THE INTERNATIONAL CAPITAL MOVEMENT AS A FACTOR OF INFLUENCE ON INNOVATIVE DEVELOPMENT TENDENCY OF UKRAINE’S ECONOMY AND ITS INTEGRATION INTO THE WORLD ECONOMY

The article represents the research results concerning Ukraine’s solving strategic tasks to develop the financial mechanism of regulating the international capital movement and strengthening its positive effect on Ukraine’s economy development tendencies and innovative renewal of its domestic enterprises.The research results regarding Ukraine’s solving the strategic task of financial mechanisms of regulating the international capital movement and strengthening its positive effect on Ukraine’s economic development and innovative renewal of its economy are considered

Endogenous tumor suppressor microRNA-193b: Therapeutic and prognostic value in acute myeloid leukemia

Purpose Dysregulated microRNAs are implicated in the pathogenesis and aggressiveness of acute myeloid leukemia (AML). We describe the effect of the hematopoietic stem-cell self-renewal regulating miR-193b on progression and prognosis of AML. Methods We profiled miR-193b-5p/3p expression in cytogenetically and clinically characterized de novo pediatric AML (n = 161) via quantitative real-time polymerase chain reaction and validated our findings in an independent cohort of 187 adult patients. We investigated the tumor suppressive function of miR-193b in human AML blasts, patient-derived xenografts, and miR-193b knockout mice in vitro and in vivo. Results miR-193b exerted important, endogenous, tumor-suppressive functions on the hematopoietic system. miR-193b-3p was downregulated in several cytogenetically defined subgroups of pediatric and adult AML, and low expression served as an independent indicator for poor prognosis in pediatric AML (risk ratio 6 standard error, 20.56 6 0.23; P = .016). miR-193b-3p expression improved the prognostic value of the European LeukemiaNet risk-group stratification or a 17-gene leukemic stemness score. In knockout mice, loss of miR-193b cooperated with Hoxa9/Meis1 during leukemogenesis, whereas restoring miR-193b expression impaired leukemic engraftment. Similarly, expression of miR-193b in AML blasts from patients diminished leukemic growth in vitro and in mouse xenografts. Mechanistically, miR-193b induced apoptosis and a G1/S-phase block in various human AML subgroups by targeting multiple factors of the KIT-RAS-RAF-MEK-ERK (MAPK) signaling cascade and the downstream cell cycle regulator CCND1. Conclusion The tumor-suppressive function is independent of patient age or genetics; therefore, restoring miR-193b would assure high antileukemic efficacy by blocking the entire MAPK signaling cascade while preventing the emergence of resistance mechanisms

Challenges in QCD matter physics - The Compressed Baryonic Matter experiment at FAIR

Substantial experimental and theoretical efforts worldwide are devoted to explore the phase diagram of strongly interacting matter. At LHC and top RHIC energies, QCD matter is studied at very high temperatures and nearly vanishing net-baryon densities. There is evidence that a Quark-Gluon-Plasma (QGP) was created at experiments at RHIC and LHC. The transition from the QGP back to the hadron gas is found to be a smooth cross over. For larger net-baryon densities and lower temperatures, it is expected that the QCD phase diagram exhibits a rich structure, such as a first-order phase transition between hadronic and partonic matter which terminates in a critical point, or exotic phases like quarkyonic matter. The discovery of these landmarks would be a breakthrough in our understanding of the strong interaction and is therefore in the focus of various high-energy heavy-ion research programs. The Compressed Baryonic Matter (CBM) experiment at FAIR will play a unique role in the exploration of the QCD phase diagram in the region of high net-baryon densities, because it is designed to run at unprecedented interaction rates. High-rate operation is the key prerequisite for high-precision measurements of multi-differential observables and of rare diagnostic probes which are sensitive to the dense phase of the nuclear fireball. The goal of the CBM experiment at SIS100 (sqrt(s_NN) = 2.7 - 4.9 GeV) is to discover fundamental properties of QCD matter: the phase structure at large baryon-chemical potentials (mu_B > 500 MeV), effects of chiral symmetry, and the equation-of-state at high density as it is expected to occur in the core of neutron stars. In this article, we review the motivation for and the physics programme of CBM, including activities before the start of data taking in 2022, in the context of the worldwide efforts to explore high-density QCD matter.Comment: 15 pages, 11 figures. Published in European Physical Journal

Is there Progress? An Overview of Select Biomarker Candidates for Major Depressive Disorder

Major Depressive Disorder (MDD) contributes to a significant worldwide disease burden, expected to be second only to heart disease by 2050. However, accurate diagnosis has been a historical weakness in clinical psychiatry. As a result, there is a demand for diagnostic modalities with greater objectivity that could improve on current psychiatric practice that relies mainly on self-reporting of symptoms and clinical interviews. Over the past two decades, literature on a growing number of putative biomarkers for MDD increasingly suggests that MDD patients have significantly different biological profiles compared to healthy controls. However, difficulty in elucidating their exact relationships within depression pathology renders individual markers inconsistent diagnostic tools. Consequently, further biomarker research could potentially improve our understanding of MDD pathophysiology as well as aid in interpreting response to treatment, narrow differential diagnoses, and help refine current MDD criteria. Representative of this, multiplex assays using multiple sources of biomarkers are reported to be more accurate options in comparison to individual markers that exhibit lower specificity and sensitivity, and are more prone to confounding factors. In the future, more sophisticated multiplex assays may hold promise for use in screening and diagnosing depression and determining clinical severity as an advance over relying solely on current subjective diagnostic criteria. A pervasive limitation in existing research is heterogeneity inherent in MDD studies, which impacts the validity of biomarker data. Additionally, small sample sizes of most studies limit statistical power. Yet, as the RDoC project evolves to decrease these limitations, and stronger studies with more generalizable data are developed, significant advances in the next decade are expected to yield important information in the development of MDD biomarkers for use in clinical settings

Public Painting - Malerei und Handlung

Das Magazin "Public Painting – Malerei und Handlung" versammelt künstlerischen Projekte, die auf unterschiedliche Weise Verhältnisse von Malerei zum öffentlichen Raum reflektieren, und Verhältnisse thematisieren, die im öffentlichen Raum ausagiert werden. Die Beiträge entstanden als Resultat der Kooperation des kunstwissenschaftlichen Seminars "Malerei als Handlung" von Anne Röhl und des kunstpraktischen Seminars "public painting" von Sebastian Freytag während des Sommersemesters 2021 an der Universität Siegen. Unter dem Titel "public painting" wurden Schnittstellen von malerischer Praxis und öffentlichen Raum diskutiert. Die Studierenden des Seminars "Malerei als Handlung" haben sich wiederum damit beschäftigt, wie die Gattung Malerei im Verlauf des 20. Jahrhunderts durch die Abkehr von traditionellen Entstehungsprozessen und Malhandlungen befragt wurde und skulptural und/oder performativ wird. Daneben widmeten sich die Studierenden des kunsthistorischen Seminars der schriftlichen Auseinandersetzung mit den künstlerischen Resultaten des kunstpraktischen Seminars. Die Auseinandersetzung mit dem öffentlichen Raum stellte im Sommersemester 2021 eine besondere Herausforderung dar, da er pandemiebedingt nur eingeschränkt nutzbar war. Die künstlerischen Ergebnisse dokumentieren somit auch diese Zeit

The interaction between bentonite and water vapor

The influence of water vapor on bentonites or smectites, respectively, is of interest in many different fields of applied mineralogy like nuclear waste sealing or casting in foundry industry. The water vapor affects the smectite surface and perhaps its structure, which leads probably to achange of its properties in a mostly unfavorable way. Therefore, the influence of hot water vapor (200 ℃) on the physico-chemical, mineralogical, and electrokinetic parameters and properties of smectite-group minerals has been studied. After the steam treatment, turbidity measurements, methylene blue sorption, water adsorption, and cation exchange capacity were measured on both untreated and treated samples. Mineralogical changes were checked by X-ray diffraction (XRD), X-ray photon spectroscopy (XPS) was done on O, Al, and Si, respectively. Only few parameters showed differences between vapor-treated and raw samples. The measurement of sedimentation volumes (SV) resulted in a decreased SV after the treatment. As shown by XRD and XPS, the crystalline structure of smectite remained unaffected by the steam treatment. Equivalent sphere diameters (ESD) were not systematically affected by the steam treatment. Differences in cation exchange capacity (CEC) between unprocessed and treated samples were observed, but only for smectites with monovalent interlayer cations. From the variety of different measurements and its results, the conclusion is that due to thesteam treatment the charge properties at or near the particle surface of smectite change. While most of physico-chemical and mineralogical properties remained unaffected by watervapor, electrokinetic, rheological, and surface properties react due to exposure of smectite to hotwater vapor. The first physico-chemical and mineralogical experiments suggested that monovalent smectitesoffered changes after steaming, whereas the divalent smectites remained unaffected. This statement is partially true in terms of the experiments of this work. As well the magnitude of the dynamic mobility and isoconductive point, as viscosity and shearstress, derived from electrokinetics and conductometric titrations, potentiometric titrations andrheological measurements react due to the exposure of smectite to water vapor. However, not only the sodium smectites how edchanges comparing unprocessed and vapor treated samples - also the calcium smectite offered almost differences. The comparison of dynamic mobility of this work with electrokinetic potentials of sulfated polystyrene particles, obtained from streaming potentials in plugs (Lyklema & Minor, 1998), indicates a modification of the surface conductance of the smectite particles due to the steam treatment. The idea of a surface charge modification of the smectite due to the exposure to hot watervapor was confirmed by the experiments and its results of this work. Furthermore, the author speculates about a dissolution process of amorphous silica from the rough smectite surface, which was indicated by the determination of fractal dimension and the measurement of silicon. This process would influence the diffuse double layer and hence, electrokinetic parameters, like dynamic mobility and surface conductance. After all performed experiments and calculated parameters a clear statement about the interaction of bentonite or smectite with water vapor is finally only conditionally available. However, a lot of ideas and potential declarations were given, resulting in the assumption, that water vapor or steam affects the surface structure and its charge conditions of the smectite particles

Die Geschichte des Zahnärztlichen Institutes der Philipps-Universität Marburg a. d. Lahn

Layoutgetreues Digitalisat der Ausg.: Marburg, 1959 Standort: Universität Marburg, Zentralbibliothek (000) Signatur: 4 Z 59/360 Bemerkungen: Marburg, Univ., Diss., 1959. - Maschinenschriftlich vervielfältigt. Digitalisiert 201