10 research outputs found

    Cardiovascular risk in carotid disease: assessment of doppler sonography and biomarker results Risco cardiovascular e doença carotídea: avaliação de resultados de doppler e biomarcadores

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    INTRODUCTION: Atherosclerosis and correlated cardiovascular problems, whose mechanical and physiological disorders cause thickening and hardening of blood vessels, are among the main causes of death worldwide. OBJECTIVE: To assess plasma concentrations of biomarkers from the lipid metabolism and carotid doppler sonography results by correlating them with atherogenic carotid disease. METHODS: the study comprised 66 patients aged 57.5 ± 15.5 years (20-77), from which 63% were female. Serum markers and doppler sonography images were used to evaluate the association with atherogenic carotid disease (ACD). RESULTS: There was a higher prevalence of ACD among females (33% vs. 15%), age range 56-65, showing a relative risk (RR) of 1.56 among females (p 40 mg/dl and 19% had HDL-C ≥ 40 mg/dl. The prevalence of HDL-C > 40 mg/dl at levels II, III and IV was considerable. There was no difference in HDL-C among the groups (p = 0.4910; unpaired t test). Furthermore, there was no difference in paraoxonase (PON1) activity when stratified to HDL-C > and 0.05). CONCLUSION: The female group displayed higher ACD prevalence at 56-65 age range, with RR of 1.56 times higher. These findings substantiate the importance of analyzing this group and age range carefully, inasmuch as the absence of hormonal protection may increase ACD risk and ultimately influence HDL antioxidant activity due to its direct action on PON1. Triglycerides (TG)/HDL-C ratio indicates cardiovascular risk and impaired reverse cholesterol transport.INTRODUÇÃO: ComplicaçÔes da aterosclerose agregam as principais causas de morte no mundo por problemas cardiovasculares relativos a distĂșrbio da condição mecĂąnica e fisiolĂłgica que promove espessamento e endurecimento nas artĂ©rias. OBJETIVO: Avaliar as concentraçÔes plasmĂĄticas de biomarcadores do metabolismo lipĂ­dico e os resultados de doppler de carĂłtidas, relacionando-os com a doença aterogĂȘnica de carĂłtidas. MÉTODOS: Foram acompanhados 66 pacientes, com a mĂ©dia de idade entre 57,5 ± 15,5 anos, (20 a 77), sendo 63% mulheres. Utilizaram-se biomarcadores sĂ©ricos e imagens (doppler) para avaliar a associação com a doença aterogĂȘnica carotĂ­dea (DCA). RESULTADOS E DISCUSSÃO: A DCA foi mais prevalente no gĂȘnero feminino (33% vs. 15%) entre as idades de 56-65 anos, risco relativo (RR) 1,56 nas mulheres (p 40 mg/dl em comparação com 19% que tinham concentração de HDL-C ≥ 40 mg/dl. A prevalĂȘncia de HDL-C > 40 mg/dl nos graus II, III e IV foi significativa. NĂŁo houve diferença de HDL-C entre os grupos (p = 0,4910, teste t nĂŁo pareado). NĂŁo foi observada diferença entre as atividades de paraoxonase (PON1) quando estratificada para HDL-C > e 0,05). CONCLUSÃO: O gĂȘnero feminino teve maior prevalĂȘncia de DCA entre 56-65 anos, RR 1,56 vezes maior. Esse achado revela a importĂąncia de atenção nesse gĂȘnero e nessa faixa etĂĄria, uma vez que a ausĂȘncia de proteção hormonal agrava o risco de DCA, podendo influenciar na atividade antioxidante da HDL por atuar diretamente na PON1. A razĂŁo triglirecĂ­deos (TG)/HDL-C aponta para risco cardiovascular e deficiĂȘncias no transporte reverso do colesterol

    Determinação de HbA1c por CLAE: interferĂȘncia de variantes de hemoglobinas S e C e alta concentração de HbF

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    INTRODUÇÃO: O diabetes mellitus (DM) Ă© considerado um problema importante de saĂșde pĂșblica; possui prevalĂȘncia elevada e nos Ășltimos anos observa-se aumento progressivo na sua incidĂȘncia. OBJETIVO: verificar possĂ­veis variaçÔes na concentração de hemoglobina (Hb) glicada (HbA1c) na presença de Hbs S e C e avaliar o impacto da redução da HbA1c na avaliação clĂ­nica e no monitoramento do paciente diabĂ©tico. MATERIAL E MÉTODOS: Foram incluĂ­dos no estudo, 150 indivĂ­duos diabĂ©ticos oriundos da cidade de Salvador, Bahia, de ambos os gĂȘneros, com idade mĂ©dia de 56 anos. Foram determinadas a glicemia de jejum e a HbA1c por metodologia de oxidase-peroxidase e cromatografia lĂ­quida de alta eficiĂȘncia (CLAE), respectivamente. RESULTADOS: Foram observadas variaçÔes na concentração da HbA1c em função da presença de variantes de Hb, como 7,85%, AA; 7,30%, AS e 7,15%, AC. DISCUSSÃO E CONCLUSÃO: A metodologia analĂ­tica a ser utilizada para determinação de HbA1c deve ser escolhida com base nas caracterĂ­sticas gerais da população atendida e nas comorbidades associadas, pois a presença de Hbs S e C ocasiona reduçÔes significativas de glicação. Essa redução pode levar a interpretaçÔes clĂ­nicas inadequadas relativas ao controle glicĂȘmico dos pacientes

    NEOTROPICAL XENARTHRANS: a data set of occurrence of xenarthran species in the Neotropics

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    Xenarthrans—anteaters, sloths, and armadillos—have essential functions for ecosystem maintenance, such as insect control and nutrient cycling, playing key roles as ecosystem engineers. Because of habitat loss and fragmentation, hunting pressure, and conflicts with domestic dogs, these species have been threatened locally, regionally, or even across their full distribution ranges. The Neotropics harbor 21 species of armadillos, 10 anteaters, and 6 sloths. Our data set includes the families Chlamyphoridae (13), Dasypodidae (7), Myrmecophagidae (3), Bradypodidae (4), and Megalonychidae (2). We have no occurrence data on Dasypus pilosus (Dasypodidae). Regarding Cyclopedidae, until recently, only one species was recognized, but new genetic studies have revealed that the group is represented by seven species. In this data paper, we compiled a total of 42,528 records of 31 species, represented by occurrence and quantitative data, totaling 24,847 unique georeferenced records. The geographic range is from the southern United States, Mexico, and Caribbean countries at the northern portion of the Neotropics, to the austral distribution in Argentina, Paraguay, Chile, and Uruguay. Regarding anteaters, Myrmecophaga tridactyla has the most records (n = 5,941), and Cyclopes sp. have the fewest (n = 240). The armadillo species with the most data is Dasypus novemcinctus (n = 11,588), and the fewest data are recorded for Calyptophractus retusus (n = 33). With regard to sloth species, Bradypus variegatus has the most records (n = 962), and Bradypus pygmaeus has the fewest (n = 12). Our main objective with Neotropical Xenarthrans is to make occurrence and quantitative data available to facilitate more ecological research, particularly if we integrate the xenarthran data with other data sets of Neotropical Series that will become available very soon (i.e., Neotropical Carnivores, Neotropical Invasive Mammals, and Neotropical Hunters and Dogs). Therefore, studies on trophic cascades, hunting pressure, habitat loss, fragmentation effects, species invasion, and climate change effects will be possible with the Neotropical Xenarthrans data set. Please cite this data paper when using its data in publications. We also request that researchers and teachers inform us of how they are using these data

    Elective Cancer Surgery in COVID-19–Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study

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    Delaying surgery for patients with a previous SARS-CoV-2 infection

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