The South Shetland Islands, Antarctica: unified lithostratigraphy and geological map

Over the last few decades, numerous geological studies have been carried out in the South Shetland Islands, which have greatly contributed to a better understanding of its geological evolution. However, few attempts have been conducted to correlate the geological units throughout this archipelago. We present herein a lithostratigraphical correlation, which constitutes a coherent and unified stratigraphy for the main Mesozoic and Cenozoic units rocks of the South Shetland Islands along with a new geological map. The lithostratigraphical correlation shows that the geological evolution comprises three main stages: (i) deep marine sedimentation from ~164 to 140 Ma, (ii) subaerial volcanism and sedimentation with a proliferation of plants and fauna from ~140 to 35 Ma and (iii) glacial and interglacial deposits from ~35 Ma. The lithostratigraphical correlation also shows a broad geographical trend of decreasing age of volcanism from southwest to northeast, which has been previously suggested. However, this spatial age trend is disrupted by the presence of Eocene magmatism in Livingston Island, located in the centre of the archipelago. We suggest that the migration of volcanism occurred from the Late Cretaceous until the early Eocene. Subsequently, enhanced magmatic activity took place from the mid-Eocene until the Miocene, which we associate with processes related with the waning of subduction, such as roll-back. Finally, constraining the protolith age of the metamorphic complex of Smith Island remains challenging, yet holds key implications for the tectonic and accretionary evolution of the Antarctic Peninsula. The rocks recording the glaciation of this sector of Antarctica are well exposed in the northern South Shetland Islands and hold critical information for understanding the timings and processes that lead to the greenhouse-icehouse transition towards the Eocene end. Contemporaneous rocks to the breakup of Antarctic Peninsula from Patagonia, which led to the Drake Passage opening and the development of the Scotia Sea, are exposed in the north-centre of the archipelago. A better age constrain of these units may lead to further understanding the paleontological evolution of this region. The dataset containing the geological map is shared as a shapefile and KML file

Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study

Introduction: The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals. Materials and Methods: A set of miRNAs was chosen based on published associations with human disease conditions that constitute SNAEs. This case: control study compared 126 cases (individuals who died whilst on therapy), and 247 matched controls (individuals who remained alive). Cases and controls were ART treated participants of two pivotal HIV-1 trials. The relative abundance of each miRNA in serum was measured, by RTqPCR. Associations with mortality (all-cause, cardiovascular and malignancy) were assessed by logistic regression analysis. Correlations between miRNAs and CD4+ T cell count, hs-CRP, IL-6 and D-dimer were also assessed. Results: None of the selected miRNAs was associated with all-cause, cardiovascular or malignancy mortality. The levels of three miRNAs (miRs -21, -122 and -200a) correlated with IL-6 while miR-21 also correlated with D-dimer. Additionally, the abundance of miRs -31, -150 and -223, correlated with baseline CD4+ T cell count while the same three miRNAs plus miR- 145 correlated with nadir CD4+ T cell count. Discussion: No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection

Gestión del conocimiento. Perspectiva multidisciplinaria. Volumen 9

El libro “Gestión del Conocimiento. Perspectiva Multidisciplinaria”, volumen 9, de la Colección Unión Global, es resultado de investigaciones. Los capítulos del libro, son resultados de investigaciones desarrolladas por sus autores. El libro es una publicación internacional, seriada, continua, arbitrada de acceso abierto a todas las áreas del conocimiento, que cuenta con el esfuerzo de investigadores de varios países del mundo, orientada a contribuir con procesos de gestión del conocimiento científico, tecnológico y humanístico que consoliden la transformación del conocimiento en diferentes escenarios, tanto organizacionales como universitarios, para el desarrollo de habilidades cognitivas del quehacer diario. La gestión del conocimiento es un camino para consolidar una plataforma en las empresas públicas o privadas, entidades educativas, organizaciones no gubernamentales, ya sea generando políticas para todas las jerarquías o un modelo de gestión para la administración, donde es fundamental articular el conocimiento, los trabajadores, directivos, el espacio de trabajo, hacia la creación de ambientes propicios para el desarrollo integral de las instituciones

Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

Ristola M. on työryhmien DAD Study Grp ; Royal Free Hosp Clin Cohort ; INSIGHT Study Grp ; SMART Study Grp ; ESPRIT Study Grp jäsen.Background Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. Methods and Findings A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with >= 3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7-6.7; median follow-up 6.1 y, range 0.3-9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was -2 (interquartile range -4 to 2). There was a 1: 393 chance of developing CKD in the next 5 y in the low risk group (risk score = 5, 505 events), respectively. Number needed to harm (NNTH) at 5 y when starting unboosted atazanavir or lopinavir/ritonavir among those with a low risk score was 1,702 (95% CI 1,166-3,367); NNTH was 202 (95% CI 159-278) and 21 (95% CI 19-23), respectively, for those with a medium and high risk score. NNTH was 739 (95% CI 506-1462), 88 (95% CI 69-121), and 9 (95% CI 8-10) for those with a low, medium, and high risk score, respectively, starting tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor. The Royal Free Hospital Clinic Cohort included 2,548 individuals, of whom 94 individuals developed CKD (3.7%) during 18,376 PYFU (median follow-up 7.4 y, range 0.3-12.7 y). Of 2,013 individuals included from the SMART/ESPRIT control arms, 32 individuals developed CKD (1.6%) during 8,452 PYFU (median follow-up 4.1 y, range 0.6-8.1 y). External validation showed that the risk score predicted well in these cohorts. Limitations of this study included limited data on race and no information on proteinuria. Conclusions Both traditional and HIV-related risk factors were predictive of CKD. These factors were used to develop a risk score for CKD in HIV infection, externally validated, that has direct clinical relevance for patients and clinicians to weigh the benefits of certain antiretrovirals against the risk of CKD and to identify those at greatest risk of CKD.Peer reviewe

Trayectoria, evolución y estructura del sistema de ciudades: el caso de la región del Bío-Bío (Chile)

Spatial interaction is one of the\ud foundations for understanding the\ud dynamics occurring in the geographic\ud space. City systems behave under\ud this spatial logic and the interactions\ud between urban centers largely determine\ud the dependency and differentiation\ud relationships in the territory. Using\ud population data and a combination of\ud the methodology of graph theory and\ud ascending hierarchical classification,\ud this article analyzes the system of cities\ud in the Bío-Bío Region of Chile. The\ud results express the hierarchical stability\ud of populated centers, the increase in\ud spatial disparities and the decline of\ud small and intermediate cities, explained\ud by historical-economic processes and\ud functional aspects

Análisis y tendencias migratorias en la región del Biobío (Chile) entre 1982 y 2002. Aplicación desde el modelo gravitacional

El proceso de migraciones internas en la región del Biobío expresa un proceso de redistribución espacial que tiende a la polarización del espacio hacia la capital regional –Concepción metropolitano– y a las comunas contiguas a ésta. De igual manera, se observa una fuerte atracción migratoria de las capitales provinciales pero circunscrita a su hinterland . Además, se determina que el perfil del migrante desde estas ciudades hacia la capital regional se caracterizaría por una alta educación, a diferencia de los migrantes de las comunas aledañas a las capitales provinciales, que se compondrían más bien por población joven con bajos grados de escolaridad

Trayectoria, evolución y estructura del sistema de ciudades: el caso de la región del Bío-Bío (Chile)

La interacción espacial es uno de los fundamentos principales para comprender las dinámicas que se desarrollan en el espacio geográfico. Los sistemas de ciudades se comportan bajo esta lógica espacial y las interacciones entre centros urbanos determinan, en gran medida, las relaciones de dependencia y diferenciación que plasman estos en el territorio. En este artículo se analiza el sistema de ciudades de la región del Bío-Bío (Chile), a partir de datos de población, metodología de la teoría de grafos y clasificación ascendente jerárquica. Los resultados expresan la estabilidad jerárquica de los centros poblados, el incremento de las disparidades espaciales y la decadencia de las ciudades pequeñas e intermedias, explicado por procesos histórico-económicos y aspectos funcionales

Uncooled Thermal Camera Calibration and Optimization of the Photogrammetry Process for UAV Applications in Agriculture

The acquisition, processing, and interpretation of thermal images from unmanned aerial vehicles (UAVs) is becoming a useful source of information for agronomic applications because of the higher temporal and spatial resolution of these products compared with those obtained from satellites. However, due to the low load capacity of the UAV they need to mount light, uncooled thermal cameras, where the microbolometer is not stabilized to a constant temperature. This makes the camera precision low for many applications. Additionally, the low contrast of the thermal images makes the photogrammetry process inaccurate, which result in large errors in the generation of orthoimages. In this research, we propose the use of new calibration algorithms, based on neural networks, which consider the sensor temperature and the digital response of the microbolometer as input data. In addition, we evaluate the use of the Wallis filter for improving the quality of the photogrammetry process using structure from motion software. With the proposed calibration algorithm, the measurement accuracy increased from 3.55 °C with the original camera configuration to 1.37 °C. The implementation of the Wallis filter increases the number of tie-point from 58,000 to 110,000 and decreases the total positing error from 7.1 m to 1.3 m

Agreement in the assessment of metastatic spine disease using scoring systems

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