Study of the within-breed genetic diversity in the murciano-granadina goat with microsatellites

Granadina goats, Murciana goats and their crosses are included in the same genealogical book that is managed by two different breeders associations: the Asociación Nacional de Criadores de Caprinos de Raza Murciano-Granadina and the Asociación de Criadores de Cabras Murcianas ACRIMUR. Both populations form the Murciano-Granadina breed, reported in this way in the Catálogo Oficial de Razas de Ganado de España. This common genetic management has had excellent benefits like the international recognition of the Murciano-Granadina breed, but it is possible that the no distinction between crossbreed animals would produce a genetic absorption of the Granadina population by the Murciana one. This fact would conduce to an important lost of genetic diversity, especially for Andalucía that would lost one of their most emblematic genetic resource. There are a lot of scientific publications about productive, reproductive or genetic characters of the Murciano-Granadina considering one unique population. In this work we study the within-breed diversity of the Murciano-Granadina breed in order to determine the real genetic differences between these two populations: Murciana and Granadina.Actualmente tanto las cabras Granadinas como las cabras Murcianas, así como sus cruces se inscriben en un único libro genealógico gestionado por dos asociaciones de criadores: la Asociación Nacional de Criadores de Caprinos de Raza Murciano-Granadina y la Asociación de Criadores de Cabras Murcianas ACRIMUR. Oficialmente ambas poblaciones se integran en una única raza llamada Murciano-Granadina, incluida como tal en el catálogo Oficial de Razas de Ganado de España. Esta gestión genética común por una parte ha producido efectos muy beneficiosos como ha sido el reconocimiento internacional de la raza Murciano-Granadina, pero puede que no discriminar animales cruzados entre ambas poblaciones esté produciendo un fenómeno de absorción de la cabra Granadina tradicional por parte de la cabra Murciana, algo que sería una pérdida de diversidad muy grave, especialmente para Andalucía que estaría perdiendo uno de sus recursos genéticos más emblemáticos. Debido a la gran importancia que tiene esta raza caprina como la más representativa de España en el panorama internacional, son muchos los trabajos científicos que se han desarrollado sobre distintos aspectos productivos, reproductivos e incluso genéticos, todos ellos considerando una única población denominada Murciano-Granadina. En este estudio se aborda el estudio de la diversidad genética intrarracial de la raza Murciano-Granadina para determinar de una manera fiable y objetiva las diferencias genéticas reales entre estas dos poblaciones caprinas: Murciana y Granadina

Estimation of morphoestructural traits in moxoto breed goats

The raising goat systems in Brazil are characterized as extensive or semi-extensive in the majority of them. In native breeds dominate the extensive system, being common introduction of exotic breed as Anglo Nubian and Boer. In addition, the geographic isolation difficulty change of sires, promote genetic isolation and changes in breed pattern, consequently. The objective of the present work were to evaluate eleven quantitative morphoestructural traits: raised to the withers (RW), raised to the entrance of croup (RC), thoracic perimeter (PT), width of croup (WC), length of croup (LC), width of head (WH), face length (FL), width of face (WF), ear size (ES), shin circumference of the cinnamon (CCi) of 313 Moxoto animal breed of several municipality of Pernambuco and Paraíba States, northeastern, semi arid region of Brazil. According to canonical analyses it is possible to verify diferentiation and sub populations formation.Os sistemas de produção de caprinos no Brasil caracterizam-se na sua maioria como extensivo ou semi-extensivo. Porém, na criação de caprinos nativos predomina o sistema ultra-extensivo, sendo comum a introdução de animais exóticos, principalmente das raças Anglo Nubiana e Boer para cruzamento com o rebanho local, fato que tem contribuído para diluição genética e perda das características raciais.. Além disso, o isolamento geográfico a que estão submetidos, dificulta a troca de reprodutores entre rebanhos, promove isolamento genético e como conseqüência final, mudanças no padrão racial. O presente trabalho teve como objetivo utilizar onze variáveis morfo-estruturais de natureza quantitativas, tais como: longitude da cabeça (LC); longitude do rosto (LR); largura da cabeça (LCa); comprimento do corpo (CC); perímetro torácico (PT); altura da cernelha (AC); altura da região sacral (ARS); largura da garupa (LG); longitude da garupa (LGa); perímetro da canela (PCa) e; tamanho da orelha (TO) de 313 animais da raça caprina Moxotó, de diferentes municípios dos Estados de Pernambuco e Paraíba, região semi-árida do Nordeste brasileiro. Pela análise canônica foi possível verificar diferenciação e formação de sub-populações dentro da raça

Cissus Sicyoides: Pharmacological Mechanisms Involved In The Anti-inflammatory And Antidiarrheal Activities

The objective of this study was to evaluate the pharmacological mechanisms involved in anti-inflammatory and antidiarrheal actions of hydroalcoholic extract obtained from the leaves of Cissus sicyoides (HECS). The anti-inflammatory effect was evaluated by oral administration of HECS against acute model of edema induced by xylene, and the mechanisms of action were analysed by involvement of arachidonic acid (AA) and prostaglandin E2 (PGE2). The antidiarrheal effect of HECS was observed and we analyzed the motility and accumulation of intestinal fluid. We also analyzed the antidiarrheal mechanisms of action of HECS by evaluating the role of the opioid receptor, α2 adrenergic receptor, muscarinic receptor, nitric oxide (NO) and PGE2. The oral administration of HECS inhibited the edema induced by xylene and AA and was also able to significantly decrease the levels of PGE2. The extract also exhibited significant anti-diarrheal activity by reducing motility and intestinal fluid accumulation. This extract significantly reduced intestinal transit stimulated by muscarinic agonist and intestinal secretion induced by PGE2. Our data demonstrate that the mechanism of action involved in the anti-inflammatory effect of HECS is related to PGE2. The antidiarrheal effect of this extract may be mediated by inhibition of contraction by acting on the intestinal smoothmuscle and/or intestinal transit. © 2016 by the authors; licensee MDPI, Basel, Switzerland.17

Photoinduced antibacterial activity of the essential oils from Eugenia brasiliensis lam and Piper mosenii C. DC. by blue led light

The objective of this work was to evaluate the phytochemical composition and the antibacterial and antibiotic-modulating activities of the essential oils of Eugenia brasiliensis Lam (OEEb) and Piper mosenii C. DC (OEPm) singly or in association with blue LED (Light-emitting diode) light. The antibacterial and antibiotic-modulatory activities of the essential oils on the activity of aminoglycosides were evaluated to determine the minimum inhibitory concentration (MIC, \u3bcg/mL) in the presence or absence of exposure to blue LED light. The chemical analysis showed \u3b1-pinene and bicyclogermacrene as major constituents of OEPm, whereas \u3b1-muurolol was the main compound of OEEb. Both OEEb and OEPm showed MIC 65 512 \u3bcg/mL against the strains under study. However, the association of these oils with the blue LED light enhanced the action of the aminoglycosides amikacin and gentamicin. In conclusion, the association of aminoglycosides with the blue LED light and essential oils was effective against resistant bacteria

Horizontal Branch Stars: The Interplay between Observations and Theory, and Insights into the Formation of the Galaxy

We review HB stars in a broad astrophysical context, including both variable and non-variable stars. A reassessment of the Oosterhoff dichotomy is presented, which provides unprecedented detail regarding its origin and systematics. We show that the Oosterhoff dichotomy and the distribution of globular clusters (GCs) in the HB morphology-metallicity plane both exclude, with high statistical significance, the possibility that the Galactic halo may have formed from the accretion of dwarf galaxies resembling present-day Milky Way satellites such as Fornax, Sagittarius, and the LMC. A rediscussion of the second-parameter problem is presented. A technique is proposed to estimate the HB types of extragalactic GCs on the basis of integrated far-UV photometry. The relationship between the absolute V magnitude of the HB at the RR Lyrae level and metallicity, as obtained on the basis of trigonometric parallax measurements for the star RR Lyrae, is also revisited, giving a distance modulus to the LMC of (m-M)_0 = 18.44+/-0.11. RR Lyrae period change rates are studied. Finally, the conductive opacities used in evolutionary calculations of low-mass stars are investigated. [ABRIDGED]Comment: 56 pages, 22 figures. Invited review, to appear in Astrophysics and Space Scienc

Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment

This paper describes an analysis of the angular distribution of W->enu and W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with the ATLAS detector at the LHC in 2010, corresponding to an integrated luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and the missing transverse energy, the W decay angular distribution projected onto the transverse plane is obtained and analysed in terms of helicity fractions f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw > 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour, are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017 +/- 0.030, where the first uncertainties are statistical, and the second include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables, revised author list, matches European Journal of Physics C versio

Observation of a new chi_b state in radiative transitions to Upsilon(1S) and Upsilon(2S) at ATLAS

The chi_b(nP) quarkonium states are produced in proton-proton collisions at the Large Hadron Collider (LHC) at sqrt(s) = 7 TeV and recorded by the ATLAS detector. Using a data sample corresponding to an integrated luminosity of 4.4 fb^-1, these states are reconstructed through their radiative decays to Upsilon(1S,2S) with Upsilon->mu+mu-. In addition to the mass peaks corresponding to the decay modes chi_b(1P,2P)->Upsilon(1S)gamma, a new structure centered at a mass of 10.530+/-0.005 (stat.)+/-0.009 (syst.) GeV is also observed, in both the Upsilon(1S)gamma and Upsilon(2S)gamma decay modes. This is interpreted as the chi_b(3P) system.Comment: 5 pages plus author list (18 pages total), 2 figures, 1 table, corrected author list, matches final version in Physical Review Letter