2,537 research outputs found
Identification of C-C Chemokine Receptor 1 (CCR1) as the Monocyte Hemofiltrate C-C Chemokine (HCC)-1 Receptor
Hemofiltrate C-C chemokine (HCC)-1 is a recently cloned C-C chemokine that is structurally similar to macrophage inflammatory protein (MIP)-1α. Unlike most chemokines, it is constitutively secreted by tissues and is present at high concentrations in normal human plasma. Also atypical for chemokines, HCC-1 is reported not to be chemotactic for leukocytes. In this paper, we have investigated the chemokine receptor usage and downstream signaling pathways of HCC-1. Cross-desensitization experiments using THP-1 cells suggested that HCC-1 and MIP-1α activated the same receptor. Experiments using a panel of cloned chemokine receptors revealed that HCC-1 specifically activated C-C chemokine receptor (CCR)1, but not closely related receptors, including CCR5. HCC-1 competed with MIP-1α for binding to CCR1-transfected cells, but with a markedly reduced affinity (IC50 = 93 nM versus 1.3 nM for MIP-1α). Similarly, HCC-1 was less potent than MIP-1α in inducing inhibition of adenylyl cyclase in CCR1-transfected cells. HCC-1 induced chemotaxis of freshly isolated human monocytes, THP-1 cells, and CCR1-transfected cells, and the optimal concentration for cell migration (100 nM) was ∼100-fold lower than that of MIP-1α (1 nM). These data demonstrate that HCC-1 is a chemoattractant and identify CCR1 as a functional HCC-1 receptor on human monocytes
A preliminary analysis of therapeutic horseback riding
Abstract We evaluated the effects of implementing therapeutic horseback riding procedures with three young children with Autism Spectrum Disorder (ASD
Starcounts Redivivus. IV. Density Laws Through Photometric Parallaxes
In an effort to more precisely define the spatial distribution of Galactic
field stars, we present an analysis of the photometric parallaxes of 70,000
stars covering nearly 15 square degrees in seven Kapteyn Selected Areas. We
address the affects of Malmquist Bias, subgiant/giant contamination,
metallicity and binary stars upon the derived density laws. The affect of
binary stars is the most significant. We find that while the disk-like
populations of the Milky Way are easily constrained in a simultaneous analysis
of all seven fields, no good simultaneous solution for the halo is found. We
have applied halo density laws taken from other studies and find that the
Besancon flattened power law halo model (c/a=0.6, r^-2.75) produces the best
fit to our data. With this halo, the thick disk has a scale height of 750 pc
with an 8.5% normalization to the old disk. The old disk scale height is
280-300 pc. Corrected for a binary fraction of 50%, these scale heights are 940
pc and 350-375 pc, respectively. Even with this model, there are systematic
discrepancies between the observed and predicted density distributions. Our
model produces density overpredictions in the inner Galaxy and density
underpredictions in the outer Galaxy. A possible solution is modeling the
stellar halo as a two-component system in which the halo has a flattened inner
distribution and a roughly spherical, but substructured outer distribution.
Further reconciliation could be provided by a flared thick disk, a structure
consistent with a merger origin for that population. (Abridged)Comment: 66 pages, accepted to Astrophysical journal, some figures compresse
Mass-Losing Semiregular Variable Stars in Baade's Windows
By cross-correlating the results of two recent large-scale surveys, the
general properties of a well defined sample of semi-regular variable stars have
been determined. ISOGAL mid-infrared photometry and MACHO lightcurves are
assembled for approximately 300 stars in the Baade's Windows of low extinction
towards the Galactic bulge. These stars are mainly giants of late M spectral
type, evolving along the asymptotic giant branch (AGB). They are found to
possess a wide and continuous distribution of pulsation periods and to obey an
approximate log~period -- bolometric magnitude relation or set of such
relations.
Approximate mass-loss rates in the range of 1e-8 to 5e-7 M_sun per year are
derived from ISOGAL mid-infrared photometry and models of stellar spectra
adjusted for the presence of optically-thin circumstellar silicate dust.
Mass-loss rates depend on luminosity and pulsation period. Some stars lose mass
as rapidly as short-period Miras but do not show Mira-like amplitudes. A period
of 70 days or longer is a necessary but not a sufficient condition for mass
loss to occur.
For AGB stars in the mass-loss ranges that we observe, the functional
dependence of mass-loss rate on temperature and luminosity is found to be in
agreement with recent theoretical predictions. If we include our mass-loss
rates with a sample of extreme mass-losing AGB stars in the Large Magellanic
Cloud, we get the general result for AGB stars that mass-loss rate is
proportional to luminosity^{2.7}, valid for AGB stars with 10^{-8} to 10^{-4}
M_sun per year (Abridged).Comment: to appear in The Astrophysical Journal, 51 pages, 9 figures, 3
tables; table 1 will be available in machine-readable format at the
electronic Ap
Re-imagining the growth process: (co)-evolving metaphorical representations of entrepreneurial growth
We investigate the role and influence of the biological metaphor ‘growth’ in studies of organizations, specifically in entrepreneurial settings. We argue that we need to reconsider metaphorical expressions of growth processes in entrepreneurship studies in order to better understand growth in the light of contemporary challenges, such as environmental concerns. Our argument is developed in two stages: first, we review the role of metaphor in organization and entrepreneurship studies. Second, we reflect critically on three conceptualizations of growth that have drawn on biological metaphors: the growing organism, natural selection and co-evolution. We find the metaphor of co-evolution heuristically valuable but under-used and in need of further refinement. We propose three characteristics of the co-evolutionary metaphor that might enrich our understanding of entrepreneurial growth: relational epistemology; collectivity; and multidimensionality. Through this we provide a conceptual means of reconciling an economic impetus for entrepreneurial growth with an environmental imperative for sustainability
Auditory Physiology
Contains reports on one research projects split into ten sections.National Institutes of Health (Grant 5 P01 NS13126)National Institutes of Health (Grant 5 RO1 NS18682)National Institutes of Health (Grant 5 RO1 NS20322)National Institutes of Health (Grant 5 RO1 NS20269)National Institutes of Health (Grant 5 PO1 NS23734)National Institutes of Health (Grant 5 T32 NS07047)Symbion, Inc
Implications of climate change for agricultural productivity in the early twenty-first century
This paper reviews recent literature concerning a wide range of processes through which climate change could potentially impact global-scale agricultural productivity, and presents projections of changes in relevant meteorological, hydrological and plant physiological quantities from a climate model ensemble to illustrate key areas of uncertainty. Few global-scale assessments have been carried out, and these are limited in their ability to capture the uncertainty in climate projections, and omit potentially important aspects such as extreme events and changes in pests and diseases. There is a lack of clarity on how climate change impacts on drought are best quantified from an agricultural perspective, with different metrics giving very different impressions of future risk. The dependence of some regional agriculture on remote rainfall, snowmelt and glaciers adds to the complexity. Indirect impacts via sea-level rise, storms and diseases have not been quantified. Perhaps most seriously, there is high uncertainty in the extent to which the direct effects of CO2 rise on plant physiology will interact with climate change in affecting productivity. At present, the aggregate impacts of climate change on global-scale agricultural productivity cannot be reliably quantified
Measurement of the cross-section and charge asymmetry of bosons produced in proton-proton collisions at TeV with the ATLAS detector
This paper presents measurements of the and cross-sections and the associated charge asymmetry as a
function of the absolute pseudorapidity of the decay muon. The data were
collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with
the ATLAS experiment at the LHC and correspond to a total integrated luminosity
of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements
varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the
1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured
with an uncertainty between 0.002 and 0.003. The results are compared with
predictions based on next-to-next-to-leading-order calculations with various
parton distribution functions and have the sensitivity to discriminate between
them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables,
submitted to EPJC. All figures including auxiliary figures are available at
https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13
Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector
A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13 TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139 fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV
Gender specific age-related changes in bone density, muscle strength and functional performance in the elderly: a-10 year prospective population-based study
Background: Age-related losses in bone mineral density (BMD), muscle strength, balance, and gait have been linked to an increased risk of falls, fractures and disability, but few prospective studies have compared the timing, rate and pattern of changes in each of these measures in middle-aged and older men and women. This is important so that targeted strategies can be developed to optimise specific musculoskeletal and functional performance measures in older adults. Thus, the aim of this 10-year prospective study was to: 1) characterize and compare age- and gender-specific changes in BMD, grip strength, balance and gait in adults aged 50 years and over, and 2) compare the relative rates of changes between each of these musculoskeletal and functional parameters with ageing.Methods: Men (n = 152) and women (n = 206) aged 50, 60, 70 and 80 years recruited for a population-based study had forearm BMD, grip strength, balance and gait velocity re-assessed after 10-years.Results: The annual loss in BMD was 0.5-0.7% greater in women compared to men aged 60 years and older (p < 0.05- < 0.001), but there were no gender differences in the rate of loss in grip strength, balance or gait. From the age of 50 years there was a consistent pattern of loss in grip strength, while the greatest deterioration in balance and gait occurred from 60 and 70 years onwards, respectively. Comparison of the changes between the different measures revealed that the annual loss in grip strength in men and women aged <70 years was 1-3% greater than the decline in BMD, balance and gait velocity.Conclusion: There were no gender differences in the timing (age) and rate (magnitude) of decline in grip strength, balance or gait in Swedish adults aged 50 years and older, but forearm BMD decreased at a greater rate in women than in men. Furthermore, there was heterogeneity in the rate of loss between the different musculoskeletal and function parameters, especially prior to the age of 70 years, with grip strength deteriorating at a greater rate than BMD, balance and gait.</div
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