoukh Muriel
- Fartoukh Muriel sarah
- Faure Morgane
- Fayali Takoua
- Feldman Hagit Baris
- Feldman Hagit Baris
- Fellay Jacques
- Fermaut Marion
- Ferrer Ricard
- Ferreres Jose
- Fiorentino Alessio
- Fiorentino Arianna
- Fleuren Lucas
- Fliss Souha
- Flores Carlos
- Florkin Benoit
- Foti Giuseppe
- Fouchard Julie
- Fournier Benjamin
- Fournier Marie-Céline
- Franco Jose Luis
- Franco José Luis
- Francois Bruno
- Francois Hélène
- French COVID Cohort Study Group [missing]
- Freynet Olivia
- Frezouls Wahiba
- Frigout Yvann
- Froidure Antoine
- Fromont Isaure
- Fuentes Axelle
- Fumadó Victoria
- Fung Kitty S. C.
- Furet Thomas
- Fusco Francesca
- Gagneux-Brunon Amandine
- Gagro Alenka
- Galand Joris
- Garnier Marc
- Garçon Pierre
- Gatineau Audrey Giraud
- Gaubert Agnes
- Gaudry Stéphane
- Gaugain Samuel
- Gault Nathalie
- Gaussem Pascale
- Gauthier Damien
- Gautier Maxime
- Gaymard Alexandre
- Gayretli Zeynep
- Geijtenbeek Suzanne Geerlings Theo
- Georgin-Lavialle Sophie
- Geromin Daniela
- Gervais Adrian
- Ghalayini Mohamed
- Ghaleh Bijan
- Ghezal Myriam
- Ghosn Jade
- Gibelin Aude
- Gigante Tristan
- Gil-Herrera Juana
- Gilardin Laurent
- Gilg Morgane
- Gimeno Linda
- Girard Benoit
- Girbes Armand
- Girona-Alarcón Mònica
- Gissot Valérie
- Goas Carole L. E.
- Godínez Karen Alejandra Cifuentes
- Goffard Jean-Christophe
- Gomes Doryan
- Gomes-Pires Elisabete
- Gonzales Nacho
- Gonzalez-Granado Luis I.
- González-Montelongo Rafaela
- Goorhuis Bram
- Gorochov Guy
- Gouge Anne
- Gouja Amel
- Goulet Helene
- Goupil Sylvain
- Gras Julien
- Greffe Segolene
- Gregersen Peter K.
- Grimaldi Lamiae
- Grobusch Martin P.
- Guedeney Paul
- Guedj Jérémie
- Guerder Antoine
- Guidet Bertrand
- Guillo Matthias
- Gulczynski Mariechristelle
- Gumucio Victor Daniel
- Gunst Jan
- Gut Marta
- Gysembergh-Houal Anne
- Gérardin Patrick
- Gülhan Belgin
- Hadjadj Jérôme
- Hadjam Tassadit
- Haerynck Filomeen
- Hafkamp Florianne
- Hagens Laura
- Hagin David
- Haguenauer Didier
- Halwani Rabih
- Hamann Jorg
- Hammal Soumeya
- Hammarström Lennart
- Hammoudi Nadjib
- Hancerli Selda
- Hanitsch Leif Gunnar
- Hanon Olivier
- Hariyan Tetyana
- Harris Vanessa
- Harrois Anarole
- Hatipoglu Nevin
- Hatipoğlu Nevin
- Hausfater Pierre
- Hautem Coraline
- Heath James R.
- Heijmans Catherine
- Hekimian Guillaume
- Heming Nicholas
- Hemke Robert
- Hendou Samia
- Henrickson Sarah E.
- Heppekcan Deniz
- Hermine Olivier
- Hernandez-Brito Elisa
- Heunks Sabine M. Hermans Leo
- Ho Po-ki
- Ho Sylvie
- Hoctin Alexandre
- Hoffmann Isabelle
- Holanda-Peña María Soledad
- Hollmann Markus
- Horcajada Juan P.
- Horn Janneke
- Hoste Eric
- Hoste Levi
- Houas Ikram
- Houhou Nadhira
- Houllier Marie
- Hovius Joppe W.
- Hraiech Sami
- Hsieh Elena W. Y.
- Hulot Jean-Sébastien
- Humbert Linda
- Hung Ivan F. N.
- Huot Benjamin
- Hupalo Daniel N.
- Huscenot Tessa
- Husebye Eystein
- Iglesias Alejandro D.
- Ikherbane Ghilas
- Imai Kohsuke
- Imarazene Meriem
- Imberti Luisa
- Ingiliz Patrick
- Iratni Lina
- Itan Yuval
- Jaafoura Salma
- Jamme Matthieu
- Jarvis Erich D.
- Jaureguiberry Stephane
- Jean-Marc Jean-Francois
- Jeulin Hélène
- Jeyarajasingham Deleena
- Jimeno Marie-Thérèse
- Jordan Iolanda
- Jouanguy Emmanuelle
- Jouany Pauline
- Jouis Veronique
- Jourdaine Clement
- Kaci Marc Ait
- Kafif Ouifiya
- Kafif Ouifiya
- Kafif Ouifiya
- Kaguelidou Florentia
- Kahn-Kirby Amanda
- Kali Sabrina
- Kallala Rim
- Kara Yalcin Burak
- Karahan Aydın
- Karamitros Timokratis
- Karbuz Adem
- Kasapcopur Ozgur
- Kashimada Kenichi
- Katsahian Sandrine
- Kayani Sandrine Dautheville Guibal El
- Keles Sevgi
- Kelesyan Lilit
- Keo Vixra
- Kermanach Nathalie Saidenberg
- Ketz Flora
- Khalifa Jihane El
- Khalil Antoine
- Khamis Warda
- Khan Coralie
- Khan Taj Ali
- Khelili Enfel
- Khellaf Mehdi
- Kido Yasutoshi
- Kılıç Ahmet Osman
- Kisand Kai
- Kizil Can
- Klocperk Adam
- Koning Rutger
- Kounis Ilias
- Koutsoukou Antonia
- Kpalma Gaelle
- Krause Jessica
- Król Zbigniew J.
- Ksouri Hatem
- Ku Cheng-Lung
- Kuentz Paul
- Kwan Arthur M. C.
- Kwan Yat Wah M.
- Kwok Janette S. Y.
- Kyheng Christèle
- Labbe Vincent
- Lack Justin
- Lacombe Karine
- Lacorte Jean-Marc
- Lafont Anne Gaelle
- Lafont Emmanuel
- Lagha Lynda
- Lagier Jean-Christophe
- Laine Fabrice
- Lam David S. Y.
- Lamarre Yannie Cuvillier
- Lambrecht Bart
- Lamhaut Lionel
- Lampropoulou Vicky
- Lancelot Aymeric
- Landman Cecilia
- Lanternier Fanny
- Lanternier Fanny
- Laouénan Cédric
- Larcheveque Cecile
- Laribi Samira
- Larmurier Isabelle Nion
- Lasa Maria Pilar Etxart
- Lassel Ludovic
- Lau Yu-Lung
- Laverdant Benjamin
- Lavergne Christophe
- Lavillegrand Jean-Rémi
- Laviolle Bruno
- Lazureanu Pompilia
- Le Bourgeois Fleur
- Le Guennec Loïc
- Le Hingrat Quentin
- Le Mestre Soizic
- Le Nagard Hervé
- Le Minh
- Leberre Lamia
- Leblanc Claire
- Leboyer Marion
- Lecomte Francois
- Lecorre Marine
- Leenhardt Romain
- Lefebvre Bénédicte
- Lefebvre Marylou
- Lefévre Benjamin
- Legendre Paul
- Leger Anne
- Legrand Karine
- Legros Laurence
- Legrosse Justyna
- Lehacaut Jonathan
- Lehuunghia Sébastien
- Lemarec Julien
- Leo Yee-Sin
- Leon-Lopez Rafael
- Leporrier-Ext Jeremie
- Leprieur Bénédicte Giroux
- Lermine Alban
- Lescure François-Xavier
- Lesein Manon
- Lesur Hubert
- Letrou Sophie
- Letrou Sophie
- Leung Daniel
- Levin Michael
- Levy Albert
- Levy Michael
- Levy Vincent
- Levy Yves
- Li Zhi
- Lien Olivia Tran Dinh Thanh
- Lifton Richard P.
- Lilleri Daniele
- Lim Endry H. T.
- Lima Breno Melo
- Lima Edson Jose Adrian Bolanos
- Lina Bruno
- Lina Bruno
- Ling Yun
- Lingas Guillaume
- Linglart Agnes
- Llovich Alex Serra
- Lomazzi Sandra
- Lopes Amanda
- Lopes Edwige
- Lopez Rafael Leon
- Lopez Vanessa
- Lopinto Julien
- Lorenzo-Salazar José M.
- Lortholary Olivier
- Louadah Badr
- Louapre Céline
- Loze Bénédicte
- Lubetzki Catherine
- Lucarelli Aude
- Lucas Carrie L.
- Lucas Marie-Laure
- Lucasamichi Axelle
- Lucet Jean Christophe
- Lucet Jean-Christophe
- Lung Kwok-Cheung
- Luong Liem Binh
- Luyt Charles-Edouard
- Lye David C.
- Lévy Romain
- López-Collazo Eduardo
- Magazimama-Ext Arouna
- Magnone Cinthia
- Maillot Adrien
- Maingret David
- Malhotra Surbi
- Malvy Denis
- Malvy Denis
- Mambert Marina
- Mameri Lakhdar
- Manchon Pauline
- Maniatis Tom
- Manivet Philippe
- Manry Jeremy
- Mansouri Cylia
- Mansouri Davood
- Marcault Estelle
- Marchal Astrid
- Marchioni Enrico
- Marey Jonathan
- Marin Nathalie
- Marioli Carola
- Marjani Majid
- Marois Clémence
- Marques Laura
- Martin Olivier
- Martin-Nalda Andrea
- Martineau Lou
- Martinez Antonio Morales
- Martinez-Lopez Cannelle
- Martinez-Picado Javier
- Martyniuck Pierre
- Martín-Nalda Andrea
- Marzana Iciar
- Marzouk Nessrine
- Maródi László
- Masmoudi Rafik
- Mata-Martínez Carmen
- Mathian Alexis
- Matos Larissa R. B.
- Matthews Gail V.
- Mattiaccio Alessandro
- Matuozzo Daniela
- Mayaux Julien
- McLaughlin-Garcia Raquel
- Mebazaa Alexandre
- Mechai Frédéric
- Mecozzi Fabio
- Medina Yeray Novoa
- Mediouni Chamseddine
- Meersseman Philippe
- Megarbane Bruno
- Meghadecha Mohamed
- Mejean Élodie
- Mekinian Arsene
- Mekni Rania
- Mekontso-Dessap Armand
- Meliti Thinhinan Sabrina
- Melián Abián Montesdeoca
- Melki Isabelle
- Meloni Federica
- Meng Paris
- Mentre France
- Mentré France
- Merbah Soraya
- Mergeay-Fabre Mayka
- Meritet Jean-François
- Merlani Paolo
- Messani Fadhila
- Messaoudi Yasmine
- Metin Akcan Ozge
- Meunier Alexandre
- Mewasing Baboo-Irwinsingh
- Meyts Isabelle
- Meyts Isabelle
- Meyts Isabelle
- Meziane Amina
- Meziane Lydia
- Mezidi Mehdi
- Michelot-Burger Carole
- Migaud Maria-Claire
- Migeotte Isabelle
- Mignot Françoise
- Milisavljevic Baptiste
- Milla Sonia Ayllon
- Millereux Maude
- Million Matthieu
- Milner Joshua D.
- Minka Fadi Hillary
- Mirault Tristan
- Mircher Clotilde
- Mironska Kristina
- Mirsaeidi Mehdi
- Miyara Makoto
- Mizoguchi Yoko
- Modi Bhavi P.
- Mogensen Trine H.
- Moine Pierre
- Mojoli Francesco
- Molina Jean-Michel
- Moncomble Elsa
- Monnory Fatima-Zohra Djamouri
- Montagne Samatha
- Montegnies-Boulet Anaïs
- Monti Alexandra
- Montlahuc Claire
- Montout Anne-Lise
- Moores Alexandre
- Morandeira Francisco
- Morange Pierre-Emmanuel
- Morbieu Caroline
- Mordacq Cléemence
- Morelle Guillaume
- Morio Tomohiro
- Mortelette Helene
- Mouly Stéphane
- Mouly Stéphane J.
- Mouquet Hugo
- Mullaert Jimmy
- Muzaffar Rosita
- Muñoz-Barrera Adrián
- Mège Jean-Louis
- Nacerddine Cherifa Iness
- Nadal Marine
- Nadif Hajer
- Nadji Seyed Alireza
- Naesens Leslie
- Nafati Cyril
- Nagashima Shintaro
- Nakagama Yu
- Narvaez Rafael Usubillaga
- Nassarmadji Kladoum
- Natella Pierre
- Ndingamondze Sandrine
- Neant Nadège
- Nellen Jeaninne
- Neraal Stefan
- Neven Bénédicte
- Neves João Farela
- Ng Lisa F. P.
- Ng Lisa F. P.
- Ng Yuk-Yung
- Nguyen Caroline
- Nguyen Duc
- Nguyen Duc
- NIAID-USUHS COVID Study Group [missing]
- Nicolas Leturque
- Nielly hubert
- Nlomenyengue Luc
- Noel Nicolas
- Noret Marion
- Nossent Esther J.
- Notarangelo Luigi D.
- Notarangelo Luigi D.
- Nouroudine Mariama
- Novelli Antonio
- Novelli Giuseppe
- Nseir Saad
- Nunes Hilario
- Nussbaum Robert
- N’Guyen Bao
- Ocejo-Vinyals J. Gonzalo
- Okada Satoshi
- Okamoto Keisuke
- Oler Andrew J.
- Omar Edris
- Orchestra Working Group [missing]
- Oualha Mehdi
- Ouazene Zineb
- Ouedrani Amani
- Ouedraogo Elise
- Ouelaa Wassila
- Oufella Hafid Ait
- Oukhedouma Anissa
- Oya Herve
- Ozcelik Tayfun
- Oziel Johanna
- Ozkaya-Parlakay Aslinur
- O’Farrelly Cliona
- Padilla Thomas
- Pagani Michele
- Paillaud Elena
- Paiva Solenne
- Palabiyik Figen
- Pan-Hammarström Qiang
- Papadaki Maria
- Papadopoulos Aurélie
- Parfait Beatrice
- Paris Christophe
- Parize Perrine
- Parizot Christophe
- Parizot Christophe
- Parola Philippe
- Parrot Antoine
- Pascreau Tiffany
- Paul Christelle
- Paul Stéphane
- Paulus Frederique
- Pavot Arthur
- Payet Christine
- Paz-Artal Estela
- Peaudecerf Laetitia
- Pedraza Sigifredo
- Peiffer-Smadja Nathan
- Pellecer Nancy Carolina González
- Pellegrini Silvia
- Pene Frédéric
- Pepin Marion
- Pereira Jesus Marquez
- Pernet Julie
- Pernin Claire
- Perpoint Thomas
- Perreau Pauline
- Pesci Alberto
- Peters Edgar
- Petit Mylène
- Petrov-Sanchez Ventzislava
- Peyrony Olivier
- Peytavin Gilles
- Pham Huong
- Philippe Aurélien
- Philippot Quentin
- Picod Adrien
- Picone Olivier
- Pietri Marie-Pierre
- Pietri Olivia
- Pina-Fuentes Dan A. I.
- Pinson Michelle
- Pintado Claire
- Pippucci Tommaso
- Piquard Valentine
- Piquard Valentine
- Piquard Valentine
- Piralla Antonio
- Pires Christine
- Pistone Thierry
- Planas Anna M.
- Planas-Serra Laura
- Planquette Benjamin
- Pleguezuelo Daniel E.
- Ploin Dominique
- Poirier Sandrine
- Poissy Julien
- Pomel Anne-Laure
- Poncelet Géraldine
- Pons Stéphanie
- Ponscarme Diane
- Poulakou Garyphallia
- Pouletty Marie S.
- Pourcelot Annegaelle
- Pourcher Valérie
- Pourshahnazari Persia
- Pouvaret Anne
- Prando Carolina
- Preckel Bennedikt
- Prever Florian
- Previlon Miresta
- Prevost Margot
- Prins Jan M.
- Provoost Marie-Julie
- Puel Anne
- Pueyo David Martínez
- Pujol Aurora
- Puéchal Oriane
- Pérez-Fernández Xosé Luis
- Qiu-Chen Jia Li
- Quaresima Virginia
- Quemeneur Cyril
- Quentric Paul
- Quintana-Murci Lluis
- Quintin Caroline
- Quiros-Roldan Eugenia
- Raasveld Jorinde
- Rabaud Christian
- Rafat Cédric
- Ramaswamy Sathishkumar
- Rambaud Thomas
- Rami Agathe
- Ramos Miquel Alfonso
- Ranque Brigitte
- Raoult Didier
- Raoult Violette
- Raphael Maurice
- Raphalen Jean Herle
- Rastoin Anna
- Raux Mathieu
- Rebai Amani
- Rebillat Anne-Sophie
- Reby Michael
- Redin Claire
- Regent Alexis
- Regrag Asma
- Reijnders Tom
- Renia Laurent
- Resche-Rigon Matthieu
- Resmini Léa
- Resnick Igor
- Ressaire Quentin
- Reyes Luis Felipe
- Ricart Pilar
- Richard Christian
- Richard Jean-Christophe
- Richard Lucie
- Richard Mariecaroline
- Rigo-Bonnin Raúl
- rivet Nadia
- Rivière Jacques G.
- Robert Maxence
- Rocamora-Blanch Gemma
- Rodero Mathieu P.
- Rodrigo Carlos
- Rodriguez Luis Antonio
- Rodriguez-Gallego Carlos
- Rodriguez-Palmero Agustí
- Rodríguez-Gallego Carlos
- Rohaut Benjamin
- Rojas Julian
- Rolland-Debord Camille
- Romero Carolina Soledad
- Ropers Jacques
- Roque-Afonso Anne-Marie
- Rosa-Calatrava Manuel
- Rosenberger John
- Rossi Camillo
- Rossignol Bénédicte
- Rossignol Patrick
- Rosso Charlotte
- Rothenbuhler Anya
- Roufai Layidé
- Rousseaux Mélanie
- Rousseaux Nabila
- Roux Damien
- Roux Lorène
- Roux Swasti
- Rouzaud Claire
- Rovere-Querini Patrizia
- Rovina Nikoletta
- Roy Carine
- Rozenberg Flore
- Rozes Antoine
- Rubenstein Emma
- Ruch Yvon
- Ruiz Montse
- Ruiz-Rodriguez Juan Carlos
- Sabate Jean-Marc
- Sabater-Riera Joan
- Sabet Sheila
- Sacleux Sophie-Caroline
- Saied Wafa Ibn
- Saks Kai
- Salagianni Maria
- Saliba Faouzi
- Salmon Dominique
- Sanchez Oliver
- Sancho-Shimizu Vanessa
- Savale Laurent
- Savary Guillaume
- Sberro Rebecca
- Scemla Anne
- Schidlowski Laire
- Schinkel Michiel
- Schlemmer Frederic
- Schluter Agatha
- Schlüter Agatha
- Schmidt Julien
- Schmidt Matthieu
- Schneider Marion
- Schrauwen Femke A. P.
- Schuetz Catharina
- Schultz Marcus J.
- Schuurmans Alex
- Schuurmans Jaap
- Schwartz Mathieu
- Schweitzer Cyril E.
- Scolari Francesco
- Sedfi Saïd
- Sediva Anna
- Sediva Anna
- Seeleuthner Yoann
- Sefir-Kribel Samia
- Seijo Luis
- Seksik Philippe
- Sellier Pierre
- Selves Agathe
- Sembach Nicole
- Semerano Luca
- Seminario Analia Gisela
- Senat Marie-Victoire
- Sene Damien
- Sene Damien
- Seng Piseth
- Senoglu Sevtap
- Seppänen Mikko
- Seppänen Mikko R. J.
- Seri Marco
- Serris Alexandra
- Sese Lucile
- Sghiouar Naima
- Shahrooei Mohammad
- Shcherbina Anna
- Shcherbina Anna
- Sigaloff Kim
- Sigaux Johanna
- Siguier Martin
- Siguret Virginie
- Silvain Johanne
- Simon Noémie
- Simon Tabassome
- Siouti Eleni
- Skandri Lina Innes
- Slabbynck Hans
- Slaby Ondrej
- Slim Marleen A.
- Slimani Miassa
- Smadja David M.
- Smeele Patrick
- Smit Marry
- Smith Nikaia
- Snauwaert Aurélie
- Snow Andrew L.
- Snow Andrew L.
- Sobh Ali
- Sokol Harry
- Solanich Xavier
- Soler Catherine
- Soler-Palacin Pere
- Soler-Palacín Pere
- Soler-Palacín Pere
- Soliman Heithem
- Solis Blanca Garcia
- Soltani Nisrine
- Solé-Violán Jordi
- Sottini Alessandra
- Soyer Benjamin
- Sozeri Betul
- Spaan András N.
- Steg Gabriel
- Stella Giulia Maria
- Stepanovskiy Yuriy
- Stijnis Cornelis S.
- Stilma Willemke
- Stoclin Annabelle
- Su Helen C.
- Su Helen C.
- Su Richa
- Suarez Lydia
- Sukumar Gauthaman
- Szwebel Tali-Anne
- Sánchez-Montalvá Adrián
- Sánchez-Ramón Silvia
- Sözeri Betül
- Taccone Fabio
- Tacconelli Evelina
- Taffame Kossi
- Talouarn Estelle
- Tancevski Ivan
- Tandjaoui-Lambiotte Yacine
- Tangye Stuart G.
- Tantet Claire
- Tardivon Coralie
- Tardy Bernard
- Tateo Mariagrazia
- Taupin Jean-Luc
- Tavernier Simon
- Tellier Marie-Capucine
- Tello Loreto Vidaur
- Terrier Benjamin
- Terrier Olivier
- Teunissen Charlotte
- Theodose Igor
- Thiebaud Pierre clement
- Thiery Guillaume
- Thomas Caroline
- Thoral Patrick
- Thorball Christian
- Thorn Karolina
- Thumerelle Caroline
- Thy Michael
- Tiercelet Kelly
- Timsit Jean-François
- Tipu Imran
- Tisserand Julie
- Tolstrup Martin
- Tomasoni Gabriele
- Tomczak Carole
- Tompkins Miranda F.
- Torelino Krystel
- Touam-Ext Fatima
- Toubiana Julie
- Toumi Lilia
- Toury Gustave
- Toy-Miou Mireille
- Trandinh Alexy
- Treluyer Jean-Marc
- Tresoldi Cristina
- Triantafyllia Vasiliki
- Trinque Baptiste
- Trouillet-Assant Sophie
- Troya Jesus
- Troya Jesús
- Truchot Jennifer
- Tsang Owen T. Y.
- Tserel Liina
- Tso Eugene Y. K.
- Tsonas Anissa M.
- Tual Christelle
- Tubach Florence
- Tubiana Sarah
- Tucci Alessandra
- Tuinman Pieter R.
- Tunesi Simone
- Turpin Agathe
- Turpin Matthieu
- Turvey Stuart E.
- Téoulé François
- Uddin Furkan
- Uddin Mohammed J.
- Urbina Tomas
- Ursini Matilde Valeria
- Utsumi Takanori
- Uzunhan Yurdagul
- Uzunhan Yurdagul
- Vabres Pierre
- Vacher Yannick
- Vaittinadaayar Prabakar
- Valencia-Ramos Juan
- Valent Arnaud
- Valentian Maelle
- Valin Nadia
- Vallet Hélène
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- Van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- Van Den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- Van Der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- Van Praet Jens
- van Vugt Michèle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vaz Marina
- Vazquezibarra Miguel-Alejandro
- Vedie Benoit
- Veelo Denise
- Vega Clara Campos
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Velly Laetitia
- Verstuyft Celine
- Viallette Cedric
- Vicaut Eric
- Vidaud Michel
- Vidigal Mateus C.
- Viel Sébastien
- Vignali Valérie
- Vignes Dorothee
- Vilaire-Meunier Marie E.
- Villain Cédric
- Villar-García Judit
- Vimpere Damien
- Vincent Audrey
- Vinh Donald C.
- Virlouvet Myriam
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander P. J.
- Voiriot Guillaume
- Voiriot Guillaume
- Voisot Lena
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- Vught Lonneke A.
- Vuotto Fanny
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Weiss Emmanuel
- Weiss Nicolas
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wilkerson Matthew D.
- Winchenne Anaïs
- Wouters Dorien
- Wu Alan K. L.
- Wu Tak-Chiu
- Yahşi Aysun
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yesilbas Osman
- Yildiz Mehmet
- Yordanov Youri
- Youkou Christy Gaëlla Kotokpo
- Young Barnaby E.
- Yüksek Saliha Kanık
- Yükselmiş Ufuk
- Zafrani Lara
- Zaidan Mohamad
- Zaidi Wissem
- Zak Cathia
- Zarhrate-Ghoul Aida
- Zatout Ouassila
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zecca Marco
- Zeino Suzanne
- Zeitouni Michel
- Zemirli Naïma
- Zerah Lorene
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Xijun
- Zhang Yu
- Zia Ounsa
- Ziol Marianne
- Zolario Oceane
- Zuber Julien
- Zuccaro Valentina
- Zwinderman A. H.
- Íñigo-Campos Antonio
- Öz Şadiye Kübra Tüter
- Özkan Esra Akyüz
- Özçelik Tayfun
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 01/01/2023
- Field of study
No full textBackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
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- Abad Capa Jorge
- Abel Laurent
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- Universitat Autònoma de Barcelona
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- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
Get PDFInternational audienceInterindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men
