497 research outputs found
Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice
Hearing relies on the mechanosensory inner and outer hair cells (OHCs) of the organ of Corti, which convert mechanical deflections of their actin-rich stereociliary bundles into electrochemical signals. Several actin-associated proteins are essential for stereocilia formation and maintenance, and their absence leads to deafness. One of the most abundant actin-bundling proteins of stereocilia is plastin 1, but its function has never been directly assessed. Here, we found that plastin 1 knock-out (Pls1 KO) mice have a moderate and progressive form of hearing loss across all frequencies. Auditory hair cells developed normally in Pls1 KO, but in young adult animals, the stereocilia of inner hair cells were reduced in width and length. The stereocilia of OHCs were comparatively less affected; however, they also showed signs of degeneration in ageing mice. The hair bundle stiffness and the acquisition of the electrophysiological properties of hair cells were unaffected by the absence of plastin 1, except for a significant change in the adaptation properties, but not the size of the mechanoelectrical transducer currents. These results show that in contrast to other actin-bundling proteins such as espin, harmonin or Eps8, plastin 1 is dispensable for the initial formation of stereocilia. However, the progressive hearing loss and morphological defects of hair cells in adult Pls1 KO mice point at a specific role for plastin 1 in the preservation of adult stereocilia and optimal hearing. Hence, mutations in the human PLS1 gene may be associated with relatively mild and progressive forms of hearing loss
Differential geometry construction of anomalies and topological invariants in various dimensions
In the model of extended non-Abelian tensor gauge fields we have found new
metric-independent densities: the exact (2n+3)-forms and their secondary
characteristics, the (2n+2)-forms as well as the exact 6n-forms and the
corresponding secondary (6n-1)-forms. These forms are the analogs of the
Pontryagin densities: the exact 2n-forms and Chern-Simons secondary
characteristics, the (2n-1)-forms. The (2n+3)- and 6n-forms are gauge invariant
densities, while the (2n+2)- and (6n-1)-forms transform non-trivially under
gauge transformations, that we compare with the corresponding transformations
of the Chern-Simons secondary characteristics. This construction allows to
identify new potential gauge anomalies in various dimensions.Comment: 27 pages, references added, matches published versio
Menus for Feeding Black Holes
Black holes are the ultimate prisons of the Universe, regions of spacetime
where the enormous gravity prohibits matter or even light to escape to
infinity. Yet, matter falling toward the black holes may shine spectacularly,
generating the strongest source of radiation. These sources provide us with
astrophysical laboratories of extreme physical conditions that cannot be
realized on Earth. This chapter offers a review of the basic menus for feeding
matter onto black holes and discusses their observational implications.Comment: 27 pages. Accepted for publication in Space Science Reviews. Also to
appear in hard cover in the Space Sciences Series of ISSI "The Physics of
Accretion onto Black Holes" (Springer Publisher
Transverse Beam Spin Asymmetries in Forward-Angle Elastic Electron-Proton Scattering
We have measured the beam-normal single-spin asymmetry in elastic scattering
of transversely-polarized 3 GeV electrons from unpolarized protons at Q^2 =
0.15, 0.25 (GeV/c)^2. The results are inconsistent with calculations solely
using the elastic nucleon intermediate state, and generally agree with
calculations with significant inelastic hadronic intermediate state
contributions. A_n provides a direct probe of the imaginary component of the
2-gamma exchange amplitude, the complete description of which is important in
the interpretation of data from precision electron-scattering experiments.Comment: 5 pages, 3 figures, submitted to Physical Review Letters; shortened
to meet PRL length limit, clarified some text after referee's comment
Strange Quark Contributions to Parity-Violating Asymmetries in the Forward G0 Electron-Proton Scattering Experiment
We have measured parity-violating asymmetries in elastic electron-proton
scattering over the range of momentum transfers 0.12 < Q^2 < 1.0 GeV^2. These
asymmetries, arising from interference of the electromagnetic and neutral weak
interactions, are sensitive to strange quark contributions to the currents of
the proton. The measurements were made at JLab using a toroidal spectrometer to
detect the recoiling protons from a liquid hydrogen target. The results
indicate non-zero, Q^2 dependent, strange quark contributions and provide new
information beyond that obtained in previous experiments.Comment: 5 pages, 2 figure
The G0 Experiment: Apparatus for Parity-Violating Electron Scattering Measurements at Forward and Backward Angles
In the G0 experiment, performed at Jefferson Lab, the parity-violating
elastic scattering of electrons from protons and quasi-elastic scattering from
deuterons is measured in order to determine the neutral weak currents of the
nucleon. Asymmetries as small as 1 part per million in the scattering of a
polarized electron beam are determined using a dedicated apparatus. It consists
of specialized beam-monitoring and control systems, a cryogenic hydrogen (or
deuterium) target, and a superconducting, toroidal magnetic spectrometer
equipped with plastic scintillation and aerogel Cerenkov detectors, as well as
fast readout electronics for the measurement of individual events. The overall
design and performance of this experimental system is discussed.Comment: Submitted to Nuclear Instruments and Method
MHD equilibrium properties of tokamak fusion reactor designs
The equilibrium properties of several Tokamak Reactor Designs are analyzed and compared for varying pressure and current profiles using the Princeton Equilibrium Code. It is found that the UWMAK configuration has a broader range of equilibria than the Princeton Reference Design configuration, but that the safety factor on axis is less than unity for peaked current distributions. The Argonne Experimental Power Reactor has a satisfactory range of equilibria, but a means of limiting or diverting the plasma has not yet been proposed, and this may substantially change the results obtained. (auth
Search for displaced vertices arising from decays of new heavy particles in 7 TeV pp collisions at ATLAS
We present the results of a search for new, heavy particles that decay at a
significant distance from their production point into a final state containing
charged hadrons in association with a high-momentum muon. The search is
conducted in a pp-collision data sample with a center-of-mass energy of 7 TeV
and an integrated luminosity of 33 pb^-1 collected in 2010 by the ATLAS
detector operating at the Large Hadron Collider. Production of such particles
is expected in various scenarios of physics beyond the standard model. We
observe no signal and place limits on the production cross-section of
supersymmetric particles in an R-parity-violating scenario as a function of the
neutralino lifetime. Limits are presented for different squark and neutralino
masses, enabling extension of the limits to a variety of other models.Comment: 8 pages plus author list (20 pages total), 8 figures, 1 table, final
version to appear in Physics Letters
Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment
This paper describes an analysis of the angular distribution of W->enu and
W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with
the ATLAS detector at the LHC in 2010, corresponding to an integrated
luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and
the missing transverse energy, the W decay angular distribution projected onto
the transverse plane is obtained and analysed in terms of helicity fractions
f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV
and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw
> 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour,
are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017
+/- 0.030, where the first uncertainties are statistical, and the second
include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables,
revised author list, matches European Journal of Physics C versio
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