Vocal Techniques for the Instrumentalist

Vocal Techniques, the course title used at many institutions, is essentially a voice class for instrumentalists, and is a required course for instrumental music education majors seeking all-level certification. Students take at least one Vocal Techniques course to learn proper singing technique along with basic pedagogy and can include teaching techniques as they apply to adolescent singers. The focus of the course is the development of the individual singing voice. This includes breathing, tone production, articulation, musicality and textual expression and understanding. Students also develop confidence in front of groups, improve their general vocal quality, and learn that a healthy voice serves them well in the general and performance classroom. The purpose of this text is to teach instrumental music education students about vocal production as it applies to solo singing. Beginning with a foundational understanding of breathing, singers will learn about the vocal instrument (anatomy), how to create clear, pleasant, tone (phonation and resonance), pronounce words clearly (articulation and diction) and how singing is similar, and different, from playing an external instrument. This is the first textbook to explore teaching voice as it directly pertains to playing an instrument.https://newprairiepress.org/ebooks/1025/thumbnail.jp

Vocal Techniques for the Instrumentalist 2nd Edition

Vocal Techniques, the course title used at many institutions, is essentially a voice class for instrumentalists, and is often a required course for instrumental music education majors seeking all-level certification. Students take at least one Vocal Techniques course to learn proper singing technique along with basic pedagogy. Some courses include teaching techniques as they apply to adolescent singers. The focus of the course is the development of the individual singing voice. This includes breathing, tone production, articulation, musicality and textual expression and understanding. Students also develop confidence in front of groups, improve their general vocal quality, and learn that a healthy voice serves them well in general and performance classrooms. The purpose of this text is to teach instrumental music education students about vocal production as it applies to solo singing. Beginning with a foundational understanding of breathing, singers will learn about the vocal instrument (anatomy), how to create clear, pleasant, tone (phonation and resonance), pronounce words clearly (articulation and diction) and the similarities and differences of singing technique when compared to that of their major instrument. This is the first textbook to explore teaching voice as it directly pertains to playing an instrumenthttps://newprairiepress.org/ebooks/1044/thumbnail.jp

Identification of a BRCA2-Specific modifier locus at 6p24 related to breast cancer risk

Common genetic variants contribute to the observed variation in breast cancer risk for BRCA2 mutation carriers; those known to date have all been found through population-based genome-wide association studies (GWAS). To comprehensively identify breast cancer risk modifying loci for BRCA2 mutation carriers, we conducted a deep replication of an ongoing GWAS discovery study. Using the ranked P-values of the breast cancer associations with the imputed genotype of 1.4 M SNPs, 19,029 SNPs were selected and designed for inclusion on a custom Illumina array that included a total of 211,155 SNPs as part of a multi-consortial project. DNA samples from 3,881 breast cancer affected and 4,330 unaffected BRCA2 mutation carriers from 47 studies belonging to the Consortium of Investigators of Modifiers of BRCA1/2 were genotyped and available for analysis. We replicated previously reported breast cancer susceptibility alleles in these BRCA2 mutation carriers and for several regions (including FGFR2, MAP3K1, CDKN2A/B, and PTHLH) identified SNPs that have stronger evidence of association than those previously published. We also identified a novel susceptibility allele at 6p24 that was inversely associated with risk in BRCA2 mutation carriers (rs9348512; per allele HR = 0.85, 95% CI 0.80-0.90, P = 3.9×10−8). This SNP was not associated with breast cancer risk either in the general population or in BRCA1 mutation carriers. The locus lies within a region containing TFAP2A, which encodes a transcriptional activation protein that interacts with several tumor suppressor genes. This report identifies the first breast cancer risk locus specific to a BRCA2 mutation background. This comprehensive update of novel and previously reported breast cancer susceptibility loci contributes to the establishment of a panel of SNPs that modify breast cancer risk in BRCA2 mutation carriers. This panel may have clinical utility for women with BRCA2 mutations weighing options for medical prevention of breast cancer

An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers

Introduction: Individuals carrying pathogenic mutations in the BRCA1 and BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. Mitochondrial genome variations affect electron transport chain efficiency and reactive oxygen species production. Individuals with different mitochondrial haplogroups differ in their metabolism and sensitivity to oxidative stress. Variability in mitochondrial genetic background can alter reactive oxygen species production, leading to cancer risk. In the present study, we tested the hypothesis that mitochondrial haplogroups modify breast cancer risk in BRCA1/2 mutation carriers. Methods: We genotyped 22,214 (11,421 affected, 10,793 unaffected) mutation carriers belonging to the Consortium of Investigators of Modifiers of BRCA1/2 for 129 mitochondrial polymorphisms using the iCOGS array. Haplogroup inference and association detection were performed using a phylogenetic approach. ALTree was applied to explore the reference mitochondrial evolutionary tree and detect subclades enriched in affected or unaffected individuals. Results: We discovered that subclade T1a1 was depleted in affected BRCA2 mutation carriers compared with the rest of clade T (hazard ratio (HR) = 0.55; 95% confidence interval (CI), 0.34 to 0.88; P = 0.01). Compared with the most frequent haplogroup in the general population (that is, H and T clades), the T1a1 haplogroup has a HR of 0.62 (95% CI, 0.40 to 0.95; P = 0.03). We also identified three potential susceptibility loci, including G13708A/rs28359178, which has demonstrated an inverse association with familial breast cancer risk. Conclusions: This study illustrates how original approaches such as the phylogeny-based method we used can empower classical molecular epidemiological studies aimed at identifying association or risk modification effects.Peer reviewe

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat

Janie Brokenicky, Soprano, Faculty Artist Recital

Thursday, February 8th, 2018 - 7:30pm All Faiths Chapel G.F. Handel - Selections from Samson, HWV 57 Let the bright Seraphim My faith and truth Bela Bartok - Eight Hungarian Folksongs 1. Fekete fod, feher as en zsebkendom 2. Istenem, istenem, araszd meg a vizet 3. Asszonyok, had' legyek tarsatok 4. Annyi banat a szuvemen 5. Ha kimegyek arr' a magos tetore 6. Toltik a nagy erdo utjat 7. Eddig valo dolgom a tavaszi szantas 8. Olvad a ho, csardas kisangyalom tavasz akar lenni Igor Stravinksy - The Rake's Progress Act 1, Scene 3 No word from Tom Cabaletta Alex Wakim - The Night is Hushed Paola Prestini - Body Map

Amy Rosine, Soprano, Faculty Artist Recital

October 18, 2018 7:30 pm All Faiths Chapel W.A. Mozart - Laudmus te (Mass in C minor KV 427) Felix Mendelssohn - Ave Maris stella Frank Ticheli - Songs of Tagore - Movement 1 - Nightfall Frank Ticheli - Songs of Tagore - Movement 2 - Light Frank Ticheli - Songs of Tagore - Movement 3 - Departure Samuel Barber - Knoxville: Summer of 1915 Johnathan Dove - Adelaide's Aria (It's my Wedding

Common variants of the <i>BRCA1</i> wild-type allele modify the risk of breast cancer in <i>BRCA1</i> mutation carriers

Mutations in the &lt;i&gt;BRCA1&lt;/i&gt; gene substantially increase a woman's lifetime risk of breast cancer. However, there is great variation in this increase in risk with several genetic and non-genetic modifiers identified. The &lt;i&gt;BRCA1&lt;/i&gt; protein plays a central role in DNA repair, a mechanism that is particularly instrumental in safeguarding cells against tumorigenesis. We hypothesized that polymorphisms that alter the expression and/or function of &lt;i&gt;BRCA1&lt;/i&gt; carried on the wild-type (non-mutated) copy of the &lt;i&gt;BRCA1&lt;/i&gt; gene would modify the risk of breast cancer in carriers of &lt;i&gt;BRCA1&lt;/i&gt; mutations. A total of 9874 &lt;i&gt;BRCA1&lt;/i&gt; mutation carriers were available in the Consortium of Investigators of Modifiers of &lt;i&gt;BRCA1/2&lt;/i&gt; (CIMBA) for haplotype analyses of &lt;i&gt;BRCA1&lt;/i&gt;. Women carrying the rare allele of single nucleotide polymorphism rs16942 on the wild-type copy of &lt;i&gt;BRCA1&lt;/i&gt; were at decreased risk of breast cancer (hazard ratio 0.86, 95% confidence interval 0.77–0.95, &lt;i&gt;P&lt;/i&gt; = 0.003). Promoter &lt;i&gt;in vitro&lt;/i&gt; assays of the major &lt;i&gt;BRCA1&lt;/i&gt; haplotypes showed that common polymorphisms in the regulatory region alter its activity and that this effect may be attributed to the differential binding affinity of nuclear proteins. In conclusion, variants on the wild-type copy of &lt;i&gt;BRCA1&lt;/i&gt; modify risk of breast cancer among carriers of &lt;i&gt;BRCA1&lt;/i&gt; mutations, possibly by altering the efficiency of &lt;i&gt;BRCA1&lt;/i&gt; transcription