35 research outputs found
Holonomic Gradient Descent and its Application to Fisher-Bingham Integral
We give a new algorithm to find local maximum and minimum of a holonomic
function and apply it for the Fisher-Bingham integral on the sphere ,
which is used in the directional statistics. The method utilizes the theory and
algorithms of holonomic systems.Comment: 23 pages, 1 figur
PICO-LON Project for WIMPs search
Highly segmented inorganic crystal has been shown to have good performance
for dark matter search. The energy resolution of ultra thin and large area
NaI(Tl) scintillator has been developed. The estimated sensitivity for
spin-dependent excitation of 127I was discussed. The recent status of low
background measurement at Oto Cosmo Observatory is reportedComment: 3 pages, 1 figure, Proceedings of TAUP200
Efficacy of 23-valent pneumococcal vaccine in preventing pneumonia and improving survival in nursing home residents: double blind, randomised and placebo controlled trial
Objective To determine the efficacy of a 23-valent pneumococcal polysaccharide vaccine in people at high risk of pneumococcal pneumonia
Photonic hydrogel sensors
Analyte-sensitive hydrogels that incorporate optical structures have emerged as sensing platforms for point-of-care diagnostics. The optical properties of the hydrogel sensors can be rationally designed and fabricated through self-assembly, microfabrication or laser writing. The advantages of photonic hydrogel sensors over conventional assay formats include label-free, quantitative, reusable, and continuous measurement capability that can be integrated with equipment-free text or image display. This Review explains the operation principles of photonic hydrogel sensors, presents syntheses of stimuli-responsive polymers, and provides an overview of qualitative and quantitative readout technologies. Applications in clinical samples are discussed, and potential future directions are identified
Precipitate Formation by Metal Ions and Antibiotics, Particularly Tetracycline Substances
Many investigators have reported on the influence of various metal ions on antibiotics. The direct evidence for binding of metal ions with antibiotics is, however, very rare. The authors happened to find the precipitate formation by Mg⁺⁺ ion and aureomycin, and studied this phenomenon on various sorts of metal ions and antibiotics. The results are summarized as follows: 1) A marked yellow precipitate was formed by 10⁻² 10⁻³ M Mg⁺⁺ and 10⁻³-10⁻⁴M aureomycin. 2) A yellow precipitate was formed by 10⁻³M Mn⁺⁺ and 10⁻³-10⁻⁴M aureomycin, and was also formed by 10⁻⁴M Mn⁺⁺ and 10⁻³M aureomycin. 3) Just, like aureomycin, terramycin formed a yellow precipitate in the presence of Mg⁺⁺ or Mn⁺⁺. The degree of precipitate formation was, however, very weak as compared with aureomycin. 4) The precipitate formation between Mg⁺⁺ and aureomycin appeared at the pHs over 6.5 and became more marked with the rise of pH. 5) The acid solution of the yellow precipitate formed by Mg⁺⁺ and aureomycin showed a strong antibacterial action
A Physiological Aspect of the Citric Acid Cycle of Micrococcus pyogenes var. aureus (Terashima)
In 1957, Yabe reported that the combined administration of glutamate and glucose markedly accelerated the respiration of Micrococcus pyogenes var. aureus (Terashima) over the sum of those in each of the two substrates, and that this phenomenon was due to the important role of glutamate as a sole sparker or entering site of the citric acid cycle of M. pyogenes var. aureus (Terashima). In the present experiments, the authors investigated this phenomenon in regard to pH. In the presence of glutamate and glucose, oxygen consumption or carbon dioxide evolution was nearly the same at all pHs tested, whereas ammonia formation was the best at pH 6.2, which was the optimum for glutamate oxidation by M. pyogenes var. aureus (Terashima); this result seems to sustain the conclusion given by Yabe. For all of glutamate, aspartate and alanine, the oxidation optimum pHs were lower in M. pyogenes var. aureus (Terashima) than in pyogenes var. albus and citreus. From thsee results, it is easily inferred that the cytoplasmic membrane of M. pyogenes var. aureus (Terashima) is a pretty peculiar one compared with those of the other two micrococci, and that these peculiar physiological properties of the cytoplasmic membrane have something to do with the previously reported peculiar aspect of the citric acid cycle of M. pyogenes var. aureus (Terashima)
A Comparative Study on the Action of Aureomycin and Terramycin
Both of aureomycin and terramycin belong to the tetracycline, and their action has been considered to be nearly the same. The authors made a comparative study on the action of aureomycin and terramycin and obtained the following results: 1) The respiration of Escherichia coli in the presence of glucose, pyruvate, aspartate and glutamate is markedly inhibited by both of aureomycin and terramycin. The respiration inhibitory action of aureomycin is quantitatively about 3 times higher than that of terramycin. 2) The respiration of Micrococcus pyogenes var. aureus (Terashima) in the presence of glutamate, alanine, pyruvate and lactate is inhibited by both of aureomycin and terramycin. As for the respiration inhibitory action, aureomycin is quantitatively about 3 times stronger than terramycin. 3) The respiration of M. pyogenes var. sureus (Terashima) in the presence of glucose is not inhibited by aureomycin or terramycin, but is rather accelerated by these, particularly by terramycin. 4) As for the growth inhibitory action, aureomycin is somewnat stronger than terramycin