A Host state regulatory right in Fair and Equitable Treatment (FET) in Bilateral Investment Treaties (BITs)

A host state has become a victim of “fair and equitable treatment” investment standard offered to the foreign investment protection. Foreign investment dissatisfied with host state legitimate public measures affecting their investment demand FET protection alleging investment protection violation. Foreign investors strong pitching for FET standard protection subordinating every sovereign host state regulatory action is creating friction between the parties. While host state insists non-discriminatory police power inherited in FET regulation for public measures, in contrast, foreign investors demand absolute protection of foreign investment. Emerging and developing host country were early targets of foreign investment. A capital export from developed source state to emerging and developing host state is not anymore unidirectional but bidirectional. The investment from emerging and developing economies to developed countries are in rapid increase. Earlier emerging and developing host country were in voracious attack from established source state foreign investors. These suffering host states were fighting for their sovereign rights to regulate for public protection and interests, however, no to avail. Developed source state supporting implicitly for their investor’s investment protection became a victim of themselves. Rules applied to other became a loop to themselves whom they are now fighting to defend host state administrative rights for the public purpose. The absolute FET has become more fickle and in a way of balancing stage recognising outstanding and value of regulatory rights in FET. My dissertation explores on the same line that FET protection standard for foreign investors and their investment is reciprocal to host state just and equitable regulatory public measures. Host state non-discriminatory measures are non-compensable and legitimate of sovereign rights when public protection and security demands. This adduces long believed and practiced host state necessary steps of domestic law and order. It is evidence by Modern Model BIT, in arbitration practices and even developed source states opposing absolute FET standard protection. These methods proved that predatory nature of alleging FET violations are not only harming host country but also negativity in foreign investors and their investment. The future is not about only host state rights regulatory measures but also foreign investors and their investment self-regulatory measures like corporate social responsibility

Practice of Women's Rights in Himalayan Region Focused on Upper Mustang.

This study is focused on the women and girls of 7 villages called Upper Mustang and middle Mustang in Mustang district. To explore the situation of women and girls with the angle of their rights as per the provisions made by international convention and national legal aspects is the main objective of the study. About 60 women and girls are interviewed, experts and authority have been consulted and the focal group discussions and verification meetings are held with the intensive observation of two weeks to get the objective respecting all the formalities of the research methods. Finally findings and recommendations have been made that the lack of the government policy and program for the facilitation and supporting to the women and girls in the region is the point which is highlighted with the several logic and evidences. A glimpse on the findings of the study can be synopsized as follows: • Women and girls have got more workload than the men and boys in the region of Upper Mustang • About 95 percent of the women have not got any fix property in their names • Women and girls are deprived to the opportunity and facility of the education and health care • They don’t have knowledge on their rights defined by international conventions and local legislative • They don’t have access to the proper agencies for the remedies as they been assaulted and abused • More than two thousands women and girls are desperately waiting for the supports that bring them up turning to be a normal citizen of the civilized society respecting all ideal indicators

A conserved domain important for association of eukaryotic J-protein co-chaperones Jjj1 and Zuo1 with the ribosome

AbstractJ-proteins, obligate co-chaperones, provide specialization for Hsp70 function in a variety of cellular processes. Two of the 13 J-proteins of the yeast cytosol/nucleus, Zuo1 and Jjj1, are associated with 60S ribosomal subunits. Abundant Zuo1 facilitates folding of nascent polypeptides; Jjj1, of much lower abundance, functions in ribosome biogenesis. However, overexpression of Jjj1 substantially rescues growth defects of cells lacking Zuo1. We analyzed a region held in common by Zuo1 and Jjj1, outside the signature J-domain found in all J-proteins. This shared “zuotin homology domain” (ZHD) is important for ribosome association of both proteins. An N-terminal segment of Jjj1, containing the J-domain and ZHD, is ribosome-associated and, like full-length Jjj1, is competent to rescue both the cold- and cation-sensitivity of ∆zuo1. However, this fragment, when expressed at normal levels, cannot rescue the cytosolic ribosome biogenesis defect of ∆jjj1. Our results are consistent with a model in which the primary functions of Zuo1 and Jjj1 occur in the cytosol. In addition, our data suggest that Zuo1 and Jjj1 bind overlapping sites on ribosomes due to an interaction via their common ZHDs, but Jjj1 binds primarily to pre-60S particles and Zuo1 to mature subunits. We hypothesize that ZUO1 and JJJ1, which are conserved throughout eukaryotes, arose from an ancient duplication of a progenitor J-protein gene that encoded the ZHD ribosome-binding region; subsequently, specialized roles and additional ribosome interaction sites evolved

Variation in brachial plexus formation, branching pattern and relation with major vessels

Background: Anatomical variations in the formation, branching pattern and relations of the brachial plexus have been described in humans by many authors; however these have not been extensively catalogued. The aim of the study was to describe variations in brachial plexus formation, branching pattern and relation with major vessels.Methods: This study included thorough dissection of 60 brachial plexuses which belonged to 30 cadavers (male: female ratio = 28:02 ) with age range of 20-60 years, obtained from the Department of Anatomy, College of Medical Sciences (CMS-TH), following standard guidelines. Results: Out of 60 limbs dissected in present study, the variation in formation was found in 20 limbs (33.3%), out of which 12 limbs (20%) had variations in the trunk and 8 limbs (13.3%) had variations in the cord, remaining 40 limbs (66.6%) were normal in the formation of brachial plexus. Normal branching pattern of the posterior cord was encountered in 52 (86.67%) limbs, the remaining 8 (13.33%) being variants in one form or the other. The upper subscapular nerve, the thoracodorsal nerve, the lower subscapular nerve and the axillary nerve were found to arise normally in 91.66%, 96.66%, 96.66% and 98.33% of the limbs respectively.Conclusion: The present study carried out on adult human cadavers revealed some rare variations in the formation, branching pattern and relations of the brachial plexus. These variations are of clinical significance for the surgeons, radiologists and the anesthesiologists.

Nepal paediatric society clinical guidance for management of sepsis and septic shock in the paediatric intensive care units in Nepal

Justification: Sepsis is a major cause of morbidity and mortality in Nepal. There is a lack of standardisation in the management of severe sepsis and septic shock. Additionally, international guidelines may not be completely applicable to resource limited countries like Nepal. Objective: Create a collaborative standardised protocol for management of severe sepsis and septic shock for Nepal based on evidence and local resources. Process / Methods: Paediatricians representing various paediatric intensive care units all over Nepal gathered to discuss clinical practice and delivery of care of sepsis and septic shock under the aegis of Nepal Paediatric Society. After three meetings and several iterations a standardised protocol and algorithm was developed by modifying the existing Surviving Sepsis Guidelines to suit local experience and resources. Recommendations: Paediatric sepsis and septic shock definitions and management in the early hours of presentation are outlined in text and flow diagram format to simplify and standardise delivery of care to children in the paediatric intensive care setting. These are guidelines and may need to be modified as necessary depending on the resources availability and lack thereof. It is recommended to analyse data moving forward and revise every few years in the advent of additional data

Use of Smart Mobile and Web Application Kobotoolbox/ Kobocollect for Community Health Diagnosis: Sharing Experience from the Remote Area of Nepal

Community Health Diagnosis (CHD) is part of teaching-learning activities at medical and public health schools to recognize the health-related issues in the community, identify social and other problems in depth, and find solutions by shaking hands with community people. Every year, the household survey is conducted by medical, nursing, and public health students as a part of CHD. Our experiences revealed that the student faces several challenges while using paper-based data collection and management during CHD. To overcome such challenges, we used a web-based and smart mobile application called KoboToolbox/KoboCollect to conduct household surveys in CHD in remote areas of Nepal for the first time. Our experience suggests that mobile-based Applications can be used conveniently in CHD which saves time and money for students as well as for schools and can conserve the environment trees. Those students who are not familiar with smart technology need to be trained before using this app

Gestational Age Specific Postnatal Growth Curves for Singleton Babies in Tertiary Hospital of Western Nepal

Introduction: Measurement of birth weight (BW), crown heel length (CHL), head circumference (HC) and chest circumference used to assess the intrauterine growth of a baby vary with altitude, race, gender, socio economic status, maternal size, and maternal diseases. The study aimed to construct centile charts for BW, CHL and HC for new born at different gestational ages in western Nepal. Methods:  This was a descriptive cross sectional study done over a period of 15 months in a tertiary care hospital of western Nepal. BW, length, HC and CC were measured within 12-24 hours of birth. Gestational age was estimated from first day of last menstrual period, maternal ultrasonology and New Ballard’s scoring system. Microsoft 2007 Excel and SPSS-16 was used for data analysis. Cole’s Lambda Mu Sigma method was used for constructing centile curves. Results: Out of 2000 babies analysed, 1910 samples were used to construct smoothed intrauterine growth curve of BW, CHL, and HC from 33-42 weeks of gestation. 57.35% (1147) were male, mean gestational age was 38.13 ±2.44 weeks, where 21.5% were preterm and 1.7% post term. The means of BW, CHL, HC and CC were 2744.78 gm, 47.80 cm, 33.18 cm, and 30.20 cm with standard deviations of 528.29, 3.124, 1.78, and 2.35 respectively. These data vary as compared to the Kathmandu data, in case of birth weight for 10th and 90th centiles, and at 90th centile in case of length. Conclusions: This necessitates the update in the existing growth charts and develop in different geographical regions of a country

Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is a very common indication for liver transplantation. How fat-rich diets promote progression from fatty liver to more damaging inflammatory and fibrotic stages is poorly understood. Here, we show that disrupting phosphorylation at Ser196 (S196A) in the liver X receptor alpha (LXRα, NR1H3) retards NAFLD progression in mice on a high-fat-high-cholesterol diet. Mechanistically, this is explained by key histone acetylation (H3K27) and transcriptional changes in pro-fibrotic and pro-inflammatory genes. Furthermore, S196A-LXRα expression reveals the regulation of novel diet-specific LXRα-responsive genes, including the induction of Ces1f, implicated in the breakdown of hepatic lipids. This involves induced H3K27 acetylation and altered LXR and TBLR1 cofactor occupancy at the Ces1f gene in S196A fatty livers. Overall, impaired Ser196-LXRα phosphorylation acts as a novel nutritional molecular sensor that profoundly alters the hepatic H3K27 acetylome and transcriptome during NAFLD progression placing LXRα phosphorylation as an alternative anti-inflammatory or anti-fibrotic therapeutic target

Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector

Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02  TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1  μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos⁡2Δϕ modulation for all ΣETPb ranges and particle pT