834 research outputs found
The effect of stress on the expression of the amyloid precursor protein in rat brain
AbstractThe abnormal processing of the amyloid precursor protein (APP) is a pivotal event in the development of the unique pathology that defines Alzheimer's disease (AD). Stress, and the associated increase in corticosteroids, appear to accelerate brain ageing and may increase vulnerability to Alzheimer's disease via altered APP processing. In this study, rats were repeatedly exposed to an unavoidable stressor, an open elevated platform. Previous studies in this laboratory have shown that a single exposure produces a marked increase in plasma corticosterone levels but animals develop tolerance to this effect between 10 and 20 daily sessions. Twenty-four hours after stress, there was an increase in the ratio of the deglycosylated form of APP in the particulate fraction of the brain, which subsequently habituated after 20 days. The levels of soluble APP (APPs) tended to be lower in the stress groups compared to controls except for a significant increase in the hippocampus after 20 days of platform exposure. Since APPs is reported to have neurotrophic properties, this increased release may represent a neuroprotective response to repeated stress. It is possible that the ability to mount this response decreases with age thus increasing the vulnerability to stress-induced AD-related pathology
Electromagnetic field angular momentum in condensed matter systems
Various electromagnetic systems can carry an angular momentum in their {\bf
E} and {\bf B} fields. The electromagnetic field angular momentum (EMAM) of
these systems can combine with the spin angular momentum to give composite
fermions or composite bosons. In this paper we examine the possiblity that an
EMAM could provide an explanation of the fractional quantum Hall effect (FQHE)
which is complimentary to the Chern-Simons explanation. We also examine a toy
model of a non-BCS superconductor (e.g. high superconductors) in terms of
an EMAM. The models presented give a common, simple picture of these two
systems in terms of an EMAM. The presence of an EMAM in these systems might be
tested through the observation of the decay modes of a charged, spin zero
unstable particle inside one of these systems.Comment: 17 pages, no figures, to be published in Phys. Rev.
Stochastic Vehicle Routing with Recourse
We study the classic Vehicle Routing Problem in the setting of stochastic
optimization with recourse. StochVRP is a two-stage optimization problem, where
demand is satisfied using two routes: fixed and recourse. The fixed route is
computed using only a demand distribution. Then after observing the demand
instantiations, a recourse route is computed -- but costs here become more
expensive by a factor lambda.
We present an O(log^2 n log(n lambda))-approximation algorithm for this
stochastic routing problem, under arbitrary distributions. The main idea in
this result is relating StochVRP to a special case of submodular orienteering,
called knapsack rank-function orienteering. We also give a better approximation
ratio for knapsack rank-function orienteering than what follows from prior
work. Finally, we provide a Unique Games Conjecture based omega(1) hardness of
approximation for StochVRP, even on star-like metrics on which our algorithm
achieves a logarithmic approximation.Comment: 20 Pages, 1 figure Revision corrects the statement and proof of
Theorem 1.
Scenario of Accelerating Universe from the Phenomenological \Lambda- Models
Dark matter, the major component of the matter content of the Universe,
played a significant role at early stages during structure formation. But at
present the Universe is dark energy dominated as well as accelerating. Here,
the presence of dark energy has been established by including a time-dependent
term in the Einstein's field equations. This model is compatible with
the idea of an accelerating Universe so far as the value of the deceleration
parameter is concerned. Possibility of a change in sign of the deceleration
parameter is also discussed. The impact of considering the speed of light as
variable in the field equations has also been investigated by using a well
known time-dependent model.Comment: Latex, 9 pages, Major change
Consistent Anisotropic Repulsions for Simple Molecules
We extract atom-atom potentials from the effective spherical potentials that
suc cessfully model Hugoniot experiments on molecular fluids, e.g., and
. In the case of the resulting potentials compare very well with the
atom-atom potentials used in studies of solid-state propertie s, while for
they are considerably softer at short distances. Ground state (T=0K) and
room temperatu re calculations performed with the new potential resolve
the previous discrepancy between experimental and theoretical results.Comment: RevTeX, 5 figure
Using artificial intelligence to risk stratify COVID-19 patients based on chest X-ray findings
Background: Deep learning-based radiological image analysis could facilitate use of chest x-rays as a triaging tool for COVID-19 diagnosis in resource-limited settings. This study sought to determine whether a modified commercially available deep learning algorithm (M-qXR) could risk stratify patients with suspected COVID-19 infections. Methods: A dual track clinical validation study was designed to assess the clinical accuracy of M-qXR. The algorithm evaluated all Chest-X-rays (CXRs) performed during the study period for abnormal findings and assigned a COVID-19 risk score. Four independent radiologists served as radiological ground truth. The M-qXR algorithm output was compared against radiological ground truth and summary statistics for prediction accuracy were calculated. In addition, patients who underwent both PCR testing and CXR for suspected COVID-19 infection were included in a co-occurrence matrix to assess the sensitivity and specificity of the M-qXR algorithm. Results: 625 CXRs were included in the clinical validation study. 98% of total interpretations made by M-qXR agreed with ground truth (p = 0.25). M-qXR correctly identified the presence or absence of pulmonary opacities in 94% of CXR interpretations. M-qXR's sensitivity, specificity, PPV, and NPV for detecting pulmonary opacities were 94%, 95%, 99%, and 88% respectively. M-qXR correctly identified the presence or absence of pulmonary consolidation in 88% of CXR interpretations (p = 0.48). M-qXR's sensitivity, specificity, PPV, and NPV for detecting pulmonary consolidation were 91%, 84%, 89%, and 86% respectively. Furthermore, 113 PCR-confirmed COVID-19 cases were used to create a co-occurrence matrix between M-qXR's COVID-19 risk score and COVID-19 PCR test results. The PPV and NPV of a medium to high COVID-19 risk score assigned by M-qXR yielding a positive COVID-19 PCR test result was estimated to be 89.7% and 80.4% respectively. Conclusion: M-qXR was found to have comparable accuracy to radiological ground truth in detecting radiographic abnormalities on CXR suggestive of COVID-19
Academic freedom: in justification of a universal ideal
This paper examines the justification for, and benefits of, academic freedom to academics, students, universities and the world at large. The paper surveys the development of the concept of academic freedom within Europe, more especially the impact of the reforms at the University of Berlin instigated by Wilhelm von Humboldt. Following from this, the paper examines the reasons why the various facets of academic freedom are important and why the principle should continue to be supported
Unconventional Cosmology
I review two cosmological paradigms which are alternative to the current
inflationary scenario. The first alternative is the "matter bounce", a
non-singular bouncing cosmology with a matter-dominated phase of contraction.
The second is an "emergent" scenario, which can be implemented in the context
of "string gas cosmology". I will compare these scenarios with the inflationary
one and demonstrate that all three lead to an approximately scale-invariant
spectrum of cosmological perturbations.Comment: 45 pages, 10 figures; invited lectures at the 6th Aegean Summer
School "Quantum Gravity and Quantum Cosmology", Chora, Naxos, Greece, Sept.
12 - 17 2012, to be publ. in the proceedings; these lecture notes form an
updated version of arXiv:1003.1745 and arXiv:1103.227
Replacing natural wetlands with stormwater management facilities: biophysical and perceived social values
Urban expansion replaces wetlands of natural origin with artificial stormwater management facilities. The literature suggests that efforts to mimic natural wetlands in the design of stormwater facilities can expand the provision of ecosystem services. Policy developments seek to capitalize on these improvements, encouraging developers to build stormwater wetlands in place of stormwater ponds; however, few have compared the biophysical values and social perceptions of these created wetlands to those of the natural wetlands they are replacing. We compared four types of wetlands: natural references sites, natural wetlands impacted by agriculture, created stormwater wetlands, and created stormwater ponds. We anticipated that they would exhibit a gradient in biodiversity, ecological integrity, chemical and hydrologic stress. We further anticipated that perceived values would mirror measured biophysical values. We found higher biophysical values associated with wetlands of natural origin (both reference and agriculturally impacted). The biophysical values of stormwater wetlands and stormwater ponds were lower and indistinguishable from one another. The perceived wetland values assessed by the public differed from the observed biophysical values. This has important policy implications, as the public are not likely to perceive the loss of values associated with the replacement of natural wetlands with created stormwater management facilities. We conclude that 1) agriculturally impacted wetlands provide biophysical values equivalent to those of natural wetlands, meaning that land use alone is not a great predictor of wetland value; 2) stormwater wetlands are not a substantive improvement over stormwater ponds, relative to wetlands of natural origin; 3) stormwater wetlands are poor mimics of natural wetlands, likely due to fundamental distinctions in terms of basin morphology, temporal variation in hydrology, ground water connectivity, and landscape position; 4) these drivers are relatively fixed, thus, once constructed, it may not be possible to modify them to improve provision of biophysical values; 5) these fixed drivers are not well perceived by the public and thus public perception may not capture the true value of natural wetlands, including those impacted by agriculture
Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment
This paper describes an analysis of the angular distribution of W->enu and
W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with
the ATLAS detector at the LHC in 2010, corresponding to an integrated
luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and
the missing transverse energy, the W decay angular distribution projected onto
the transverse plane is obtained and analysed in terms of helicity fractions
f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV
and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw
> 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour,
are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017
+/- 0.030, where the first uncertainties are statistical, and the second
include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables,
revised author list, matches European Journal of Physics C versio
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