Correlation Between PlayerTek Performance Data and Fatigue as Measured by the RESTQ-76 Sport Over the Course of a Collegiate Soccer Season

Please enjoy Volume 6, Issue 1 of the JSMAHS. In this issue, you will find Professional, Graduate, and Undergraduate research abstracts, and case reports. Thank you for viewing this 6th Annual OATA Special Edition

Lateral wedge insoles for medial knee osteoarthritis: 12 month randomised controlled trial

Objective To assess the effect of lateral wedge insoles compared with flat control insoles on improving symptoms and slowing structural disease progression in medial knee osteoarthritis

Genes and lipids that impact uptake and assimilation of exogenous coenzyme Q in Saccharomyces cerevisiae.

Coenzyme Q (CoQ) is an essential player in the respiratory electron transport chain and is the only lipid-soluble antioxidant synthesized endogenously in mammalian and yeast cells. In humans, genetic mutations, pathologies, certain medical treatments, and aging, result in CoQ deficiencies, which are linked to mitochondrial, cardiovascular, and neurodegenerative diseases. The only strategy available for these patients is CoQ supplementation. CoQ supplements benefit a small subset of patients, but the poor solubility of CoQ greatly limits treatment efficacy. Consequently, the efficient delivery of CoQ to the mitochondria and restoration of respiratory function remains a major challenge. A better understanding of CoQ uptake and mitochondrial delivery is crucial to make this molecule a more efficient and effective therapeutic tool. In this study, we investigated the mechanism of CoQ uptake and distribution using the yeast Saccharomyces cerevisiae as a model organism. The addition of exogenous CoQ was tested for the ability to restore growth on non-fermentable medium in several strains that lack CoQ synthesis (coq mutants). Surprisingly, we discovered that the presence of CoQ biosynthetic intermediates impairs assimilation of CoQ into a functional respiratory chain in yeast cells. Moreover, a screen of 40 gene deletions considered to be candidates to prevent exogenous CoQ from rescuing growth of the CoQ-less coq2Δ mutant, identified six novel genes (CDC10, RTS1, RVS161, RVS167, VPS1, and NAT3) as necessary for efficient trafficking of CoQ to mitochondria. The proteins encoded by these genes represent essential steps in the pathways responsible for transport of exogenously supplied CoQ to its functional sites in the cell, and definitively associate CoQ distribution with endocytosis and intracellular vesicular trafficking pathways conserved from yeast to human cells

On the Breeds of Cattle—Historic and Current Classifications

Classification of cattle breeds contributes to our understanding of the history of cattle and is essential for an effective conservation of genetic diversity. Here we review the various classifications over the last two centuries and compare the most recent classifications with genetic data. The classifications devised during the 19th to the late 20th century were in line with the Linnaean taxonomy and emphasized cranial or horn morphology. Subsequent classifications were based on coat color, geographic origin or molecular markers. Several theories were developed that linked breed characteristics either to a supposed ancestral aurochs subspecies or to a presumed ethnic origin. Most of the older classifications have now been discarded, but have introduced several Latin terms that are still in use. The most consistent classification was proposed in 1995 by Felius and emphasizes the geographic origin of breeds. This is largely in agreement with the breed clusters indicated by a biochemical and molecular genetic analysis, which reflect either groups of breeds with a common geographic origin or single breeds that have expanded by export and/or crossbreeding. We propose that this information is also relevant for managing the genetic diversity of cattl

Project Themyscira

Currently, both governments and private corporations are developing lunar exploration projects for scientific research and spaceflight operations. However, a viable plan for a lunar base is yet to be developed. The goal of Project Themyscira is to design a self-sufficient, sustainable lunar base capable of supporting five crew members for a period of six months. The feasibility study is two-fold. It will test the effectiveness and efficiency of the life-support systems to accomplish the mission, as well as evaluate its financial and logistic feasibility. In order to study the required systems to support human life, the team conducted an extensive literature survey on previous designs for human settlements in space and their limitations. This assessment yielded a series of constraints for oxygen production, atmospheric modeling, energy production, water treatment, and thermal regulation. Preliminary findings show that while some of the necessary support systems have the technology required to provide the necessary outputs, the logistics to set up the lunar base are not financially feasible. Nonetheless, artificial atmosphere models, artificial photosynthesis and radiation-protected photovoltaic cells are some of the existing technologies that would allow the lunar base to sustain human life. Consequently, optimizing the technologies so that they can be taken to space in smaller dimensions could result in logistical feasibility. The team will focus on developing testing methods to optimize the systems necessary to sustain the lunar base

Empowering Students in Higher-Education to Teach and Learn

We explored opportunities, advantages and barriers to enabling students to establish student-led learning events at a New Zealand university. We used an action-research approach to explore if students felt empowered to use the infrastructure of this university to realise something that they themselves set out to achieve. We discovered that, in achieving a series of open discussions about sustainability, students adopted a democratic, distributed form of decision-making, not unlike a typical academic model, with leaders taking temporary roles that included passing on responsibility to those who followed. Students were proud of the events they created and identified the discussion format as something different from their experience as undergraduate students in our institution. This article, co-authored by staff and students, considers whether higher education processes that do empower students do so adequately and the extent to which students are prepared by higher education to take on powerful roles after they graduate

No difference in effects of ‘PACE steps to success’ palliative care program for nursing home residents with and without dementia : a pre-planned subgroup analysis of the seven-country PACE trial

Background: 'PACE Steps to Success' is a multicomponent training program aiming to integrate generalist and non-disease-specific palliative care in nursing homes. This program did not improve residents' comfort in the last week of life, but it appeared to improve quality of care and dying in their last month of life. Because this program included only three dementia-specific elements, its effects might differ depending on the presence or stage of dementia. We aimed to investigate whether the program effects differ between residents with advanced, non-advanced, and no dementia. Methods: Pre-planned subgroup analysis of the PACE cluster-randomized controlled trial in 78 nursing homes in seven European countries. Participants included residents who died in the previous 4 months. The nursing home staff or general practitioner assessed the presence of dementia; severity was determined using two highly-discriminatory staff-reported instruments. Using after-death questionnaires, staff assessed comfort in the last week of life (Comfort Assessment in Dying-End-of-Life in Dementia-scale; primary outcome) and quality of care and dying in the last month of life (Quality of Dying in Long-Term Care scale; secondary outcome). Results: At baseline, we included 177 residents with advanced dementia, 126 with non-advanced dementia and 156 without dementia. Post-intervention, respectively in the control and the intervention group, we included 136 and 104 residents with advanced dementia, 167 and 110 with non-advanced dementia and 157 and 137 without dementia. We found no subgroup differences on comfort in the last week of life, comparing advanced versus without dementia (baseline-adjusted mean sub-group difference 2.1; p-value = 0.177), non-advanced versus without dementia (2.7; p = 0.092), and advanced versus non-advanced dementia (- 0.6; p = 0.698); or on quality of care and dying in the last month of life, comparing advanced and without dementia (- 0.6; p = 0.741), non-advanced and without dementia (- 1.5; p = 0.428), and advanced and non-advanced dementia (0.9; p = 0.632). Conclusions: The lack of subgroup difference suggests that while the program did not improve comfort in dying residents with or without dementia, it appeared to equally improve quality of care and dying in the last month of life for residents with dementia (regardless of the stage) and those without dementia. A generalist and non-disease-specific palliative care program, such as PACE Steps to Success, is a useful starting point for future palliative care improvement in nursing homes, but to effectively improve residents' comfort, this program needs further development

Polarimetric observations of OH masers in proto-planetary nebulae

The 1612 and 1667 MHz OH maser lines have been measured in all four Stokes parameters in 47 proto-planetary nebula (PPN) candidates. Out of 42 objects detected, 40 and 34 are 1612 and 1667 MHz emitters, respectively. The spectral extent of the 1667 MHz line overshoots that of the 1612 MHz line in about 80% of the targets. 52% and 26% of the 1612 and 1667 MHz sources, respectively, show linear polarization in at least some features. Circular polarization is more frequent, occurring in 78% and 32% of sources of the respective OH lines. The percentage polarization is usually small (<15%) reaching up to 50-80% in a few sources. Features of linearly polarized emission are usually weak (0.5-4Jy) and narrow (0.3-0.5kms^{-1}). The strength of magnetic field inferred from likely Zeeman pairs in two sources of a few mG is consistent with values reported elsewhere for those classes of objects. An upper limit of the electron density in the envelope of OH17.7-2.0 derived from the difference in the position angle of polarization vectors for the two OH lines is about 1cm^{-3}. Distinct profiles of polarization position angle at 1612 and 1667 MHz are seen in about one third of the sources and strongly suggest that the envelopes are permeated with structured magnetic fields. The geometry of the magnetic field is implicated as an important cause of the depolarization found in some PPN candidates. For the subset of targets which show axisymmetric shells in the optical or radio images we found a dominance of magnetic field components which are orthogonal to the long axis of the nebulae. This finding supports the hypothesis that such bipolar lobes are shaped by the magnetic field.Comment: Accepted for publication in A&A; 11 pages, 7 figure