39 research outputs found
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
- Author
- Abdallah J
- Abdul Ghani R
- Abdul Kadir K
- Abdullah R
- Abejuela Z
- Abouglila K
- Abraham O
- Abrahamsen I
- Abraira Munoz Ld
- Abramowitz M
- Abusnana S
- Accini Mendoza Jl
- Acosta I
- Agafyina A
- Agarwal R
- Agarwal Rajiv
- Aggarwal N
- Agra J
- Ahmed F
- Ahuad Guerrero Ra
- Aiello J
- Ainsworth P
- Aizenberg D
- Akiyama H
- Akright L
- Akyea-Djamson A
- Al-Karadsheh A
- Alamartine E
- Alappan R
- Albisu Jp
- Ali N
- Ali Z
- Alicic R
- Allison Dc
- Alvarez Garcia P
- Alvarisqueta A
- Alves da Costa Fa
- Amerena J
- Amigo A
- Amodeo C
- Andreeva V
- Andreotti Turatti La
- Angelescu Lm
- Angelova A
- Anghel V
- Antic S
- Aoki H
- Aquitania G
- Arauz-Pacheco C
- Arcos E
- Arfeen S
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- Arutchelvam V
- Arvind M
- Asano A
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- Bellary S
- Belo D
- Belobradkova J
- Bentley-Lewis R
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- Berenguer R
- Berli Ma
- Bermudez L
- Bernardo M
- Bhushan Rs
- Bijata-Bronisz R
- Bilyk Sd
- Bin Shudim Ss
- Biscoveanu M
- Bompoint Severine
- Bonadonna R
- Bordonava A
- Borot S
- Botsyurko V
- Bowman-Stroud C
- Brandon D
- Breedt J
- Bregman R
- Brenner Barry M
- Brenner Bm
- Brusco O
- Buganova I
- Bull Scott
- Burst V
- Busch R
- Busegeanu Mm
- Calella P
- Camelo Sanches Fc
- Canaan Y
- Canani Lh
- Cannon Christopher P
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- Capuano George
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- Cariou B
- Cartasegna Lr
- Castellino P
- Cercos E
- Cereto Castro F
- Ceriello A
- Chacra Ar
- Chae Dw
- Chang Ct
- Chang T
- Chapin L
- Charytan David M
- Charytan Dm
- Che Yusof Md
- Cheifetz A
- Chen E
- Chen N
- Chen Q
- Cherney D 3rd
- Chertow G
- Cheung Nw
- Chilito A
- Chiovato L
- Chizhov D
- Cho Ym
- Chouinard G
- Christensen T
- Christiano C
- Christofides E
- Chu Pei-Ling
- Chuang Lm
- Chuateco C
- Cif A
- Cigarran Guldris S
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- Cohen K
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- Cohen-Stein D
- Coloma Gc
- Colombo H
- Comia Rs
- Commendatore V
- Conway J
- Cook C
- Correa Rotter Jr
- Cosma D
- Cournoyer S
- Coyne D
- Crisan C
- Cruz Jb
- Csecsei G
- Csiky B
- Cuadrado J
- Culak J
- Cuneo Ca
- Cunha Borges Jl
- Cunha V\ueancio Sa
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- D'Avila D
- da Silva Franco Rj
- Daboul N
- Danos P
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- Darwish R
- Daswani A
- David C
- Davies E
- Davies M
- Davies S
- Dawson A
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- de Carvalho Contieri Fl
- De Cosmo S
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- de Souza Portes E
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- de Zeeuw D
- de Zeeuw Dick
- Deak L
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- Deepak D
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- Desouza C
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- Dhillon M
- Di Carlo A
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- Diaz Escalante T
- Diaz Ruiz Jea
- Dimitrov S
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- Djordjevic M
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- Dominquez Lopez M
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- Edwards Robert
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- Elosegui Am
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- Fauvel Jp
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- Ignjatovic J
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- Kong Wy
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- Trevisan R
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- Ulla Mr
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- Urbanaviciene E
- Uriasyev O
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- Vargas Alonso Rd
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- Vizir V
- Vlasenko M
- von Ingersleben G
- Vorobyev S
- Vukotic G
- Vyasam Rc
- Wada T
- Wadud K
- Wahba M
- Wakasugi M
- Wakeling J
- Wakida Y
- Walker R
- Wang G
- Wang H
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- Wassermann A
- Watanabe T
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- Watson H
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- Weiner D
- Weiner P
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- Wheeler David C
- Wheeler Dc
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- Williams S
- Winocour P
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- Woo V
- Yakov A
- Yamada M
- Yamada S
- Yanagida K
- Yanase T
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- Yao C
- Yap Ye
- Yavin Yshai
- Ygpuara Mdl
- Yin A
- Yoiti Hayashida C
- Yoon Kh
- Yost L
- Young S
- Yu X
- Yumita W
- Yupanqui H
- Zaidman Cj
- Zalunardo N
- Zamarripa Escobedo R
- Zanata Petry Tb
- Zanella Mt
- Zaniewski-Singh M.
- Zanoli L
- Zaoui P
- Zateyshchikova A
- Zateyshshikov D
- Zaviriukha V
- Zemek S
- Zhang H
- Zhang Hong
- Zhao M
- Zheng H
- Zinman B
- Zinman Bernard
- Zlova T
- Zsom M
- Zub L
- Zykova T
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m 2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Measurement of the tt¯ production cross section, the top quark mass, and the strong coupling constant using dilepton events in pp collisions at √s = 13 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdalla H
- Abdullah WATW
- Abdullin S
- Abdulsalam A
- Abercrombie D
- Abu Zeid S
- Acharya H
- Ackert A
- Acosta D
- Acosta JG
- Adam W
- Adams MR
- Adams T
- Adzic P
- Afanasiev S
- Agapitos A
- Agaras MN
- Aggleton R
- Agram J-L
- Ahmad A
- Ahmad M
- Ahmad M
- Ahuja S
- Akbiyik M
- Akchurin N
- Akgun B
- Al-bataineh A
- Albajar C
- Albergo S
- Albert A
- Albrow M
- Alcaraz Maestre J
- Aleksandrov A
- Alexander J
- Alhusseini M
- Ali MABM
- Alimena J
- Allen B
- Almond J
- Alvarez Fernandez A
- Alverson G
- Alves FL
- Alves GA
- Alyari M
- Amapane N
- Ambrogi F
- Amendola C
- Amin N
- Amsler C
- Anagnostou G
- Anampa KH
- Anderson D
- Andrea J
- Andreev V
- Andreev Y
- Andrews MB
- Androsov K
- Angioni GLP
- Antonelli L
- Antropov I
- Antunovic Z
- Apanasevich L
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- Apyan A
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- Arcaro D
- Arcidiacono R
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- Asghar MI
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- Attikis A
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- Autermann C
- Auzinger G
- Avdeeva E
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- Barrio Luna M
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- Yetkin EA
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- Yumiceva F
- Yusli MN
- Zabi A
- Zaganidis N
- Zahid S
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- Zalewski P
- Zanetti A
- Zanetti M
- Zarubin A
- Zarucki M
- Zeinali M
- Zenaiev O
- Zenz SC
- Zeuner WD
- Zeyrek M
- Zghiche A
- Zhang A
- Zhang F
- Zhang H
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- Zhang S
- Zhang Z
- Zhao J
- Zhokin A
- Zhu DH
- Zhu RY
- Zientek M
- Zobec J
- Zoi I
- Zolkapli Z
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- Zuo X
- Zuolo D
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 29/04/2019
- Field of study
A measurement of the top quark–antiquark pair production cross section σtt¯ in proton–proton collisions at a centre-of-mass energy of 13TeV is presented. The data correspond to an integrated luminosity of 35.9fb−1, recorded by the CMS experiment at the CERN LHC in 2016. Dilepton events (e ± μ ∓, μ+μ−, e+e−) are selected and the cross section is measured from a likelihood fit. For a top quark mass parameter in the simulation of mMCt=172.5GeV the fit yields a measured cross section σtt¯=803±2(stat)±25(syst)±20(lumi)pb, in agreement with the expectation from the standard model calculation at next-to-next-to-leading order. A simultaneous fit of the cross section and the top quark mass parameter in the POWHEG simulation is performed. The measured value of mMCt=172.33±0.14(stat)+0.66−0.72(syst)GeV is in good agreement with previous measurements. The resulting cross section is used, together with the theoretical prediction, to determine the top quark mass and to extract a value of the strong coupling constant with different sets of parton distribution functions
Measurement of B_{s}^{0} meson production in pp and PbPb collisions at \sqrt{SNN}
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdalla H
- Abdelalim AA
- Abdullah WATW
- Abdullin S
- Abdulsalam A
- Abercrombie D
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
- Adam W
- Adams MR
- Adams T
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- Afanasiev S
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- Agaras MN
- Aggleton R
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- Ahmad A
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- Ahmed I
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- Yumiceva F
- Yusli MN
- Zabi A
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- Zahid S
- Zaleski S
- Zalewski P
- Zanetti A
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- Zarubin A
- Zarucki M
- Zeinali M
- Zenaiev O
- Zenz SC
- Zeuner WD
- Zeyrek M
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- Zhang A
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- Zhu DH
- Zhu RY
- Zientek M
- Zito G
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- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
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- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Publication venue
- 'Elsevier BV'
- Publication date
- 10/09/2019
- Field of study
The production cross sections of B_{s}^{0} mesons and charge conjugates are measured in proton-proton (pp) and PbPb collisions via the exclusive decay channel B_{s}^{0}→J/ψϕ→μ^{+}μ^{−}K^{+}K^{−} at a center-of-mass energy of 5.02 TeV per nucleon pair and within the rapidity range |y|<2.4 using the CMS detector at the LHC. The pp measurement is performed as a function of transverse momentum (p_{T}) of the B_{s}^{0} mesons in the range of 7 to 50 GeV/c and is compared to the predictions of perturbative QCD calculations. The B_{s}^{0} production yield in PbPb collisions is measured in two p_{T} intervals, 7 to 15 and 15 to 50 GeV/c, and compared to the yield in pp collisions in the same kinematic region. The nuclear modification factor (R_{AA}) is found to be 1.5±0.6(stat)±0.5(syst) for 7–15 GeV/c, and 0.87±0.30(stat)±0.17(syst) for 15–50 GeV/c, respectively. Within current uncertainties, the B_{s}^{0} results are consistent with models of strangeness enhancement, and suppression by parton energy loss, as observed for the B+ mesons
Measurement of the energy density as a function of pseudorapidity in proton-proton collisions at root \sqrt{s} = 13 TeV
- Author
- Aarrestad TK
- Abbaneo D
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- Yumiceva F
- Yusli MN
- Zabi A
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- Zahid S
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- Zalewski P
- Zanetti A
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- Zarucki M
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- Zenz SC
- Zeuner WD
- Zeyrek M
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- Zientek M
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- Zuo X
- Zuolo D
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/01/2019
- Field of study
A measurement of the energy density in proton–proton collisions at a centre-of-mass energy of s√=13 TeV is presented. The data have been recorded with the CMS experiment at the LHC during low luminosity operations in 2015. The energy density is studied as a function of pseudorapidity in the ranges −6.6<η<−5.2 and 3.15<|η|<5.20. The results are compared with the predictions of several models. All the models considered suggest a different shape of the pseudorapidity dependence compared to that observed in the data. A comparison with LHC proton–proton collision data at s√=0.9 and 7TeV confirms the compatibility of the data with the hypothesis of limiting fragmentation
Constraints on anomalous HVV couplings from the production of Higgs bosons decaying to τ lepton pairs
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim AA
- Abdullah WATW
- Abdullin S
- Abdulsalam A
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- Yumiceva F
- Yusli MN
- Zabi A
- Zaganidis N
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti A
- Zanetti M
- Zarubin A
- Zarucki M
- Zeinali M
- Zenaiev O
- Zenz SC
- Zeuner WD
- Zeyrek M
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- Zhokin A
- Zhu DH
- Zhu RY
- Zientek M
- Zobec J
- Zoi I
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zou D
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Publication venue
- AMER PHYSICAL SOC
- Publication date
- 04/12/2019
- Field of study
A study is presented of anomalous HVV interactions of the Higgs boson, including its CP properties. The study uses Higgs boson candidates produced mainly in vector boson fusion and gluon fusion that subsequently decay to a pair of τ leptons. The data were recorded by the CMS experiment at the LHC in 2016 at a center-of-mass energy of 13 TeV and correspond to an integrated luminosity of 35.9 fb−1. A matrix element technique is employed for the analysis of anomalous interactions. The results are combined with those from the H→4ℓ decay channel presented earlier, yielding the most stringent constraints on anomalous Higgs boson couplings to electroweak vector bosons expressed as effective cross section fractions and phases: the CP-violating parameter fa3cos(ϕa3)=(0.00±0.27)×10−3 and the CP-conserving parameters fa2cos(ϕa2)=(0.08+1.04−0.21)×10−3, fΛ1cos(ϕΛ1)=(0.00+0.53−0.09)×10−3, and fZγΛ1cos(ϕZγΛ1)=(0.0+1.1−1.3)×10−3. The current dataset does not allow for precise constraints on CP properties in the gluon fusion process. The results are consistent with standard model expectations
Search for an exotic decay of the Higgs boson to a pair of light pseudoscalars in the final state with two bquarks and two tau leptons in proton-proton collisions at root s=13 TeV The CMS Collaboration
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdalla H
- Abdelalim AA
- Abdullah Wan WAT
- Abdullin S
- Abdulsalam A
- Abercrombie D
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
- Adam W
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- Publication venue
- Publication date
- 01/01/2018
- Field of study
A search for an exotic decay of the Higgs boson to a pair of light pseudoscalar bosons is performed for the first time in the final state with two b quarks and two tau leptons. The search is motivated in the context of models of physics beyond the standard model (SM), such as two Higgs doublet models extended with a complex scalar singlet (2HDM + S), which include the next-to-minimal supersymmetric SM (NMSSM). The results are based on a data set of proton-proton collisions corresponding to an integrated luminosity of 35.9 fb(-1), accumulated by the CMS experiment at the LHC in 2016 at a center-of-mass energy of 13 TeV. Masses of the pseudoscalar boson between 15 and 60 GeVare probed, and no excess of events above the SM expectation is observed. Upper limits between 3 and 12% are set on the branching fraction B(h -> aa -> 2 tau 2b) assuming the SM production of the Higgs boson. Upper limits are also set on the branching fraction of the Higgs boson to two light pseudoscalar bosons in different 2HDM + S scenarios. Assuming the SM production cross section for the Higgs boson, the upper limit on this quantity is as low as 20% for a mass of the pseudoscalar of 40 GeV in the NMSSM. (C) 2018 The Author(s). Published by Elsevier B.V.Peer reviewe
Search for contact interactions and large extra dimensions in the dilepton mass spectra from proton-proton collisions at \sqrt{s} = 13 TeV
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- Xiao R
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- Xu Q
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- Yates BR
- Yazgan E
- Yetkin EA
- Yohay R
- Yoo HD
- Yoo J
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- Yu D
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- Yu I
- Yu SS
- Yuan L
- Yumiceva F
- Yusli MN
- Zabi A
- Zaganidis N
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti A
- Zanetti M
- Zarubin A
- Zarucki M
- Zeinali M
- Zenaiev O
- Zenz SC
- Zeuner WD
- Zeyrek M
- Zghiche A
- Zhang A
- Zhang F
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- Zhokin A
- Zhu DH
- Zhu RY
- Zientek M
- Zito G
- Zobec J
- Zoi I
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zou D
- Zucchetta A
- Zumerle G
- Zuolo D
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/01/2019
- Field of study
A search for nonresonant excesses in the invariant mass spectra of electron and muon pairs is presented. The analysis is based on data from proton-proton collisions at a center-of-mass energy of 13 TeV recorded by the CMS experiment in 2016, corresponding to a total integrated luminosity of 36 fb^{-1}. No significant deviation from the standard model is observed. Limits are set at 95% confidence level on energy scales for two general classes of nonresonant models. For a class of fermion contact interaction models, lower limits ranging from 20 to 32 TeV are set on the characteristic compositeness scale Λ. For the Arkani-Hamed, Dimopoulos, and Dvali model of large extra dimensions, the first results in the dilepton final state at 13 TeV are reported, and values of the ultraviolet cutoff parameter Λ_{T} below 6.9 TeV are excluded. A combination with recent CMS diphoton results improves this exclusion to Λ_{T} below 7.7 TeV, providing the most sensitive limits to date in nonhadronic final states
Search for the production of W^{\pm} W^{\pm} W^{\mp} events at \sqrt{s} = 13 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WATW
- Abdullin S
- Abercrombie D
- Acharya H
- Acosta D
- Acosta JG
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- Zorbilmez C
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- Zumerle G
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- Zuolo D
- Publication venue
- AMER PHYSICAL SOC
- Publication date
- 01/07/2019
- Field of study
A search for the production of events containing three W bosons predicted by the standard model is reported. The search is based on a data sample of proton-proton collisions at a center-of-mass energy of 13 TeV recorded by the CMS experiment at the CERN LHC and corresponding to a total integrated luminosity of 35.9 fb^{-1}. The search is performed in final states with three leptons (electrons or muons), or with two same-charge leptons plus two jets. The observed (expected) significance of the signal for W^{\pm} W^{\pm} W^{\mp} production is 0.60 (1.78) standard deviations, and the ratio of the measured signal yield to that expected from the standard model is 0.34_{-0.34}^{+0.62}. Limits are placed on three anomalous quartic gauge couplings and on the production of massive axionlike particles
Measurement of the WZ production cross section in pp collisions at root s=13 Tev
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
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- Publication venue
- Publication date
- 01/01/2015
- Field of study
Peer reviewe
Relative Modification of Prompt psi(2S) and J/psi Yields from pp to PbPb Collisions at root(S)(NN)=5.02 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WATW
- Abdullin S
- Abdulsalam A
- Abercrombie D
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam W
- Adams JR
- Adams MR
- Adams T
- Adiguzel A
- Adzic P
- Afanasiev S
- Agapitos A
- Aggleton R
- Agram J-L
- Ahmad A
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- Publication venue
- Publication date
- 04/11/2016
- Field of study
Peer reviewe