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12 research outputs found

MicroRNA profiling reveals age-dependent differential expression of nuclear factor κB and mitogen-activated protein kinase in adipose and bone marrow-derived human mesenchymal stem cells

Author: Bunnell Bruce A
Gimble Jeffery M
Glowacki Julie
Kaushal Deepak
O'Sullivan Regina P
Pandey Amitabh C
Semon Julie A
Publication venue: BioMed Central
Publication date: 01/01/2011
Field of study

Introduction: Mesenchymal stem cells (MSCs) play a central role in mediating endogenous repair of cell and tissue damage. Biologic aging is a universal process that results in changes at the cellular and molecular levels. In the present study, the role of microRNA (miRNA) in age-induced molecular changes in MSCs derived from adipose tissue (ASCs) and bone marrow (BMSCs) from young and old human donors were investigated by using an unbiased genome-wide approach. Methods: Human ASCs and BMSCs from young and old donors were cultured, and total RNA was isolated. The miRNA fraction was enriched and used to determine the expression profile of miRNA in young and old donor MSCs. Based on miRNA expression, differences in donor MSCs were further investigated by using differentiation assays, Western blot, immunocytochemistry, and bioinformatics. Results: Biologic aging demonstrated reduced osteogenic and adipogenic potential in ASCs isolated from older donors, whereas cell size, complexity, and cell-surface markers remained intact with aging. Analysis of miRNA profiles revealed that small subsets of active miRNAs changed secondary to aging. Evaluation of miRNA showed significantly decreased levels of gene expression of inhibitory kappa B kinase (I

\kappa

B), interleukin-1

\alpha

, inducible nitric oxide synthase (iNOS), mitogen-activated protein kinase/p38, ERK1/2, c-fos, and c-jun in MSCs from older donors by both bioinformatics and Western blot analysis. Nuclear factor kappa B (NF-

\kappa

B), myc, and interleukin-4 receptor mRNA levels were significantly elevated in aged cells from both the adipose and bone marrow depots. Immunocytochemistry showed nuclear localization in young donors, but a cytosolic predominance of phosphorylated NF-

\kappa

B in ASCs from older donors. Western blot demonstrated significantly elevated levels of NF-

\kappa

B subunits, p65 and p50, and AKT. Conclusions: These findings suggest that differential expression of miRNA is an integral component of biologic aging in MSCs

Crossref

Harvard University - DASH

PubMed Central

Missouri University of Science and Technology (Missouri S&T): Scholars' Mine

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

Author: Aawsaj Y.
Abad Gurumeta A.
Abad-Motos A.
Abate E.
Abatini C.
Abbadessa F.
Abbas A. M.
Abbassi-Ghadi N.
Abbott D.
Abbott T.
Abd Elazeem H. A. S.
Abdalla M.
Abdallah M.
Abdel Al S.
Abdel Jalil R.
Abdeldayem H.
Abdelkader Salama I.
Abdelkarem M. M.
Abdelkarim M.
Abdelmajeed A.
Abdelrahman A.
Abdelrahman S.
Abdelsamed A.
Abdou M.
Abdulkareem A.
Abdulwahed E.
Abdur-Rahman L.
Abel M. K.
Abellan M.
Aboelkassem Ibrahim A.
Abosamak N. E.
Abou Chaar M. K.
Abou-Khalil J.
Abouassi A.
Aboulkassem H.
Abreu Da Silva A.
Abu J.
Abu Za'nouneh F. J.
Abu-Nayla I.
Abubakar A.
Acebes Garcia F.
Achalandabaso Boira M.
Acher A.
Acrich E.
Adamina M.
Adamoli L.
Addae-Boateng E.
Aderombi A.
Adeyeye A.
Adiamah A.
Adishesh M.
Agapov M.
Aggarwal A.
Aghayeva A.
Agilinko J.
Agnes A.
Agostini C.
Agoston P.
Agrawal A.
Agresta F.
Aguado H.
Aguilar Gonzalez M.
Aguzzoli L.
Ahad S.
Ahmadi N.
Ahmeidat A.
Ahn J. H.
Aiken T.
Aime A.
Ajlan A.
Akalin M.
Akaydin E.
Akeel N.
Akgor U.
Akhtar M. A.
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Akilli H.
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Akmenkalne L.
Al Abdallah M.
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Yang W.
Yassin N.
Ye G.
Yesantharao P.
Yesilyurt D.
Yetkin G.
Yiallourou A.
Yildirim A.
Yildiz A.
Ying Y.
Yip V.
Yordanov S.
Young R.
Yousof E. A.
Youssef A.
Youssef M.
Yuksel E.
Yurttas C.
Zacharoulis D.
Zafar S. N.
Zakai D.
Zakaria A. D.
Zakaria R.
Zakaria Z.
Zambelli M. F.
Zambon M.
Zamora L.
Zamvar V.
Zani S.
Zanotti S.
Zanus G.
Zapardiel I.
Zarabini A. G.
Zatecky J.
Zegarac M.
Zelic M.
Zeller N.
Zengin A. K.
Zerbib P.
Zervas K.
Zese M.
Zhang H.
Zivanovic M.
Zivkovic M.
Zizzo M.
Zografos C.
Zonta S.
Zorrilla Ortuzar J.
Zourntou S.
Zouzoulas D.
Zubaidi A.
Zullo A.
Publication venue: J Clin Oncol
Publication date: 01/01/2020
Field of study

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

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Institutional Research Information System University of Turin

Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

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Abad-Motos A.
Abate E.
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Vieira B.
Vieira Caroco T.
Vieira P.
Vieira Paiva Lopes A. C.
Vignali A.
Vigorita V.
Vijayan D.
Vilatoba M.
Vilendecic Z.
Villalabeitia Ateca I.
Vimalachandran D.
Vinayagam R.
Violante T.
Visgauss J.
Viswambaram P.
Viswanath Y.
Vitali A.
Vitone L.
Vives R. V.
Vo U. G.
Vogel J.
Vollkommer T.
Von Papen M.
Vovola F.
Vucic N.
Vujanac V.
Wade R.
Wadham B.
Waheed S.
Wai K.
Wali A.
Walker C.
Walker D.
Walkes K.
Wallwork K.
Walton G.
Walton T.
Waqar S. H.
Warburton H.
Ward D.
Ward S.
Waris Farooka M.
Warren O.
Waseem S.
Wasim T.
Watson D.
Watson L. J.
Watson N.
Weaver H.
Webber L.
Weitz J.
Welsch T.
Wensley F.
Werner J.
West C.
West D.
Westwood E.
Whelan M.
Whelan P.
Whisker L.
Whitehall E.
Whitmore H.
Wilkin R.
Wilkins A.
Williams G.
Williams J.
Williams K.
Williams M. A.
Williams T.
Williamson K.
Wilson M.
Wimberger P.
Wimmer A.
Winnand P.
Winter D.
Winter S.
Wolfer S.
Wong M. P. K.
Wong S.
Wong W. J.
Woodham A.
Woodun H.
Worku D.
Wright G.
Wullschleger M.
Wustrack R.
Xenaki S.
Xu M. J.
Xyda S. E.
Xynos E.
Yahaya A. S.
Yanez C.
Yang W.
Yassin N.
Ye G.
Yesantharao P.
Yesilyurt D.
Yetkin G.
Yiallourou A.
Yildirim A.
Yildiz A.
Ying Y.
Yip V.
Yordanov S.
Young R.
Yousof E. A.
Youssef A.
Youssef M.
Yuksel E.
Yurttas C.
Zacharoulis D.
Zafar S. N.
Zakai D.
Zakaria A. D.
Zakaria R.
Zakaria Z.
Zambelli M. F.
Zambon M.
Zamora L.
Zamvar V.
Zani S.
Zanotti S.
Zanus G.
Zapardiel I.
Zarabini A. G.
Zatecky J.
Zegarac M.
Zelic M.
Zeller N.
Zengin A. K.
Zerbib P.
Zervas K.
Zese M.
Zhang H.
Zivanovic M.
Zivkovic M.
Zizzo M.
Zografos C.
Zonta S.
Zorrilla Ortuzar J.
Zourntou S.
Zouzoulas D.
Zubaidi A.
Zullo A.
Publication venue: 'American Society of Clinical Oncology (ASCO)'
Publication date: 01/01/2021
Field of study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Archivio istituzionale della Ricerca - Università degli Studi di Parma

Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

Author: Abbas Sh
Abbas Sh
Abbassi Oa
Abbott T
Abdelgadir Am
Abdelrahman A
Abdelrahman M
Abdelrahman M
Abdelwahed A
Abellan M
Abellán Am
Abellán Am
Abulafi M
Acharya A
Acosta A
Adam Me
Adams Re
Adegbola So
Adegbola So
Adimonye A
Adnan M
Afshar S
Agresta F
Agua Ia
Aguayo Jl
Agudo Ar
Ahad A
Ahel J
Ahern Dp
Ahmad A
Ahmed B
Ahmed G
Ahmed Os
Ahmed Os
Ahmed S
Ainsworth P
Ais G
Ais G
Aisoni F
Akbari K
Akhtar K
Akinsola O
Akram F
Al-Faham Z
Al-Khafaji N
Al-Khyatt W
Al-Musawi S
Al-Sarireh B
Al-Sheikh M
Alagna V
Alani M
Alberca-Paramo A
Aldrey I
Alexander R
Alhammali T
Alhammali T
Ali M
Aljorfi A
Allen M
Allington J
Alonzo A
Alshafei A
Altomare Ma
Alvarez Cm
Alvarez E
Alvarez-Gallego M
Amaducci E
Amarasinghe R
Amayo A
Ambrona-Zafra D
Amin V
Ammendola M
Amtul N
Amtul N
Amuthalingam T
Anandan L
Anania G
Anania M
Anderson Dj
Anderson O
Andolfi E
Andreani Sm
Andreani Sm
Andrews B
Ang A
Ang A
Angelieri D
Angelini M
Angrisani M
Anguita F
Ansaloni L
Ansari A
Aravind B
Archer Je
Arcuri Ga
Arcuri Ga
Aremu Ma
Arenal-Vera Jj
Aresu S
Aresu S
Argenio G
Argenti F
Armellini A
Arnau M
Arredondo J
Arroyo A
Arshad F
Arunachalam S
Arunachalam S
Arunachalam S
Aruparayil N
Asensio-Gomez L
Ashmore Dl
Ashmore Dl
Ashour O
Ashraf N
Asmadi Aa
Assaf N
Assaf N
Assaf N
Athersmith Mj
Atzeni J
Avalapati H
Avanzolini A
Avanzolini A
Awokoya Oo
Ayllón-Gámez S
Ayube-Brown J
Azabdaftari A
Azevedo J
Azevedo Jm
Baddams Ts
Badenoch T
Badii B
Badran A
Baeza-Murcia M
Bagga R
Baginski A
Bailey Ja
Bailey S
Bailey S
Bailon-Cuadrado M
Baird C
Bairos F
Baker B
Balai Ej
Balasubramaniam A
Balestra F
Ball A
Ball A
Ball A.
Ballabio M
Ballester Mm
Bandyopadhyay Sk
Banks A
Bansal H
Baraghini M
Barbosa L
Barker T
Barker T
Barnieh W
Baronio G
Baronio G
Barrie A
Barter Ca
Bartoli A
Bascuas-Rodrigo B
Baseggio M
Bastianpillai J
Bawa S
Baz-Figueroa C
Bazán-Hinojo Mc
Bazán-Hinojo Mc
Beasley Wd
Bedoya S
Beggs A
Bell Cr
Bell J
Bellochi R
Beltran-De-Heredia J
Beltran-De-Heredia J
Belvedere A
Benevento A
Bennett Jm
Beral D
Beral D
Bernal-Sprekelsen Jc
Berry B
Berti S
Bevan Ke
Bevan V
Beverstock A
Bhanderi S
Bhanderi S
Bhanderi S
Bhanderi S
Bhanderi S.
Bhangu A. Nepogodiev D
Bhangu A
Bhangu A
Bhangu A
Bhangu A
Bhargava A
Biancafarina A
Biancafarina A
Bianchi Cl
Bianchi Cl
Bianco A
Bilku D
Birindelli A
Birindelli A
Birindelli A
Blackford Od
Blackwell J
Blake L
Blanco F
Blanco-Colino R
Blanco-Colino R
Blanco-Colino R
Blanco-Colino R
Blanco-Colino R.
Blazeby Jm
Blencowe N. S.
Blencowe Ns
Blencowe Ns
Blencowe Ns
Blencowe Ns
Boddy Ap
Boereboom C
Bogdan M
Bohra P
Boland M
Boland M
Bolger Jc
Bolger Jc
Bolton W
Bolzon S
Bond S
Bond-Smith G
Bondurri A
Bonfante P
Bonomo M
Borg Cm
Borges Fc
Borghi F
Borghol K
Boshier Pr
Botelho P
Bowen J
Bowerman H
Bowley D
Bowman Cr
Bowman Cr
Boyd-Carson H
Boza K
Bradshaw Cj
Branagan G
Bravo-Gutiérrez Af
Bravo-Gutiérrez Af
Brennan S
Brett M
Brewer H
Brewer Hk
Brewer Hk
Brews R
Brien Jo
Bronder C
Brown A
Brown Ag
Brown Ce
Brown Ce
Brown Ce
Brown M
Brown M
Brown Od
Brown R
Bruce Js
Brunelli Db
Bryan Es
Buckley-Jones S
Bukhari W
Bull C
Bullivant Jk
Burke J
Burns Km
Burnside D
Busuttil A
Byrne Be
Byrnes Ck
Caballero A
Caldeira Ab
Caldwell M
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Calussi M
Calvo H
Calvo M
Cameron Fc
Campagnaro T
Campagnaro T
Campbell U
Campbell Um
Campbell W
Cannata G
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Capelli P
Carcoforo P
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Carder C
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Cardoso D
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Carrano Fm
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Cartwright H
Carvalho Lc
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Casimiro C
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Caula C
Caula C
Cavallo D
Cavero A
Cay P
Ceccarelli G
Cerdán-Santacruz C
Cerdán-Santacruz C
Cerdán-Santacruz C
Cerdán-Santacruz C
Cervellera M
Cesari Mc
Chalk A
Chambers B
Chan D
Chan T
Chan Wh
Chandler Sb
Chandratreya N
Chandratreya N
Chapman J
Chapman Sj
Chapple Ks
Charalabopoulos A
Charalambous Mp
Chasty B
Chatzikonstantinou M
Chatzikonstantinou M
Chauhan P
Chauhan P
Chauhan P.
Cheah Wl
Chean Cs
Chean Cs
Checcacci P
Cheng Sa
Cheruvu M
Chessa A
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Chetta G
Chetta N
Chianese G
Chillitupa Cz
Chimetto A
Chin My
Chishti Ia
Chitsabesan P
Chng S
Choi S
Chok Sm
Chok Sm
Chong B
Choolani-Bhojwani E
Choong Jh
Choong Jh
Choong Jh
Chowdhary M
Chowdhury F
Chowdhury F
Choy Ch
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Chrastek D
Christian L
Christides A
Christopoulos P
Chudek D
Chui K
Cianchi F
Cidoncha A
Cillara N
Cillara N
Cillara N
Cipparrone M
Cirillo B
Clark Gl
Clark S
Clement Kd
Clement Kd
Clements B
Clements C
Clements J
Clements J.
Clements Ja
Clements Jd
Clements Jm
Clements Jm
Clements Js
Clerici F
Clingan R
Cloney L
Clough E
Coccolini F
Coccolini F
Cocorullo G
Coe Po
Cohen Ja
Colangelo E
Coletta D
Coletta D
Coletti M
Collado-Roura F
Collier-Wakefield O
Colombo F
Colombo F
Colvin Da
Colvin Da
Compagnoni B
Conci S
Connelly Tm
Connor Kl
Connor Kl
Connor Mj
Connor Mj
Conti D
Contine Ac
Contreras Rg
Contreras-Saiz E
Cook V
Cooke F
Coppola M
Coratti F
Corbellini C
Cordoba E
Cordoba E
Cormenzana Ob
Correia D
Correia J
Cortés Gv
Cosci M
Cossu F
Costa Sd
Costamagna D
Cotton Ae
Couch Dg
Cousins L
Couso Jr
Cox M
Coyle D
Creasy W
Cremades P
Criado Adc
Crone A
Crozier J
Cruccu A
Cruickshank N
Cuadrado Mm
Cucinotta E
Cuello-Guzmán E
Cunha P
Currow C
Curti R
Curtis Nj
Curtis-Martínez C
Cynthia G
Cánovas-Moreno G
D'Ambra L
D'Amico Fe
D'Amico Fe
D'Amico Fe
D'Auria M
D'Auria M
D'Souza N
Daga O
Dalmia S
Dandy R
Daniels I
Danquah-Boateng D
Dar Fa
Dar Fa
Dart K
Das A
Daureeawoo R
Davidson Jr
Davidson S
Davies Pl
Davis S
De Andres U
De Burgos Cb
De Chaves-Rodríguez Pg
De Freitas S
De Luca E
De Marchi F
De Marco P
De Nardi P
De Nardi P
De Nisco C
De Padua C
De Prizio M
De-La-Herranz-Guerrero P
De-Manzoni-Garberini A
De-Manzoni-Garberini A
De-Manzoni-Garberini A
De-Marchi Ja
De-Marchi Ja
De-Soto-Cardenal B
Dean Ea
Dean S
Del Basso C
Del Pozo E
Del-Valle-Ruiz Sr
Delgado-Plasencia Lj
Delimpalta C
Delimpalta C
Delogu D
Denley S
Dennison G
Depalma N
Deserra A
Desiderio J
Devezas V
Devine Aa
Dhar M
Dharamavaram S
Dhari Aa
Dhesi S
Di Cintio A
Di Franco F
Di Gioia P
Di Saverio S
Di Zitti L
Diaz A
Dickson Ea
Divekar Ga
Dixon F
Dobbs S
Dobson C
Docherty Ja
Doherty C
Dominguez-Sanchez C
Donaldson G
Donaldson G
Donohoe No
Donohoe No
Douka E
Doulias T
Dova L
Downey M
Doyle C
Doyle C
Drake T. M.
Drake Tm
Drye N
Du Dt
Dubois As
Dubois As
Dudek Jg
Dujovne P
Dujovne P
Dunning Pg
Duran-Muñoz-Cruzado Vm.
Durbacz M
Dyal A
Dyson S
Díaz-Vico T
Eardley Nj
Earnshaw L
Easdon S
Ebied H
Echazarreta E
Edwards Se
Egan Rj
Egan Rj
Eguaras I
Eiben I
Eiben Ie
Eiben P
El-Masry S
El-Tayar O
El-Tayar O
Elbetti C
Elgaddal S
Elia M
Ellis B
Elseedawy M
Elshaer M
Elshaer M
Emslie Km
Engall N
Engall N
Engall N
English Wj
Ercolani G
Erdas E
Erdas E
Eretta Co
Escoll-Rufino J
Escuder J
Esmail Hd
Espin-Basany E
Espin-Basany E
Espina B
Espinosa J
Esteves Mb
Ettles C
Evans J
Evans Jd
Everden A
Evoli Le
Ezerska E
Fadel M
Fahmy Se
Fahmy Se
Fairfield Cj
Falaschi F
Falco N
Fanibi Bf
Fareleira A
Farhan-Alanie M
Farina V
Faris Ar
Farrell Sm
Farrow Ez
Farrow Ez
Farrés R
Fasuyi Ja
Faulkner G
Fawzi F
Fehervari M
Feleppa C
Feliu F
Feo Cv
Ferguson N
Fermiñán A
Fernandes C
Fernández Ec
Fernández Md
Fernández-Candela A
Fernández-Martínez D
Fernández-Martínez D
Fernández-Martínez D
Feroci F
Ferrara F
Ferrara F
Ferreira Js
Ferreira Ms
Ferrer-Vilela I
Fijo Lm
Finch Jg
Finlayson H
Finotti E
Fiore L
Fiorot A
Flack T
Fleming Ta
Fleres F
Foers W
Foley Nm
Foley Nm
Fontaine C
Fontana T
Fontani A
Fooks P
Foppa C
Forgie A
Fornasier C
Fornell-Ariza M
Forouzanfar A
Foschi D
Foster A
Fox A
Francis N
Franco M
Francone E
Francone E
Franklin D
Frasson M
Frasson M
Frasson M
Frasson M
Frasson M.
Froud H
Fueyo J
Fung E
Gabbianelli C
Gaines E
Gallo G
Gallo G
Galofre-Recasens M
Galvez P
Gamero-Huaman Jc
Gammeri E
Gammeri E
Gammeri E
Garcea A
Garcea A
Garcea G
Garcia-Marin Ja
García M
García M
García Na
García V
García-Carrero M
García-Catalá L
García-Catalá L
García-Granero A
García-Granero A
García-Gutierrez C
García-Novoa A
García-Novoa A
García-Pérez Jm
García-Rivera Co
García-Santos E
Garg Ag
Garg Ag
Garnham J
Garrido L
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Garvin J
Garzi A
Gates Z
Gatti M
Gavagna L
Gavagna L
Gee O
Gemini A
Gennai A
Gentry R
Genzor S
Geretto P
Ghaffari I
Ghatorae S
Ghazala R
Ghazanfar Ma
Giaccari S
Giani I
Gidwani Al
Gil J
Gilbert A
Gilbert Tg
Gilbert Tm
Gilbert Tm
Gilgan J
Gill S
Gillespie M
Gillick J
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Giraudo G
Giubilo C
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Giuliani Ng
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Glasbey Jc
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Glen P
Golda T
Golder Am
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Gomes Ap
Gomez Cj
Gomez-Carmona Z
Gomez-Facundo H
Gomez-Rosado Jc
Gomez-Rosado Jc
Gonzalez M
González-Nicolás T
Gonzálvez-Guardiola P
Gonçalves D
Gopalakrishnan K
Gopalswamy S
Gopinath S
Gordini L
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Grifell Ms
Griffith D
Griffith Jp
Griffiths E
Griffiths Ea
Griffiths Np
Griffiths Np
Griffiths Sn
Griggs R
Grimaldo Eg
Groppo G
Grosvenor S
Grove T
Guerra F
Guevara-Martinez J
Guglielmi A
Guimarães Jm
Gulamhussein M
Guliani J
Gummaraju A
Gunning S
Gurjar Sv
Guru-Naidu S
Gurung S
Gusai Gp
Gómez Aa
Gómez Aa
Gómez N
Gómez-Abril Sa
Habib H
Hackney L
Haddow Jb
Haddow Jb
Hagger R
Haines S
Hajibandeh S
Halkias C
Halmer S
Hamelmann Rn
Hanif Z
Hanley C
Hann Aj
Hann Aj
Hanna T
Hannan E
Hannay J
Harder G
Hardy E
Harlinska A
Harper F
Harries Rl
Harris G
Harris Mp
Hartnett J
Hasan R
Hassane A
Hatt Jr
Haveliwala Z
Hawkins W
Hayat Z
Hayes C
Hebbar K
Hebbar K
Henderson L
Henderson L
Hernaez A
Hernandez-Gimenez L
Hernando A
Herrod P
Herrod P
Herrod P
Herrod P. J. J.
Hever P
Hickey Lm
Hickey Lm
Hickey Lm
Hicks G
Hicks G
Hidalgo-Rosas Jm
Hill Ad
Hill Ad
Hill J
Hobson Bm
Hodgson Jm
Hoff M
Hollingsworth A
Hollyman M
Hollyman M
Hontoria Ms
Hook A
Hornby St
Hornby St
Horsfield E
Howie Ee
Hraishawi I
Huang J
Hudson-Peacock Nj
Hudson-Peacock Nj
Hunter I
Hureibi Ka
Hureibi Ka
Hussain A
Hussain N
Hussaini Sa
Hussein A
Hussein A
Hutchinson B
Iannone I
Ibrahim Y
Ikram S
Ilozue T
Imperatore M
Inama M
Inama M
Infante H
Iosif E
Iqbal Mr
Iqbal Mr
Irukulla S
Irwin R
Isherwood Jd
Islam N
Islam S
Isolani Sm
Issa E
Issa E
Itsurg
Ivey P
Jackson A
Jackson Nj
Jah S
Jain A
Jain S
Jain S
Jama Gm
Jamieson Nb
Jamieson Nb
Jamieson Nb
Janardanan S
Jansen T
Jasinski B
Jenkins M
Jenner D
Jerome E
Jimenez-Ballester Ma
Jiménez-Rosellón R
Johnson J
Johnston Z
Johnstone A
Jokhan S
Jones A
Jones Cs
Jones E
Jones E
Jones L
Jones N
José Hs
João Aa
Julià D
Jung J
Kabir M
Kabir U
Kabwama S
Kalia K
Kamal M
Kamande Iw
Kamande Iw
Kanakala V
Kannegieser-Bailey M
Kaptanis S
Kara A
Kara A
Karim Mj
Karim Mj
Karwal Rs
Kaubrys M
Kaur G
Kay Oh
Kay Oh
Keegan R
Kelly M
Kelly Sd
Kennedy Nd
Kennedy Nd
Kennedy Nd
Kent Da
Khair A
Khan K
Khan Ms
Khan S
Khasria A
Khaw Ra
Kho H
Kilkenny J
Kinross J
Kirkby-Bott J
Kirkham En
Knight B
Knight Ka
Knight Sr
Knight Sr
Kochupapy R
Kong Cy
Kosti A
Kosti A
Kouli O
Kouroumpas E
Krishnamoorthy A
Krivan S
Kumar K
Kumar S
Kung V
Kung V
Kuo R
Kälviäinen Hk
La Valle G
Ladwa N
Lafaurie G
Lai Cw
Lal N
Lal N
Landaluce-Olavarria A
Landaluce-Olavarria A
Lara Mc
Lara-Fernandez Y
Lau E
Laughlin Dm
Laurenson M
Laviano E
Law Jj
Lawday S
Lawday S
Layman S
Layton Gr
Lazzari G
Lazzaro A
Lecky-Thompson L
Lee Ka
Lee Ka
Lee Kj
Lee M
Leighton Pa
Leitch Rp
Lek C
Lennox-Warburton Hc
Leon C
Leung El
Leusink A
Li Ch
Liaw G
Licari L
Lim Jm
Lima F
Lima M
Limb C
Limbada M
Listorti C
Littlehales Dj
Lizzi V
Ljungqvist G
Llacer E
Llewelyn O
Lloyd G
Lodhia S
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Long P
Long Rh
Longheu A
Longshaw A
Lopez M
Lopez M
Lopez M
Lopez-Duran Bl
Lopez-Ruiz Ja
Lorettu A
Louro Hc
Louw C
Lucchi A
Lucchi A
Lui Dh
Lund Jn
Lund Jn
Luzzi Ap
Ly C
Lynch L
Lyons A
López Af
Ma J
Macinnes E
Macinnes E
Macleod C
Maderuelo Vm
Maffioli A
Magalhães Js
Magnoli M
Magro T
Mahapatra R
Mahendran B
Mahmood F
Mahmood F
Mahmoud A
Mahon D
Mahon-Daly Fp
Mahoney R
Mai D
Maina A
Makhija R
Malabarba S
Malam Y
Malik A
Malik A
Malik K
Malik Sn
Malik Y
Mambrilla-Herrero S
Manas Oc
Manda Vm
Manektella Km
Manias T
Mann C
Manoharan P
Manson R
Mansoor S
Mansour Mm
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Maqboul F
Maragouthakis D
Marangoni G
Marano A
Marano L
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Mardhiah S
Maretto I
Marinello F
Maripi H
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Marsh L
Marshall Cm
Marshall G
Martin A
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Mashar R
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Mathew G
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Matthews Jh
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Mcilwrath Ac
Mcintyre R
Mckay Sc
Mckelvie Ma
Mckenna M
Mckeon J
Mckevitt Kl
Mckinley Nc
Mckinley Nc
Mcmahon Sv
Mcmorran D
Mcnally L
Mcquaid M
Mcwhirter Dm
Mealy K
Medina-Arana V
Mehigan B
Melis A
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Menzies D
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Merai H
Merichal-Resina M
Merker L
Merlini Da
Mersh Rj
Mersh Rj
Messias Fm
Messina A
Mestres-Petit N
Michelini M
Miegge A
Miegge A
Miguras M
Milgrom D
Millan M
Miller B
Miller K
Milward J
Miranda E
Mirza S
Misky At
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Mistry D
Mitchard Mj
Mitchell Jh
Mitru Rm
Moggia E
Mohamed I
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Mohamed I.
Mohamed Im
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Mohamed Wo
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Moratalla Cn
Moreda R
Moreno-Gijón M
Moreno-Suero F
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Morgan R
Morley G. L.
Morley Gl
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Moroni P
Morowala A
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Morrison T
Morrison-Jones V
Morton Dg
Mothe Bs
Mothe Bs
Motiwala Fh
Motter D
Mowbray Ng
Mowbray Ng
Mozo As
Mughal Z
Muhibullah N
Muinelo M
Muinelo-Lorenzo M
Mulas S
Mulas S
Mulas S
Mulsow J
Mundkur N
Muntean A
Mura Fa
Muriel-Álvarez P
Murphy C
Murphy R
Murray Mp
Murru Ml
Mustafa Ak
Muzaffar M
Muñoz-Muñoz E
Myatt A
Nadeem A
Nagarajan D
Nagendram S
Nair A
Nair Mk
Nair Ms
Naismith Kn
Nambiar K
Nana Gr
Nana Gr
Napetti S
Nascimento Ca
Nash D
Nash Z
Nastro P
Naumann D. N.
Naumann Dn
Navarro G
Navarro-Morales L
Navas-Cuéllar Ja
Navas-Cuéllar Ja
Navas-Cuéllar Ja
Navas-Cuéllar Ja
Navidad Ms
Navidad Ms
Nazarian S
Nazarian S
Neagle G
Neale A
Neary Pm
Nehikhare I
Nelli T
Neophytou Gi
Nepogodiev D
Nepogodiev D
Nepogodiev D
Nepogodiev D.
Newton Rc
Newton Rc
Ng J
Ng M
Ng S
Ngu Ws
Ngu Ws
Niaz O
Nickson S
Nicol D
Nicolosi A
Nigro A
Nimako E
Niolu P
Nistri C
Nitti D
Nogueira St
Nora Mf
Norcia Gg
Nyeko-Lacek M
O'Brien J
O'Connor Br
O'Connor Br
O'Hagan Sc
O'Leary Dp
O'Neill E
O'Neill M
O'Neill N
O'Neill R
O'Sullivan D
Oakey M
Obeid N
Occhioni G
Odeh A
Ogboru S
Ogbuokiri C
Ojea-Ruiz-Yherla L
Okekunle B
Okorocha E
Olagbaiye O
Oliva I
Olivares-Oliver C
Oliver Jr
Olivier Jb
Olivier Jb
Olmos V
Ooi R
Orawiec P
Orizu M
Orizu M
Orlando G
Orme N
Ormiston R
Ormiston R
Osterberg A
Padilla E
Padilla-Valverde D
Paget C
Pais M
Pala M
Palani-Velu Lk
Palani-Velu Lk
Pan Y
Panagiotopoulos Sp
Panda N
Panda N
Panda N
Pandey V
Pandya D
Pandya R
Paniagua M
Pankin Gp
Papandrea M
Parajó Ae
Paramasevon Kr
Pareja-Ciuró F
Parisi A
Park Jh
Park Jh
Parkola Mj
Parra Jm
Parwaiz I
Pascua-Sole M
Pascual-Miguelañez I
Pasquali S
Pata F
Pata F
Pata F
Pata F
Pata F
Pata F.
Pata G
Pata G
Pata G
Patel As
Patel By
Patel By
Patel C
Patel H
Patel Mm
Patel N
Patel Pk
Patel Rt
Patil Sd
Patti S
Pau R
Payne Cj
Payne Re
Payá-Llorente C
Payá-Llorente C
Peacock M
Pearce J
Pearce J
Pearce L
Pearce L
Pearson R
Pedder A
Peirce Cb
Peiris Gb
Peixoto R
Peleki A
Peleki A
Pellegrino L
Pellicanò Ga
Pellicer-Franco E
Pellino G
Pento V
Pento V
Peponis C
Peprah D
Pereira A
Pereira Am
Pereira J
Pereira-Mosquera E
Perera Mi
Perez-Calvo J
Perin A
Pertile D
Pertile D
Peña-Barturen C
Phelan L
Photiou D
Pierre R
Pietrabissa A
Pigem A
Pila U
Pilkington Jp
Pineño-Flores C
Pinillos-Somalo A
Pinkney Td
Pinkney Td
Pinkney Td
Pinna E
Pino-Perez O
Pirari Pf
Pisanu A
Piu F
Planellas P
Plua-Muniz Kt
Poacher A
Podda F
Podda M
Podda M
Podda M
Poillucci G
Pollard H
Ponchietti L
Popova D
Poudevigne M
Prats Ma
Prideaux A
Prieto-Nieto Mi
Primo Jc
Pronin S
Provenza G
Puerta E
Pulighe F
Pullabatla-Venkata Up
Punj S
Pérez-Sanchez Le
Quddus A
Quill S
Quinn Em
Quinn Hc
Rabie M
Rabie Ma
Rabie Mr
Radwan Rw
Radwan Rw
Rahim A
Rahman M
Rahmani Ls
Rajagopal S
Rajaram R
Rajaretnam N
Rajjoub Y
Rallage H
Ramcharan S
Ramirez L
Ramirez-Redondo Aa
Ramos Xh
Ramos-Bernado Mi
Ramírez-Faraco M
Ranathunga S
Rangarajan K
Rao M
Rao V
Raofi A
Rashid M
Rate A
Ravindran R
Raymond M
Raza Ss
Recreo Ac
Reddy A
Reddy A
Redmond Ae
Redondo E
Redondo E
Redondo-Calvo Fj
Reese G
Regina G
Rehman S
Rehman S
Rekhraj S
Ren Kz
Renshaw S
Renshaw S
Renzi Cr
Resende Fm
Rezacova M
Rezvani S
Riaz W
Riba-Combatti L
Ribaudo M
Ribeiro B
Rich Je
Richardson Td
Ridaura N
Riera E
Rigby S
Rigney B
Rinkoff S
Ripoli Mc
Robb Hd
Robertson C
Robinson A
Robinson A
Robinson D
Robinson D
Rocha R
Rodger V
Rodicio-Miravalles Jl
Rodriguez L
Rodriguez-Lopez M
Rodriguez-Lopez M
Rodriguez-Lopez M
Rodríguez Ec
Rojo Ja
Roldán-Ortiz S
Rolph R
Romano J
Romano R
Romario Uf
Romoli L
Roncero Ls
Ronda Rn
Roomi S
Rosa Mj
Rosat A
Roscio F
Roscio F
Roscio F
Rossi C
Rossi D
Rossi Gm
Roth N
Rothnie K
Roxburgh C
Roy C
Ruano A
Rubbini M
Rudland I
Ruffolo C
Rufo E
Ruggiu Gv
Ruiz-Marín M
Ruiz-Marín M
Rupani S
Rupasinghe Sn
Rupasinghe Sn
Rutherford Dg
Ruzvidzo F
Ruzzenente A
Saad M
Saad M
Saavedra-Chacón M
Saba A
Sabia D
Sacco R
Sacks R
Sadek S
Saghir N
Sagnotta A
Sagnotta A
Saha A
Sahay Sj
Sahnan K
Sahnan K
Sainz B
Sainz B
Sajid Ms
Salama Y
Salamone G
Salamone G
Salamone G
Salamone G
Salandini Mc
Salem A
Salim S
Salva Ab
Salvador H
Samartin C
Sammarco G
Sammarco G
Samuel M
Sana S
Sanchez Er
Sanchez Er
Sanchez L
Sanchez-Garcia S
Sanchez-Guillen L
Sanchez-Guillen L
Sanchez-Martinez A
Sancho-Muriel J
Sandu L
Sanna S
Santamaria C
Santamaría Pc
Santarrufina-Martínez S
Santos Sc
Santurro L
Sanz-Navarro S
Sarmah P
Sarmah P
Sarmah P
Sarveswaran J
Sasia D
Sasia D
Saunders S
Savill A
Savino G
Savino G
Savioli F
Scabini S
Scabini S
Scabini S
Scandroglio Is
Scanlon K
Scatizzi M
Scialandrone G
Scricciolo M
Sebastian Jf
Sebastián-Tomás Jc
Seddon Tc
Segalini E
Segura-Sampedro Jj
Sena G
Sena-Ruiz F
Seneviratne N
Sepe C
Serventi F
Serventi F
Seth M
Setshwaelo T
Sezen E
Sgardelis P
Sgrò A
Sgrò A
Sgrò A
Shah J
Shah K
Shah Sm
Shah Sm
Shaikh Ia
Shakoor Z
Shanmuganathan V
Shanmugarajah K
Sharma A
Sharma A
Sharma P
Sharp Ol
Sharp Ol
Shaw Av
Shepherd Ja
Sherif Ma
Shet S
Shetty Vd
Shingler G
Shiwani Mh
Shrestha D
Shurlock J
Sian T
Siaw O
Siddique K
Siddiqui Mn
Siddiqui Za
Sierra-Grañón Je
Siggens Kl
Sihra N
Silva A
Silva I
Silvestri V
Simioni A
Simmonds L
Simmonds L
Simo V
Simoes J
Simpson Dj
Singh A
Singh J
Singh P
Singh S
Singhal T
Singhal T
Sivaloganathan P
Skalamera I
Skerritt C
Slezak I
Smallcombe N
Smart Cj
Smart Cj
Smart Nj
Smart Nj
Smoker H
Soares A. S.
Soares As
Soares As
Soares As
Soares As
Soares As
Soh B
Solaini L
Solar-García L
Soliani P
Solinas L
Sooriyamoorthy T
Soria-Aledo V
Soria-Aledo V
Soriano Jt
Sorrentino L
Sousa Hs
Souter J
Sparta C
Spaziani A
Speake D
Speake D
Springate El
Sreedharan L
Sreedharan L
Staderini F
Stecca T
Stella M
Stephens Gf
Stephens Gf
Stevenson R
Stewart Dj
Stoica I
Storey R
Stoyanov Ti
Strachan E
Strange Ja
Stubbs Bm
Stupalkowska W
Stupalkowska W
Suarez-Cabrera A
Suero Ca
Sultana A
Summerfield L
Sunter H
Surg Pt
Suriyakumar S
Suárez-Sánchez A
Swords C
Symons N
Szentpali K
Szucs A
Szucs A
Sánchez-Cifuentes A
Sánchez-Fuentes Mn
Sánchez-Rubio M
Tabain V
Taglietti L
Tague Le
Tahir W
Tailor K
Tallon-Aguilar L
Tallon-Aguilar L
Tamayo-López Mj
Tamborska A
Tamini N
Tamini N
Tamini N
Tan Cy
Tan Cy
Tan E
Tan Hl
Tan S
Tang Am
Tapiolas I
Tarazi M
Tatulli F
Tay Yh
Tayeh S
Taylor M
Taylor Ns
Taylor Ns
Taze D
Tee A
Tejero-Pintor Fj
Tenconi Sm
Tezas S
Thaha Ma
Thakral N
Thakur D
Thava B
Thavanesan N
Thavanesan N
Thaventhiran Aj
Theodoropoulou K
Thomas At
Thomas L
Thompson C
Thompson Db
Thompson Db
Thompson R
Thompson R
Thoukididou Sn
Tiedt La
Tiedt La
Ting N
Tinoco-González J
Tinsley Bj
Tognarelli Jm
Tojal A
Tokidis E
Tomasoni M
Tonini V
Toomey D
Toomey Db
Torkington J
Torkington J
Torrado Aa
Torrance A
Torrance A
Townsend Dc
Townsend Dc
Tozer Pj
Trail M
Trail M
Trastulli S
Trew F
Trostchansky I
Trujillo-Diaz Jj
Tsang B
Tudyka V
Tudyka V
Turnbull A
Turner Ej
Tutino R
Twum-Barima Cs
Twum-Barima Cs
Tyler R
Tyler R
Ugarte-Sierra B
Vacca A
Vaccari S
Vakis S
Valente Pm
Valiani Sv
Vallejo-Bernad C
Vallve-Bernal M
Van Boxel Gi
Vance-Daniel J
Vannucchi A
Varcada M
Vargas-Pierola Hj
Vaughan Em
Vaughan Em
Vazquez-Fernandez Ap
Vega L
Velchuru Vr
Velho R
Venkata Up
Venkatasubramaniam Ak
Venn Ml
Venn Ml
Venugopal R
Verea S
Veres T
Veres T
Verroiotou M
Vescio G
Vettoretto N
Vigorita V
Vijay V
Vila-Zarate C
Villarejo-Campos P
Vinnicombe Z
Viscosi F
Vitish-Sharma P
Viviani E
Viñas Nl
Vohra R
Vohra R
Vulcano I
Waite K
Walji Hd
Walsh E
Walsh Tn
Walters Kj
Walters U
Wardle Bg
Wardle Bg
Wardle Sd
Warren O
Warren Oj
Warusavitarne J
Watfah J
Watson N
Wauchope J
Weatherburn Lw
Weaver J
Weegenaar Cr
Weegenaar Cr
Welsh S
Wensley F
West H
West H
Wheatstone S
Wheeler C
Whewell He
White F
Whitehorn Se
Whitehorn Se
Whitehouse P
Whiteman E
Whittaker L
Wiggill S
Wijesundera K
Wilcox G
Wilkin R
Wilkin R
Wilkin R
Wilkin R
Wilkin R. J. W.
Williams Gl
Williams M
Williams R
Williams S
Wilson Ej
Wilson M
Winter Dc
Winter Dc
Wolff J
Wong A
Wong C
Wong J
Wong J
Wong Ml
Wong Sy
Woo R
Wood Cs
Woodrow C
Woodward A
Woodward B
Woodward B
Worku D
Worku D
Wright E
Wright Hl
Wu F
Xidas A
Yalamarthi S
Yang P
Yanni F
Yardimci E
Yasin T
Yen Sk
Yeung K
Yeung K
Yoganathan S
Yoong S
Youssef H
Yow L
Yow L
Zaborowski A
Zadi Az
Zalla T
Zarka Za
Zarka Za
Zarog Ma
Zelazek M
Zerpa C
Zhang Ay
Zhou S
Zorrilla L
Zuin M
Zurleni Tz
Publication venue: 'Wiley'
Publication date: 01/01/2019
Field of study

Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent). Conclusion Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified

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Explore Bristol Research

Influence of gamma and electron beam sterilization on the stability of a premixed injectable calcium phosphate cement for trauma indications

Author: Alan Murphy (4852702)
Brian McEvoy (124375)
Carol O'Sullivan (12588481)
Catriona O'Neill (12588487)
Declan M. Devine (12580444)
Gerard Insley (8436090)
Guang Ren (4468525)
Jaroslaw Sadło (12588478)
Kieran A. Murray (12588472)
Maurice N. Collins (3909235)
Oliver Vrain (12588484)
Regina P. O'Sullivan (12588475)
Publication venue
Publication date: 01/01/2018
Field of study

Premixed calcium phosphate cements (CPC's) are becoming the material of choice for injectable cements as a result of their effective delivery to the target implantation site. For orthopaedic use, it is of vital importance that the attributes of these CPC's are not compromised by irradiation sterilization. Therefore, the aim of this study is to determine the influence of irradiation sterilization on a range of premixed CPC's, with an emphasis on improving product shelf life through the use of optimal packaging configurations and annealing steps. Electron spin resonance (ESR) confirmed the presence of free radicals in the inorganic phase of the CPC paste following irradiation. The inclusion of a 24-h annealing step was the only successful method in reducing the degree of free radical formation. Based on the results of injectability force testing, it was revealed that an annealing step greater than 24-h significantly altered the viscosity, however; at 24-h the key attributes of the CPC paste were minimally effected. Overall, it was established that vacuum packing the CPC paste, placing the contents into a foil pouch, gamma irradiating at the minimal dose required and using an annealing step of ≤ 24-h, has the potential to extend the shelf life of the cement

University of Limerick Institutional Repository

Irish Universities

Inflammatory cytokines induce an unique mineralizing phenotype in mesenchymal stem cells derived from human bone marrow

Author: Adele Boskey
Anderson
Arthur
Bastian
Bellows
Bonewald
Boskey
Caplan
Christopher H. Evans
Daniel M. Estok
Diefenderfer
Ding
Elisabeth Ferreira
Fangjun Liu
Fleisch
Gilbert
Gowen
Guardavaccaro
Harmey
Hessle
James W. Wells
Johnson
Johnson
Kaneki
Kuroki
Lacey
Mark S. Vrahas
McNamara
Mitchell B. Harris
Murshed
Nathalie Wehling
Ni Choileain
Okawa
Pape
Pfaffl
Porter
Regina P. O'Sullivan
Rutsch
Ryan M. Porter
Scrivo
Sonomoto
Southerland
Terkeltaub
Wehling
Wei
Xiao
Yao
Publication venue: 'American Society for Biochemistry & Molecular Biology (ASBMB)'
Publication date: 22/08/2013
Field of study

Bone marrow contains mesenchymal stem cells (MSCs) that can differentiate along multiple mesenchymal lineages. In this capacity they are thought to be important in the intrinsic turnover and repair of connective tissues while also serving as a basis for tissue engineering and regenerative medicine. However, little is known of the biological responses of human MSCs to inflammatory conditions. When cultured with IL-1β, marrow- derived MSCs from 8 of 10 human subjects deposited copious hydroxyapatite, in which authenticity was confirmed by Fourier transform infrared spectroscopy. Transmission electron microscopy revealed the production of fine needles of hydroxyapatite in conjunction with matrix vesicles. Alkaline phosphatase activity did not increase in response to inflammatory mediators, but PPi production fell, reflecting lower ectonucleotide pyrophosphatase activity in cells and matrix vesicles. Because PPi is the major physiological inhibitor of mineralization, its decline generated permissive conditions for hydroxyapatite formation. This is in contrast to MSCs treated with dexamethasone, where PPi levels did not fall and mineralization was fuelled by a large and rapid increase in alkaline phosphatase activity. Bone sialoprotein was the only osteoblast marker strongly induced by IL-1β; thus these cells do not become osteoblasts despite depositing abundant mineral. RT-PCR did not detect transcripts indicative of alternative mesenchymal lineages, including chondrocytes, myoblasts, adipocytes, ligament, tendon, or vascular smooth muscle cells. IL-1β phosphorylated multiple MAPKs and activated nuclear factor-κB (NF-κB). Certain inhibitors of MAPK and PI3K, but not NF-κB, prevented mineralization. The findings are of importance to soft tissue mineralization, tissue engineering, and regenerative medicine

Crossref

University of Queensland eSpace

Inter-individual variation in blood pressure is associated with regional white matter integrity in generally healthy older adults

Author: Andersson
Andersson
Barrick
Basser
Bastin
Benedetti
Bohnstedt
Breteler
Budde
Chobanian
D'Agostino
David H. Salat
David M. Schnyer
de Laat
DeCarli
Desikan
Elizabeth C. Leritz
Fischl
Fortuny
Goldstein
Gons
Greve
Hannesdottir
He
Hoptman
James L. Rudolph
Jeerakathil
Jones
Kennedy
Kennedy
Lee
Leritz
Leritz
Lewis A. Lipsitz
Longstreth
Manolio
O'Sullivan
O'Sullivan
Pantoni
Patel
Pfefferbaum
Pierpaoli
Pierpaoli
Raz
Raz
Reese
Regina E. McGlinchey
Rueckert
Salat
Salat
Salat
Salat
Seshadri
Smith
Smith
Smith
Sullivan
Sun
Swan
Victoria J. Williams
Virta
Werring
Wheeler-Kingshott
William P. Milberg
Yoshita
Publication venue: 'Elsevier BV'
Publication date
Field of study

Crossref

Violacein, an indole-derived purple-colored natural pigment produced by Janthinobacterium lividum, inhibits the growth of head and neck carcinoma cell lines both in vitro and in vivo

Author: A Elmann
A Matta
AJ Levine
AM Chakrabarty
Andrea Modesti
C Matz
C Theisen
C Waes Van
CB Menezes
CR Andrighetti-Fronher
CT Allen
CV Ferreira
D Platt
DD Carvalho de
DG Jackson-Bernitsas
DJ Newman
E Galanis
E Tasdemir
EE Caicedo-Granados
Enrica Di Stefano
F Ballestriero
F Ondrey
F Pantanella
Fabrizio Pantanella
G Wille
Giuseppe La Regina
J Lian
J Nemunaitis
J O'sullivan
JH Johnson
KC Queiroz
L Dufosse
L Leon
L Masuelli
L Masuelli
L Masuelli
L Masuelli
L Masuelli
L Masuelli
Laura Masuelli
LL Kodach
Massimo Fantini
Maurizio Mattei
ML Circu
Monica Benvenuto
N Bernardes
N Bromberg
N Durán
NJ Roberts
NT Bui
P Forsyth
R Bei
R Wilken
Roberto Bei
Romano Silvestri
Rosanna Mattera
S Fujiwara
Serena Schippa
SM Hashimi
SM Rothenberg
T Pannellini
V D’Amato
Vittorio Manzari
W Vanden Berghe
Y Dessaux
Y Tsujimoto
Publication venue: 'Springer Science and Business Media LLC'
Publication date
Field of study

Crossref

Delaying surgery for patients with a previous SARS-CoV-2 infection

Author: A A Ali Karar
A A Kerawala
A A Marra
A Abad Gurumeta
A Abad-Motos
A Abdelmajeed
A Abdelrahman
A Abdelsamed
A Abdulkareem
A Aboelkassem Ibrahim
A Abouassi
A Abreu da Silva
A Abubakar
A Acher
A Aderombi
A Adeyeye
A Adiamah
A Aggarwal
A Aghayeva
A Agnes
A Agrawal
A Ahmeidat
A Aimé
A Ajlan
A Al-Habib
A Al-Mohammad
A Al-Mukhtar
A Aladeojebi
A Alamri
A Alanbuki
A Alatar
A Alburakan
A Alfaro-Goldaracena
A Alhamed
A Alhefdhi
A Almeciga
A Almeida
A Alomair
A Alonso Poza
A Alsaif
A Anastasi
A Antic
A Anzak
A Aprile
A Arminio
A Arulanantham
A Askari
A Asqalan
A Athanasiou
A Ayhan
A Ayman
A Ayubi
A Azizi
A B Martins
A Bacon
A Baker
A Balakrishnan
A Bandiera
A Banerjee
A Barrabe
A Beamish
A Bellacci
A Belli
A Belvedere
A Benkabbou
A Bhalla
A Bhangu
A Billè
A Bin Nasser
A Biondi
A Blatt
A Blazquez Martin
A Boddy
A Bokhari
A Bondurri
A Boulton
A Boutall
A Branquinho
A Brunelli
A Brunt
A Bruscino
A Budacan
A Burahee
A Böttcher
A C Almeida
A C Deus
A C Roslani
A C Soares
A C Vieira Paiva Lopes
A Caiado
A Camillo
A Canas-Martinez
A Cano
A Carabias
A Chandock
A Charalabopoulos
A Che Jusoh
A Chebaro
A Chessa
A Chiappini
A Chitul
A Choudhry
A Chowdhury
A Colquhoun
A Conesa
A Cordova
A Costanzi
A Cotoia
A Cotter
A Crichton
A Cuadrado-García
A Currie
A Cvetkovic
A D Bueno Cañones
A D Rajgor
A D Zakaria
A D'Amore
A D'Urso
A Daly
A Davies
A Day
A De Gea Rico
A De Manzoni Garberini
A De Pablo García-Cuenca
A De Troia
A De Virgilio
A Dehal
A Desai
A Di Bartolomeo
A Di Bella
A Di Somma
A Diamantis
A Doyle
A Durrani
A E Arikan
A E Sherif
A Eastmond
A El Ouahabi
A Elawad
A Eldaly
A Elhamshary
A Esposito
A Esteban
A Ezanno
A Fadzli
A Fagotti
A Fancellu
A Farsi
A Faustino
A Fazenda
A Fernández-López
A Ferrero
A Ferrés
A Fiorini
A Fisher
A Fletcher
A Fowler
A Fox
A Frampton
A Frankel
A Frati
A Freitas
A Frena
A Fuson
A G Carta
A G Zarabini
A Gabre-Kidan
A Gagliano
A Gainza
A Gatti
A Gattolin
A Gaunt
A Geddes
A Gegúndez Simón
A Ghanbari
A Ghannam
A Giaglaras
A Gianni
A Giblin
A Gillis
A Gklavas
A Glencer
A Gomes da Costa
A Gori
A Goyal
A Gronchi
A Gueutier
A Guglielmi
A Guimarães
A Gupta
A Gutierrez Calvo
A Gvaramadze
A Gómez-Pedraza
A H Hussain
A H Khan
A Habeeb
A Hainsworth
A Hamad
A Hannah
A Hanson
A Harky
A Hasenburg
A Hawkins
A Haynes
A Haynes
A Henry
A Herman
A Hernández Gutierrez
A Heuer
A Hmedat
A Hogan
A Hunt
A I Gutiérrez Fernández
A I Kilani
A I Soriano
A I Tercero-Uribe
A Ibrahim
A Ionescu
A Jah
A Jain
A Jamal
A Jibril
A Jiménez
A Joshi
A Jotic
A K Ali
A K Andrade
A K Lala
A K Scafa
A K Zengin
A Kahn
A Kamocka
A Kanatas
A Kappenberger
A Karamarkovic
A Karim
A Kattakayam
A Kaufmann
A Kawai
A Kent
A Khajuria
A Khan
A Khoja
A Kirk
A Kisiel
A Kler
A Kocataş
A Koh
A Kolias
A Kollàr
A Kolusarı
A Kourdouli
A Kouyoumdjian
A Kredan
A Kumar
A Königsrainer
A L De Oliveira López
A L Ebbehøj
A L Picardo
A Laforest
A Lagares
A Laios
A Laird
A Landaluce-Olavarria
A Lanzon
A Larentzakis
A Lauretta
A Lim
A Loayza
A Loehrer
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A Louvrier
A Lovece
A Lowery
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A López Campillo
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A M Baietti
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A M Lacy
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A M Minaya Bravo
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A M Pathanki
A M Perrone
A M Scanu
A Macchi
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A Madkhali
A Maffioli
A Maffuz-Aziz
A Maghrabi
A Maiga
A Majkowska
A Mansuri
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A Marchbank
A Marco Garrido
A Margalit
A Martin-Ucar
A Martinez German
A Marçal
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A Maw
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A Mccarthy
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A McMillan
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A Mirabella
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A Mohammad
A Moro
A Morris
A Morsi
A Morton
A Mosca
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A Muratore
A Mustafa
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A Nabil
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A Nawawi
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A Oliveira
A Osorio
A Otero
A Ovaitt
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A Parente
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A Patel
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A Paunovic
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A Petrillo
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A Polydorou
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A Ruzzenente
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A Salamah
A Salazar
A Saleem
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A Samir Abdelaal
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A Seleim
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A Sharma
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A Singh
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A Ssentongo
A Stanimirovic
A Stavroglou
A Stefanovic
A Stepanyan
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A Sutherland
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A Tailor
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A Thompson
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A Valle Rubio
A Varazzani
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A Vezakis
A Vieira
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A Vitali
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A Woodham
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A Yiallourou
A Yıldırım
A Yildiz
A Youssef
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A Zullo
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Abd Elazeem Has
Abhinav Tiwari
Abigail Vallance
Adesoji Ademuyiwa
Adesoji O Ademuyiwa
Adrian Marchbank
Ahmad Qureshi
Akshay Patel
Alan McNeill
Alessandro Brunelli
Alessandro Gronchi
Alex Alamri
Alex Wilkins
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Ana Minaya-Bravo
Ana Minaya-Bravo
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Andrew G Schache
Andrew Knight
Andrew Loehrer
Andrew Schache
Andrey Litvin
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Aneel A Bhangu
Aneel Bhangu
Angelos Kolias
Angelos Kolias
Anna Fagotti
Antonino Spinelli
Antonio Ramos-De la Medina
April C Roslani
Arda Isik
Arnav Agarwal
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B Al-Sarireh
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B Ayub
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Bandara Gbk
Benjamin Lamb
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C Chan
C Chan
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C Jelley
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C Langdon
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Emily Heritage
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EuroSurg
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F Izzo
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F Jácome
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F Mosley
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F Nakatani
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F Notte
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F Oliva Mompean
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F Petraglia
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F Policarpo
F Popovic
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F Rasoaherinomenjanahary
F Raspagliesi
F Rodriguez-Covarrubias
F Rosa
F Ruggiero
F S Al Maadany
F S Ledesma
F Sanchez Cabezudo Noguera
F Sauvat
F Soggiu
F Solari
F Soliman
F Solimene
F Sorbi
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F Tavares
F Tirotta
F Toia
F Vovola
F Wensley
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Fabio Tirotta
Faith Robertson
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Faustin Ntirenganya
Felix Alakaloko
Ferrari F
Francesco Pata
Franco Servadei
G A Beltramini
G A Buerba
G Alemanno
G Alkadeeki
G Amira
G Anania
G Aresu
G Armatura
G B Fonsi
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G Bakolas
G Barisic
G Bass
G Bačić
G Bertelli
G Bertoli
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Grant D Stewart
Grant D Stewart
Gustavo Grecinos
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Haytham Ma Kaafarani
Helen M Mohan
I A Aneke
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J A Benavides Buleje
J A Elliott
J A Hoyos Castro
J A Martínez Alonso
J A Posada
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J A Tan
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J Abu
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J Á González García
J Žatecký
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Jalid Sehouli
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Janet Martin
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Keith Roberts
Kenneth A McLean
Kerry A Breen
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Ko Kyk
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Kwabena Siaw-Acheampong
L A Reyes Figueroa
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L V Comini
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Luis Chiva
M A Akhtar
M A Boeck
M A Bozkurt
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M A Hernandez Bartolome
M A Huertas Fernandez
M A Nageh
M A Onan
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M A Steiner
M A Williams
M Abdalla
M Abdallah
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M Adamina
M Adishesh
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M Angele
M Ansarin
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M Azam
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M Bordenave
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M Boutros
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M Buta
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M Casati
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M Chand
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M Claro
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M Costa
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M E Elsayed Hewalla
M Edmond
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M Estaire Gómez
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M F Ho
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M Fahim
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M Ferrari
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M Hague
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M Hernández-García
M Herrero Lopez
M Ho
M Hollyman
M I Antonopoulou
M I Bhatti
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M Ibrahim
M Idle
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M Kitchen
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M Kumar
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M Lanner
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M Lee
M Lidsky
M Lim
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M M Abdelkarem
M M Akhter Rahman
M M Carvello
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M M Rashid
M M Saad
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M Mohammed
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M N Ringressi
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M Ng
M Nordberg
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M O'Shea
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M Patel
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M Podda
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M Quante
M R Alvarez
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M R Thanapal
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M Read
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M Roberts
M Rodrigues
M Romano
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M Rottoli
M Ruiz Soriano
M Ruiz-Marín
M Rutegård
M Ryan
M S Babar
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M S Qatora
M S Santero-Ramirez
M S Uyanik
M Saez Barba
M Sait
M Salah
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M Salem
M Salvati
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M Shackcloth
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M Sherief
M Silva
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M Sodergren
M Sokolov
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M Sparavigna
M Sund
M Szpytma
M Sánchez-Rubio
M T González-Nicolás Trébol
M T Hasan
M T Montella
M T Subhi
M Taffurelli
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M Thomas
M Thornhill
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M Tolani
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M Tuveri
M Umair
M Umar
M Uno
M Usandivaras
M V Simón Sanz
M V Sosa
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M Varma
M Vatish
M Velidedeoglu
M Venn
M Vilatoba
M Von Papen
M W Hii
M W Löffler
M Waris Farooka
M Whelan
M Wilson
M Wullschleger
M Y Oudrhiri
M Youssef
M Zambon
M Zegarac
M Zelić
M Zese
M Zivanovic
M Zivkovic
M Zizzo
M Á Mercado
M Ângelo
Madalegna Gründl
Mak Jkc
Mak Twc
Malin Sund
Marco Fiore
Marco Fiore
Marco Fiore
Maria Aguilera Lorena
Maria Marta Madolo
Maria Picciochi
Maricarmen Olivos
Marie Dione Parreno-Sacdalanm
Markus Albertsmeiers
Markus W Löffler
Martin Batstone
Martin Rutegård
Mary L Venn
Max Almond
Mayaba Maimbo
Mdc De Miguel Ardevines
Mfi De La Cruz Monroy
Michael D Jenkinson
Michael D Jenkinson
Michael Ho
Michel Adamina
Miguel F Cunha
Milagros Niquen
Mohammad Chaar
Moises Cukier
Muhammad Alshaar
Muhammed Elhadi
Murat Gutelkin
N Abbassi-Ghadi
N Ahmadi
N Akeel
N Alam
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N Elson
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N Firat
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N Furbetta
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N Gouvas
N Gross
N Gusani
N Guàrdia
N Habib
N Hardy
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Naomi Wright
Neil J Smart
Neil Sharma
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NIgra Ma
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Tabassum Khan
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Thomas D Pinkney
Thomas Konney
Thomas M Drake
Tobias Klatte
Tom Ef Abbott
U Akgor
U Andaleeb
U Bork
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Veeru Kasivisvanathan
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X De Sousa
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Y Aawsaj
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Z Seymour
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Á De la Hoz Rodríguez
Á Fernández Camuñas
É Ryan
Ž Grubač
А Камалов
Publication venue: 'Wiley'
Publication date: 01/01/2020
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Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic.

Author: Aawsaj Y
Abad Gurumeta A
Abad-Motos A
Abate E
Abatini C
Abbadessa F
Abbas AM
Abbassi-Ghadi N
Abbott D
Abbott T
Abbott TEF
Abd Elazeem HAS
Abdalla M
Abdallah M
Abdelaal SA
Abdeldayem H
Abdelkarem MM
Abdelkarim M
Abdelmajeed A
Abdelrahman A
Abdelrahman S
Abdelsamed A
Abdou M
Abdulkareem A
Abdulwahed E
Abdur-Rahman L
Abel MK
Abellan M
Abosamak NE
Abou Chaar MK
Abou-Khalil J
Abouassi A
Aboulkassem H
Abreu da Silva A
Abu Za'nouneh FJ
Abu J
Abu-Nayla I
Abubakar A
Abukhalaf S
Acebes Garcia F
Achalandabaso Boira M
Acher A
Acrich E
Adamina M
Adamina M
Adamoli L
Addae-Boateng E
Ademuyiwa AO
Aderombi A
Adeyeye A
Adiamah A
Adishesh M
Agapov M
Agarwal A
Aggarwal A
Aghayeva A
Agilinko J
Agnes A
Agostini C
Agoston P
Agrawal A
Agresta F
Aguado H
Aguzzoli L
Ahad S
Ahmadi N
Ahmed NR
Ahmeidat A
Ahn JH
Aiken T
Aime A
Ajlan A
Akalin M
Akaydin E
Akeel N
Akgor U
Akhtar MA
Akilli H
Akin E
Akkour K
Akkulak M
Akmenkalne L
Al Abdallah M
Al Abdel S
Al Awwad S
Al Habes H
Al Maadany FS
Al Raddadi R
AL Sayed M
Al-Habib A
Al-Habsi R
Al-Ishaq Z
Al-Khayal K
Al-Masri M
Al-Mohammad A
Al-mukhtar A
Al-Najjar H
Al-omishy H
Al-Sarireh B
Al-Tamimi Y
Alaa S
AlAamer O
Aladeojebi A
Alakaloko F
Alam F
Alam N
Alam R
Alameer E
Alamri A
Alamri A
Alanbuki A
Alatar A
Alawneh F
Alazawi D
Albertsmeier M
Albertsmeiers M
Albi Martin B
Alburakan A
Alcaide Matas F
Alconchel F
Aldayri Z
Aldecoa Ansorregui I
Alderson D
Aldokali N
Aleksic L
Alemanno G
Alexoudi V
Alfaro-Goldaracena A
Alfieri S
Alga A
Alghamdi M
Alhalal H
Alhamed A
Alharthi M
Alharthi R
Alhassan B
Alhassan N
Alhefdhi A
Ali AK
Ali M
Ali MF
Ali S
Aliyeva Z
Aljanadi F
Aljiffry M
Alkadeeki GZ
Alkarak S
Allemand C
Allison J
Almalik O
Almasri M
Almeciga A
Almeida A
Almeida AC
Almeida JI
Almgla N
Almond M
Almond M
Alnumani T
Alobeed O
Alomair A
Alonso de la Fuente N
Alonso Poza A
Alonso-Lamberti L
Alotaibi N
Alqannas M
Alresaini F
Alriyees L
Alsaif A
Alsaif F
Alsalamah R
Alsaraireh O
Alselaim N
Alser O
Alshaar M
Alshahrani M
Alshammari S
Alshareea E
Alsharif F
Alshaygy I
Alshryda S
Alsobhi S
Althobaiti W
Altintoprak F
Alurralde C
Alvarez E
Alvarez MR
Alyami M
Alzamanan M
Amaral MJ
Ameerally P
Amira G
Amonkar S
Amorim E
Ampollini L
Amrani L
Anania G
Anastasi A
Anchuelo Latorre J
Andaleeb U
Andaya V
Andrade AK
Andrade R
Andrijasevic S
Aneke IA
Ang K
Angele M
Angelo M
Angelou D
Angelou K
Annamalai S
Annessi V
Ansarin M
Anthoulakis C
Antic A
Antic S
Antonakis P
Antoniades K
Antonopoulou MI
Anula R
Anwar S
Anzak A
Aoun S
Aprile A
Aquila F
Aragon Achig EJ
Aremu I
Aremu M
Aresu G
Aribi N
Aribi S
Arican C
Arif T
Arigoni M
Arikan AE
Arkadopoulos N
Arkha Y
Armao T
Armatura G
Arminio A
Arnaud AP
Arrangoiz R
Arrowsmith L
Artigues E
Arulanantham A
Asaad P
Ascensao J
Ashcroft J
Ashmore C
Ashoush F
ASiT AS
Askari A
Asqalan A
Assaf M
Assalaarachchi H
Asti E
Astreidis I
Athanasakis E
Athanasiou A
Athayde Nemesio R
Atherton R
Athwal R
Atici DS
Atta R
Attia D
Augestad KM
Australasian T
Avci EK
Avlund T
Awad S
Ayasra F
Ayasra F
Ayasra Y
Aydin C
Ayhan A
Ayman A
Ayorinde J
Aytac E
Ayub B
Ayubi A
Azam M
Azamat IF
Azevedo C
Azevedo J
Azevedo J
Azevedo P
Azizeldine MG
Azizi A
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Capizzi V
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Capolupo GT
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Castillejos-Molina RA
Catala Bauset JC
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Chiesa-Estomba CM
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Comini LV
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Coonar AS
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Costa Santos D
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Cotoia A
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Cotte E
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Cox D
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Cozza V
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Crichton A
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Daiko H
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De Andres Olabarria U
De Barros J
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De Miguel Ardevines MDC
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De Pablo Garcia-Cuenca A
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de Solorzano Aurusa OFJ
De Sousa X
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De Virgilio A
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Del Valle E
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Di Bella A
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Diaz Pena P
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Egbuchulem IK
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El Bouazizi Y
El Ouahabi A
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Elena GDCR
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Elghazaly MS
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Elkhayat H
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Espino Segura-Illa M
Espinosa CA
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Eveno C
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Feo CF
Feo CV
Fernandes U
Fernandes V
Fernandez Bernabe P
Fernandez Camunas A
Fernandez Pablos FJ
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Fernando D
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Ferraz I
Ferreira Pinto AP
Ferreira C
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Figari M
Figueiredo de Barros I
Findlay L
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Fiore M
Fiore M
Fiore M
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Fitzgerald C
Fitzgerald JE
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Frongia F
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Garcia Porcel VJ
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Garcia Villayzan JE
Garcia JS
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Garcia-Quijada J
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Gavalda Pellice MGP
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Ginesu GC
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Gkrinia E
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Glasbey JC
Glasbey JC
Glasbey JC
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GlobalPaedSurg
GlobalSurg
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Gracia-Roche C
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Grau-Talens EJ
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Grilo JV
Grimaldi DMS
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Guariglia CA
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Kamburoglu MB
Kamera BS
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Karamarkovic A
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Kassir R
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Koenigsrainer A
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Publication venue: Br J Surg
Publication date: 11/11/2020
Field of study

BACKGROUND: Surgical services are preparing to scale up in areas affected by COVID-19. This study aimed to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications in patients undergoing elective cancer surgery. METHODS: This international cohort study included adult patients undergoing elective surgery for cancer in areas affected by SARS-CoV-2 up to 19 April 2020. Patients suspected of SARS-CoV-2 infection before operation were excluded. The primary outcome measure was postoperative pulmonary complications at 30 days after surgery. Preoperative testing strategies were adjusted for confounding using mixed-effects models. RESULTS: Of 8784 patients (432 hospitals, 53 countries), 2303 patients (26.2 per cent) underwent preoperative testing: 1458 (16.6 per cent) had a swab test, 521 (5.9 per cent) CT only, and 324 (3.7 per cent) swab and CT. Pulmonary complications occurred in 3.9 per cent, whereas SARS-CoV-2 infection was confirmed in 2.6 per cent. After risk adjustment, having at least one negative preoperative nasopharyngeal swab test (adjusted odds ratio 0.68, 95 per cent confidence interval 0.68 to 0.98; P = 0.040) was associated with a lower rate of pulmonary complications. Swab testing was beneficial before major surgery and in areas with a high 14-day SARS-CoV-2 case notification rate, but not before minor surgery or in low-risk areas. To prevent one pulmonary complication, the number needed to swab test before major or minor surgery was 18 and 48 respectively in high-risk areas, and 73 and 387 in low-risk areas. CONCLUSION: Preoperative nasopharyngeal swab testing was beneficial before major surgery and in high SARS-CoV-2 risk areas. There was no proven benefit of swab testing before minor surgery in low-risk areas

Ezid

Crossref

AIR Universita degli studi di Milano

UCL Discovery

eScholarship - University of California

Archivio istituzionale della ricerca - Alma Mater Studiorum Università di Bologna

Apollo (Cambridge)

Bern Open Repository and Information System (BORIS)

Queen Mary Research Online

White Rose Research Online

Archivio istituzionale della ricerca - Università di Palermo