263 research outputs found
Spatial and temporal factors determine auditory-visual interactions in human saccadic eye movements
- Author
- A. J. Opstal Van
- A. J. Opstal Van
- A. J. Van Opstal
- A. T. Bahill
- B. E. Stein
- B. E. Stein
- B. F. J. Manly
- B. Fischer
- C. C. A. M. Gielen
- C. J. Bruce
- C. J. Lueck
- C. Lee
- D. A. Robinson
- D. H. Raab
- D. L. Sparks
- D. P. Munoz
- D. R. F. Irvine
- D. R. Perrott
- F. P. Ottes
- G. S. Russo
- H. C. Hughes
- H. Collewijn
- J. Blauert
- J. M. Findlay
- J. R. Simon
- J. R. Zahn
- J. T. McIlwain
- L. K. Wilkinson
- M. A. Frens
- M. A. Frens
- M. A. Meredith
- M. A. Meredith
- M. A. Meredith
- M. F. Jay
- M. T. Wallace
- P. Bertelson
- P. W. Glimcher
- P. Y. He
- R. F. Van Der Willigen
- S. M. Ross
- W. H. Press
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Multipotent adult progenitor cells sustain function of ischemic limbs in mice
- Author
- Abizanda G. (Gloria)
- Adney J. (Josuah R.)
- Aranguren X.L. (Xabier L.)
- Billiau A.D. (A.D.)
- Chen E. (E.)
- Chen W. (W.)
- Du F. (F.)
- Frommer S.A. (S. A.)
- Hagenbrock J. (J.)
- Harris N.H. (N. H.)
- Hendrickx B. (B.)
- Jiang Y. (Y.)
- Luttun A. (Aernout)
- McCue J.D. (Jonathan D.)
- Nelson-Holte M. (Molly)
- Pelacho B. (Beatriz)
- Peñuelas-Sanchez I. (Ivan)
- Prosper F. (Felipe)
- Ross J.J. (John J.)
- Schroeder B.A. (Betsy A.)
- Seaborn M.S. (Meredith S.)
- Uriz M. (Maialen)
- Verfaillie C.M. (Catherine M.)
- Zhang X. (Xiaoliang)
- Zhang Y. (Yi)
- Zhu X.H. (Xiao Hong)
- Publication venue
- 'American Society for Clinical Investigation'
- Publication date
- 01/01/2008
- Field of study
Despite progress in cardiovascular research, a cure for peripheral vascular disease has not been found. We compared
the vascularization and tissue regeneration potential of murine and human undifferentiated multipotent
adult progenitor cells (mMAPC-U and hMAPC-U), murine MAPC-derived vascular progenitors (mMAPC-VP),
and unselected murine BM cells (mBMCs) in mice with moderate limb ischemia, reminiscent of intermittent
claudication in human patients. mMAPC-U durably restored blood flow and muscle function and stimulated
muscle regeneration, by direct and trophic contribution to vascular and skeletal muscle growth. This was in
contrast to mBMCs and mMAPC-VP, which did not affect muscle regeneration and provided only limited and
transient improvement. Moreover, mBMCs participated in a sustained inflammatory response in the lower
limb, associated with progressive deterioration in muscle function. Importantly, mMAPC-U and hMAPC-U also
remedied vascular and muscular deficiency in severe limb ischemia, representative of critical limb ischemia in
humans. Thus, unlike BMCs or vascular-committed progenitors, undifferentiated multipotent adult progenitor
cells offer the potential to durably repair ischemic damage in peripheral vascular disease patients
Psychometric properties of the cardiac depression scale in patients with coronary heart disease
- Author
- Andrew Tonkin
- AS Zigmond
- AT Beck
- C Trelawny-Ross
- CD Spielberger
- David Clarke
- DC Steffens
- DL Hare
- EJ Burker
- F Astin
- F Lesperance
- FM Wise
- G Schrader
- H DeVon
- I Connerney
- Ian Meredith
- J Barefoot
- J Romanelli
- JA Blumenthal
- Julie Plunkett
- L Gholizadeh
- L Radloff
- L Thornton
- LA Doerfler
- LA Kiropoulos
- Litza A Kiropoulos
- M Di Benedetto
- M Hance
- M Sullivan
- MB Gonzalez
- N Frasure-Smith
- N Frasure-Smith
- P Joshi
- PA Pirraglia
- Paul Antonis
- R Carney
- R Ziegelstein
- RL Gorsuch
- SJ Schleifer
- The ENRICHD Investigators
- WHO-QOL Group
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Climate drives the geography of marine consumption by changing predator communities
- Author
- Aiello Erin
- Alcoverro Teresa
- Altieri Andrew H.
- Benedetti-Cecchi Lisandro
- Bertolini Camilla
- Bresch Midoli
- Bulleri Fabio
- Carnell Paul E.
- Cimon Stéphanie
- Connolly Rod M.
- Cusson Mathieu
- Diskin Meredith S.
- Duffy J. Emmett
- D’Souza Elrika
- Flores Augusto A. V.
- Frodie F. Joel
- Galloway Aaron W. E.
- Gaskins Leo C.
- Graham Olivia J.
- Hanley Torrance C.
- Henderson Christopher J.
- Hereu Clara M.
- Hessing-Lewis Margot
- Hovel Kevin A.
- Hughes A. Randall
- Hughes Brent B.
- Hultgren Kristin M.
- Janiak Dean S.
- Johnston Lane N.
- Jorgensen Pablo
- Jänes Holger
- Kelaher Brendan P.
- Kruschel Claudia
- Lanham Brendan S.
- Lee Kun-Seop
- Lefcheck Jonathan S.
- Lozano-Álvarez Enrique
- Macreadie Peter I.
- Monteith Zachary L.
- O'Leary Jennifer K.
- Olds Andrew D.
- O’Connor Nessa E.
- Patrick Christopher J.
- Pino Oscar
- Poore Alistair G. B.
- Rasheed Michael A.
- Raymond Wendel W.
- Reiss Katrin
- Rhoades O. Kennedy
- Robinson Max T.
- Ross Paige G.
- Rossi Francesca
- Schlacher T. A.
- Seemann Janina
- Silliman Brian R.
- Smee Delbert L.
- Stachowicz J. J.
- Thiel Martin
- Unsworth Richard K. F.
- van Tussenbroek Brigitta I.
- Vergés Adriana
- Whalen Matthew A.
- Whippo Ross D. B.
- Yeager Mallarie E.
- Yednock Bree K.
- York Paul H.
- Ziegler Shelby L.
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 01/01/2020
- Field of study
Este artículo contiene 7 páginas, 3 figuras, 1 tabla.The global distribution of primary production and consumption by
humans (fisheries) is well-documented, but we have no map linking
the central ecological process of consumption within food
webs to temperature and other ecological drivers. Using standardized
assays that span 105° of latitude on four continents, we show
that rates of bait consumption by generalist predators in shallow
marine ecosystems are tightly linked to both temperature and the
composition of consumer assemblages. Unexpectedly, rates of
consumption peaked at midlatitudes (25 to 35°) in both Northern
and Southern Hemispheres across both seagrass and unvegetated
sediment habitats. This pattern contrasts with terrestrial systems,
where biotic interactions reportedly weaken away from the equator,
but it parallels an emerging pattern of a subtropical peak in
marine biodiversity. The higher consumption at midlatitudes was
closely related to the type of consumers present, which explained
rates of consumption better than consumer density, biomass, species
diversity, or habitat. Indeed, the apparent effect of temperature
on consumption was mostly driven by temperature-associated turnover
in consumer community composition. Our findings reinforce
the key influence of climate warming on altered species composition
and highlight its implications for the functioning of Earth’s
ecosystems.We acknowledge funding from the Smithsonian
Institution and the Tula Foundation.Peer reviewe
Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.
- Author
- Aamir A
- Abbas J
- Abbas N
- Abbott TEF
- Abdalla M
- Abdikadir H
- Abuhussein N
- Acquaah F
- Adamson R
- Adeleye O
- Adeogun A
- Adlan A
- Aftab R
- Afzal Z
- Agarwal M
- Aglan H
- Agnew CJF
- Agrawal R
- Ahern D
- Ahluwalia J
- Ahluwalia V
- Ahmad A
- Ahmad K
- Ahmed H
- Ahmed I
- Ahmed L
- Ahmed N
- Ahmed P
- Ainger E
- Ainsworth P
- Aishwarya G
- Ajibola-Taylor O
- Akhbari M
- Akhtar A
- Akhtar R
- Akpenyi O
- Al-Ausi M
- Al-Huneidi R
- Al-Khudairi R
- Al-Masri S
- Al-Mousawi A
- Al-Saadi N
- Alagappan A
- Alberts J
- Alfa-Wali M
- Ali A
- Ali B
- Ali I
- Ali M
- Ali Q
- Ali S
- Alturki N
- Alwandi A
- Amani L
- Amarnath T
- Amer M
- Amin H
- Amin MN
- Amoah R
- Amoah-Arko A
- Anandarajah C
- Ananthavarathan P
- Andah EJE
- Andrew K
- Andrews H
- Ang A
- Ang HL
- Ang JJ
- Ani C
- Anilkumar A
- Anto N
- Anwar S
- Apperley H
- Appleton S
- Aquilina T
- Archer M
- Arif T
- Arneill M
- Arnell S
- Arnold TJ
- Arshad A
- Arthur J
- Arulkumaran N
- Arya J
- Asad M
- Asemota N
- Ashaye T
- Ashdown T
- Ashour R
- Ashraf MR
- Ashwood J
- Asif U
- Atkin G
- Atkins B
- Attalla M
- Aubrey-Jones D
- Auckburally S
- Auld F
- Auluck I
- Azam S
- Aziz R
- Azizi A
- Azmi F
- Babatunde F
- Babu VS
- Bachi A
- Bagga R
- Bains H
- Bajwa DS
- Baker A
- Baker C
- Balai E
- Balian V
- Ball M
- Bamford M
- Bana R
- Banfield DA
- Bannard-Smith J
- Barai I
- Barclay J
- Barfi L
- Barker C
- Barker M
- Barmayehvar B
- Barnfield J
- Barnor-Ahiaku E
- Baron C
- Barr CJ
- Barraclough J
- Baryan HK
- Basra M
- Bassam N
- Bath MF
- Battle J
- Beasley W
- Beattie G
- Beattie S
- Beatty M
- Beghal G
- Begum F
- Behranwala K
- Belchos J
- Belgaid DR
- Belgaumkar A
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- Ben-Gal O
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- Bernal TL
- Bertelli M
- Berthaume-Hawkins SD
- Best R
- Betts A
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- Bienias A
- Billyard C
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- Blazeby JM
- Bleakley A
- Bloom I
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- Borakati A
- Boraluwe-Rallage H
- Borg CM
- Botha A
- Boualbanat Y
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- Bowley D
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- Brannick S
- Brayley J
- Brecher J
- Breen H
- Bristow S
- Britton N
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- Burgin A
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- Chappelow I
- Chapple K
- Charnley R
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- Chin YR
- China Z
- Chitsabesan P
- Chohan K
- Choi JE
- Chong A
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- Choo S
- Chopada A
- Chouari T
- Choudhary Y
- Choudhry M
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- Christie S
- Christopher E
- Chudek D
- Chui J
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- Cipparrone M
- Claireaux HA
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- Conchie H
- Connelly A
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- Cookson P
- Cope EA
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- Copeland M
- Copley HC
- Coppel J
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- Courquin GR
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- Eastwood M
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- Fawole A
- Fearnhead N
- Feldman M
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- Hussain A
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- Punjabi N
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- Qamar MA
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- Raghuvir V
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- Reehal R
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- Renju M
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- Ridgway P
- Riley BJ
- Rimmer L
- Rinkoff S
- Riyat H
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- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators
- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators, Nepogodiev, D
- Stechman M
- Stewart D
- Stewart E
- Stewart H
- Stewart R
- Stickler E
- Stoddart MT
- Stokes E
- Stott G
- Strang S
- Stringer H
- Stringfellow TD
- Stubbing-Moore A
- Sturrock S
- Subar D
- Subratty SM
- Sukirthan N
- Sukumar S
- Sulaiman SK
- Sultan S
- Sun L
- Sundaram K
- Suresh R
- Suresh S
- Sureshkumar A
- Suri A
- Svolkinas D
- Swan A
- Swan I
- Swaray A
- Swartbol T
- Symons L
- Szczap A
- Szuman A
- Tailor S
- Tam J
- Tam JP
- Tan CY
- Tan KL
- Tan L
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- Tan TSE
- Tang A
- Tang M
- Tanna A
- Taribagil P
- Tariq A
- Tate S
- Tayeh S
- Taylor K
- Taylor O
- Taylor R
- Taylor Z
- Telfer R
- Teng T
- Tenters F
- Teo R
- Thachettu A
- Thakrar D
- Thatcher A
- Theodoropoulou K
- Thomas A
- Thomas D
- Thomas M
- Thomas O
- Thomas S
- Thompson G
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- Thorley N
- Thorn C
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- Tilliridou V
- Titu L
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- Toh C
- Toma T
- Tonks A
- Torrance HD
- Townsend D
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- Trenear R
- Tresidder S
- Trevett J
- Triniman MC
- Trotter M
- Tsang JCH
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- Vaidya A
- Vakharia A
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- Van der Laan S
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- Ventre C
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- Vernet G
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- Warusavitarne J
- Waterman A
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- Whitcroft I
- White C
- White F
- White P
- Whitham R
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- Widdison A
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- Williams LM
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- Wilson R
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- Worsfold M
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- Wynell-Mayow W
- Xu Y
- Yahaya AA
- Yalamarthi S
- Yang DD
- Yang N
- Yap J
- Yardimci E
- Yarham E
- Yasin IH
- Yasin T
- Yates J
- Ye W
- Yeo A
- Yeoh T
- Yeung J
- Yin ZD
- Yip J
- Yoganayagam N
- Yogeswara T
- York J
- Yousaf A
- Youssef H
- Yu T
- Yule A
- Zaat S
- Zanichelli D
- Zaver V
- Zeng R
- Zhang Y
- Zheleniakova T
- Zhu Y
- Zornoza A
- Zubikarai G
- Zulkifli A
- Zuzarte L
- Publication venue
- 'Wiley'
- Publication date
- 18/05/2018
- Field of study
Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability
Hemispheres Apart, a Profession Connected
- Author
- Alexi See
- Andrew F See Also
- Andrew Ross Sorkin &
- Ann Meredith
- B Christensen
- Barton
- C Roger
- Cf
- Christina L Underwood
- Dana Remus
- Deborah L L Rhode
- Deborah Rhode
- Deborah See
- E G See
- E G See
- E G See
- E G See
- E G See
- E G See
- F Barlow
- George C Leef
- George M Cf
- Id
- Id
- Ken Belson
- L Hastings
- Laurel A Rigertas
- M R Aba
- M R Aba
- M R Aba
- M R Aba
- Pa L Rev
- Quintin Johnstone
- Remus
- Rhode
- Rhode
- Rhode
- Robert Eli Rosen
- See Adam
- See Rhode
- See Rhode
- Simon Romero
- Susanna M Kim
- Zach Lowe
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
- Buzkova Petra
- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
- Campbell Harry
- Campbell Susan
- Carba Delia B
- Carlson Chris
- Carlson Olga D
- Carty Cara
- Casas Juan P
- Caspersen Ida H
- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
- Chandak Giriraj R
- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
- Charchar Fadi J
- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
- Choi Murim
- Chouraki Vincent
- Christiansen Claus
- Chu Audrey Y
- Cimponeriu Dan
- Ciullo Marina
- Clark Graeme R
- Clarke Robert
- Claudi-Boehm Simone
- Coassin Stefan
- Cochran Barbara
- Cole Shelley
- Colhoun Helen
- Colhoun Helen M
- Collins Francis S
- Collins Rory
- Connell John M
- Cooper Cyrus
- Cooper Jackie A
- Cooper Matthew N
- Cooper Richard S
- Coresh Josef
- Cornelis Marilyn C
- Corre Tanguy
- Corsi Anna Maria
- Couper David
- Cousminer Diana L
- Coviello Andrea D
- Cox David
- Crawford Dana
- Crisponi Laura
- Croteau-Chonka Damien C
- Cucca Francesco
- Cummings Steven R
- Cupples Adrienne L
- Cupples L Adrienne
- Curhan Gary
- d'Adamo Pio
- Dahgam Santosh
- Dailiana Zoe
- Danesh John
- Danoy Patrick
- Dastani Zari
- Davies Gail
- Daw E Warwick
- Day Felix R
- Day Ian N M
- de Andrade Mariza
- de Boer Ian H
- de Boer Rudolf A
- de Faire Ulf
- de Geus Eco J C
- Deary Ian J
- Dedoussis George
- Dedoussis George V
- Dedoussis George V Z
- Deelen Joris
- Deelman Ewa
- Dehghan Abbas
- Delgado Graciela
- Deloukas Panagiotis
- Deloukas Panos
- Demerath Ellen W
- Demirkan Ayse
- Demirkan Ayşe
- Den Hertog Heleen M
- Denniff Matthew
- Dennison Elaine M
- Dermitzakis Emmanouil T
- Deshmukh Harshal
- Deshmukh Harshal A
- Devuyst Olivier
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S
- Dimitriou Maria
- Ding Jingzhong
- Do Ron
- Dominiczak Anna F
- Doney Alex
- Dong Yanbin
- Donnelly Louise A
- Doumatey Ayo
- Dreisbach Albert W
- Drong Alexander W
- Duggan David
- Dumitrescu Logan
- Duncan Bruce B
- Duncan Emma L
- Dupuis Josee
- Dupuis Josée
- Durbin Richard
- Durda Peter
- Döring Angela
- Dörr Marcus
- Eastell Richard
- Easton Douglas F
- Ebrahim Shah
- Econs Michael J
- Edkins Sarah
- Egan Josephine
- Ehret Georg
- Eiriksdottir Gudny
- Eisman John A
- Eklund Niina
- El Mokhtari NourEddine
- Elks Cathy E
- Ellinghaus David
- Elliott Paul
- Elosua Roberto
- Emilsson Valur
- Endlich Karlhans
- Epstein Stephen E
- Erbel Raimund
- Erdmann Jeanette
- Erdos Michael R
- Eriksson Joel
- Eriksson Johan
- Eriksson Niclas
- Eriksson Per
- Ernst Florian
- Esko Tonu
- Esko Tõnu
- Esko Tönu
- Estrada Karol
- Eury Elodie
- Evangelou Evangelos
- Evans Alun
- Evans David M
- Eyheramendy Susana
- Eyjolfsson Gudmundur Ingi
- Fagerholm Emma
- Falhammar Henrik
- Fall Tove
- Farrall Martin
- Fauser Bart C J M
- Fava Cristiano
- Feenstra Bjarke
- Fehrmann Rudolf
- Feitosa Mary
- Feranil Alan B
- Ferrannini Ele
- Ferrario Marco M
- Ferreira Teresa
- Ferreli Liana
- Ferrières Jean
- Ferrucci Luigi
- Fischer Krista
- Florez Jose C
- Folkersen Lasse
- Folsom Aaron R
- Fontanillas Pierre
- Ford Ian
- Fornage Myriam
- Foroud Tatiana
- Forouhi Nita G
- Forrester Terrence
- Forsblom Carol
- Foster Meredith C
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- Waite Lindsay L
- Walker Mark
- Wallace Leanne
- Wallaschofski Henri
- Wallentin Lars
- Wang Hansong
- Wang Jie Jin
- Wang Thomas J
- Wang Xiaoling
- Wareham Nicholas
- Wareham Nick J
- Warrington Nicole M
- Watanabe Richard M
- Waterworth Dawn
- Watkins Hugh
- Weder Alan B
- Weedon Michael N
- Welch Ryan P
- Wells George A
- Wennauer Roman
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- Wheeler Eleanor
- Wheeler Heather E
- Whincup Peter H
- Whitfield John B
- Wichmann H Erich
- Wichmann H-Erich
- Widen Elisabeth
- Wiggins Kerri L
- Wijmenga Cisca
- Wijnands-van Gent Colette J M
- Wild Philipp S
- Wild Sarah H
- Wilk Alicja
- Wilkens Lynne
- Willems Sara M
- Willemsen Gonneke
- Willemsvan-vanDijk Ko
- Willenborg Christina
- Willer Cristen J
- Williams Frances M K
- Williams Rasheeda
- Williams Winfred W
- Willner Dana
- Wilsgaard Tom
- Wilson James F
- Wilson James G
- Wilson Sarah
- Wilson Scott G
- Winkler Thomas
- Witteman Jacqueline C
- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
- A Cowton
- A Cox
- A Crew
- A Dance
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- A Daniels
- A Dela Rosa
- A Drummond
- A Durie
- A E Heron
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- A Easthope
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- A Fofano
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- A Gardner
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- A Gherman
- A Gordon
- A Gratrix
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- A Zak
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- Achille Iolascon
- Adam Auton
- Adam Brown
- Agnese Verzuri
- Agostino Ognibene
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- Ailsa Golightly
- Alan Maclean
- Alessandra
- Alessandra Stella
- Alessandra Vergori
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- Alexander J Mentzer
- Alice Donati
- Alison M Meynert
- Alistair Nichol
- Ana da Silva Filipe
- Andrea Antinori
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- Andrew Rambaut
- Andrew Stenhouse
- Andy Law
- Anjali J Shastri
- Anna Canaccini
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- Annemarie B Docherty
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- Audrey Coutts
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- Turtle Lance
- U Poultney
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- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
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- Z Belagodu
- Z Bradshaw
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- Z Daly
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- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 × 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
- Author
- A. Abraheem
- A. Agasou
- A. Ahmed
- A. Ali
- A. Allan
- A. Altabaibeh
- A. Alvaro
- A. Aspinwall
- A. Ayers
- A. Bamford
- A. Barron
- A. Bashyal
- A. Bellini
- A. Bociek
- A. Botello
- A. Bowes
- A. Brady
- A. Brayne
- A. Brown
- A. Brown
- A. Butler
- A. Carter
- A. Collins
- A. Cowley
- A. Cowton
- A. Cowton
- A. Cox
- A. Crew
- A. Dance
- A. Daniel
- A. Daniels
- A. Dela Rosa
- A. Drummond
- A. Durie
- A. E. Heron
- A. Easthope
- A. Easthorpe
- A. Evans.
- A. Fofano
- A. Gales
- A. Ganesan
- A. Gardner
- A. Garg
- A. Gherman
- A. Gordon
- A. Gratrix
- A. Gulati
- A. Gupta
- A. Haigh
- A. Haldeos
- A. Harrison
- A. Harvey
- A. Hayes
- A. Higham
- A. Higham
- A. Hilldrith
- A. Holden
- A. Hormis
- A. Hutcheon
- A. Javaid
- A. Joseph
- A. Kaliappan
- A. Katary
- A. Kay
- A. Kayani
- A. Kent
- A. Kirkby
- A. Knight
- A. Kubisz-Pudelko
- A. Kuravi
- A. Lewis
- A. Loveridge
- A. Lyle
- A. Mayer
- A. McAlpine
- A. McCarthy
- A. McGregor
- A. McGregor
- A. Meikle
- A. Mitchell
- A. Mitra
- A. Morris
- A. Morrison
- A. Naranjo
- A. Nicholson
- A. Nicholson
- A. Noakes
- A. Patel
- A. Pickard
- A. Price
- A. Puxty
- A. Quinn
- A. Quinn
- A. Raithatha
- A. Rattray
- A. Reddy
- A. Reed
- A. Reyes
- A. Rose
- A. Rose
- A. Rostron
- A. Roy
- A. Roynon-Reed
- A. S. Raj
- A. Salberg
- A. Sanderson
- A. Serrano-Ruiz
- A. Solesbury
- A. Sukha
- A. Swain
- A. Tariq
- A. Thomas
- A. Thomas
- A. Todd
- A. Tomas
- A. Tridente
- A. Tucci
- A. Turnbull
- A. Uriel
- A. Ustianowski
- A. Vochin
- A. Vuylsteke
- A. Waite
- A. Walden
- A. Whileman
- A. Wilkinson
- A. Williams
- A. Williams
- A. Wilson
- A. Zak
- A. Zaki
- Achille Iolascon
- Adam Brown
- Adam Krętowski
- Adriana Roży
- Agnese Verzuri
- Agnieszka Adamek
- Agnieszka Bielska
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Albert Tenesa
- Aleksandra Berkan-Kawinska
- Aleksandra Jezela-Stanek
- Aleksandra Starosz
- Alessandra Guarnaccia
- Alessandra Renieri &
- Alessandra Stella
- Alessandra Vergori
- Alessandro Pancrazzi
- Alessia Giorli
- Alice Donati
- Alison Meynert
- Alistair Nichol
- Anders Larsson
- Andrea Antinori
- Andrea Cossarizza
- Andrea Gabbuti
- Andrea Tommasi
- Andrew D. Bretherick
- Andrew Law
- Andrew Stenhouse
- Andrzej Eljaszewicz
- Andrzej Horban
- Andy Law
- Angelica Pagliazzi
- Angie Fawkes
- Anke Hinney
- Anna Canaccini
- Anna Kruk
- Anna Maria Pinto
- Anna Moniuszko-Malinowska
- Anna Parfieniuk-Kowerda
- Anna Piekarska
- Anna Szałkowska
- Annarita Giliberti
- Anne Richmond
- Antonella D. ’Arminio Monforte
- Antonella Vincenti
- Antonia Ho
- Antonio Di Biagio
- Antonio Perrella
- Arianna Emiliozzi
- Arianna Gabrieli
- Arsalin Azzadin
- Asma Al Thani &
- Athanasios Kousathanas
- Audrey Coutts
- Axel Schmidt
- Axel Schmidt
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- Erola Pairo-Castineira
- Erola Pairo-Castineira
- Esther Duncan
- Eugenia Quiros-Roldan
- Eva C. Schulte
- Eva C. Schulte
- F. Anderson
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- F. Hurford
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- F. McNeela
- F. Moore
- F. Nasir
- F. Trim
- F. Wakinshaw
- F. Williams
- Fabian Brand
- Fabio Lena
- Faisal Almalki
- Federica Gaia Miraglia
- Federico Anedda
- Federico Franchi
- Ferdinando Giannattasio
- Filip Taneski
- Filippo Aucella
- Filippo Biscarini
- Fiona Griffiths
- Floriana Valentino
- Francesca Andretta
- Francesca Ariani
- Francesca Colombo
- Francesca Fava
- Francesca Gatti
- Francesca Mari
- Francesca Minnai
- Francesca Montagnani
- Francesca Vichi
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- Francesco Brancati
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- Gabriella Coiro
- Gabriella Doddato
- Gabriella Maria Squeo
- GEN-COVID Multicenter Study
- Genni Spargi
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- Sara Amitrano
- Sara Bulow Anderberg
- Sara Clohisey
- Sara Clohisey
- Sara Clohisey Peter Horby
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- Selina Rolker
- Serafina Valente
- Serena Ludovisi
- Serghei Mangul
- Sergio Daga
- Silvia Baroni
- Silvia Cappelli
- Simona Dei
- Simona Marcantonio
- Simona Sarzi-Braga
- Simone Furini
- Slawomir Czaban
- SMelling
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Busani
- Stefano Ceri
- Stefano Rusconi
- Sten Rubertsson
- Stephan Ossowski
- Susan Walker
- Susanna Croci
- Susanna Guerrini
- Sławomir Pancewicz
- T. Anderson
- T. Arden
- T. Baird
- T. Behan
- T. Bemand
- T. Cosier
- T. Coventry
- T. Duncan
- T. Felton
- T. Geary
- T. Hazleton
- T. Joefield
- T. Kannan
- T. Marsden
- T. Martin
- T. McHugh
- T. Newman
- T. Nortcliffe
- T. O. Jones
- T. Pogreban
- T. Rees
- T. Samakomva
- T. Smith
- T. Smith
- T. Szakmany
- T. Varghes
- T. Williams
- T. Wood
- Tammy Gilchrist
- Thorsten Brenner
- Tim Walsh
- Tiziana Bachetti
- Tomas Luther
- Tommaso Matucci
- Tony Wackett
- Torsten Feldt
- Trevor Paterson
- Tullio Trotta
- U. Poultney
- Ulrike Protzer
- Umberto Zuccon
- Urszula Korotko
- Urszula Lechowicz
- Urszula Polowianiuk
- V. Amin
- V. Anumakonda
- V. Bastion
- V. Cannons
- V. Crickmore
- V. Gopal
- V. Irvine
- V. Kasipandian
- V. Krishnamurthy
- V. Lake
- V. Linnett
- V. Martinson
- V. Nagarajan
- V. Page
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- V. Ratnam
- V. Rivers’
- V. Sarathy
- V. Thomas
- V. Thwaites
- V. Tuckey
- V. Turner
- V. Wagstaff
- V. Waugh
- Valentina Anemoli
- Valentina Borgo
- Valentina Perticaroli
- Verena Keitel
- Veronique Vitart
- W. Harrison
- W. Khaliq
- W. Khaliq
- W. McCormick
- W. Woodyatt
- Wadha Al-Muftah
- WES/WGS Working Group Within the HGI
- Wiktoria Izdebska
- Wilna Oosthuyzen
- X. Qiu
- Xia Shen
- Y. Baird
- Y. Choudhury
- Y. Hussain
- Y. Jackson
- Y. Thirlwall
- Yanara Marincevic-Zuniga
- Yang Wu
- Yaser Al-Sarraj
- Z. Alldis
- Z. Belagodu
- Z. Bradshaw
- Z. Coton
- Z. Daly
- Z. Farzad
- Z. Fernandez
- Z. Garland
- Z. Maqsood
- Z. Omar
- Z. Prime
- Z. Scott
- Zhijian Yang
- Publication venue
- Publication date
- 01/01/2022
- Field of study
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management. © 2021, The Author(s)
Transcriptomic insights into the genetic basis of mammalian limb diversity
- Author
- A Bairoch
- A Dobin
- A Graham
- AC Molineaux
- AK Lee
- AL Keyte
- AL Keyte
- AL Keyte
- AN Albrecht
- Anna Dowling
- AR Gehrke
- AT Kalinka
- AT Kalinka
- B Li
- BJ Haas
- BM Patten
- C Minguillon
- C Rodriguez-Esteban
- C Trapnell
- CH Chen
- Chris J. Cretekos
- CJ Cretekos
- CJ Cretekos
- CJ Cretekos
- CK Doroba
- D Hockman
- D Ross
- DW Huang
- DW Huang
- E Hazkani-Covo
- E McCrady
- F Galis
- F Galis
- F Galis
- F Spitz
- FA Jenkins
- GF Stopper
- GR de Beer
- J Gros
- J Lopez-Rios
- J Roux
- J Ye
- JA Lehoczky
- Jennifer A. Maier
- Jenny Deng
- JGM Thewissen
- JJ Rasweiler
- JM Slack
- JM Verheyden
- John J. Rasweiler
- K Lindblad-Toh
- K Theiler
- Karen E. Sears
- KE Mate
- KE Sears
- KE Sears
- KE Sears
- KE Sears
- KE Sears
- KE Sears
- KE Sears
- KE Sears
- KE von Baer
- KL Cooper
- L Taher
- L Wolpert
- L Wolpert
- LC Murtaugh
- LN Cooper
- M Hubler
- M Kmita
- M Levin
- M Quint
- MA Nieto
- MA Suckow
- Marcelo Rivas-Astroza
- MC King
- MG Grabherr
- MK Richardson
- N Gompel
- N Irie
- N Irie
- N Shubin
- N Wanek
- P Tschopp
- Paige Oboikovitz
- PD Polly
- R Ray
- R Suzuki
- R Zeller
- R Zeller
- RA Raff
- Richard R. Behringer
- RW Meredith
- S Anders
- S Pajni-Underwood
- S Poe
- SB Carroll
- SD Weatherbee
- Sheng Zhong
- T Domazet-Loso
- T Montavon
- Team RDC
- TS Kemp
- V Knezevic
- W Garstang
- WB Ballard
- WL Eckalbar
- WN Venables
- Xiaoyi Cao
- Y Chen
- Z Wang
- Z Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
- …