Shanzhai et culture du faire en Chine

Ce travail interroge la façon dont les cultures numériques produisent de l’espace géographique et comment celui-ci influence en retour l’innovation technologique. Il montre comment le mouvement du faire de Shenzhen s’est développé dans un bassin manufacturier hérité, en faisant écho à la culture shanzhai locale. Ce mouvement a permis de conceptualiser un nouveau modèle d’innovation ouverte inspiré des pratiques du logiciel libre, qui alimente l’effervescence d’une scène du faire, engendrant ainsi de nouvelles dynamiques productives et spatiales.This work investigates how digital cultures produce geographic space and how this one influences back technological innovation. It shows how Shenzhen’s maker movement has developed in an inherited manufacturing region, echoing local shanzhai culture. This movement permitted to conceptualize a new open innovation model inspired from open-source ideology, which fuels the effervescence of a maker’s scene, thus producing new spatial and productive dynamics

Dangerous misperceptions with consequences: survival of Eastern cottontails on restored grasslands surrounded by agriculture

Habitat loss and degradation is a main threat to biodiversity, and the expansion of intensive agricultural practices has negatively affected wildlife populations worldwide. To counteract these effects, large-scale restoration programs have been developed. In the Midwestern United States, where tallgrass prairies have been reduced by >99%, the Conservation Reserve Program has created patches of grassland habitat within a larger matrix dominated by agricultural fields that are temporally dynamic due to planting and harvesting of crops. The effects of the surrounding landscape on restoration success of wildlife species is largely unknown. My main objective was to examine how landscape processes interact with real and perceived predation risk to affect survival of a key herbivore and important prey species, the eastern cottontail (Sylvilagus floridanus), in restored grassland habitats and the surrounding agricultural matrix. From June 2014 through June 2016, I radio-collared 95 cottontails and tracked their movements until the transmitter failed or mortality occurred. I then constructed known-fate models in program MARK to identify factors that affected survival rates. I also conducted giving-up density (GUD) experiments in grasslands and adjacent agricultural fields to determine if there were differences in perceived predation risk. As expected, survival of cottontails was higher when they used restored grasslands relative to when they used surrounding habitats. Contrary to my prediction, however, cottontails did not accurately perceive predation risk as they perceived agricultural fields to be safer than grasslands. This mismatch could be due to their emphasis on protecting themselves from avian predation rather than mammalian predation. However, mammals were the main predators in this system, predominately coyotes (Canis latrans). My study demonstrates how adjacency of restoration sites to other landscape elements can produce unintended consequences and highlights the complexities of achieving restoration in a highly altered landscape

The Poly(ADP-ribose) polymerase inhibitors in pancreatic cancer

Genome instability and mutations are the hallmarks of cancer. Mutations within BRCA genes increase the risk of pancreatic cancer (PC) development. Poly(ADP-ribose) polymerase inhibitors (PARPi) show the synthetic lethality phenomenon in tumoral cells with BRCA mutation and improve outcomes in patients with breast, prostate and ovarian cancer. Olaparib was the first PARPi registered for the patient with metastatic PC with a deleterious or suspected deleterious germline BRCA-mutation. The POLO phase III clinical trial shows that olaparib in PC increases progression-free survival, however it does not prolong the overall survival. Currently, many clinical trials are ongoing to determine the clinical utility of PARPi in monotherapy or polytherapy of PC. The role of PARPi in PC has not been well established and many questions remain unanswered. This review aims to summarise the rationales behind the use of PARPi and current clinical data

Constraints to Waterfowl Hunting by Hunters and Anglers in the Central United States

Waterfowl hunting participation has been on the decline since the mid‐1980s. We used a web‐based survey to better understand waterfowl hunting constraints (i.e., factors that limit or prohibit participation and enjoyment in leisure activities) among hunters and anglers that hunted or did not hunt waterfowl in the central United States. Forty‐eight constraint items were condensed into 10 constraint factors: Rules and Regulations, Waterfowl Identification, Cost, Waterfowl Hunting Skills, Land Access and Permissions, Interference by Other Hunters, Travel, Social, Waterfowl Populations, and Views of Others. We observed significant effects of both state of residence and activity type (i.e., frequent waterfowl hunters, sporadic waterfowl hunters, dissociated waterfowl hunters, non‐waterfowl hunters, and anglers) but the effect sizes were mostly small. There were few meaningful differences between constraints based on state of residence, indicating that the perception of constraints was largely consistent among the states included in our study. However, Social, Waterfowl Identification, and Waterfowl Hunting Skills constraints had greater differences, particularly between frequent waterfowl hunters and non‐waterfowl hunters. Our assessment of waterfowl constraints did not indicate a single constraint that was inhibiting (or prohibiting) participation of waterfowl hunting among waterfowl hunters or non‐waterfowl hunters. However, there were numerous constraints that were slightly to moderately limiting across all activity groups similarly, which suggests that constraints may act collectively to create a perception of an insurmountable impediment to participation to the individual

An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea

Reference phylogenies are crucial for providing a taxonomic framework for interpretation of marker gene and metagenomic surveys, which continue to reveal novel species at a remarkable rate. Greengenes is a dedicated full-length 16S rRNA gene database that provides users with a curated taxonomy based on de novo tree inference. We developed a ‘taxonomy to tree' approach for transferring group names from an existing taxonomy to a tree topology, and used it to apply the Greengenes, National Center for Biotechnology Information (NCBI) and cyanoDB (Cyanobacteria only) taxonomies to a de novo tree comprising 408 315 sequences. We also incorporated explicit rank information provided by the NCBI taxonomy to group names (by prefixing rank designations) for better user orientation and classification consistency. The resulting merged taxonomy improved the classification of 75% of the sequences by one or more ranks relative to the original NCBI taxonomy with the most pronounced improvements occurring in under-classified environmental sequences. We also assessed candidate phyla (divisions) currently defined by NCBI and present recommendations for consolidation of 34 redundantly named groups. All intermediate results from the pipeline, which includes tree inference, jackknifing and transfer of a donor taxonomy to a recipient tree (tax2tree) are available for download. The improved Greengenes taxonomy should provide important infrastructure for a wide range of megasequencing projects studying ecosystems on scales ranging from our own bodies (the Human Microbiome Project) to the entire planet (the Earth Microbiome Project). The implementation of the software can be obtained from http://sourceforge.net/projects/tax2tree/

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio

Impacts of the Tropical Pacific/Indian Oceans on the Seasonal Cycle of the West African Monsoon

The current consensus is that drought has developed in the Sahel during the second half of the twentieth century as a result of remote effects of oceanic anomalies amplified by local land–atmosphere interactions. This paper focuses on the impacts of oceanic anomalies upon West African climate and specifically aims to identify those from SST anomalies in the Pacific/Indian Oceans during spring and summer seasons, when they were significant. Idealized sensitivity experiments are performed with four atmospheric general circulation models (AGCMs). The prescribed SST patterns used in the AGCMs are based on the leading mode of covariability between SST anomalies over the Pacific/Indian Oceans and summer rainfall over West Africa. The results show that such oceanic anomalies in the Pacific/Indian Ocean lead to a northward shift of an anomalous dry belt from the Gulf of Guinea to the Sahel as the season advances. In the Sahel, the magnitude of rainfall anomalies is comparable to that obtained by other authors using SST anomalies confined to the proximity of the Atlantic Ocean. The mechanism connecting the Pacific/Indian SST anomalies with West African rainfall has a strong seasonal cycle. In spring (May and June), anomalous subsidence develops over both the Maritime Continent and the equatorial Atlantic in response to the enhanced equatorial heating. Precipitation increases over continental West Africa in association with stronger zonal convergence of moisture. In addition, precipitation decreases over the Gulf of Guinea. During the monsoon peak (July and August), the SST anomalies move westward over the equatorial Pacific and the two regions where subsidence occurred earlier in the seasons merge over West Africa. The monsoon weakens and rainfall decreases over the Sahel, especially in August.Peer reviewe

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good