Diseño y desarrollo de metodologías de aprendizaje cooperativo en las enseñanzas del Máster de Profesorado de Educación Secundaria Obligatoria y Bachillerato, Formación Profesional y Enseñanzas de Idiomas

Memoria ID-0224. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2016-2017

Topografía eclesiástica de la Bética en la Antigüedad Tardía a través del corpus epigráfico

Este trabajo se centra en el estudio de la realidad arqueológica de la provincia romana de la Bética durante el periodo que media entre la caída del Imperio y la desaparición del Reino Visigodo de Toledo. El marco geográfico de nuestro estudio se ciñe grosso modo al territorio comprendido por la mitad occidental de la actual Andalucía, incluyendo también algunos territorios situados al sur de Extremadura limítrofes con aquélla. Partiendo del estado de la investigación actual, abordaremos la cristianización de la sociedad y la arquitectura eclesiástica, como máxima manifestación monumental del cristianismo, y principal estructura de la administración territorial a través de los testimonios epigráficos conservados.-----------------------------------------------------------------------This papers focuses on the study of the archaeological records of the Roman province of Baetica during the period between the collapse of the Empire and the disappearance of the Visigoth kingdom of Toledo. The geographic context of our study follows roughly the territory comprised in the western half of the current Andalusia, also including some territories bordering south of Extremadura. From the state of current research, we discuss about theChristianization of society and the ecclesiastical architecture, as the highest expression of Christianity and the main territorial administration structure through epigraphic evidence conserved

The visigoth and post visigoth ceramic contexts of the "re interpretation" of Los Hitos-Arisgotas, Orgaz (Toledo)

El presente artículo se ocupa de los contextos cerámicos visigodos y postvisigodos localizados en la Campaña 2016 en el enclave visigodo de Los Hitos –Arisgotas, Orgaz- (Toledo). Se presentan aquí los materiales cerámicos localizados en la reexcavación de los espacios excavados en las campañas realizadas en el yacimiento por el investigador Luis J. Balmaseda Muncharaz en el pasado siglo XX. A pesar de encontrarnos con un registro arqueológico alterado y excavado en su mayor parte, los contextos cerámicos localizados están relacionados con otros que conocemos en la Vega Baja de Toledo, Madrid, Recópolis (Guadalajara) o el Tolmo de Minateda (Albacete).This article deals with the visigoths and postvisigoths ceramic contexts located in the 2016 Campaign in the Visigoth enclave of Los Hitos -Arisgotas, Orgaz- (Toledo). Here we present the ceramic materials located in the re-excavation of the excavated spaces in the campaigns carried out in the deposit by the investigated Luis J. Balmaseda Muncharaz in the last century XX. Although we find an altered archaeological record and excavated for the most part, the localized ceramic contexts are related to others that we know in Vega Baja de Toledo, Madrid, Recópolis (Guadalajara) or the Tolmo de Minateda (Albacete)

Topografía eclesiástica de la Bética en la Antigüedad Tardía a través del corpus epigráfico

Este trabajo se centra en el estudio de la realidad arqueológica de la provincia romana de la Bética durante el periodo que media entre la caída del Imperio y la desaparición del Reino Visigodo de Toledo. El marco geográfico de nuestro estudio se ciñe grosso modo al territorio comprendido por la mitad occidental de la actual Andalucía, incluyendo también algunos territorios situados al sur de Extremadura limítrofes con aquélla. Partiendo del estado de la investigación actual, abordaremos la cristianización de la sociedad y la arquitectura eclesiástica, como máxima manifestación monumental del cristianismo, y principal estructura de la administración territorial a través de los testimonios epigráficos conservados.-----------------------------------------------------------------------This papers focuses on the study of the archaeological records of the Roman province of Baetica during the period between the collapse of the Empire and the disappearance of the Visigoth kingdom of Toledo. The geographic context of our study follows roughly the territory comprised in the western half of the current Andalusia, also including some territories bordering south of Extremadura. From the state of current research, we discuss about theChristianization of society and the ecclesiastical architecture, as the highest expression of Christianity and the main territorial administration structure through epigraphic evidence conserved

The non-ceramic material contexts - metals, bone, glass and lithic - of the "reexcavation" of Los Hitos -Arisgotas, Orgaz- (Toledo)

El presente artículo se ocupa de los contextos materiales no cerámicos visigodos y postvisigodos localizados en la Campaña 2016 en el enclave visigodo de "Los Hitos" –Arisgotas, Orgaz- (Toledo). Se presentan aquí los materiales no cerámicos localizados en la reexcavación de los espacios excavados en las campañas realizadas en el yacimiento por el investigador Luis J. Balmaseda Muncharaz en el pasado siglo XX. A pesar de encontrarnos con un registro arqueológico alterado y excavado en su mayor parte, los contextos materiales localizados están relacionados con otros que conocemos en las dos Mesetas.This article deals with the visigoths and postvisigoths non-ceramic contexts located in the 2016 Campaign in the Visigoth enclave of "Los Hitos" -Arisgotas, Orgaz- (Toledo). Here we present the ceramic materials located in the re-excavation of the excavated spaces in the campaigns carried out in the deposit by the investigated Luis J. Balmaseda Muncharaz in the last century XX. Although we find an altered archaeological record and excavated for the most part, the localized ceramic contexts are related to others that we know in South and North Mesetas

Parental Mosaicism in PAX6 Causes Intra-Familial Variability: Implications for Genetic Counseling of Congenital Aniridia and Microphthalmia

Mutations in PAX6 are involved in several developmental eye disorders. These disorders have considerable phenotypic variability, ranging from panocular forms of congenital aniridia and microphthalmia to isolated anomalies of the anterior or posterior segment. Here, we describe 3 families with variable inter-generational ocular expression of aniridia, iris coloboma, or microphthalmia, and an unusual transmission of PAX6 mutations from an unaffected or mildly affected parent; all of which raised suspicion of gonosomal mosaicism. We first identified two previously known nonsense mutations and one novel likely pathogenic missense variant in PAX6 in probands by means of targeted NGS. The subsequent segregation analysis by Sanger sequencing evidenced the presence of highly probable mosaic events in paternal blood samples. Mosaicism was further confirmed by droplet digital PCR analysis in several somatic tissues of mosaic fathers. Quantification of the mutant allele fraction in parental samples showed a marked deviation from 50%, with a range between 12 and 29% depending on cell type. Gonosomal mosaicsm was definitively confirmed in one of the families thanks to the availability of a sperm sample from the mosaic father. Thus, the recurrence risk in this family was estimated to be about one-third. This is the first report confirming parental PAX6 mosaicism as a cause of disease recurrence in aniridia and other related phenotypes. In addition, we demonstrated that post-zygotic mosaicism is a frequent and underestimated pathogenic mechanism in aniridia, explaining intra-familial phenotypic variability in many cases. Our findings may have substantial implications for genetic counseling in congenital aniridia. Thus, we also highlight the importance of comprehensive genetic screening of parents for new sporadic cases with aniridia or related developmental eye disease to more accurately assess recurrence risk. In conclusion, somatic and/or gonosomal mosaicism should be taken into consideration as a genetic factor to explain not only families with unaffected parents despite multiple affected children but also variable expressivity, apparent de novo cases, and even uncharacterized cases of aniridia and related developmental eye disorders, apparently lacking PAX6 mutations

Interactions between wine phenolic compounds and human saliva in astringency perception

[EN] Astringency is a complex perceptual phenomenon involving several sensations that are perceived simultaneously. The mechanism leading to these sensations has been thoroughly and controversially discussed in the literature and it is still not well understood since there are many contributing factors. Although we are still far from elucidating the mechanisms whereby astringency develops, the interaction between phenolic compounds and proteins (from saliva, oral mucosa or cells) seems to be most important. This review summarizes the recent trends in the protein–phenol interaction, focusing on the effect of the structure of the phenolic compound on the interaction with salivary proteins and on methodologies based on these interactions to determine astringency

Análisis del prácticum y las sesiones de tutoría en las carreras de odontología, informática y educación de la universidad de Salamanca

Memoria ID-114. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2018-2019