Trypsin inhibiting activity of methanolic extract of aerial parts of Mikania micrantha

ABSTRACT Objective: To investigate trypsin inhibiting activity of methanolic extract of aerial parts of Mikania micrantha.Methods: Powdered plant material was extracted with methanol at room temperature and trypsin inhibiting activity of the extract was studied using bovine serum albumin (BSA) as the substrate. Result: Percentage inhibition of trypsin activity by the methanolic extract of aerial parts of Mikania micrantha wer

Comparative Analysis of Investment Behaviour: Exploring Investment Patterns and Decision-Making between Generation X, Generation Y, and Generation Z

This research paper compares investment behaviours among Generations X, Y, and Z in Bengaluru, India, focusing on investment choices, amounts, and periods and utilising mixed methods. The study examines investment behaviour as a function of risk tolerance, financial literacy, investment choices, technological dependency, and retirement planning. A total of 301 participants from various backgrounds participated in the study, with data analysed using ANOVA tests and post hoc LSD tests to identify significant differences between generational cohorts. SPSS and MS Excel were employed for statistical analysis. The findings of this study are significant, revealing that while there were no statistically important variations in financial proficiency among the generations, Generation Z displayed the highest average scores. This underscores the importance of ongoing financial education initiatives targeted at younger individuals. Additionally, Generation Z exhibited the highest risk tolerance, followed by Generation Y and Generation X, indicating a propensity for riskier investment options among younger generations. Despite rapid technological advancements, there were no notable differences in technology dependency across generations, suggesting a consistent impact of technology on investment behaviour across age groups. Significant differences were observed in retirement investment propensity, with Generation Y showing a higher inclination towards retirement investment than Generation X. However, no notable difference was seen between Generation Z and either Generation X or Y, emphasising the importance of long-term financial planning, particularly among younger generations. Furthermore, the study highlights a correlation between financial proficiency and risk appetite, with higher literacy levels associated with increased risk-taking behaviour. Analysis of investment preferences reveals that Generation Z prefers Mutual Funds/Equity, Generation X favours Real Estate and Fixed Deposits, and Generation Y leans toward Gold. These preferences reflect the perceived stability, inflation-hedging properties, and cultural significance of the chosen investment avenues.

High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models

Abstract Lipid nanoparticles for delivering mRNA therapeutics hold immense promise for the treatment of a wide range of lung-associated diseases. However, the lack of effective methodologies capable of identifying the pulmonary delivery profile of chemically distinct lipid libraries poses a significant obstacle to the advancement of mRNA therapeutics. Here we report the implementation of a barcoded high-throughput screening system as a means to identify the lung-targeting efficacy of cationic, degradable lipid-like materials. We combinatorially synthesize 180 cationic, degradable lipids which are initially screened in vitro. We then use barcoding technology to quantify how the selected 96 distinct lipid nanoparticles deliver DNA barcodes in vivo. The top-performing nanoparticle formulation delivering Cas9-based genetic editors exhibits therapeutic potential for antiangiogenic cancer therapy within a lung tumor model in female mice. These data demonstrate that employing high-throughput barcoding technology as a screening tool for identifying nanoparticles with lung tropism holds potential for the development of next-generation extrahepatic delivery platforms