1,154 research outputs found

    Investigating a potential geothermal play in the southern Sydney Basin

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    Geothermal energy is a renewable resource that will be part of the world’s transition to clean power production. Different technologies can be utilised to extract heat or produce geothermal-based electricity. The Geological Survey of NSW has identified several regions across the state where there are higher than average geothermal gradients. These regions in the southern Sydney Basin are investigated with the aim of determining if the high temperatures might be related to subsurface rocks with relatively high concentrations of radiogenic isotopes that might create a ‘hot dry rock’ play. Rock properties are tested that would be required to generate a geothermal resource. Existing and potential engineering technologies (i.e. geothermal-based electricity, heating and cooling applications accompanied by heat pumps, geothermal-hybrid systems, and mine-based geothermal technologies) are also further reviewed. Overall this study provides insights into future opportunities and challenges to harnessing geothermal energy in NSW

    Coastline responses to changing storm patterns

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    Author Posting. © American Geophysical Union, 2006. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geophysical Research Letters 33 (2006): L18404, doi:10.1029/2006GL027445.Researchers and coastal managers are pondering how accelerated sea-level rise and possibly intensified storms will affect shorelines. These issues are most often investigated in a cross-shore profile framework, fostering the implicit assumption that coastline responses will be approximately uniform in the alongshore direction. However, experiments with a recently developed numerical model of coastline change on a large spatial domain suggest that the shoreline responses to climate change could be highly variable. As storm and wave climates change, large-scale coastline shapes are likely to shift—causing areas of greatly accelerated coastal erosion to alternate with areas of considerable shoreline accretion. On complex-shaped coastlines, including cuspate-cape and spit coastlines, the alongshore variation in shoreline retreat rates could be an order of magnitude higher than the baseline retreat rate expected from sea-level rise alone.The Andrew W. Mellon Foundation, the National Science Foundation Biocomplexity Program, and the Duke University Center on Global Change supported this work

    Along-strike fault core thickness variations of a fault in poorly lithified sediments, Miri (Malaysia)

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    Fault resistance to across-fault fluid flow is as strong as its weakest point. Processes that determine patches of the fault surface containing transmissible fault rocks must be taken into account to produce reliable predictions of cross fault fluid flow. We use a study site in Miri as a natural laboratory to investigate in detail the fault core thickness variations along-strike and down dip and to quantify the risk of discontinuities in the clay-rich fault core. Five fault core types have been identified: foliated clay-rich fault core, chaotic clay-rich fault core, attenuated clay-rich fault core, sandy anastomosing shears and sandy breccia. The sandy fault rocks are likely to have lower capillary entry pressure, and higher permeability than the clay-rich rock, so could represent potential cross-fault flow pathways. We performed a geostatistical analysis, showing a correlation over 3 m scale, suggesting the presence of ‘patches’ of thin and thick fault core generally less than 3m in length. We interpret this as superimposition of two (or more) different deformation processes at a smaller and larger scale. We speculate on the processes that could produce the observed distribution of thickness and composition, in particular processes that could have disrupted the through-going clay-rich core

    Renal sympathetic denervation restores aortic distensibility in patients with resistant hypertension: data from a multi-center trial

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    Renal sympathetic denervation (RDN) is under investigation as a treatment option in patients with resistant hypertension (RH). Determinants of arterial compliance may, however, help to predict the BP response to therapy. Aortic distensibility (AD) is a well-established parameter of aortic stiffness and can reliably be obtained by CMR. This analysis sought to investigate the effects of RDN on AD and to assess the predictive value of pre-treatment AD for BP changes. We analyzed data of 65 patients with RH included in a multicenter trial. RDN was performed in all participants. A standardized CMR protocol was utilized at baseline and at 6-month follow-up. AD was determined as the change in cross-sectional aortic area per unit change in BP. Office BP decreased significantly from 173/92 ± 24/16 mmHg at baseline to 151/85 ± 24/17 mmHg (p < 0.001) 6 months after RDN. Maximum aortic areas increased from 604.7 ± 157.7 to 621.1 ± 157.3 mm2 (p = 0.011). AD improved significantly by 33% from 1.52 ± 0.82 to 2.02 ± 0.93 × 10-3 mmHg-1 (p < 0.001). Increase of AD at follow-up was significantly more pronounced in younger patients (p = 0.005) and responders to RDN (p = 0.002). Patients with high-baseline AD were significantly younger (61.4 ± 10.1 vs. 67.1 ± 8.4 years, p = 0.022). However, there was no significant correlation of baseline AD to response to RDN. AD is improved after RDN across all age groups. Importantly, these improvements appear to be unrelated to observed BP changes, suggesting that RDN may have direct effects on the central vasculature

    Star Formation in Galaxy Mergers with Realistic Models of Stellar Feedback & the Interstellar Medium

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    We use simulations with realistic models for stellar feedback to study galaxy mergers. These high resolution (1 pc) simulations follow formation and destruction of individual GMCs and star clusters. The final starburst is dominated by in situ star formation, fueled by gas which flows inwards due to global torques. The resulting high gas density results in rapid star formation. The gas is self gravitating, and forms massive (~10^10 M_sun) GMCs and subsequent super-starclusters (masses up to 10^8 M_sun). However, in contrast to some recent simulations, the bulk of new stars which eventually form the central bulge are not born in superclusters which then sink to the center of the galaxy, because feedback efficiently disperses GMCs after they turn several percent of their mass into stars. Most of the mass that reaches the nucleus does so in the form of gas. The Kennicutt-Schmidt law emerges naturally as a consequence of feedback balancing gravitational collapse, independent of the small-scale star formation microphysics. The same mechanisms that drive this relation in isolated galaxies, in particular radiation pressure from IR photons, extend over seven decades in SFR to regulate star formation in the most extreme starbursts (densities >10^4 M_sun/pc^2). Feedback also drives super-winds with large mass loss rates; but a significant fraction of the wind material falls back onto the disks at later times, leading to higher post-starburst SFRs in the presence of stellar feedback. Strong AGN feedback is required to explain sharp cutoffs in star formation rate. We compare the predicted relic structure, mass profile, morphology, and efficiency of disk survival to simulations which do not explicitly resolve GMCs or feedback. Global galaxy properties are similar, but sub-galactic properties and star formation rates can differ significantly.Comment: 17 pages, 13 figures (+appendices), MNRAS accepted (matches published). Movies of the simulations are available at http://www.tapir.caltech.edu/~phopkins/Site/Movies_sbw_mgr.htm

    Aseismic slip and seismogenic coupling along the central San Andreas Fault

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    International audienceWe use high-resolution Synthetic Aperture Radar- and GPS-derived observations of surfacedisplacements to derive the first probabilistic estimates of fault coupling along the creeping section of theSan Andreas Fault, in between the terminations of the 1857 and 1906 magnitude 7.9 earthquakes. Usinga fully Bayesian approach enables unequaled resolution and allows us to infer a high probability ofsignificant fault locking along the creeping section. The inferred discreet locked asperities are consistentwith evidence for magnitude 6+ earthquakes over the past century in this area and may be associated withthe initiation phase of the 1857 earthquake. As creeping segments may be related to the initiation andtermination of seismic ruptures, such distribution of locked and creeping asperities highlights the centralrole of the creeping section on the occurrence of major earthquakes along the San Andreas Fault

    Moderation of the Association between Media Exposure and Youth Smoking Onset: Race/Ethnicity, and Parent Smoking

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    This study of youth smoking onset aims to replicate previously published media moderation effects for race/ethnicity in a national longitudinal multiethnic sample of U.S. adolescents. Previous research has demonstrated that associations between media and smoking during adolescence are greater for Whites than Hispanics or Blacks, and for youth living in non-smoking families. In this study, changes in smoking status over 24 months were assessed among 4,511 baseline never-smokers. The incidence of smoking onset was 14.3% by 24 months with no differences by race/ethnicity. Blacks had higher exposure to movie smoking and overall television viewing compared with Whites and Hispanics. Whites responded to movie smoking regardless of parent smoking but more strongly if their parents were non-smokers. In contrast, Black adolescents showed little behavioral response to any media, regardless of parent smoking. Hispanic adolescents responded only to TV viewing and only when their parents did not smoke. In an analysis assessing the influence of the race of smoking characters on smoking behavior of White and Black adolescents, Whites responded to both White and Black movie character smoking, whereas Blacks responded only to smoking by Black movie characters. Taken as a whole, the findings replicate and extend previous findings, suggesting media factors are more influential among adolescents at low to moderate overall risk for smoking. We draw analogies between these low-moderate risk adolescents and “swing voters” in national elections, suggesting that media effects are more apt to influence an adolescent in the middle of the risk spectrum, compared with his peers at either end of it

    Seasonal melting and the formation of sedimentary rocks on Mars, with predictions for the Gale Crater mound

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    A model for the formation and distribution of sedimentary rocks on Mars is proposed. The rate-limiting step is supply of liquid water from seasonal melting of snow or ice. The model is run for a O(10^2) mbar pure CO2 atmosphere, dusty snow, and solar luminosity reduced by 23%. For these conditions snow only melts near the equator, and only when obliquity >40 degrees, eccentricity >0.12, and perihelion occurs near equinox. These requirements for melting are satisfied by 0.01-20% of the probability distribution of Mars' past spin-orbit parameters. Total melt production is sufficient to account for aqueous alteration of the sedimentary rocks. The pattern of seasonal snowmelt is integrated over all spin-orbit parameters and compared to the observed distribution of sedimentary rocks. The global distribution of snowmelt has maxima in Valles Marineris, Meridiani Planum and Gale Crater. These correspond to maxima in the sedimentary-rock distribution. Higher pressures and especially higher temperatures lead to melting over a broader range of spin-orbit parameters. The pattern of sedimentary rocks on Mars is most consistent with a Mars paleoclimate that only rarely produced enough meltwater to precipitate aqueous cements and indurate sediment. The results suggest intermittency of snowmelt and long globally-dry intervals, unfavorable for past life on Mars. This model makes testable predictions for the Mars Science Laboratory rover at Gale Crater. Gale Crater is predicted to be a hemispheric maximum for snowmelt on Mars.Comment: Submitted to Icarus. Minor changes from submitted versio

    DETC Induces Leishmania Parasite Killing in Human In Vitro and Murine In Vivo Models: A Promising Therapeutic Alternative in Leishmaniasis

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    Background: Chemotherapy remains the primary tool for treatment and control of human leishmaniasis. However, currently available drugs present serious problems regarding side-effects, variable efficacy, and cost. Affordable and less toxic drugs are urgently needed for leishmaniasis. Methodology/Principal Findings: We demonstrate, by microscopy and viability assays, that superoxide dismutase inhibitor diethyldithiocarbamate (DETC) dose-dependently induces parasite killing (p,0.001) and is able to ??????sterilize?????? Leishmania amazonensis infection at 2 mM in human macrophages in vitro. We also show that DETC-induced superoxide production (p,0.001) and parasite destruction (p,0.05) were reverted by the addition of the antioxidant N-acetylcysteine, indicating that DETC-induced killing occurs through oxidative damage. Furthermore, ultrastructural analysis by electron microscopy demonstrates a rapid and highly selective destruction of amastigotes in the phagosome upon DETC treatment, without any apparent damage to the host cell, including its mitochondria. In addition, DETC significantly induced parasite killing in Leishmania promastigotes in axenic culture. In murine macrophages infected with Leishmania braziliensis, DETC significantly induced in vitro superoxide production (p = 0.0049) and parasite killing (p = 0.0043). In vivo treatment with DETC in BALB/C mice infected with Leishmania braziliensis caused a significant decrease in lesion size (p,0.0001), paralleled by a 100-fold decrease (p = 0.0087) in parasite burden. Conclusions/Significance: Due to its strong leishmanicidal effect in human macrophages in vitro, its in vivo effectiveness in a murine model, and its previously demonstrated in vivo safety profile in HIV treatment, DETC treatment might be considered as a valuable therapeutic option in human leishmaniasis, including HIV/Leishmania co-infection
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