39 research outputs found
The state of the Martian climate
- Author
- Aaron-Morrison Arlene P.
- Ackerman Steven A.
- Adams Nicolaus G.
- Adler Robert F.
- Albanil Adelina
- Alfaro Eric J.
- Allan Rob
- Alves Lincoln M.
- Amador Jorge A.
- Ambrose Barbara J.
- Andreassen L. M.
- Arendt A.
- Arndt Derek S.
- Arzhanova N. M.
- Arévalo Juan
- Aschan M. M.
- Azorin-Molina César
- Banzon Viva
- Bardin M. U.
- Barichivich Jonathan
- Baringer Molly O.
- Barreira Sandra
- Baxter Stephen
- Bazo Juan
- Becker Andreas
- Bedka Kristopher M.
- Behrenfeld Michael J.
- Bell Gerald D.
- Belmont M.
- Benedetti Angela
- Bernhard G.
- Berrisford Paul
- Berry David I.
- Bettolli María L.
- Bhatt Uma S.
- Bidegain Mario
- Bill Brian D.
- Billheimer Sam
- Bissolli Peter
- Blake Eric S.
- Blunden Jessica
- Borch-Johnsen K.
- Bosilovich Michael G.
- Boucher Olivier
- Boudet Dagne R.
- Box Jason E.
- Boyer Tim
- Braathen Geir O.
- Bromwich David H.
- Brown R.
- Bulygina Olga N.
- Burgess D.
- Calderón Blanca
- Camargo Suzana J.
- Campbell Jayaka D.
- Cappelen J.
- Carrasco Gualberto
- Carter Brendan R.
- Chambers Don P.
- Chandler Elise
- Christiansen Hanne H.
- Christy John R.
- Chung Daniel
- Chung E.S.
- Cinque Kathy
- Clem Kyle R.
- Coelho Caio A.
- Cogley J.G.
- Coldewey-Egbers Melanie
- Colwell Steve
- Cooper Owen R.
- Copland L.
- Cosca Catherine E.
- Cross Jessica N.
- Crotwell Molly J.
- Crouch Jake
- Davis Sean M.
- De Eyto Elvira
- De Jeu Richard A.M.
- De Laat Jos
- Degasperi Curtis L.
- Degenstein Doug
- Demircan M.
- Derksen C.
- Destin Dale
- Di Girolamo Larry
- Di Giuseppe F.
- Diamond Howard J.
- Dlugokencky Ed J.
- Dohan Kathleen
- Dokulil Martin T.
- Dolgov A. V.
- Dolman A. Johannes
- Domingues Catia M.
- Donat Markus G.
- Dong Shenfu
- Dorigo Wouter A.
- Dortch Quay
- Doucette Greg
- Drozdov Dmitry S.
- Ducklow Hugh
- Dunn Robert J.H.
- Durán-Quesada Ana M.
- Dutton Geoff S.
- Ebrahim A.
- Elkharrim M.
- Elkins James W.
- Espinoza Jhan C.
- Etienne-Leblanc Sheryl
- Evans Thomas E.
- Famiglietti James S.
- Farrell S.A.
- Fateh S.
- Fausto Robert S.
- Fedaeff Nava
- Feely Richard A.
- Feng Z.
- Fenimore Chris
- Fettweis Xavier
- Fioletov Vitali E.
- Flemming Johannes
- Fogarty Chris T.
- Fogt Ryan L.
- Folland Chris
- Fonseca C.
- Fossheim M.
- Foster Michael J.
- Fountain Andrew
- Francis S. D.
- Franz Bryan A.
- Frey Richard A.
- Frith Stacey M.
- Froidevaux Lucien
- Ganter Catherine
- Garzoli Silvia
- Gerland S.
- Gilbert Kristin
- Gobron Nadine
- Goldenberg Stanley B.
- Gomez R. Sorbonne
- Goni Gustavo J.
- Goto A.
- Griffin Jessicca
- Grooß J. U.
- Gruber Alexander
- Guard Charles Chip
- Gugliemin Mauro
- Gupta S. K.
- Gutiérrez J. M.
- Hagos S.
- Hahn Sebastian
- Haimberger Leo
- Hakkarainen J.
- Hall Brad D.
- Halpert Michael S.
- Hamlington Benjamin D.
- Hanna Edward
- Hansen K.
- Hanssen-Bauer I.
- Harris Ian A
- Heidinger Andrew K.
- Heikkilä A.
- Heil A.
- Heim Richard R., Jr.
- Hendricks S.
- Hernández Marieta
- Hidalgo Hugo G.
- Hilburn Kyle
- Ho Shu Peng Ben
- Holmes R. Max
- Hu Zeng Zhen
- Huang Boyin
- Huelsing Hannah K.
- Huffman George J.
- Hughes N.C.
- Hurst Dale F.
- Ialongo I.
- Ijampy J. A.
- Ingvaldsen R. B.
- Inness Antje
- Isaksen K.
- Ishii Masayoshi
- Jevrejeva Svetlana
- Jiménez C.
- Jin Xiangze
- Johannesen E.
- John Viju
- Johnson Bryan
- Johnson Gregory C.
- Jones Philip D.
- Joseph Annie C.
- Jumaux Guillaume
- Kabidi Khadija
- Kaiser Johannes W.
- Kato Seiji
- Kazemi A.
- Keller Linda M.
- Kendon Mike
- Kennedy John J.
- Kerr Kenneth
- Kholodov A. L.
- Khoshkam Mahbobeh
- Killick Rachel
- Kim Hyungjun
- Kim S. J.
- Kimberlain Todd B.
- Klotzbach Philip J.
- Knaff John A.
- Kobayashi Shinya
- Kohler J.
- Korhonen Johanna
- Korshunova Natalia N.
- Kovacs K.M.
- Kramarova Natalya
- Kratz David P.
- Kruger Andries
- Kruk Michael C.
- Kudela Raphael
- Kumar Arun
- Lakatos M.
- Lakkala K.
- Lander Mark A.
- Landsea Chris W.
- Lankhorst Matthias
- Lantz Kathleen
- Lazzara Matthew A.
- Lemons P.
- Leuliette Eric
- Lieser Jan L.
- Lin I. I.
- Liu Hongxing
- Liu Yinghui
- Lo Monaco Claire
- Locarnini Ricardo
- Loeb Norman G.
- Long Craig S.
- Lorrey Andrew M.
- Love-Brotak S. Elizabeth
- Loyola Diego
- Lumpkin Rick
- Luo Jing-Jia
- Luojus K.
- Lydersen C.
- Lyman John M.
- López Álvarez Luis Alfonso
- L’Heureux Michelle
- Maberly Stephen C.
- Maddux Brent C.
- Malheiros Ramos Andrea
- Malkova G. V.
- Manney G.L.
- Marcellin Vernie
- Marchenko Sergey
- Marengo José A.
- Marra John J.
- Marszelewski Wlodzimierz
- Martens B.
- Martínez-Güingla Rodney
- Massom Robert A.
- Mata Mauricio M.
- Mathis Jeremy T.
- May Linda
- Maycock Tom
- Mayer Michael
- Mazloff Matthew
- McBride Charlotte
- McCabe M.F.
- McCarthy M.
- McClelland J.W.
- McGree Simon
- McVicar Tim R.
- Mears Carl A.
- Meier Walt
- Meinen Christopher S.
- Mekonnen A.
- Mengistu Tsidu G.
- Menzel W. Paul
- Menéndez Melisa
- Merchant Christopher J.
- Meredith Michael P.
- Merrifield Mark A.
- Metzl N.
- Minnis Patrick
- Miralles Diego G.
- Misch Deborah J.
- Mistelbauer T.
- Mitchum Gary T.
- Monselesan Didier
- Monteiro Pedro M S
- Montzka Stephen A.
- Morice Colin
- Mote Thomas
- Mudryk L.
- Mullan A. Brett
- Mühle Jens
- Nash Eric R.
- Naveira-Garabato Alberto C.
- Nerem Steven R.
- Newman Paul A.
- Nieto Juan José
- Noetzli Jeannette
- Osborn Tim J.
- Osborne Susan
- Overland James
- Oyunjargal Lamjav
- O’Neel S.
- Parinussa Robert M.
- Park E. Hyung
- Parker David
- Parrington M.
- Parsons A. Rost
- Pasch Richard J.
- Pascual-Ramírez Reynaldo
- Paterson Andrew M.
- Paulik Christoph
- Pearce Petra R.
- Pelto Mauri S.
- Peng Liang
- Perkins-Kirkpatrick Sarah E.
- Perovich Donald
- Petropavlovskikh Irina
- Pezza Alexandre B.
- Phillips David
- Pinty Bernard
- Pitts Michael C.
- Pons M. R.
- Porter Avalon O.
- Primicerio R.
- Proshutinsky A.
- Quegan Sean
- Quintana Juan
- Rahimzadeh Fatemeh
- Rajeevan Madhavan
- Randriamarolaza L.
- Razuvaev Vyacheslav N.
- Reagan James R.
- Reid Phillip
- Reimer Christoph
- Renwick James A.
- Revadekar Jayashree V.
- Richter-Menge Jacqueline
- Riddle Deborah B.
- Riffler Michael
- Rimmer Alon
- Rintoul Steve
- Robinson David A.
- Rodell Matthew
- Rodríguez Solís José L.
- Romanovsky Vladimir E.
- Ronchail Josyane
- Rosenlof Karen H.
- Roth Chris
- Rusak James A.
- Rémy Samuel
- Sabine Christopher L.
- Sallée Jean Bapiste
- Santee Michelle L.
- Sawaengphokhai P.
- Sayouri Amal
- Scambos Ted A.
- Schemm Jae
- Schladow S. Geoffrey
- Schmid Claudia
- Schmid Martin
- Schmidtko Sunke
- Schreck Carl J.
- Selkirk H. B.
- Send Uwe
- Sensoy Serhat
- Setzer Alberto
- Sharp M.
- Shaw Adrian
- Shi Lei
- Shiklomanov A. I.
- Shiklomanov Nikolai I.
- Siegel David A.
- Signorini Sergio R.
- Sima Fatou
- Simmons Adrian J.
- Smeets C. J.P.P.
- Smith Sharon L.
- Spence Jaqueline M.
- Sprain Mara
- Srivastava A. K.
- Stackhouse Paul W., Jr.
- Stammerjohn Sharon
- Steinbrecht Wolfgang
- Stella José L.
- Stengel Martin
- Stennett-Brown Roxann
- Stephenson Tannecia S.
- Strahan Susan
- Streletskiy D. A.
- Sun-Mack Sunny
- Swart Sebastiaan
- Sweet William
- Sánchez-Lugo Ahira
- Talley Lynne D.
- Tamar Gerard
- Tank S.E.
- Taylor Michael A.
- Tedesco M.
- Teubner Katrin
- Thoman R. L.
- Thompson Philip
- Thomson L.
- Timmermans M. L.
- Tirnanes Joaquin A.
- Tobin Skie
- Trachte Katja
- Trainer Vera L.
- Tretiakov M.
- Trewin Blair C.
- Trotman Adrian R.
- Tschudi M.
- van As D.
- van de Wal R.S.W.
- van der A Ronald J.
- Van Der Schalie Robin
- Van Der Schrier Gerard
- Van Der Werf Guido R.
- Van Meerbeeck Cedric J.
- Veasey Sara W.
- Velicogna I.
- Verburg Piet
- Vigneswaran Bala
- Vincent Lucie A.
- Volkov Denis
- Vose Russell S.
- Wagner Wolfgang
- Wahr John
- Walsh John
- Wang Chunzai
- Wang Junhong
- Wang Lei
- Wang M.
- Wang Sheng-Hung
- Wanninkhof Rik
- Watanabe Shohei
- Weber Mark
- Weller Robert A.
- Weyhenmeyer Gesa A.
- Whitewood Robert
- Wijffels Susan E.
- Wilber Anne C.
- Wild Jeanette D.
- Willett Kate M.
- Williams Michael J.M.
- Willie Shem
- Wolken Gabriel
- Wong Takmeng
- Wood E. F.
- Woolway R. Iestyn
- Wouters B.
- Wåhlin Anna
- Xue Yan
- Yamada Ryuji
- Yim So Young
- Yin Xungang
- Young Steven H.
- Young Teresa
- Yu Lisan
- Zahid H.
- Zambrano Eduardo
- Zhang Peiqun
- Zhao Guanguo
- Zhou Lin
- Ziemke Jerry R.
- Publication venue
- 'American Meteorological Society'
- Publication date
- 01/01/2016
- Field of study
60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells.
- Author
- Aanensen DM
- Abudahab K
- Adams A
- Adams H
- Adeniji K
- Afifi S
- Aggarwal D
- Agranoff D
- Agwuh K
- Ahmad SSY
- Ahmed KA
- Aigrain L
- Ail D
- Alcolea-Medina A
- Aldera EL
- Alegria A
- Alex B
- Alikhan N-F
- Allara E
- Allen S
- Amato R
- Andrikopoulos P
- Angus B
- Angyal A
- Annett T
- Aplin S
- Ariani CV
- Armstrong JA
- Asad H
- Ash A
- Ashfield P
- Ashford F
- Ashish A
- Ashworth M
- Asiimwe IG
- Atkinson D
- Atkinson L
- Attwood SW
- Auckland C
- Aydin A
- Bach B
- Baillie JK
- Baker DJ
- Baker P
- Bakshi S
- Balcazar CE
- Ball J
- Barclay WS
- Bari S
- Barlow G
- Barlow SL
- Barnass S
- Barrett JC
- Barrett N
- Barrow M
- Barton E
- Bashton M
- Bassett AR
- Bassford C
- Basude S
- Batra R
- Baxter C
- Baxter D
- Bayzid N
- Beadsworth M
- Beaver C
- Beckett AH
- Beckwith SM
- Bedford L
- Beer R
- Beggs A
- Bellis KL
- Bernatoniene J
- Berridge J
- Berry C
- Berry L
- Bertolusso B
- Best A
- Best N
- Betteridge E
- Bibby D
- Bicknell K
- Binns D
- Birchley A
- Bird PW
- Bishop C
- Blacow R
- Blakey V
- Blane B
- Bogaert D
- Bolt F
- Bonfield J
- Bonner S
- Bonsall D
- Booth L
- Boswell T
- Bosworth A
- Bothma P
- Bourgeois Y
- Boyd O
- Bradley DT
- Breen C
- Brennan B
- Bresner C
- Breuer J
- Bridgett S
- Brittain-Long R
- Bronner IF
- Brooks E
- Broos A
- Brown JR
- Brown R
- Bucca G
- Buchan SL
- Buck D
- Bull M
- Bullock K
- Bulteel N
- Burden T
- Burns PJ
- Burtenshaw A
- Burton-Fanning S
- Byaruhanga T
- Byott M
- Campbell S
- Carabelli AM
- Cargill JS
- Carlile M
- Carlucci N
- Carracedo AD
- Carson G
- Caruth V
- Carvalho SF
- Casey A
- Cass E
- Castigador A
- Catalan J
- Catterall BWA
- Chadwick D
- Chadwick D
- Chalker V
- Chaloner NJ
- Chambler D
- Chand M
- Chand M
- Chappell JG
- Charalampous T
- Chatterton W
- Chaudhry Y
- Chechi K
- Chee N
- Child J
- Chukkambotla S
- Churcher CM
- Clark G
- Clark JJ
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- Clarke EA
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- Clohisey S
- Cogger BJ
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- Cook KF
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- Coombes J
- Cooper L
- Corden S
- Cormie C
- Correia GDS
- Cortes N
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- Coupland L
- Cox A
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- Cox M
- Craine N
- Crawford L
- Cross A
- Crown MR
- Crudgington D
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- Cupitt J
- Curran MD
- Curran T
- Cutino-Moguel M-T
- da Silva Filipe A
- da Silva Filipe A
- Dabrera G
- Dalton J
- Darby AC
- Dark P
- Davidson RK
- Davies A
- Davies RM
- Davis C
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- Dawson C
- de Angelis D
- De Lacy E
- de Oliveira Martins L
- de Silva TI
- Debebe J
- Denton-Smith R
- Dervisevic S
- Dervisevic S
- Dewar R
- Dey J
- Dias J
- Dincarslan O
- Dobie D
- Docherty AB
- Donegan C
- Dong D
- Dong T
- Donnison P
- Donohue C
- Dorman MJ
- Douthwaite S
- Downing F
- Driscoll M
- Drummond A
- du Plessis L
- Duckworth N
- Dumas M-E
- Dunachie S
- Dunn C
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- Durham J
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- Edgeworth J
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- Ensell L
- Erkiert MJ
- Essex S
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- Everson W
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- Fairley DJ
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- Farr BW
- Fearn C
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- Ferguson L
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- Foster-Nyarko E
- Foulkes BH
- Foulser L
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- Francois S
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- Fryer H
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- Fuller W
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- Galai K
- Gallagher A
- Gallagher E
- Gallagher MD
- Gallis M
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- Gemmell M
- Georgana I
- George RP
- Gifford L
- Gilbert L
- Girgis ST
- Girvan M
- Gkrania-Klotsas E
- Glaysher S
- Godden J
- Goldsmith A
- Goldstein EJ
- Golubchik T
- Gomes AN
- Gonçalves S
- Goodfellow IG
- Goodwin S
- Goudarzi S
- Gourtovaia M
- Graham C
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- Greenaway J
- Greenhalf W
- Gregory R
- Griffin JL
- Griffiths F
- Guest M
- Gunning P
- Gunson RN
- Gupta RK
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- Gutierrez B
- Haldenby ST
- Halpin S
- Hamilton WL
- Hansford SE
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- Heaney J
- Helmer T
- Henderson JH
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- Illingworth CJ
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- Iturriza-Gomara M
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- Kidd SP
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- Klenerman P
- Knight BA
- Knight JC
- Koch O
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- Koukorava C
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- Kwiatkowski D
- Lackenby A
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- Lant S
- Larkin S
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- Mantzouratou A
- Marchbank A
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- Martincorena I
- Martinez Nunez RT
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- McCluggage K
- McClure PC
- McCrone JT
- McCullough K
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- McManus GM
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- Menegazzo M
- Mentzer AJ
- Mentzer AJ
- Merrick I
- Merson L
- Metelmann S
- Meynert AM
- Miah NS
- Michell SL
- Michelsen ML
- Middleton J
- Mills G
- Minton J
- Mirfenderesky M
- Mirfenderesky M
- Mirza J
- Miskelly J
- Mitchell J
- Mohandas K
- Mok Q
- Moles-Garcia E
- Moll RJ
- Molnar Z
- Monahan IM
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- Mookerjee S
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- Morrice K
- Morris C
- Morriss A
- Mortimore K
- Moses S
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- Mower C
- Mpenge M
- Muir P
- Mukaddas A
- Mulla R
- Munemo F
- Munn R
- Murphy EG
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- Murray LJ
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- Openshaw PJM
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- Withell KT
- Witney AA
- Wolverson A
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- Workman T
- Wright DW
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- xeine O'Toole
- Xu-McCrae L
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- Zambon M
- Zamudio ME
- Zarebski AE
- Zhang JE
- Zhang P
- Publication venue
- iScience
- Publication date
- 01/01/2021
- Field of study
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-γ and cytotoxic killing assays. Complete loss of T cell responsiveness was seen due to Q213K in the A∗01:01-restricted CD8+ ORF3a epitope FTSDYYQLY207-215; due to P13L, P13S, and P13T in the B∗27:05-restricted CD8+ nucleocapsid epitope QRNAPRITF9-17; and due to T362I and P365S in the A∗03:01/A∗11:01-restricted CD8+ nucleocapsid epitope KTFPPTEPK361-369. CD8+ T cell lines unable to recognize variant epitopes have diverse T cell receptor repertoires. These data demonstrate the potential for T cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T cell as well as humoral immunity.This work is supported by the UK Medical Research Council (MRC); Chinese Academy of Medical Sciences(CAMS) Innovation Fund for Medical Sciences (CIFMS), China; National Institute for Health Research (NIHR)Oxford Biomedical Research Centre, and UK Researchand Innovation (UKRI)/NIHR through the UK Coro-navirus Immunology Consortium (UK-CIC). Sequencing of SARS-CoV-2 samples and collation of data wasundertaken by the COG-UK CONSORTIUM. COG-UK is supported by funding from the Medical ResearchCouncil (MRC) part of UK Research & Innovation (UKRI),the National Institute of Health Research (NIHR),and Genome Research Limited, operating as the Wellcome Sanger Institute. T.I.d.S. is supported by a Well-come Trust Intermediate Clinical Fellowship (110058/Z/15/Z). L.T. is supported by the Wellcome Trust(grant number 205228/Z/16/Z) and by theUniversity of Liverpool Centre for Excellence in Infectious DiseaseResearch (CEIDR). S.D. is funded by an NIHR GlobalResearch Professorship (NIHR300791). L.T. and S.C.M.are also supported by the U.S. Food and Drug Administration Medical Countermeasures Initiative contract75F40120C00085 and the National Institute for Health Research Health Protection Research Unit (HPRU) inEmerging and Zoonotic Infections (NIHR200907) at University of Liverpool inpartnership with Public HealthEngland (PHE), in collaboration with Liverpool School of Tropical Medicine and the University of Oxford.L.T. is based at the University of Liverpool. M.D.P. is funded by the NIHR Sheffield Biomedical ResearchCentre (BRC – IS-BRC-1215-20017). ISARIC4C is supported by the MRC (grant no MC_PC_19059). J.C.K.is a Wellcome Investigator (WT204969/Z/16/Z) and supported by NIHR Oxford Biomedical Research Centreand CIFMS. The views expressed are those of the authors and not necessarily those of the NIHR or MRC
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway
- Author
- Aanensen David M.
- Abraham Priyanka
- Abudahab Khalil
- Adams Alexander
- Adams Helen
- Adele Sandra
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad S. Y.
- Aigrain Louise
- Alcolea-Medina Adela
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Angyal Adrienn
- Annett Tara
- Ansari M. Azim
- Aplin Stephen
- Ariani Cristina V.
- Asad Hibo
- Asamaphan Patawee
- Ash Amy
- Ashfield Paula
- Ashford Fiona
- Ashraf Shirin
- Atkinson Laura
- Attwood Stephen W.
- Auckland Cressida
- Austin James
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barnes Eleanor
- Barrett Jeffrey C.
- Barrow Magdalena
- Barton Edward
- Bashton Matthew
- Bassett Andrew R.
- Batra Rahul
- Baxter Chris
- Bayzid Nadua
- Beaver Charlotte
- Beckett Angela H.
- Beckwith Shaun M.
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L.
- Berry Louise
- Bertolusso Beatrice
- Best Angus
- Betteridge Emma
- Bibby David
- Bicknell Kelly
- Binns Debbie
- Birchley Alec
- Bird Paul W.
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Bouzidi Kate El
- Boyd Olivia
- Bradley Declan T.
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgett Stephen
- Bronner Iraad F.
- Brooks Ellena
- Broos Alice
- Brown Anthony
- Brown Julianne R.
- Bucca Giselda
- Buchan Sarah L.
- Buck David
- Bull Matthew
- Burns Phillipa J.
- Burton-Fanning Shirelle
- Byaruhanga Timothy
- Byott Matthew
- Campbell Sharon
- Cantoni Diego
- Carabelli Alessandro M.
- Cargill James S.
- Carlile Matthew
- Carvalho Sílvia F.
- Casey Anna
- Castigador Anibolina
- Catalan Jana
- Chalker Vicki
- Chaloner Nicola J.
- Chand Meera
- Chappell Joseph G.
- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Yasmin
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- Cormie Claire
- Cortes Nicholas
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- Cotton Seb
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- Cowton Vanessa
- Cox Alison
- Cox MacGregor
- Craine Noel
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- Cross Aidan
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- Crudgington Dorian
- Cumley Nicola
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- da Silva Filipe Ana
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- de Silva Thushan
- de Silva Thushan I.
- Debebe Johnny
- Deeks Alexandra
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- Dervisevic Samir
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- Dias Joana
- Dobie Donald
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- Nomikou Kyriaki
- O?Brien Sarah
- O?Grady Justin
- O?Toole Áine
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- Payne Brendan A. I.
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- Pinckert Malte L.
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- Podplomyk Olga
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- Prestwood Liam
- Price Anna
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- Prosolek Sophie J.
- Pugh Georgia
- Pusok Monika
- Puxty Kathryn
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- Quail Michael A.
- Quick Joshua
- Radulescu Clara
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajan Diana
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- Ramadan Newara A.
- Rambaut Andrew
- Ramble John
- Randell Paul
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- Ratcliffe Liz
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- Ray Surajit
- Raza Mohammad
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- Rogan Fiona
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- Sambles Christine M.
- Sanderson Roy
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- Sang Fei
- Sass Thea
- Scher Emily
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- Sehmi Jasveen
- Shaaban Sharif
- Shaaban Sharif
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- Shelest Ekaterina
- Shepherd James G.
- Sheridan Liz A.
- Sheriff Nicola
- Shirley Lesley
- Sillitoe John
- Silva Vanessa
- Silviera Siona
- Simpson David A.
- Singh Aditi
- Singleton Dawn
- Skvortsov Timofey
- Sloan Tim J.
- Sluga Graciela
- Smith Colin P.
- Smith Darren L.
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- Smith Kim S.
- Smith Louise
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- Smith Perminder
- Smollett Katherine
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- Somassa Thomas
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- Spellman Karla
- Spencer Chapman Michael H.
- Spurgin Lewis G.
- Spyer Moira J.
- Stanley Rachael
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- Stanton Thomas D.
- Starinskij Igor
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Studholme David J.
- Sudhanva Malur
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- Taha Yusri
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- Thomson Emma C.
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- Tong Lily
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- Torok M. Estee
- Tovar-Corona Jaime M.
- Trebes Amy
- Trotter Alexander J.
- Tsatsani Ioulia
- Turnbull Robyn
- Turtle Lance
- Twohig Katherine A.
- Umpleby Helen
- Underwood Anthony P.
- Vamos Edith E.
- Vasylyeva Tetyana I.
- Vattipally Sreenu
- Vernet Gabrielle
- Vink Elen
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- Volz Erik M.
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- Warne Ben
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- Wastnedge Elizabeth
- Watkins Joanne
- Watson Louisa K.
- Waugh Sheila
- Webster Hermione J.
- Weldon Danni
- Westwick Elaine
- Whalley Thomas
- Wheeler Helen
- Whitehead Mark
- Whiteley Max
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- Wilson-Davies Eleri
- Witele Eric
- Withell Karen T.
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- Workman Trudy
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- Xu-McCrae Li
- Yavus Mehmet
- Yaze Geraldine
- Yeats Corin A.
- Yebra Gonzalo
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- Yew Wen C.
- Young Gregory R.
- Young Jamie
- Zarebski Alex E.
- Zhang Peijun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/08/2022
- Field of study
Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC to be described, harbours multiple amino acid mutations in spike, half of which lie within the receptor-binding domain. Here we demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 and mRNA-1273. These data were mirrored by a substantial reduction in real-world vaccine effectiveness that was partially restored by booster vaccination. The Omicron variants BA.1 and BA.2 did not induce cell syncytia in vitro and favoured a TMPRSS2-independent endosomal entry pathway, these phenotypes mapping to distinct regions of the spike protein. Impaired cell fusion was determined by the receptor-binding domain, while endosomal entry mapped to the S2 domain. Such marked changes in antigenicity and replicative biology may underlie the rapid global spread and altered pathogenicity of the Omicron variant
Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes
- Author
- Aanensen David M.
- Abudahab Khalil
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY.
- Aigrain Louise
- Alcolea-Medina Adela
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Angyal Adrienn
- Annett Tara
- Aplin Stephen
- Ariani Cristina V.
- Asad Hibo
- Ash Amy
- Ashfield Paula
- Ashford Fiona
- Atkinson Laura
- Attwood Stephen W.
- Auckland Cressida
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barrett Jeffrey C.
- Barrow Magdalena
- Barton Edward
- Bashton Matthew
- Bassett Andrew R.
- Batra Rahul
- Baxter Chris
- Bayzid Nadua
- Beaver Charlotte
- Beckett Angela H.
- Beckwith Shaun M.
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L.
- Berry Louise
- Bertolusso Beatrice
- Best Angus
- Betteridge Emma
- Bibby David
- Bicknell Kelly
- Binns Debbie
- Birchley Alec
- Bird Paul W.
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Bradley Declan T.
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgett Stephen
- Bronner Iraad F.
- Brooks Ellena
- Broos Alice
- Brown Julianne R.
- Bucca Giselda
- Buchan Sarah L.
- Buck David
- Bull Matthew
- Burns Phillipa J.
- Burton-Fanning Shirelle
- Byaruhanga Timothy
- Byott Matthew
- Campbell Sharon
- Carabelli Alessandro M.
- Cargill James S.
- Carlile Matthew
- Carvalho Sílvia F.
- Casey Anna
- Castigador Anibolina
- Catalan Jana
- Chalker Vicki
- Chaloner Nicola J.
- Chand Meera
- Chappell Joseph G.
- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Yasmin
- Churcher Carol M.
- Clark Gemma
- Clarke Phillip
- Cogger Benjamin J.
- Cole Kevin
- Collins Jennifer
- Colquhoun Rachel
- Connor Thomas R.
- Cook Kate F.
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cotic Marius
- Cotton S.
- Cotton Seb
- Cottrell Simon
- Coupland Lindsay
- Cox Alison
- Cox MacGregor
- Craine Noel
- Crawford Liam
- Cross Aidan
- Crown Matthew R.
- Crudgington Dorian
- Cumley Nicola
- Curran Martin D.
- Curran Tanya
- Cutino-Moguel Teresa
- da Silva Filipe Ana
- Dabrer Gavin
- Darby Alistair C.
- Davidson Rose K.
- Davies Alisha
- Davies Robert M.
- Davis Thomas
- de Angelis Daniela
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I.
- Debebe Johnny
- Delgado Callico Laia
- Denton-Smith Rebecca
- Dervisevic Samir
- Dewar R.
- Dewar Rebecca
- Dey Jayasree
- Dias Joana
- Dobie Donald
- Dorman Matthew J.
- Downing Fatima
- Driscoll Megan
- du Plessis Louis
- Duckworth Nichola
- Durham Jillian
- Eastick Kirstine
- Easton Lisa J.
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- El Bouzidi Kate
- Eldirdiri Sahar
- Ellaby Nicholas
- Elliott Scott
- Eltringham Gary
- Ensell Leah
- Erkiert Michelle J.
- Essex Sarah
- Evans Cariad
- Evans Johnathan M.
- Everson William
- Fairley Derek J.
- Fallon Karlie
- Fanaie Arezou
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- Fearn Christopher
- Feltwell Theresa
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- Fleming Vicki M.
- Forrest Sally
- Foster-Nyarko Ebenezer
- Foulkes Benjamin H.
- Foulser Luke
- Fragakis Mireille
- Frampton Dan
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M.
- Fryer Helen
- Fuchs Marc
- Fuller William
- Gajee Kavitha
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- Gallagher Abbie
- Gallagher Eileen
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- Irish-Tavares Dianne
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- Mantzouratou Anna
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- McMurray Claire
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- Moore Catherine
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- Morcrette Helen
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- Somassa Thomas
- Southgate Joel
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- Spencer Chapman Michael H.
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- Spyer Moira J.
- Stanley Rachael
- Stanley William
- Stanton Thomas D.
- Starinskij Igor
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Studholme David J.
- Sudhanva Malur
- Swindells Emma
- Taha Yusri
- Tan Ngee Keong
- Tang Julian W.
- Tang Miao
- Taylor Ben EW.
- Taylor Joshua F.
- Taylor Sarah
- Temperton Ben
- Templeton K.
- Templeton Kate E.
- Thomas Claire
- Thomas-McEwen Peter MD.
- Thomson Emma C.
- Thomson Laura
- Thornton Alicia
- Thurston Scott AJ.
- Todd John A.
- Tomb Rachael
- Tong Lily
- Tonkin-Hill Gerry
- Tovar-Corona Jaime M.
- Trebes Amy
- Trotter Alexander J.
- Tsatsani Ioulia
- Turnbull Robyn
- Twohig Katherine A.
- Umpleby Helen
- Underwood Anthony P.
- Vamos Edith E.
- Vasylyeva Tetyana I.
- Vattipally Sreenu
- Vernet Gabrielle
- Vipond Barry B.
- Volz Erik M.
- Walsh Sarah
- Wang Dennis
- Warne Ben
- Warwick-Dugdale Joanna
- Wastnedge Elizabeth
- Watkins Joanne
- Watson DipHE Louisa K.
- Waugh Sheila
- Webster Hermione J.
- Weldon Danni
- Westwick Elaine
- Whalley Thomas
- Wheeler Helen
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
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- Williams Catryn
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- Williams Cheryl
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- Williams Rebecca
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- Witele Eric
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- Wolverson Paige
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- Workma Trudy
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- Wright Victoria
- Wyatt Tim
- Wyllie Sarah
- Xu-McCrae Li
- Yavus Mehmet
- Yaze Geraldine
- Yeats Corin A.
- Yebra Gonzalo
- Yew Wen C.
- Young Gregory R.
- Young Jamie
- Zarebski Alex E.
- Zhang Peijun
- Publication venue
- 'Elsevier BV'
- Publication date
- 09/03/2023
- Field of study
Background
The first epidemic wave of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Scotland resulted in high case numbers and mortality in care homes. In Lothian, over one-third of care homes reported an outbreak, while there was limited testing of hospital patients discharged to care homes.
Aim
To investigate patients discharged from hospitals as a source of SARS-CoV-2 introduction into care homes during the first epidemic wave.
Methods
A clinical review was performed for all patients discharges from hospitals to care homes from 1st March 2020 to 31st May 2020. Episodes were ruled out based on coronavirus disease 2019 (COVID-19) test history, clinical assessment at discharge, whole-genome sequencing (WGS) data and an infectious period of 14 days. Clinical samples were processed for WGS, and consensus genomes generated were used for analysis using Cluster Investigation and Virus Epidemiological Tool software. Patient timelines were obtained using electronic hospital records.
Findings
In total, 787 patients discharged from hospitals to care homes were identified. Of these, 776 (99%) were ruled out for subsequent introduction of SARS-CoV-2 into care homes. However, for 10 episodes, the results were inconclusive as there was low genomic diversity in consensus genomes or no sequencing data were available. Only one discharge episode had a genomic, time and location link to positive cases during hospital admission, leading to 10 positive cases in their care home.
Conclusion
The majority of patients discharged from hospitals were ruled out for introduction of SARS-CoV-2 into care homes, highlighting the importance of screening all new admissions when faced with a novel emerging virus and no available vaccine
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alonso Veronica
- Alqallaf Abdullah
- Alqaseer Asma
- Alrayes Bourhan
- Alsefri Maryam
- Alser Osaid
- Alsharif Mohammed
- Alsori Mohamed
- Altaf Abdulmalik
- Altinel Yuksel
- Altiner Saygin
- Altouny Ahmad
- Altun Demet
- Alvarez Natalia
- Alvarez-Lozada Luis Adrian
- Alvi Abdul
- Alwael Athari
- Alwash Mohammed
- Alyami Ziyad
- Alyousef Mohammed
- Alzahrani Saud
- Alzerwi Nasser
- Amin Shivang
- Amir Mohammed
- Ammar Ahmed Siddique
- Ammendola Michele
- Amores Remedios Revilla
- Amrayev Sultan
- Anastasiadou Sofia
- Ancans Guntis
- Anderson Caroline
- Andreani Lorenzo
- Andreotti Dario
- Andreuccetti Jacopo
- Andrianakis Alexandros
- Andro Christophe
- Anesi Alexandre
- Angamuthu Stephen
- Angeles Martina Aida
- Angelico Roberta
- Angelis Fragkiskos
- Angelou Dimitrios
- Angelou Kyveli
- Angulo Victor Pinto
- Anjum Arfa
- Anjum Muhammad Ayyub
- Annicchiarico Alfredo
- Anoldo Pietro
- Ansaloni Luca
- Anthoulakis Christos
- Antonelli Amedeo
- Anwar Mohamed
- Anwar Sumadi Lukman
- Anwer Mariyah
- Anyanwu Lofty-John
- Apostolou Christos
- Apostolou Konstantinos
- Appiah-Kubi Adu
- Aprea Giovanni
- Arbab Hana
- Archer James
- Ardura Francisco
- Aremu Muyiwa
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- Arkani Samara
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- Arrangoiz Rodrigo
- Arshad Muhammad
- Arthur Joshua
- Ashcroft James
- Ashford Bruce
- Ashraf Fariha
- Asiimwe Daniel
- Asirifi Samuel Amoako
- Asla Amir
- Aslam Ramisha
- Aspide Raffaele
- Ataya Karim
- Ateca Ibabe Villalabeitia
- Atici Semra Demirli
- Atis Gokhan
- Atkins William
- Atkinson Kate
- Attwood Joseph
- Auerkari Aino
- Augestad Knut Magne
- Augustin Goran
- Aujayeb Avinash
- Avella Pasquale
- Awad Ahmed K.
- Awad Hadeel
- Awad Rabih
- Awad Selmy
- Ayad Kusay
- Ayana Birhanu
- Aydin Yener
- Ayeni Funbi
- Aytac Erman
- Azab Ahmed
- Azami Rizwan
- Azize Diallo Abdoul
- Azzam Ahmed Y.
- Azzis Olivier
- Baba Yabasin Iddrisu
- Babis George
- Bacalbasa Nicolae
- Badiani Sarit
- Badran Saif
- Baduell Albert
- Baeesa Saleh
- Baertschiger Reto
- Bafaquh Mohammed
- Bahassan Omar Mohammed
- Bahrami-Hessari Michael
- Baia Marco
- Baidoo Ebikela Ivie
- Bailey Karen
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Baiocchi Glauco
- Baiyewu Lateef Ayodele
- Bajaj Ankur
- Bajunaid Khalid
- Balagobi Balasingam
- Balasubramanian Ishwarya
- Balduzzi Alberto
- Baldwin Alexander
- Balla Andrea
- Balogh Zsolt J.
- Balogun James A.
- Balogun Simon
- Baloyiannis Ioannis
- Ban Vin Shen
- Bandyopadhyay Samik Kumar
- Bandyopadhyay Soham
- Banerjee Sumit
- Banipal Gurpreet Singh
- Banky Balazs
- Bannone Elisa
- Bansal Sujesh
- Barberis Andrea
- Barbosa-Breda Joao
- Bareka Metaxia
- Barišić Tatjana
- Barlas Aziz Mutlu
- Barlow Ciaran
- Barmayehvar Behrad
- Baroffio Paolo
- Barone Mirko
- Barra Fabio
- Barranquero Alberto G.
- Barugola Giuliano
- Basendowah Mohammed
- Bashir Mahmod
- Basnayake Oshan
- Bass Gary Alan
- Basu Somprakas
- Bateman Antony
- Bateman Kellie
- Batista Sylvia
- Batstone Martin
- Bauer Marlies
- Bauset Juan Carlos Catalá
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- Uldry Emilie
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- Ulkucu Attila
- Ulman Elif Akbas
- Ulman Hilmican
- Ulutaş Mehmet Eşref
- Underwood Kirk
- Unsworth Richard
- Uprak Tevfik Kivilcim
- Urriza Pablo Vallés
- Usman Muhammad
- Usman Mustapha Ibrahim
- Vaassen Lauretta
- Vaccara Vincenzo La
- Vagena Xanthoula
- Vagge Aldo
- Vailas Michail
- Valadez Andrea Estefania Cueto
- Valadez Tania Abigail Cueto
- Valanci Sofia
- Valdespino Cristina Puentes
- Valeanu Liana
- Valioulis Ioannis
- Valladares Sergio Chávez
- Vallve-Bernal Marc
- Van Acker Jill
- Van Den Eynde Jef
- Van Goor Harry
- Van Vliet Helen
- Van Wyk Naomi Natasha
- Vanni Camilla
- Vas Aurelia
- Vasarhelyi Edward
- Vaschetti Roberto
- Vassiliu Panteleimon
- Vatansever Dogan
- Vatish Jamie
- Vaughan-Shaw Peter G.
- Vaysburg Dennis
- Veglia Antonella
- Velten Markus
- Velázquez Maria Jose Martinez
- Venkatappa Sunil Kumar
- Venketeswaran Meenakshi
- Venskutonis Donatas
- Verbic Milena Senica
- Verdi Daunia
- Vergara-Fernandez Omar
- Verhoeff Kevin
- Veroux Massimiliano
- Verras Georgios-Ioannis
- Verre Luigi
- Vida Lucian
- Vidya Raghavan
- Viglietta Edoardo
- Vijay Vardhini
- Vijgen Guy
- Vilaró Blanca Capdevila
- Villanueva Julio
- Vilz Tim O.
- Vincent Elizabeth
- Vinci Danilo
- Viola Simona
- Violante Tommaso
- Vishnoi Jeewan Ram
- Vissapragada Ravi
- Vivancos Laura Guillamon
- Vives Josep Maria Muñoz
- Vizzielli Giuseppe
- Vohra Lubna
- Vokshi Ismail
- Vosinakis Christos
- Vásquez Javier Alberto Gutiérrez
- Vázquez Gil
- Vázquez Irene Ortega
- Vǎcǎraşu Andrei Bogdan
- Wade Ryckie
- Wafi Omar
- Wagner Gabriela
- Wallis Christopher
- Wanjara Samuel
- Waqar Shahzad Hussain
- Warden Claire
- Warner Christian
- Wasim D.
- Wason Shaun
- Wasserman Isaac
- Watcyn-Jones Tom
- Waterson Ben
- Watson David
- Watson Matthew
- Weber Clemens
- Wheatstone P.
- Wheeler James
- Wheldon Luke
- White Michelle
- White Stuart
- White William
- Wickramasinghe Dakshitha
- Widmer Lukas Werner
- Wiedemann Dominik
- Wiesinger Clemens Georg
- Wijekoon Naveen
- Wijenayake Wasantha
- Wijeyaratne Manuk
- Wijeysundera Duminda
- Wiles Matthew
- Wilkin Richard
- Wilkins Alex
- Wilkins James
- William Tinka George
- Williams Omolara Modupe
- Williams Shekinah
- Windsor John
- Winnand Philipp
- Wittmann Maria
- Wolde Amanuel
- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
- Wurm Markus
- Xenaki Sofia
- Yadev Ip
- Yahaya Ahmad Shuib
- Yakubu Mustapha
- Yang Wah
- Yanik Özge
- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
A Novel Peptide-MHC Targeted Chimeric Antigen Receptor T Cell Forms a T Cell-like Immune Synapse
- Author
- Publication venue
- 'MDPI AG'
- Publication date
- 01/12/2021
- Field of study
Chimeric Antigen Receptor (CAR) T cell therapy is a promising form of adoptive cell therapy that re-engineers patient-derived T cells to express a hybrid receptor specific to a tumour-specific antigen of choice. Many well-characterised tumour antigens are intracellular and therefore not accessible to antibodies at the cell surface. Therefore, the ability to target peptide-MHC tumour targets with antibodies is key for wider applicability of CAR T cell therapy in cancer. One way to evaluate the effectiveness and efficiency of ligating tumour target cells is studying the immune synapse. Here we generated a second-generation CAR to targeting the HLA-A*02:01 restricted H3.3K27M epitope, identified as a possible therapeutic target in ~75% of diffuse midline gliomas, used as a model antigen to study the immune synapse. The pMHCI-specific CAR demonstrated specificity, potent activation, cytokine secretion and cytotoxic function. Furthermore, we characterised killing kinetics using live cell imaging as well as CAR synapse confocal imaging. Here we provide evidence of robust CAR targeting of a model peptide-MHC antigen and that, in contrast to protein-specific CARs, these CARs form a TCR-like immune synapse which facilitates TCR-like killing kinetics
Prospective associations between marital adjustment and life satisfaction
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Carbon dioxide concentrations in the environment of sleeping infants
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
MYB is essential for mammary tumorigenesis
- Author
- Publication venue
- 'American Association for Cancer Research (AACR)'
- Publication date
- 15/11/2011
- Field of study
MYB oncogene upregulation is associated with estrogen receptor (ER)-positive breast cancer, but disease requirements for MYB function in vivo have not been explored. In this study, we provide evidence of a critical requirement for MYB functions in models of human and murine breast cancer. In human breast cancer, we found that MYB expression was critical for tumor cell growth both in vitro and in vivo in xenograft settings. In transgenic knockout mice, tissue-specific deletion of the murine MYB gene caused a transient defect in mammary gland development that was reflected in delayed ductal branching and defective apical bud formation. In mouse mammary tumor virus (MMTV)-NEU mice where tumors are initiated by activation of HER2, MYB deletion was sufficient to abolish tumor formation. In the more aggressive MMTV-PyMT model system, MYB deletion delayed tumorigenesis significantly. Together, the findings in these transgenic knockout models implied that MYB was critical during an early window in mammary development when it was essential for tumor initiation, even though MYB loss did not exert a lasting impact upon normal mammary function. Two important MYB-target genes that promote cell survival, BCL2 and GRP78/BIP, were each elevated compared with nontransformed mammary epithelial cells, thereby promoting survival as confirmed in colony formation assays in vitro. Taken together, our findings establish a role for MYB at the hub of ER-and HER2-dependent pathways in mammary carcinogenesis
Ethical tensions: A qualitative systematic review of new graduate perceptions
- Author
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study