Reingeniería del proceso logístico en la empresa Rehco S.A. a nivel de pre-factibilidad

Trabajo de InvestigaciónSe realiza una reingeniería al proceso logístico de la empresa REHCO S.A a nivel de prefactibilidad, tomando como base las cuatro perspectivas (Procesos, Financiera, Clientes, Aprendizaje) del cuadro de mando integral. Dichas perspectivas se analizan desde los estudios Administrativo, Técnico y Financiero. Es así como se dan las recomendaciones para el correcto desarrollo del área en evaluación.INTRODUCCIÓN 1. DEFINICIÓN DEL CONCEPTO DE PRE FACTIBILIDAD 2. ESTUDIO ADMINISTRATIVO 3. ESTUDIO TÉCNICO 4. ESTUDIO FINANCIERO CONCLUSIONES BIBLIOGRAFÍAEspecializaciónEspecialista en Formulación y Evaluación Social y Económica de Proyecto

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Primary care physician satisfaction with patients diagnosed with depression: International Depression Project results from Colombia Satisfação do médico de cuidados primários com pacientes diagnosticados com depressão: resultados colombianos do Projeto Internacional de Depressão

OBJECTIVE: To characterize physician satisfaction with doctor-patient encounters, distinguishing between those involving patients diagnosed with depression and those involving patients without depression, as well as to determine the impact of an educational intervention aimed at improving the recognition and management of depression in primary care practice, in Bogotá, Columbia. METHOD: Physician satisfaction when treating outpatients in primary care centers was assesed by means of a questionnaire applied before and after the intervention. RESULTS: The intervention was given to 18 physicians and 5 nurses. A total of 1650 questionnaires related to visits were collected in the first phase, and 1832 were collected in the second one. The percentage of patients diagnosed with depression increased from 5.9% (95% CI: 4.8-7.1%) before the intervention to 10.6% (95% CI: 9.2-12.06%) after. The total duration of the clinical encounter did not change significantly. The percentage of time spent on the physical problems/concerns of the patients decreased in both types of visits. CONCLUSIONS: Health professional satisfaction was the greatest when dealing with the physical problems of the patient. However, in both types of visits, the degree of satisfaction when dealing with the psychological aspects increased after the intervention.OBJETIVO: Caracterizar a satisfação dos clínicos com os encontros médico-paciente, distinguindo entre aqueles que envolvem pacientes diagnosticados com depressão e aqueles que envolvem pacientes sem depressão, bem como determinar o impacto de uma intervenção educacional visando a melhorar o reconhecimento e o gerenciamento da depressão na prática de atendimento primário em Bogotá, Colômbia. MÉTODO: A satisfação dos clínicos ao tratarem de pacientes ambulatoriais em centros de atendimento primário foi avaliada por meio de um questionário aplicado antes e depois da intervenção. RESULTADOS: A intervenção foi ministrada a 18 clínicos e cinco enfermeiras. Um total de 1.650 questionários relativos às visitas foram coletados na primeira fase e 1.832 foram coletados na segunda fase. O percentual de pacientes diagnosticados com depressão aumentou de 5,9% (IC 95%: 4,8-7,1%), antes da intervenção, para 10,6% (IC 95%I: 9,2-12,06%) após a mesma. A duração total do encontro clínico não se modificou significativamente. O percentual de tempo despendido como os problemas/preocupações físicos dos pacientes decresceu em ambos os tipos de visitas. CONCLUSÕES: A satisfação dos profissionais de saúde foi mais alta ao tratarem dos problemas físicos dos pacientes. No entanto, em ambos os tipos de visitas o grau de satisfação ao tratarem dos aspectos psicológicos aumentou após a intervenção

Cytokine expression in the placenta of pregnant cattle after inoculation with Neospora caninum

13 páginas, 4 tablas, 2 figuras.Neospora caninum is recognized as a major cause of reproductive losses worldwide but its pathogenesis is not completely understood. Immune mediated placental pathology has been reported as being responsible for compromising pregnancy probably due to the adverse effects of exacerbated Th1 type response at the maternal-foetal interface. Different clinical outcomes are known to occur following experimental infections of cattle at different stages of gestation, with foetal death being the most common finding during early gestation, and the birth of live congenitally infected calves following infection later in gestation. The aim of the current study was to characterize the cytokine expression in the placenta of cattle experimentally challenged with tachyzoites of the Nc-1 strain during early, mid and late gestation. Moderate to severe infiltration of IL-12, IFN-γ and TNF-α expressing cells was observed in the placentas collected at early gestation and this infiltration was more pronounced in the samples collected from challenged dams carrying non-viable foetuses, compared with the mothers carrying viable foetuses. In contrast, the infiltration of Th1 cytokine expressing-cells was mild following N. caninum infection in mid gestation and scarce during infection in late gestation. Scarce expression of IL-4 was observed in the placentas from N. caninum-challenged and negative control animals throughout gestation. The milder Th1 immune response observed during later stages of gestation following Nc-1 infection could partially explain the less severe clinical outcome when compared to early pregnancy. © 2014 Elsevier B.V.The authors acknowledge the Scottish Government's Rural and Environment Science and Analytical Services Division (RESAS), UK, and Instituto Nacional de Tecnología Agropecuaria (INTA), Argentina.Peer Reviewe