Social pairing of Seychelles warblers under reduced constraints: MHC, neutral heterozygosity, and age

The prevalence and significance of precopulatory mate choice remains keenly debated. The major histocompatibility complex (MHC) plays a key role in vertebrate adaptive immunity, and variation at the MHC influences individual survival. Although MHC-dependent mate choice has been documented in certain species, many other studies find no such pattern. This may be, at least in part, because in natural systems constraints may reduce the choices available to individuals and prevent full expression of underlying preferences. We used translocations to previously unoccupied islands to experimentally reduce constraints on female social mate choice in the Seychelles warbler ( Acrocephalus sechellensis ), a species in which patterns of MHC-dependent extrapair paternity (EPP), but not social mate choice, have been observed. We find no evidence of MHC-dependent social mate choice in the new populations. Instead, we find that older males and males with more microsatellite heterozygosity are more likely to have successfully paired. Our data cannot resolve whether these patterns in pairing were due to male–male competition or female choice. However, our research does suggest that female Seychelles warblers do not choose social mates using MHC class I to increase fitness. It may also indicate that the MHC-dependent EPP observed in the source population is probably due to mechanisms other than female precopulatory mate choice based on MHC cues

Debris disks as signposts of terrestrial planet formation. II Dependence of exoplanet architectures on giant planet and disk properties

We present models for the formation of terrestrial planets, and the collisional evolution of debris disks, in planetary systems that contain multiple unstable gas giants. We previously showed that the dynamics of the giant planets introduces a correlation between the presence of terrestrial planets and debris disks. Here we present new simulations that show that this connection is qualitatively robust to changes in: the mass distribution of the giant planets, the width and mass distribution of the outer planetesimal disk, and the presence of gas in the disk. We discuss how variations in these parameters affect the evolution. Systems with equal-mass giant planets undergo the most violent instabilities, and these destroy both terrestrial planets and the outer planetesimal disks that produce debris disks. In contrast, systems with low-mass giant planets efficiently produce both terrestrial planets and debris disks. A large fraction of systems with low-mass outermost giant planets have stable gaps between these planets that are frequently populated by planetesimals. Planetesimal belts between outer giant planets may affect debris disk SEDs. If Earth-mass seeds are present in outer planetesimal disks, the disks radially spread to colder temperatures. We argue that this may explain the very low frequency of > 1 Gyr-old solar-type stars with observed 24 micron excesses. Among the (limited) set of configurations explored, the best candidates for hosting terrestrial planets at ~1 AU are stars older than 0.1-1 Gyr with bright debris disks at 70 micron but with no currently-known giant planets. These systems combine evidence for rocky building blocks, with giant planet properties least likely to undergo destructive dynamical evolution. We predict an anti-correlation between debris disks and eccentric giant planets, and a positive correlation between debris disks and terrestrial planets.Comment: Astronomy and Astrophysics, in press. Movies from simulations are at http://www.obs.u-bordeaux1.fr/e3arths/raymond/movies_debris.htm

Effectiveness of enhanced diabetes care to patients of South Asian ethnicity : the United Kingdom Asian Diabetes Study (UKADS) : a cluster randomised controlled trial

Background: Delivering high quality and evidence based healthcare to deprived sectors of the community is a major goal for society. We investigated the effectiveness of a culturally sensitive enhanced care package in UK general practice in improving cardiovascular risk factors in South Asian patients with type 2 diabetes. Methods: 21 inner city practices were randomised to intervention (enhanced practice nurse time, link worker and diabetes specialist nurse support) (n=868) or control (standard care) (n=618) groups. Prescribing algorithms with clearly defined targets were provided for all practices. Main outcome measures comprised changes in blood pressure, total cholesterol and glycaemic control (HbA1c) after 2 years. Findings: At baseline, groups were similar with respect to age, sex and cardiovascular risk factors. Comparing treatment groups, after adjustment for confounders, and clustering, differences in diastolic blood pressure (1.91mmHg, P=0.0001) and mean arterial pressure (1.36mmHg, P=0.0180) were significant. There were no significant differences between groups for total cholesterol or HbA1c. Economic analysis indicates the nurse-led intervention was not cost-effective. Across the whole study population systolic blood pressure, diastolic blood pressure and cholesterol decreased significantly by 4.9mmHg, 3.8mmHg and 0.45mmol/L respectively, but there was no change in HbA1c. Interpretation: Additional, although limited, benefits were observed from our culturally enhanced care package over and above the secular changes achieved in the UK in recent years. Stricter targets in general practice and further measures to motivate patients are needed to maximise healthcare outcomes in South Asian patients with diabetes

A detailed analysis of the HD 73526 2:1 resonant planetary system

We present six years of new radial velocity data from the Anglo-Australian and Magellan Telescopes on the HD 73526 2:1 resonant planetary system. We investigate both Keplerian and dynamical ( interacting) fits to these data, yielding four possible configurations for the system. The new data now show that both resonance angles are librating, with amplitudes of 40 degrees and 60 degrees, respectively. We then perform long-term dynamical stability tests to differentiate these solutions, which only differ significantly in the masses of the planets. We show that while there is no clearly preferred system inclination, the dynamical fit with i = 90 degrees provides the best combination of goodness-of-fit and long-term dynamical stability.Peer reviewe

Molecular techniques reveal cryptic life history and demographic processes of a critically endangered marine turtle

The concept of ‘effective population size’ (Ne), which quantifies how quickly a population will lose genetic variability, is one of the most important contributions of theoretical evolutionary biology to practical conservation management. Ne is often much lower than actual population size: how much so depends on key life history and demographic parameters, such as mating systems and population connectivity, that often remain unknown for species of conservation concern. Molecular techniques allow the indirect study of these parameters, as well as the estimation of current and historical Ne. Here, we use genotyping to assess the genetic health of an important population of the critically endangered hawksbill turtle (Eretmochelys imbricata), a slow-to-mature, difficult-to-observe species with a long history of severe overhunting. Our results were surprisingly positive: we found that the study population, located in the Republic of Seychelles, Indian Ocean, has a relatively large Ne, estimated to exceed 1000, and showed no evidence of a recent reduction in Ne (i.e. no genetic bottleneck). Furthermore, molecular inferences suggest the species' mating system is conducive to maintaining a large Ne, with a relatively large and widely distributed male population promoting considerable gene flow amongst nesting sites across the Seychelles area. This may also be reinforced by the movement of females between nesting sites. Our study underlines how molecular techniques can help to inform conservation biology. In this case our results suggest that this important hawksbill population is starting from a relatively strong position as it faces new challenges, such as global climate change

Optical Alignment of the JWST ISIM to the OTE Simulator (OSIM): Current Concept and Design Studies

The James Webb Space Telescope's (JWST) Integrated Science Instrument Module (ISIM) contains the observatory's four science instruments and their support subsystems. During alignment and test of the integrated ISIM at NASA's Goddard Space Flight Center (GSFC), the Optical'telescope element SIMulator (OSIM) will be used to optically stimulate the science instruments to verify their operation and performance. In this paper we present the design of two cryogenic alignment fixtures that will be used to determine and verify the proper alignment of OSIM to ISIM during testing at GSFC. These fixtures, the Master Alignment Target Fixture (MAW) and the ISIM Alignment Target Fixture (IATF), will provide continuous, six degree of freedom feedback to OSIM during initial ambient alignment as well as during cryogenic vacuum testing. These fixtures will allow us to position the OSIM and maintain OSIM-ISIM alignment to better than 10 microns in translation and 250 micro-radians in rotation. We will provide a brief overview of the OSIM system and calibration and we will also discuss the relevance of these fixtures in the context of the overall ISIM alignment and verification plan

From Select Agent to an Established Pathogen: The Response to \u3ci\u3ePhakopsora pachyrhizi\u3c/i\u3e (Soybean Rust) in North America

The pathogen causing soybean rust, Phakopsora pachyrhizi, was first described in Japan in 1902. The disease was important in the Eastern Hemisphere for many decades before the fungus was reported in Hawaii in 1994, which was followed by reports from countries in Africa and South America. In 2004, P. pachyrhizi was confirmed in Louisiana, making it the first report in the continental United States. Based on yield losses from countries in Asia, Africa, and South America, it was clear that this pathogen could have a major economic impact on the yield of 30 million ha of soybean in the United States. The response by agencies within the United States Department of Agriculture, industry, soybean check-off boards, and universities was immediate and complex. The impacts of some of these activities are detailed in this review. The net result has been that the once dreaded disease, which caused substantial losses in other parts of the world, is now better understood and effectively managed in the United States. The disease continues to be monitored yearly for changes in spatial and temporal distribution so that soybean growers can continue to benefit by knowing where soybean rust is occurring during the growing season

X-ray spectral study of the hot gas in three Clusters of Galaxies

We study the physical properties of three clusters of galaxies, selected from a BeppoSAX Wide Field Camera (WFC) survey. These sources are identified as 1RXS J153934.7-833535, 1RXS J160147.6-754507, and 1RXS J081232.3-571423 in the ROSAT All-Sky Survey catalogue. We obtained XMM-Newton follow-up observations for these three clusters. We fit single and multi-temperature models to spectra obtained from the EPIC-pn camera to determine the temperature, the chemical composition of the gas and their radial distribution. Since two observations are contaminated by a high soft-proton background, we develop a new method to estimate the effect of this background on the data. For the first time, we present the temperature and iron abundance of two of these three clusters. The iron abundance of 1RXS J153934.7-33535 decreases with radius. The fits to the XMM-Newton and Chandra data show that the radial temperature profile within 3' towards the centre either flattens or lowers. A Chandra image of the source suggests the presence of X-ray cavities. The gas properties in 1RXS J160147.6-754507 are consistent with a flat radial distribution of iron and temperature within 2' from the centre. 1RXS J081232.3-571423 is a relatively cool cluster with a temperature of about 3 keV. The radial temperature and iron profiles suggest that 1RXS J153934.7-833535 is a cool core cluster. The Chandra image shows substructure which points toward AGN feedback in the core. The flat radial profiles of the temperature and iron abundance in 1RXS J160147.6-754507 are similar to the profiles of non-cool-core clusters.Comment: Accepted for publication in A&A, 8 pages, 8 figures; corrected typos, added data points on which fig 1 and 2 are based as comment to source file

Ursinus College Alumni Journal, November 1958

President\u27s page • President\u27s inaugural address • Dr. D. L. Helfferich inaugurated President of Ursinus College • Ursinus College opens with 839 • The Evening School • New preceptress at 944 • Library • The Messiah • The faculty cornered • The cornered faculty turns • Tracking the Alder Flycatcher • Old Timers\u27 Day almost rained out • Face lifting on campus • Ursinus Woman\u27s Club plans holiday luncheon • Ursinus Forum, 1958-59 • A challenge for alumni giving • Fall play Joan of Lorraine • Annual alumni Schoolmen\u27s Week luncheon • Five years of alumni sponsorship completed: 1958 Loyalty Fund report • Workshop in economic education • Paul S. Craigie, class Chairman of the year • Honor roll by classes • Contributors for the 1958 Loyalty Fund campaign • Varsity football • Varsity and J.V. basketball schedule 1958-59 • Alumnae continue winning ways • Varsity wrestling schedule 1959 • Two new assistant football coaches • Varsity has strong potential • Ursinus appoints a new wrestling coach • News about ourselves • Weddings • Births • Necrology • Two Spanish majors receive honorshttps://digitalcommons.ursinus.edu/alumnijournal/1063/thumbnail.jp

Crater gradation in Gusev crater and Meridiani Planum, Mars

The Mars Exploration Rovers investigated numerous craters in Gusev crater and Meridiani Planum during the first ∼400 sols of their missions. Craters vary in size and preservation state but are mostly due to secondary impacts at Gusev and primary impacts at Meridiani. Craters at both locations are modified primarily by eolian erosion and infilling and lack evidence for modification by aqueous processes. Effects of gradation on crater form are dependent on size, local lithology, slopes, and availability of mobile sediments. At Gusev, impacts into basaltic rubble create shallow craters and ejecta composed of resistant rocks. Ejecta initially experience eolian stripping, which becomes weathering-limited as lags develop on ejecta surfaces and sediments are trapped within craters. Subsequent eolian gradation depends on the slow production of fines by weathering and impacts and is accompanied by minor mass wasting. At Meridiani the sulfate-rich bedrock is more susceptible to eolian erosion, and exposed crater rims, walls, and ejecta are eroded, while lower interiors and low-relief surfaces are increasingly infilled and buried by mostly basaltic sediments. Eolian processes outpace early mass wasting, often produce meters of erosion, and mantle some surfaces. Some small craters were likely completely eroded/buried. Craters \u3e100 m in diameter on the Hesperian-aged floor of Gusev are generally more pristine than on the Amazonian-aged Meridiani plains. This conclusion contradicts interpretations from orbital views, which do not readily distinguish crater gradation state at Meridiani and reveal apparently subdued crater forms at Gusev that may suggest more gradation than has occurred