45 research outputs found
Short Psycho-Therapy and Hypnosis
- Author
- Publication venue
- ProQuest Dissertations & Theses,
- Publication date
- 01/01/1953
- Field of study
This thesis comprises I. an Introduction in which three topics are discussed:-(a) Hypnosis - with particular reference to its present status in this country and abroad: the psychological emphasis here, the physiological stress on the Continent. (b) The relations between hypnosis and psycho-analysis, from their early divergence to the present period in which there are signs of a resynthesis. (c) Certain trends within the body of psycho-analysis : the development of schisms : the divergence from the views of Freud : the concentration by one school (in Chicago) on short psychotherapy in the light of certain views which concern particularly the significance of regressive material. The need for a short but effective psycho-therapy is emphasised. II. Observations on a series of 28 cases. Of that number, 23 were treated by the writer : the treatment varying from reassurance (Ross (1941)) or direct hypnotic suggestion to two attempts at hypno-analysis. The length of treatment varied from 1 interview (5 cases) to 160 interviews - in 12 months (2 cases). Hypnosis was employed in the treatment of 18 cases : in 5 it was not used. In the 5 cases which were not treated by the writer, hypnosis was used in one (0) as a diagnostic measure, in a second no useful level of hypnosis could be obtained, (X) : a third patient is reported because of the effects of hypnosis induced by a stage hypnotist (V) : a fourth (M) because of the spontaneous outburst of traumatic memories which followed induction : a fifth (E) because of a narcoleptic phenomenon perhaps related to hypnosis. Many of the patients treated were very severely ill. D. for example - an intelligent officer with an excellent war record - when first seen was immobilised in bed because of his fear of death. R. had a history of hallucinations and suicidal tendencies apart from his extremely severe addiction to alcohol (and to various drugs). The 5 patients whose treatment at length was attempted are noteworthy in this respect. S. had been driven into hospital repeatedly by her acute panics. T. and U. similarly faced the psychiatric ward - willingly - rather than face the fears associated with the outside world. The patients 1 and 2 had already been admitted to hospital when first seen by the writer. The patient 1 had at that time already spent some months in hospital, and was seen to weep copiously at times. He had not worked for a year and had once spent a year in bed because of his chronic neurotic symptoms. Patient 2 had been unable to leave the hospital - even for the briefest space of time - for 4 years, prior to which hospital admission on account of psychological symptoms had been frequent : clinically, she was psychotic. Of these 5 patients, three (S,T,1) had already failed to respond more than temporarily if at all, to treatment by other psychotherapists. The patient 1 had in fact undergone 9 months of analysis by a psychotherapist who had not only been fully trained in Jungian methods, but had had a full Freudian training analysis. It is not proposed to analyse all the therapeutic techniques and results, but it is at once obvious that neither attempt at hypno-analysis constituted the equivalent of a full Freudian analysis though in each case treatment was continued for 12 months. Nor did the results approach anything like a complete cure, though in Case 2 especially a marked, and so far lasting, social improvement was obtained. Among the shorter cases the positive results regarded by the writer as being significant are the following: (1) the marked relief of symptoms by the Ross (1941) technique : (a) after one half-hour interview - A. (b) after 3 brief interviews - with the emergence of buried memories-B. (c) in a few weeks treatment of a very severe neurosis - D. But follow-up was inadequate in all three (some months in Case A). (2) (a) The cure-of stammering-which followed the use of direct hypnotic suggestion and the hypnotic eliciting of childhood memories (Case L.) The total treatment time was about 5 hours. The follow-up showed him to be symptom-free nearly three years later. (b) The partial relief of hysterical symptoms for at least 5 years in a case of amnesia and fugue. The treatment, which was as in Case L., occupied less than one hour. (Case H.) In these two cases superficial insight was gained, but (c) in cases I and K., no insight whatsoever resulted. Treatment was by direct hypnotic suggestion : it occupied 6-7 hours (less in Case I.) The results, though probably temporary, were of great value to both patients. (3) It appears that the lasting improvement in Q., after one non-hypnotic interview can best be explained in the terms of Alexander and French (1946). (4) The similar lasting improvement in Case U. was perhaps best understood as a transference cure, in the sense of French (1946ab). III. Discussion: the material provided by the writer's observations is reviewed, with reference to the literature. Certain main conclusions are summarised below
Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis
- Author
- Aahlin Eirik Kjus
- Aamer Ahmed
- Aaniana Kenneth
- Ababneh Ali
- Abaliksta Tomas
- Abantanga Francis
- Abbas Athar
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- Abdallah Emad
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- Abdel-Hameed Noran
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- Abdelaty Mohamed
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- Abdelazim Galaleldin
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- Vasquez Idelso
- Veen Torhild
- Velasquez Ricardo
- Venclauskas Linas
- Vendramin Elena
- Venskutonis Donatas
- Venskutonis Donatas
- Verbeek Anna
- Vergara Mejia Angelica Genoveva
- Verjee Azmina
- Vermaas Maarten
- Vicario Erika
- Vicenta Collado Maria
- Vida Lucian Corneliu
- Vilcinskas Mantas
- Villalobos Santiago
- Violi Paola
- Visinskas Petras
- Voulgaris Evangelos
- Wael Noha
- Wakefield Rebecca
- Waledziak Maciej
- Walker Michael
- Walker Nathan
- Walls Luke
- Walsh Michael
- Waqar Muhammad
- Warren Oliver
- Waterman Ade
- Werder Gabriela
- Whitaker John
- White Rebecca
- Whitehurst Katharine
- Wiborg Joachim
- Widiastini T. Ariani
- Widmer Lukas Werner
- Wijayarathna L. S.
- Williams Omolara
- Wilson Ling
- Wilson Michael
- Wilson Michael
- Wimalge P. M. S. N.
- Wogensen Fredrik
- Wolf Bernhard
- Wondoh Paul
- Wondoh Paul
- Wong Chui Yee
- Wong Francisca
- Wong Hong Yee
- Wood Greta
- Worku Mengistu
- Worku Tewodros
- Wright Naomi
- Yahaya Muhammad Taqiyuddin
- Yakubu Musah
- Yam Sir Young
- Yang James
- Yap Suhhuey
- Yau Jih Dar
- Ye Joselyn
- Yeang Li Jing
- Yeung Man Hon Andrew
- Yifieyeh Abiboye
- Yildirim Reyyan
- Yip Chingwan
- Ymeri Shpetim
- Yoganathan Pigeneswaren
- Yolcu Sinem
- Yong Guo Liang
- Younis Abobaker
- Youssef Mohamed
- Yuksek Mahmut Arif
- Yusufali Taha
- Zaa'treh Rula
- Zadoroznas Antanas
- Zahran Diaaaldin
- Zakaria Esraay
- Zakaria Mahmoud
- Zakaria Yehia
- Zaki Ahmed
- Zammit Stefan
- Zampitis Nikolaos
- Zani Augusto
- Zani Augusto
- Zanini Nicola
- Zapata Felipe
- Zarb Ciskje
- Zeta Solis Ludwing Alexander
- Zielinski Martin
- Zilinskas Justas
- Zilinskas Justas
- Zilinskas Justas
- Zilinskiene Reda
- Ziubryte Greta
- Zohair Ahmed
- Zuber Markus
- Zuk Grzegorz
- Zulkifli Athirah
- Zumbuhl Lucius
- Publication venue
- Elsevier
- Publication date
- 01/06/2003
- Field of study
BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
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- Porteous David J
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- S Yussuf
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- Samreen Ijaz
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- Sandro Panese
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- Sara McDonald
- Sarah Law
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- Stefano Rusconi
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- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
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- T Smith
- T Smith
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- T Wood
- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
- Tom Fletcher
- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
- V Cannons
- V Crickmore
- V Gopal
- V Irvine
- V Kasipandian
- V Krishnamurthy
- V Lake
- V Linnett
- V Martinson
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- V Page
- V Parris
- V Parris
- V Pristopan
- V Ratnam
- V Rivers
- V Sarathy
- V Thomas
- V Thwaites
- V Tuckey
- V Turner
- V Wagstaff
- V Waugh
- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 × 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
The James Webb Space Telescope Mission
- Author
- Abbott Randy
- Abell James S.
- Abernathy Mark
- Abney Faith E.
- Abraham John G.
- Abraham Roberto
- Abul-Huda Yasin M.
- Acton Scott
- Adams Cynthia K.
- Adams Evan
- Adler David S.
- Adriaensen Maarten
- Aguilar Jonathan Albert
- Ahmed Mansoor
- Ahmed Nasif S.
- Ahmed Tanjira
- Alarcon Rafael Ramos
- Albat Rüdeger
- Albert Loïc
- Alberts Stacey
- Aldridge David
- Allen Mary Marsha
- Allen Shaune S.
- Altenburg Martin
- Altunc Serhat
- Alvarez Jose Lorenzo
- Ambrose Leslie L.
- Anandakrishnan Satya M.
- Andersen Gregory C.
- Anderson Harry James
- Anderson Jay
- Anderson Kristen
- Anderson Sara M.
- Aprea Julio
- Archer Benita J.
- Arenberg Jonathan W.
- Argyriou Ioannis
- Arribas Santiago
- Artigau Étienne
- Arvai Amanda Rose
- Atcheson Paul
- Atkinson Charles B.
- Averbukh Jesse
- Aymergen Cagatay
- Bacinski John J.
- Baggett Wayne E.
- Bagnasco Giorgio
- Baker Lynn L.
- Balzano Vicki Ann
- Banks Kimberly A.
- Baran David A.
- Barker Elizabeth A.
- Barrett Larry K.
- Barringer Bruce O.
- Barto Allison
- Bast William
- Baudoz Pierre
- Baum Stefi
- Beatty Thomas G.
- Beaulieu Mathilde
- Bechtold Kathryn
- Beck Tracy
- Beddard Megan M.
- Beichman Charles
- Bellagama Larry
- Bely Pierre
- Berger Timothy W.
- Bergeron Louis E.
- Bertch Maria D.
- Beskow Charlotte
- Betz Laura E.
- Biagetti Carl P.
- Birkmann Stephan
- Bjorklund Kurt F.
- Blackwood James D.
- Blazek Ronald Paul
- Blossfeld Stephen
- Bluth Marcel
- Boccaletti Anthony
- Boegner Jr. Martin E.
- Bohlin Ralph C.
- Boia John Joseph
- Bonaventura N.
- Bond Nicholas A.
- Bosley Kari Ann
- Boucarut Rene A.
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- Bowers Ariel S.
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- Bunker A. J.
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- Cara Mihai
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- Case Michael Eli
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- Chance Don R.
- Chandler Lynn
- Chaney Dave
- Chapman George N.
- Charlot S.
- Chayer Pierre
- Cheezum Jeffrey I.
- Chen Bin
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- Cherinka Brian
- Chichester Sarah C.
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- Clampin Mark
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- Cossou Christophe
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- Coulais Alain
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- Dailey Christopher T.
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- Davidson Greg S.
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- Doggett Jesse B.
- Dominguez Keisha L.
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- Golimowski David A.
- Gonzaga Shireen P.
- Gordon Karl D.
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- Goudfrooij Paul
- Gough Michael J.
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- Greene Gretchen R.
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- Groe Frank E.
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- Grumm David M.
- Grundy Timothy
- Guillard Pierre
- Guldalian John
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- Gutman Irvin Meyer
- Guy Paul D.
- Guyot Benjamin
- Gáspár András
- Güdel Manuel
- Hack Warren J.
- Haderlein Peter
- Hagan James B.
- Hagedorn Andria
- Hainline Kevin
- Haley Craig
- Hamel Zaky El
- Hami Maryam
- Hamilton Forrest Clifford
- Hammann Jeffrey
- Hammel Heidi B.
- Hanley Christopher J.
- Hansen Carl August
- Hardy Bruce
- Harnisch Bernd
- Harr Michael Hunter
- Harris Pamela
- Hart Jessica Ann
- Hartig George F.
- Hasan Hashima
- Hashim Kathleen Marie
- Hashimoto Ryan
- Haskins Sujee J.
- Hawkins Robert Edward
- Hayden Brian
- Hayden William L.
- Healy Mike
- Hecht Karen
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- Hejal Reem
- Helm Kristopher A.
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- Henry Alaina
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- Hickey David L.
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- Hines Dean C.
- Hinz Michael R.
- Hirsch Michael
- Hitcho Robert S.
- Hodapp Klaus
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- Jaffe Daniel T.
- Jahic Jasmin
- Jahromi Amir
- Jakobsen Peter
- James Bryan
- James John C.
- James LeAndrea Rae
- Jamieson William Brian
- Jandra Raymond D.
- Jayawardhana Ray
- Jedrzejewski Robert
- Jeffers Basil S.
- Jensen Peter
- Joanne Egges
- Johns Alan T.
- Johnson Carl A.
- Johnson Eric L.
- Johnson Patricia
- Johnson Phillip Stephen
- Johnson Thomas K.
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- Johnstone Doug
- Jollet Delphine
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- Jones Olivia C.
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- Jue Reginald
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- Kalirai Jason S.
- Kalmanson Phillip Cabrales
- Kaltenegger Lisa
- Kammerer Jens
- Kan Samuel K.
- Kanarek Graham Childs
- Kao Shaw-Hong
- Karakla Diane M.
- Karl Hermann
- Kassin Susan A.
- Kauffman David D.
- Kavanagh Patrick
- Kelley Leigh L.
- Kelly Douglas M.
- Kendrew Sarah
- Kennedy Herbert V.
- Kenny Deborah A.
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- Khan Ali
- Kidwell Richard C.
- Kimble Randy A.
- King James S.
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- Kinzel Wayne M.
- Kirk Jeffrey R.
- Kirkpatrick Marc E.
- Klaassen Pamela
- Klingemann Lana
- Klintworth Paul U.
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- Knollenberg Perry J.
- Knutsen Daniel Mark
- Koehler Robert
- Koekemoer Anton M.
- Kofler Earl T.
- Kontson Vicki L.
- Kovacs Aiden Rose
- Kozhurina-Platais Vera
- Krause Oliver
- Kriss Gerard A.
- Krist John
- Kristoffersen Monica R.
- Krogel Claudia
- Krueger Anthony P.
- Kulp Bernard A.
- Kumari Nimisha
- Kwan Sandy W.
- Kyprianou Mark
- Labador Aurora Gadiano
- Labiano Álvaro
- Lafrenière David
- Lagage Pierre-Olivier
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- Laine Benoit
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- Lajoie Charles-Philippe
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- Lampenfield Richard Joseph
- Lander Matthew Ed
- Langston James Hutton
- Larson Kirsten
- Larson Melora
- LaVerghetta Robert Joseph
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- Lee Janice
- Lee Yat-Ning Paul
- Leisenring Jarron
- Leveille Michael Dunlap
- Levenson Nancy A.
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- Wislowski Emily Christine
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- Zondag Elisabeth
- Álvarez-Márquez Javier
- Östlin Göran
- Publication venue
- Publication date
- 10/04/2023
- Field of study
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least 4m.
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the 6.5m James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study
- Author
- Aahlin Eirik Kjus
- Aamer Ahmed
- Aaniana Kenneth
- Ababneh Ali
- Abaliksta Tomas
- Abantanga Francis
- Abbas Athar
- Abbasy Jibran
- Abbo Olivier
- Abbott Tom
- Abbouch Meryem
- Abd El-Latif Nadia Khalid
- Abd Elkhalek Esraa
- Abd-Elmawla Manar
- Abdallah Emad
- Abdel-Aty Abdulrahman
- Abdel-Hameed Noran
- Abdel-Kader Sara Mahmoud
- Abdelaal Abdelaziz
- Abdelaty Mohamed
- Abdelazeam Anan Rady
- Abdelazim Galaleldin
- Abdelaziz Mohamed A
- Abdelbadeai Kholoud
- Abdelfatah Afnan
- Abdelhady Samar
- Abdelhamed Rasha
- Abdelhamid Amina
- Abdelhaq Aram
- Abdelkader Mostafa
- Abdelkader Omar
- Abdelkhalek Mohamed
- Abdelmageed Eman
- Abdelmotaleb Ibrahem
- Abdelraouf Ahmed Mahmoud
- Abdelrouf Doaa Maher
- Abdelshakour Mahmoud
- Abdrabou Abdulshafi Khaled
- Abdul-Latif Saiba
- Abdulaziz Hager
- Abdulaziz Mustafa
- Abdulbagi Omar
- Abdulhakeem Eman Mahmoud
- Abdullah Mohamed Abozed
- Abdullah Nik Azim Nik
- Abdullah Noha
- Abdullahi Lawal
- Abdurrazzaaq Abdussemiu
- Abem Owusu Emmanuel
- Abiola Olajide
- Aboelella Majed
- Aboelmagd Omnia
- Aboelsoud Moustafa R
- Aboul-Naga Mariam Saad
- Abouzaid Arwa
- Abu Qumbos Amjad
- Abu-toyour Maram
- Abubakr Marwan
- Abuowda Yousef
- Abuqwaider Eman
- Abusalem Lana
- Abushamleh Soha
- Ackom Eric
- Acquah Emmanuel
- Adam Ali
- Adam Nourhan
- Adamu Ahmed
- Adawi Ihdaa
- Adawi Mohammad
- Adebanjo Ademola
- Adebola Oluwaseyi
- Adedeji Adesina
- Adel Badr Eldin
- Adel Israa
- Adella Fidelis Jacklyn
- Adelshone Abdelrahman
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Ademuyiwa Adesoji O
- Adenekan Babajide
- Adeniran James
- Adeniyi Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adeyeye Ademola
- Adeyeye Ademola
- Adhitama Novia
- Adil Muhammad
- Adisa Adewale O
- Adiyaman Can
- Adu-Aryee Niiarmah
- Afana Samah
- Agalianos Christos
- Agarwal Arnav
- Agarwal Arnav
- Agbedinu Kwabena
- Aglan Amro
- Aguado Suarez Nuria
- Aguilera Maria Lorena
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlonsou Germain
- Ahlqvist Sandra
- Ahlqvist Sandra
- Ahmed Asdaq
- Ahmed Ataa
- Ahmed Hayam
- Ahmed Hussien
- Ahmed Lopna Ahmed Mohamed
- Ahmed Sara
- Ahmed Saraibrahim
- Ahounou Ernest Yemalin Stephane
- Ajah Jonathan
- Ajai Olalekan
- Ajao Akinlabi
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- Akoto Elliot
- Akpenyi Onyinye
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- Al Attar Samaa Mahmoud
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- Al-Bahrani Ahmed
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- Al-faqawi Maha
- Al-farram Hadeel
- Al-khatib Ahmed
- Al-Marakby Dina
- Al-saqqa Sara
- Al-Saqqa Sara W
- Al-Slaibi Ibrahim
- Al-taher Taher
- AlaaelDein Shahinaz
- Alada Muslimat
- Alakaloko Felix
- Alaloul Enas
- Alamin Shadid
- Alamoudi Mohammed
- Albiety Adel
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- Alejos Bermudez Ysabel Esthefany
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- Alexander Philip
- Alexandre Challine
- Alghamdi Ahmed
- Alghamdi Mohammed Saleh A
- Alhady Khaled
- Alhammali Tariq
- Alhassan Basmah
- Alhazmi Wedyan
- Alherz Mohammad
- Ali Ahmed
- Ali Citra Dewi Mohd
- Ali Elsayed
- Ali Safia
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- Alihonou Thierry
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- Alser Osaid H
- Alshareef Reham
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- Altibi Ahmed
- Altinel Yuksel
- Altinel Yuksel
- Altwijri Abdulaziz
- Alvi Abdul Rehman
- Aly Mohammed Yahia Mohamed
- Alyacoubi Said
- Alyahya Reem
- Alzahrani Ahmed
- Aman Nowrin F
- Amandito Radhian
- Amandito Radhian
- Ambrona-Zafra David
- Amin Hager Abdul Aziz
- Amjad Mohammadasim
- Amoah Michael
- Amoako Joachim
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- Amreia Mahmoud
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- Anthoulakis Christos
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- Anwar Nourhan
- Anyanwu Lofty-John
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- Aquilino Fabrizio
- Arafa Omar
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- Arango Maria Clara Mendoza
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- Arnaud Alexis
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- Arshad Mohammad Mohsin
- Arslan Ekin
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- Aruldas Neerav
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- Ashour Ahmad
- Ashour Ahmad
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- Aviles Susan
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- Aziz Mohamed Rezal Abdul
- Aziz Nora Abdul
- Azizeldine Mohammed G
- Azzie Georges
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- Bhangu Anna
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- Billy Matthew
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- Bustangi Nasir
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- D'Souza Michelle S
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- Saar Sten
- Sabe Ahmad
- Sabe Ahmad Khaled
- Sabour Fahd Abdel
- Sacco Michele
- Sacco Rosario
- Saeed Manar
- Sahbaz Nuri Alper
- Sahel Sarah
- Saidbadr Ahmed
- Sakr Ahmad
- Salah Asmaa
- Salah Maram
- Salah Mohamed
- Salah Osama Mohamed
- Salama Mahmoud
- Salama Yahya
- Salamone Giuseppe
- Salcedo Jannin
- Sale Danjuma
- Saleh Amr Ahmed
- Salem Hosni Khairy
- Salem Hosni Khairy
- Salem Hosni Khairy
- Salem Menatalla
- Salem Mohammed Mousa
- Sallam Abd Elkhalek
- Salleh Afizah
- Sallinen Ville
- Salma Mahmoud
- Salma Umme
- Salman Ayman
- Salusso Paola
- Sam Zi Hao
- Samalavicius Narimantas E
- Samison Luc Herve
- Sammarco Giuseppe
- Sammut Keith
- Samson Garba
- Samuel Sani Ali
- Samy Mostada
- Samy Mostafa
- Sanad Aly
- Sanchez Rosenberg Guillermo
- Sanchez Samaniego Camila
- Sanchez Belen
- Sanchez Diana
- Sander Anthony
- Sandler Simone
- Sandoval Barrantes Ana Maria
- Sanni Hakeem Ayomi
- Sanz Sandra
- Sapci Ipek
- Saqlain Muhammad
- Sarafilovic Hannah
- Saraste Deborah
- Saravia Fridiz
- Sasia Diego
- Saw Jian Er
- Sayed Farrag
- Sayed Marwa
- Scalabre Aurelien
- Scalabre Aurelien
- Schadde Erik
- Schiavone Roberto
- Schmid Roger
- Schmitt Francoise
- Schuetz Tobias
- Schultz Johannes Kurt
- Scicluna Ruth
- Segovia Lohse Helmut Alfredo
- Seisay Sam
- Selvaggi Francesco
- Selvaggi Lucio
- Semeda Nourhan
- Semiz Anil
- Sena-Ruiz Fatima
- Senanayake Kithsiri J
- Setiawan Jonny
- Seto Djifid Morel
- Seyoum Nebyou
- Sfougaris Dimitrios
- Shachykava Tatsiana
- Shaharuddin Shahadatul
- Shahbaz Aized Raza
- Shaheen Alaa
- Shahine Ahmed
- Shahzad Noman
- Shaikh Nihaal
- Shakshouk Hend Adel Gawad
- Shalabi Ahmad
- Shalaby Mahmoud
- Shalaby Mostafa
- Shamasneh Ala
- Shamsedine Ahmed W
- Sharma Abhishek
- Sharpin Claire
- Shatkar Veeranna
- Shaw Catherine A
- Shaw Catherine A
- Shawky Martina Yusuf
- Shawqi Muhammad
- Sheshe Abdurrahaman
- Sheta Ahmed
- Shillito Sam
- Shiwani Haaris A
- Sholadoye Tunde
- Shrimanker Nikhita
- Shu Sebastian
- Shu Sebastian
- Shu Sebestian
- Shubianok Maryna
- Shwky Ayman
- Siaw Jia Yng
- Sierra Sebastian
- Sigurdadottir Johanna
- Sii Samuel SY
- Sileri Pierpaolo
- Silvestri Vania
- Simioni Andrea
- Simutis Gintaras
- Skerritt Clare
- Slapelyte Evelina
- Sleem Ahmad Saber
- Sleem Mohamed
- Smart Neil
- Smart Neil
- Smedley Alexander
- Smith Christopher
- Sobnach Sanju
- Sokratous Arestis
- Solaini Leonardo
- Solar Garcia Lorena
- Soldevila-Verdeguer Carla
- Soledad Merlo Maria
- Soley Rafael
- Soliman Abdelrahman
- Soliman Ahmed
- Soliman Noha Abdullah
- Soliman Nourhan
- Soliman Samar
- Soliman Yasmin
- Sollazzo Viviana
- Soon Wai Cheong
- Soreide Jon Arne
- Soreide Kjetil
- Soreide Kjetil
- Souaibou Yacoubou Imorou
- Soulou Vasiliki
- Spence Richard
- Spence Richard
- Spence Richard
- Spence Richard
- Sproule Lorraine
- Srinivasan Ravi
- Sroor Fathy
- Sruogiene Elena Zdanyte
- Steccanella Francesca
- Stefanopoulos Anastasios
- Stock Simon
- Stoddart Michael
- Stoddart Michael
- Stourton Frederick
- Strupas Kestutis
- Stuva Jessica
- Styles Kristian
- Suarez Aida
- Subocius Andrejus
- Sund Malin
- Suresh Sukrit
- Sutandi Nathania
- Suyadi Arlindawati
- Swaroop Mamta
- Syibrah Khuzaimah Zahid
- Tabiri Stephen
- Tabiri Stephen
- Tabiri Stephen
- Tabiri Stephen
- Tackie Enoch
- Taddei Antonio
- Tahboub Haya
- Taher Ayman And
- Taher Mustafa Mohammed
- Taieb Chouikh
- Taiwo Agboola
- Taiwo Ogechukwu
- Talaat Muhammed
- Tale Luis
- Talving Peep
- Talving Peep
- Tan Charlene
- Tan Choy Ling
- Tan Joel Kin
- Tan Keith Say Kwang
- Tan Ryan Choon Kiat
- Tan Yee Wen
- Tan Yi Koon
- Tang Lingshan
- Tani Sobhana Iftekhar
- Tansoker Ilkan
- Tarek Adham
- Tarek Dina
- Targa Simone
- Tariq Sherif
- Tata Mahadevan Deva
- Tawfik Badreldin Adel
- Tawfik Gehad
- Teasdale Ella
- Teasdale Ella
- Teasdale Ella
- Tedeschi Umberto
- Tembo Thelma
- Tennakoon Athula
- Teo Shuang Yi
- Ter Eunice Zuling
- Tew Yong Yong
- Tew Yong Yong
- Thabet Waleed
- Thalgaspitiya SPB
- Theodosopoulos Theodosios
- Thollot Aurore
- Thorarinsdottir Hildur
- Thorell Anders
- Timothy Oyediran Kehinde
- Ting Jesse Ron Swire
- To Kathleen
- Tolonen Matti
- Tolotra Todisoa Emmanuella Christina
- Tomas Kadir
- Tori Sayeeda Aktar
- Toribio Orbegozo Pedro Angel
- Torrance Hew D
- Torres Cardozo Jorge
- Torres Rodriguez Servio Tulio
- Toto Omer Faruk
- Townsend Dominic
- Trompetto Mario
- Tselos Angelos
- Tshisola Serge Kapenda
- Tugnoli Gregorio
- Tun Myint
- Turati Luca
- Turkustani Sondos
- Turpo Espinoza Kenny
- Turpo Espinoza Kevin
- Tutino Roberta
- Tverskis Zygimantas
- Tyler Robert
- Tze R Goh Ern
- Tzikos Georgios
- Ubiali Paolo
- Ukwenya Yahaya
- ul Razi Syed Asaat
- Ulusahin Mehmet
- Upadhyaya Vijaid
- Urbonas Tomas
- Urniezius Zigmantas
- Uscinas Laimonas
- Uzabumwana Norbert
- Vaicius Arturas
- Valcarcel-Saldana Maria
- Valioulis Ioannis
- Van Der Naald Niels
- Van Niekerk Michael
- Van Straten Stephanie
- Vargas Marvin
- Vartanoglu Talar
- Vartic Mihaela
- Vasquez Giorgio
- Vasquez Idelso
- Veen Torhild
- Velasquez Ricardo
- Venclauskas Linas
- Vendramin Elena
- Venskutonis Donatas
- Venskutonis Donatas
- Verbeek Anna
- Vergara Mejia Angelica Genoveva
- Verjee Azmina
- Vermaas Maarten
- Vicario Erika
- Vicenta Collado Maria
- Vida Lucian Corneliu
- Vilcinskas Mantas
- Villalobos Santiago
- Violi Paola
- Visinskas Petras
- Voulgaris Evangelos
- Wael Noha
- Wakefield Rebecca
- Waledziak Maciej
- Walker Michael
- Walker Nathan
- Walls Luke
- Walsh Michael
- Waqar Muhammad
- Warren Oliver
- Waterman Ade
- Werder Gabriela
- Whitaker John
- White Rebecca
- Whitehurst Katharine
- Wiborg Joachim
- Widiastini T Ariani
- Widmer Lukas Werner
- Wijayarathna LS
- Williams Omolara
- Wilson Ling
- Wilson Michael
- Wilson Michael
- Wimalge PMSN
- Wogensen Fredrik
- Wolf Bernhard
- Wondoh Paul
- Wondoh Paul
- Wong Chui Yee
- Wong Francisca
- Wong Hong Yee
- Wood Greta
- Worku Mengistu
- Worku Tewodros
- Wright Naomi
- Yahaya Muhammad Taqiyuddin
- Yakubu Musah
- Yam Sir Young
- Yang James
- Yap Suhhuey
- Yau Jih Dar
- Ye Joselyn
- Yeang Li Jing
- Yeung Man Hon Andrew
- Yifieyeh Abiboye
- Yildirim Reyyan
- Yip Chingwan
- Ymeri Shpetim
- Yoganathan Pigeneswaren
- Yolcu Sinem
- Yong Guo Liang
- Younis Abobaker
- Youssef Mohamed
- Yuksek Mahmut Arif
- Yusufali Taha
- Zaa'treh Rula
- Zadoroznas Antanas
- Zahran Diaaaldin
- Zakaria Esraay
- Zakaria Mahmoud
- Zakaria Yehia
- Zaki Ahmed
- Zammit Stefan
- Zampitis Nikolaos
- Zani Augusto
- Zani Augusto
- Zanini Nicola
- Zapata Felipe
- Zarb Ciskje
- Zeta Solis Ludwing Alexander
- Zielinski Martin
- Zilinskas Justas
- Zilinskas Justas
- Zilinskas Justas
- Zilinskiene Reda
- Ziubryte Greta
- Zohair Ahmed
- Zuber Markus
- Zuk Grzegorz
- Zulkifli Athirah
- Zumbuhl Lucius
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world.
Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231.
Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001).
Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication
A prenylated dsRNA sensor protects against severe COVID-19
- Author
- Adeniji Kayode
- Agranoff Daniel
- Agwuh Ken
- Ahmed Katie A.
- Ail Dhiraj
- Aldera Erin L.
- Alegria Ana
- Alex Beatrice
- Allan Jay
- Allen Sam
- Andrikopoulos Petros
- Angus Brian
- Armstrong Jane A.
- Ashish Abdul
- Ashworth Milton
- Asiimwe Innocent G.
- Atkinson Dougal
- Bach Benjamin
- Baillie J. Kenneth
- Baillie J. Kenneth
- Bakshi Siddharth
- Barclay Wendy S.
- Bari Shahedal
- Barlow Gavin
- Barlow Samantha L.
- Barnass Stella
- Barrett Nicholas
- Bassford Christopher
- Basude Sneha
- Baxter David
- Beadsworth Michael
- Bernatoniene Jolanta
- Berridge John
- Berry Colin
- Best Nicola
- Bogaert Debby
- Booth Laura
- Bothma Pieter
- Brennan Benjamin
- Brittain-Long Robin
- Bullock Katie
- Bulteel Naomi
- Burden Tom
- Burtenshaw Andrew
- Cameron-Ruiz Natalia
- Carlucci Nicola
- Carracedo Alejandra Doce
- Carson Gail
- Caruth Vikki
- Cass Emily
- Castello Alfredo
- Catterall Benjamin W. A.
- Chadwick David
- Chadwick David
- Chambler Duncan
- Chand Meera
- Chechi Kanta
- Chee Nigel
- Child Jenny
- Chukkambotla Srikanth
- Clark Jordan J.
- Clark Tom
- Clarke Emily A.
- Clohisey Sara
- Clohisey Sara
- Cole Sarah
- Cole Sarah
- Collini Paul
- Connor Marie
- Cooke Graham S.
- Cooper Louise
- Cosgrove Catherine
- Cox Helen
- Crozier Thomas W. M.
- Cupitt Jason
- Cutino-Moguel Maria-Teresa
- Da Silva Filho Joao Luiz
- da Silva Filipe Ana
- Dalton Jo
- Dark Paul
- Davies Emma L.
- Davis Christopher
- Davis Ilan
- Dawson Chris
- de Lima Ferreira Luiz Carlos
- de Silva Thushan
- Dervisevic Samir
- Dincarslan Oslem
- Docherty Annemarie B.
- Donegan Cara
- Donnison Phil
- Donohue Chloe
- dos Santos Correia Gonçalo
- Douthwaite Sam
- Drake Thomas M.
- Drummond Andrew
- Dumas Marc-Emmanuel
- Dunn Chris
- Dunning Jake
- DuRand Ingrid
- Dushianthan Ahilanadan
- Dyer Philip
- Dyer Tristan
- Elliott Angela
- Evans Anthony
- Evans Cariad
- Eziefula Chi
- Fairfield Cameron J.
- Fawkes Angie
- Fegan Chrisopher
- Finch Lorna
- Finn Adam
- Fisher Lewis W. S.
- Flaherty Lisa
- Fletcher Tom
- Foster Terry
- Freire Santana Monique
- Fullerton Duncan
- Gamble Carrol
- Garcia-Dorival Isabel
- Garg Atul
- Garg Sanjeev
- Girvan Michelle
- Gkrania-Klotsas Effrossyni
- Godden Jo
- Goldsmith Arthur
- Graham Clive
- Green Christopher A.
- Greenhalf William
- Greenhalf William
- Greenwood Edward J. D.
- Griffin Julian L.
- Griffiths Fiona
- Grimes Graeme
- Gu Quan
- Gunning Philip
- Gupta Rishi K.
- Halpin Sophie
- Hardwick Hayley
- Hardy Elaine
- Harrison Ewen M.
- Harrison Janet
- Hartley Catherine
- Hartshorn Stuart
- Harvey Daniel
- Havalda Peter
- Hawcutt Daniel B.
- Hendry Ross
- Herder Vanessa
- Ho Antonia
- Ho Antonia Ying Wai
- Hobrok Maria
- Hodgson Luke
- Holmes Anthony
- Horby Peter W.
- Hormis Anil
- Hughes Joseph
- Ijaz Samreen
- Iselin Louisa
- Jackson Clare
- Jacobs Michael
- Jain Susan
- Jarmson Innes
- Jarrett Ruth F.
- Jennings Paul
- Jensen Rebecca L.
- Jones Christopher B.
- Jones Trevor R.
- Kaliappan Agilan
- Kasipandian Vidya
- Keating Seán
- Kegg Stephen
- Kelsey Michael
- Kendall Jason
- Kerrison Caroline
- Kerslake Ian
- Khandaker Shadia
- Khoo Saye
- King Katharine
- Kiy Robyn T.
- Klenerman Paul
- Knight Stephen R.
- Koch Oliver
- Koduri Gouri
- Koshy George
- Koukorava Chrysa
- Kuchi Srikeerthana
- Laha Shondipon
- Laird Steven
- Lake Annette
- Lant Suzannah
- Larkin Susan
- Latawiec Diane
- Lavelle-Langham Lara
- Law Andrew
- Law Andrew
- Lee James
- Lee Jeffrey Y.
- Leeming Gary
- Lefteri Daniella
- Lehner Paul J.
- Leiner Tamas
- Lett Lauren
- Lewis Matthew R.
- Liggi Sonia
- Lillie Patrick
- Lim Wei Shen
- Limb James
- Linnett Vanessa
- Little Jeff
- Livoti Lucia A.
- Loney Colin
- Lytras Spyros
- Lyttle Mark
- MacLean Alan
- MacMahon Michael
- MacNaughton Emily
- Mancini Maria
- Mankregod Ravish
- Marsh Laura
- Marti Matthias
- Maslen Lynn
- Massey Hannah
- Masson Huw
- Matovu Elijah
- Maziere Nicole
- McCafferty Sarah
- McCullough Katherine
- McDonald Sarah
- McDonald Sarah E.
- McEvoy Laurence
- McEwen Ruth
- McLauchlan John
- Mclean Kenneth A.
- Meda Manjula
- Mentzer Alexander J.
- Merson Laura
- Metelmann Soeren
- Meynert Alison
- Meynert Alison M.
- Miah Nahida S.
- Middleton Joanna
- Mills Gary
- Minton Jane
- Mirfenderesky Mariyam
- Mitchell Joyce
- Mohandas Kavya
- Mok Quen
- Moon James
- Moore Elinoor
- Moore Shona C.
- Moore Shona C.
- Morgan Patrick
- Morrice Kirstie
- Morris Craig
- Mortimore Katherine
- Moses Samuel
- Mpenge Mbiye
- Mulla Rohinton
- Murphy Derek
- Murphy Ellen G.
- Murphy Lee
- Murphy Lee
- Murphy Michael
- Nagarajan Thapas
- Nagel Megan
- Nelson Mark
- Noerenberg Marko
- Norman Lisa
- Norris Lillian
- Noursadeghi Mahdad
- O?Shea Matthew K.
- Olanipekun Michael
- Oosthuyzen Wilna
- Openshaw Peter J. M.
- Openshaw Peter J. M.
- Osagie Anthonia
- Ostermann Marlies
- Otahal Igor
- Pais Mark
- Palmalux Natasha
- Palmarini Massimo
- Palmarini Massimo
- Palmieri Carlo
- Palmieri Carlo
- Panchatsharam Selva
- Papakonstantinou Danai
- Papineni Padmasayee
- Paraiso Hassan
- Patel Brij
- Pattison Natalie
- Paxton William A.
- Penrice-Randal Rebekah
- Pepperell Justin
- Peters Mark
- Phull Mandeep
- Pilgrim Jack
- Pinto Rute M.
- Pintus Stefania
- Pius Riinu
- Planche Tim
- Plotkin Daniel
- Pollakis Georgios
- Post Frank
- Price David
- Price Nicholas
- Prince Tessa
- Prout Rachel
- Rae Nikolas
- Rambaut Andrew
- Reschreiter Henrik
- Reynolds Tim
- Reynolds Will
- Richardson Neil
- Ridley P. Matthew
- Rihn Suzannah J.
- Roberts Devender
- Roberts Mark
- Roberts Stephanie
- Robertson David L.
- Robertson David L.
- Rose Alistair
- Rousseau Guy
- Ruge Bobby
- Russell Clark D.
- Ryan Brendan
- Sales Debby
- Saluja Taranprit
- Sancho-Shimizu Vanessa
- Sands Caroline J.
- Saviciute Egle
- Schmid Matthias L.
- Scott Janet T.
- Scott-Brown James
- Semple Malcolm G.
- Semple Malcolm G.
- Shah Aarti
- Shankar-Hari Manu
- Shanmuga Prad
- Sharma Anil
- Shaw Catherine A.
- Shaw Victoria
- Shaw Victoria E.
- Shawcross Anna
- Shears Rebecca K.
- Sigfrid Louise
- Singh Pooni Jagtur
- Sizer Jeremy
- Small Benjamin
- Smith Richard
- Snelson Catherine
- Solomon Tom
- Spencer Rebecca G.
- Spittle Nick
- Sriskandan Shiranee
- Staines Nikki
- Stambach Tom
- Stanton Richard J.
- Stewart Douglas G.
- Stewart Richard
- Stuart David
- Subramaniam Krishanthi S.
- Subudhi Pradeep
- Sugrue Elena
- Summers Charlotte
- Swann Olivia V.
- Swingler Simon
- Szakmany Tamas
- Szemiel Agnieska
- Taggart Aislynn
- Takats Zoltan
- Takis Panteleimon
- Tanianis-Hughes Jolanta
- Tatham Kate
- Tedder Richard S.
- Thomas Jo
- Thomas Jordan
- Thompson A. A. Roger
- Thompson Chris
- Thompson Robert
- Thomson Emma C.
- Thwaites Ryan S.
- Tridente Ascanio
- Trindade Maranhão Costa Fabio
- Trochu Erwan
- Tupper-Carey Darell
- Turnbull Matthew L.
- Turtle Lance C. W.
- Twagira Mary
- Vallotton Nick
- van Tonder Libby
- Vancheeswaran Rama
- Varjak Margus
- Vincent-Smith Lisa
- Visuvanathan Shico
- Vuylsteke Alan
- Waddy Sam
- Wake Rachel
- Walden Andrew
- Wang Bo
- Wang Eddie C. Y.
- Welters Ingeborg
- Wham Murray
- Whitehouse Tony
- Whittaker Paul
- Whittington Ashley
- Wickenhagen Arthur
- Wijesinghe Meme
- Wilcock Eve
- Williams Martin
- Wilson Lawrence
- Wilson Sam J.
- Winchester Stephen
- Wiselka Martin
- Wolverson Adam
- Wootton Daniel G.
- Workman Andrew
- Wrobel Nicola
- Yates Bryan
- Young Peter
- Zambon Maria
- Zhang J. Eunice
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 29/10/2021
- Field of study
Inherited genetic factors can influence the severity of COVID-19, but the molecular explanation underpinning a genetic association is often unclear. Intracellular antiviral defenses can inhibit the replication of viruses and reduce disease severity. To better understand the antiviral defenses relevant to COVID-19, we used interferon-stimulated gene (ISG) expression screening to reveal that OAS1, through RNase L, potently inhibits SARS-CoV-2. We show that a common splice-acceptor SNP (Rs10774671) governs whether people express prenylated OAS1 isoforms that are membrane-associated and sense specific regions of SARS-CoV-2 RNAs, or only express cytosolic, nonprenylated OAS1 that does not efficiently detect SARS-CoV-2. Importantly, in hospitalized patients, expression of prenylated OAS1 was associated with protection from severe COVID-19, suggesting this antiviral defense is a major component of a protective antiviral response
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
- Author
- Adeniji Kayode
- Aggleton John P.
- Agranoff Daniel
- Agwuh Ken
- Ahmed Katie A.
- Ail Dhiraj
- Al-Chalabi Ammar
- Aldera Erin L.
- Alegria Ana
- Alex Beatrice
- Allen Christopher M.
- Allen Sam
- Amin Jay
- Andrikopoulos Petros
- Angus Brian
- Armour Cherie
- Armstrong Jane A.
- Ashish Abdul
- Ashworth Milton
- Asiimwe Innocent G.
- Atkinson Dougal
- Bach Benjamin
- Baillie J. Kenneth
- Baillie J. Kenneth
- Baker Mark R.
- Bakshi Siddharth
- Barclay Wendy S.
- Bari Shahedal
- Barlow Gavin
- Barlow Samantha L.
- Barnass Stella
- Barrett Nicholas
- Barrett Suzanne
- Bassford Christopher
- Basu Neil
- Basude Sneha
- Batra Rahul
- Baxter David
- Beadsworth Michael
- Benjamin Laura
- Bernatoniene Jolanta
- Berridge John
- Berry Colin
- Best Nicola
- Bethlehem Richard
- Blackledge Bethan
- Boardman Sarah A.
- Bogaert Debby
- Booth Laura
- Bothma Pieter
- Bradley John R.
- Bradley John R.
- Breen David P.
- Breen Gerome
- Breen Gerome
- Brennan Benjamin
- Breuer Judith
- Brittain-Long Robin
- Broome Matthew R.
- Bullmore Edward
- Bullock Katie
- Bulteel Naomi
- Burden Tom
- Burtenshaw Andrew
- Butler Matthew
- Carlucci Nicola
- Carracedo Alejandra D.
- Carson Alan
- Carson Gail
- Caruth Vikki
- Cass Emily
- Catterall Benjamin W.
- Cavanagh Jonathan
- Cavanagh Jonathan
- Chadwick David
- Chambler Duncan
- Chand Meera
- Chechi Kanta
- Chee Nigel
- Child Jenny
- Chinnery Patrick F.
- Chiollaz Anne-Cecile
- Christmas David
- Christmas David M.
- Chukkambotla Srikanth
- Clark Jordan J.
- Clark Jordan J.
- Clark Richard
- Clark Tom
- Clarke Emily A.
- Clohisey Sara
- Cole Sarah
- Coleman Jonathan R.
- Coles Alaisdair
- Coles Alasdair J.
- Collie Ceryce
- Collie Ceryce
- Collini Paul
- Connor Marie
- Cooke Graham S.
- Cooper Louise
- Cosgrove Catherine
- Cossette Nadine
- Cousins David
- Coutts Audrey
- Cox Helen
- Cupitt Jason
- Cutino-Moguel Maria-Teresa
- da Silva Ana
- Dalton Jo
- Darby Alastair
- Dark Paul
- David Anthony S.
- Davies Nicholas
- Davis Christopher
- Dawson Chris
- de Silva Thushan
- Defres Sylviane
- Dervisevic Samir
- Digby Richard
- Dincarslan Oslem
- Docherty Annemarie B.
- Dodd Katherine C.
- Donegan Cara
- Donnelly Lorna
- Donnison Phil
- Donohue Chloe
- dos Santos Gonçalo
- Douthwaite Sam
- Drake Thomas M.
- Dregan Alex
- Drummond Andrew
- Duff Eugene
- Dumas Marc-Emmanuel
- Dunai Cordelia
- Dunai Cordelia
- Dunn Chris
- Dunning Jake
- DuRand Ingrid
- Dushianthan Ahilanadan
- Dyer Philip
- Dyer Tristan
- Easton Ava
- Ebrahimi Soraya
- Egbe Franklyn N.
- Elliott Angela
- Ellul Mark A.
- Evangelou Nikos
- Evans Anthony
- Evans Cariad
- Eziefula Chi
- Facer Bethany
- Fairfield Cameron J.
- Fawkes Angie
- Fegan Chrisopher
- Fernandes Peter M.
- Finch Lorna
- Finn Adam
- Fisher Lewis W.
- Flaherty Lisa
- Fletcher Tom
- Foster Terry
- Fower Andrew
- Fox Hannah
- Francis Richard
- Fullerton Duncan
- Gamble Carrol
- Garcia-Dorival Isabel
- Garg Atul
- Garg Sanjeev
- Garjani Afagh
- George Lily
- Gilchrist Tammy
- Girvan Michelle
- Gkrania-Klotsas Effrossyni
- Glen Kiran
- Godden Jo
- Goldsmith Arthur
- Graham Clive
- Grammatikopoulos Tassos
- Green Christoper A.
- Greenhalf William
- Gregory Rebecca
- Griffin Julian L.
- Griffiths Fiona
- Griffiths Michael
- Griffiths Michael
- Grimbly Victoria
- Grundmann Alexander
- Grundmann Alexander
- Gunatilake Savini
- Gunning Philip
- Gupta Rishi K.
- Hafezi Katarzyna
- Halpin Sophie
- Hamid Shahd H.
- Hampshire Adam
- Hannah C.
- Hardwick Hayley
- Hardwick Marc
- Hardy Elaine
- Harris Jade D.
- Harrison Ewan
- Harrison Ewen M.
- Harrison Janet
- Harrison Neil
- Harrison Neil A.
- Harrison Paul J.
- Hartley Catherine
- Hartmann Monika
- Hartshorn Stuart
- Harvey Daniel
- Havalda Peter
- Hawcutt Daniel B.
- Held Marie
- Hendry Ross
- Hetherington Claire
- Hiscox Julian
- Hobrok Maria
- Hodel Eva M.
- Hodgson Luke
- Holden Karl
- Holland Angela E.
- Holmes Anthony
- Horby Peter W.
- Hormis Anil
- Hotopf Matthew
- Howard Joanne
- Huang Yun
- Hughes Stella
- Husain Masud
- Ijaz Samreen
- Irani Sarosh
- Irani Sarosh R.
- Jackson Clare
- Jackson Thomas
- Jacobs Michael
- Jain Susan
- Jenkins Thomas M.
- Jennings Paul
- Jensen Rebecca L.
- Jezzard Peter
- Jones Christopher B.
- Jones Trevor R.
- Kaliappan Agilan
- Kasipandian Vidya
- Keating Seán
- Kegg Stephen
- Keller Simon
- Kelsey Michael
- Kendall Jason
- Kerrison Caroline
- Kerslake Ian
- Khandaker Shadia
- Khoo Saye
- King Katharine
- Kingston Nathalie
- Kiy Robyn T.
- Klenerman Paul
- Knight Stephen R.
- Knight Susan
- Koch Oliver
- Koduri Gouri
- Koshy George
- Koukorava Chrysa
- Kyaw Sandar
- Laha Shondipon
- Lahnsteiner Eva
- Laird Steven
- Lake Annette
- Lant Suzannah
- Larkin Susan
- Latawiec Diane
- Lavelle-Langham Lara
- Law Andrew
- Lee James
- Leek Charles
- Leeming Gary
- Lefteri Daniella
- Leibowitz Maya
- Leiner Tamas
- Lett Lauren
- Lewis Gabriella
- Lewis Matthew R.
- Liggi Sonia
- Lilleker James B.
- Lillie Patrick
- Lim Wei S.
- Limb James
- Linnett Vanessa
- Little Jeff
- Livoti Lucia A.
- Lunn Michael P.
- Lyttle Mark
- MacGillivray Louise
- MacIver Claire L.
- Maclean Alan
- MacMahon Michael
- MacNaughton Emily
- Madarshahian Daniel
- Mancini Maria
- Mankregod Ravish
- Mansoori Parisa
- Marsh Laura
- Martin Naomi
- Maslen Lynn
- Massey Hannah
- Masson Huw
- Matovu Elijah
- Maziere Nicole
- McCafferty Sarah
- McCullough Katherine
- McDonald Sarah
- McDonald Sarah E.
- McDonnell Gavin
- McEvoy Laurence
- McEwen Ruth
- McGlinchey Emily
- McIlwaine Ryan
- McIntosh Andrew M.
- McLauchlan John
- Mclean Kenneth A.
- Meda Manjula
- Menon David K.
- Menon David K.
- Mentzer Alexander J.
- Merson Laura
- Metelmann Soeren
- Meynert Alison M.
- Miah Nahida S.
- Michael Benedict D.
- Michael Benedict D.
- Middleton Joanna
- Miller Karla
- Mills Gary
- Minton Jane
- Mitchell Joyce
- Mohandas Kavya
- Mok Quen
- Monssen Dina
- Moon James
- Moore Elinoor
- Moore Shona C.
- Morgan Patrick
- Morrice Kirstie
- Morris Christopher M.
- Morris Craig
- Mortimore Katherine
- Moses Samuel
- Mpenge Mbiye
- Mulholland Ciaran
- Mulla Rohinton
- Murphy Derek
- Murphy Ellen G.
- Murphy Lee
- Murphy Michael
- Nagarajan Thapas
- Nagel Megan
- Nair Akshay
- Needham Edward
- Needham Edward J.
- Nelson Mark
- Newcombe Virginia
- Nicholas Nathalie
- Nicholson Timothy
- Norman Lisa
- Norris Lillian
- Norris Lucy
- Norton Emma
- Noursadeghi Mahdad
- O'Malley Ronan
- O'Shea Matthew K.
- Olanipekun Michael
- Oosthuyzen Wilna
- Openshaw Peter J.
- Openshaw Peter J.
- Osagie Anthonia
- Ostermann Marlies
- Otahal Igor
- Paddick Stella-Maria
- Pais Mark
- Palmarini Massimo
- Palmieri Carlo
- Palmos Alish
- Palmos Alish
- Panchatsharam Selva
- Papakonstantinou Danai
- Papineni Padmasayee
- Paraiso Hassan
- Patel Arvind
- Patel Brij
- Pattison Natalie
- Paxton William A.
- Peacock Sharon
- Pendered Sophie
- Penrice-Randal Rebekah
- Pepperell Justin
- Peters Mark
- Phull Mandeep
- Pilgrim Jack
- Pintus Stefania
- Pius Riinu
- Planche Tim
- Plotkin Daniel
- Pollak Thomas
- Pollakis Georgios
- Pooni Jagtur S.
- Post Frank
- Price David
- Price Nicholas
- Prince Tessa
- Prout Rachel
- Rae Nikolas
- Rambaut Andrew
- Ren Alexander
- Reschreiter Henrik
- Reynolds Tim
- Reynolds Will
- Richardson Neil
- Ridley P. M.
- Roberts Angela
- Roberts Devender
- Roberts Mark
- Roberts Stephanie
- Robertson David L.
- Rogers Henry C.
- Rose Alistair
- Rota Silvia
- Rousseau Guy
- Ruge Bobby
- Russell Clark D.
- Ryan Brendan
- Sales Debby
- Salman Rustam A.
- Saluja Taranprit
- Samuel Merna
- Sanchez Jean-Charles
- Sancho-Shimizu Vanessa
- Sands Caroline J.
- Sargent Brendan
- Saviciute Egle
- Sawcer Stephen J.
- Schmid Matthias L.
- Scott Janet T.
- Scott-Brown James
- Seed Adam W.
- Semple Malcolm G.
- Semple Malcolm G.
- Semple Scott
- Shah Aarti
- Shankar-Hari Manu
- Shanmuga Prad
- Sharma Anil
- Sharma Parul
- Shaw Catherine A.
- Shaw Pamela J.
- Shaw Victoria
- Shaw Victoria E.
- Shawcross Anna
- Shears Rebecca K.
- Sieradzki Adam
- Sigfrid Louise
- Singh Bhagteshwar
- Sizer Jeremy
- Small Benjamin
- Smith Craig J.
- Smith Jacqueline
- Smith Richard
- Smith Stephen
- Snelson Catherine
- Solomon Tom
- Solomon Tom
- Spencer Rebecca G.
- Spittle Nick
- Sriskandan Shiranee
- Staines Nikki
- Stambach Tom
- Stewart James P.
- Stewart Richard
- Stirrups Kathy
- Stuart David
- Subramaniam Krishanthi
- Subramaniam Krishanthi S.
- Subudhi Pradeep
- Summers Charlotte
- Sunderland Geraint
- Swann Olivia V.
- Szakmany Tamas
- Szemiel Agnieska
- Taams Leonie
- Taams Leonie S.
- Taggart Aislynn
- Tait Sarah
- Takats Zoltan
- Takis Panteleimon
- Tamborska Arina
- Tanianis-Hughes Jolanta
- Tatham Kate
- Tato Esteban
- Taylor John-Paul
- Tedder Richard S.
- Tharmaratnam Kukatharmini
- Thomas Jo
- Thomas Jordan
- Thomas Rhys H.
- Thompson A. A. R.
- Thompson Chris
- Thompson Robert
- Thomson Emma
- Thomson Emma C.
- Thwaites Ryan S.
- Tonder Libby v.
- Tridente Ascanio
- Trochu Erwan
- Tupper-Carey Darell
- Turtle Lance C.
- Twagira Mary
- Underwood Jonathan
- Upthegrove Rachel
- Vallotton Nick
- van Daniel J.
- Vancheeswaran Rama
- Veenith Tonny
- Venneri Annalena
- Vincent Angela
- Vincent Angela
- Vincent Rachel
- Vincent-Smith Lisa
- Visuvanathan Shico
- Vuylsteke Alan
- Waddy Sam
- Wai Antonia Y.
- Wake Rachel
- Walden Andrew
- Welters Ingeborg
- Wham Murray
- Whitehouse Tony
- Whittaker Paul
- Whittington Ashley
- Wijesinghe Meme
- Wilcock Eve
- Williams Guy B.
- Williams Martin
- Williams Robyn
- Williams Steven
- Wilson Lawrence
- Winchester Stephen
- Wiselka Martin
- Wolverson Adam
- Wong Sui H.
- Wood Greta K.
- Wood Greta K.
- Wood Nicholas
- Wootton Daniel G.
- Workman Andrew
- Wrobel Nicola
- Yates Bryan
- Young Peter
- Zambon Maria
- Zandi Michael S.
- Zelaya Fernando
- Zhang J. E.
- Publication venue
- Nature Research
- Publication date
- 22/12/2023
- Field of study
To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely
Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials
- Author
- Aaronson Keith
- Abadier Rafik
- Abbasi Siddique A.
- Abdullah Shuaib
- Abelson Mark
- Abhayaratna Walter
- Ablasser Klemens
- Aboyans Victor
- Abo‐Auda Wael
- Abuannadi Mohammad
- Adams Kirkwood
- Adams Kirkwood F.
- Adhya Shaumik
- Adler Alexander
- Aggarwala Gaurav
- Agostoni Piergiuseppe
- Ahmad Saad
- Aiub Jorge Roberto
- Al Mohammad Abdallah
- Alharethi Rami
- Alieksieieva Liudmyla
- Almeida Filipa
- Almousalli Omar
- Amano Tetsuya
- Amanullah Aman
- Ambardekar Amrut
- Amerena John
- Anand Inder
- Anderson William
- Ando Kenji
- Andreka Peter
- Antalik Lubomir
- Aradi Daniel
- Araiza Raul Reyes
- Arbolishvili Georgy
- Ariani Mehrdad
- Arias‐Mendoza Alexandra
- Arora Raveen
- Arroyo Julian Alonso Coronel
- Artis Andre
- Asakura Masanori
- Asano Hiroshi
- Ashcom Thomas
- Aslam Shamaila
- Asubiaro Joshua
- Atherton John
- Avaca Horacio Alberto
- Babapulle Mohan
- Bacal Fernando
- Badak Ozer
- Badariene Jolita
- Badat Aysha
- Baker Mathue
- Balsam Pawel
- Banerji Sourin
- Barbarash Olga
- Barbetseas Ioannis
- Barr Craig
- Barros e Silva Pedro Gabriel Melo
- Barua Rajat
- Bauerlein Eugene Joseph
- Baweja Paramdeep
- Bednarkiewicz Zbigniew
- Beelen Driek
- Begg Alistair
- Bekar Lutfu
- Belenkiy Dmitriy
- Belohlavek Jan
- Beltrame John
- Berdague Philippe
- Berglund Stefan
- Berk Martin
- Berkowski Piotr
- Berra Fernando Colombo
- Bertolet Barry
- Besada Diego Alejandro
- Beug Daniel
- Bezzegh Katalin
- Bhagwat Ravi
- Bhargava Rakesh
- Biering‐Sørensen Tor
- Bilato Claudio
- Blicharski Tomasz
- Boccalandro Fernando
- Boehm Michael
- Boehmer John
- Bogaev Roberta
- Bolshakova Olga
- Boman Kurt
- Bonderman Diana
- Bonet Luis Almenar
- Bonfanti Alberto Cadena
- Bordonava Anselmo Paulino
- Bostick Brian
- Boswijk Dirk
- Bourgeois Ronald
- Bourhaial Hakima
- Bouza Manuel
- Braga Joao Carlos
- Brasca Daniela Garcia
- Brinkley Douglas
- Brito Dulce
- Brunetti Natale Daniele
- Bruno Marco Raul Litvak
- Bu Peili
- Burgess Lesley
- Busak Ladislav
- Buynak Robert
- Buysschaert Ian
- Bykov Alexander
- Böhm Michael
- Caccavo Alberto
- Canesin Manoel
- Cardona Jose
- Cardoso Juliano
- Carluccio Erberto
- Carrasco Jose Alfredo Pagola
- Carson Peter
- Castillo Armando Garcia
- Cavallini Claudio
- Cavusoglu Yuksel
- Cech Vladimir
- Celik Ahmet
- Celutkiene Jelena
- Cepelak Michal
- Cerci Rodrigo Julio
- Chandra Lokesh
- Chandrasekaran Badrinathan
- Chang David
- Chaves Renato
- Chehayeb Raja
- Cheirif Jorge
- Chen Guoqin
- Chen Jiyan
- Chmielak Zbigniew
- Chouchane Iman
- Chung Eugene
- Cid Maria Cristina Schnettler
- Civitello Andrew
- Clark Andrew
- Cleland John G.F.
- Clifford Piers
- Coletti Andrew
- Collins John
- Colque Roberto
- Constance Christian
- Contreras Johanna
- Corbalan Ramon
- Corbalan Ramon
- Correa Luis Eduardo Echeverria
- Corredor Miguel Alfredo Moncada
- Cosansu Kahraman
- Costa‐Vitali Atilio
- Cotarlan Vladimir
- Coufal Zdenek
- Cox Jeremy
- Crespo‐Leiro Maria G.
- Cruz Kimberly
- Cubero Javier Segovia
- Cui Hanbin
- Cymerman Krzysztof
- Dahlström Ulf
- Damy Thibaud
- Dauber Ira
- De Geeter Guillaume
- De los Rios Ibarra Manuel Odin
- De Pasquale Carmine
- Decoulx Eric
- Demir Mesut
- Desai Pratik
- Diaz Rafael
- Diaz Rafael
- Diaz Victor Alfonso Jimenez
- Dib Nabil
- Diez Mirta
- Dimov Bojidar
- Doblas Juan Jose Gomez
- Doi Masayuki
- Domae Hiroshi
- Donal Erwan
- Dong Yugang
- Donnelly Patrick
- Dorobantu Maria
- Dovgolis Svetlana
- Doyle Timothy
- Drexel Heinz
- Dronov Dmitry
- Droogne Walter
- Drozdz Jaroslaw
- Duarte Tatiana
- Duengen Hans‐Dirk
- Dujardin Karl
- Dupont Matthias
- Duran Ruben Omar Garcia
- Duzenli Mehmet
- Dzupina Andrej
- Eaton Charles
- Ebato Mio
- Ebelt Henning
- Eberly Arthur
- Ebner Christian
- Echeverria Correa Luis E.
- Elliott James
- Elmahi Einas
- Elvan Arif
- Esperon Guillermo Antonio Llamas
- Ezekowitz Justin
- Ezhov Marat
- Fang James
- Fang James C.
- Farris Neil
- Feitell Scott
- Felker G. Michael
- Fernandez Alberto
- Fernando Ronald
- Ferraz Almir
- Figal Domingo Andres Pascual
- Filho Otavio Coelho
- Filho Pedro Pimentel
- Filippatos Gerasimos
- Fisher Daniel
- Florea Viorel
- Flores Ana Maria De Leon
- Floresta Agata Marina
- Fonseca Candida
- Fonseca Cândida
- Forman Steven
- Forster Tamas
- Fortes Jose Augusto Ribas
- Fourie Nyda
- Franchi Francesco
- Frank Theodore
- Frankenstein Lutz
- Freire Ramon Bover
- Fremont Richard
- French John
- Friedman Keith
- Frigerio Maria
- Friz Hernan Emilio Francisco Polo
- Fu Xin
- Fucili Alessandro
- Fuente Galan Luis
- Fuente Ricardo Alfonso Leon
- Fujii Kenshi
- Fujii Shigeru
- Fujiwara Wakaya
- Fukuzawa Shigeru
- Fulop Peter
- Gabriel George
- Gajardo Victor Areli Saavedra
- Galinier Michel
- Ganeshram Vedampattu
- Ganji Jagadeesh
- Garrido Marcelo Alejandro
- Gass Alan
- Gaudet Daniel
- Geltman Edward
- Gemignani Anthony
- Genth‐Zotz Sabine
- Georges Jean‐Louis
- Giamouzis Grigorios
- Gianfagna Robert
- Giannetti Nadia
- Gilmore Richard
- Giorgeto Flavio Eduardo
- Giraldo Clara Ines Saldarriaga
- Giuca Alina
- Giudici Vittorio
- Glover Jason
- Gogia Harinder
- Gohara Seiichiro
- Gola Zbigniew
- Goloshchekin Boris
- Goncalvesova Eva
- Goncalvesova Eva
- Goncharov Ivan
- Gonsorcik Jozef
- Gonzalez Ricardo Garcia
- Gonzalez Salvador Leon
- Gordon Brian
- Gorodeski Eiran
- Gottlieb Stephen
- Goudev Assen
- Goudev Assen R.
- Gray Wayne
- Grazette Luanda
- Greco Oswaldo
- Grewal Gurinder
- Groote Pascal De
- Gueffet Jean‐Pierre
- Guerrero Rodolfo Andres Ahuad
- Gupta Dinesh
- Gupta Milan
- Guray Umit
- Haddad Tariq
- Haehling Stephan
- Hajko Erik
- Hal John
- Halpern Stephen
- Hametz Craig
- Hamilton Andrew
- Han Qinghua
- Han Yajun
- Handel Franklin
- Hara Hisao
- Harris John
- Hart Hamish
- Hart Terence
- Hartleib Michael
- Hasni Syed
- Hata Yoshiki
- Hattler Brack
- Hearne Steven
- Hedgepeth Chester
- Heilman Karl
- Heitner John
- Henderson David
- Herczeg Bela
- Hermans Walter
- Herzog William
- Hidaka Takayuki
- Hidalgo Mario Yanez
- Higashino Yorihiko
- Hiroi Shitoshi
- Hominal Miguel Angel
- Horacek Thomas
- Houra Marek
- Houston Brian
- Howlett Jonathan G.
- Huang He
- Huber Kurt
- Huelsmann Martin
- Hullin Roger
- Hunter Vernon
- Huynh Thao
- Ibañez Julio
- Ibrahim Hassan
- Indolfi Ciro
- Inomata Takayuki
- Iseki Harukazu
- Ishikawa Masahiro
- Isnard Richard
- Isshiki Takaaki
- Itchhaporia Dipti
- Ito Hiroshi
- Jackson Bruce
- Jacob Binu
- Jadbabaie Farid
- Jaeger Cristiano Pederneiras
- Jaffrani Naseem
- Jalaf Margarita Gertrudis Vejar
- Janik Matthew
- Jankowski Piotr
- Janmohamed Munir
- Jarasuniene Dalia
- Jattin Fernando Manzur
- Javier Julian
- Jeppesen Jorgen
- Jerabek Ondrej
- Jimenez Juan Francisco Delgado
- Jofre Christian Paolo Pincetti
- Jondeau Guillaume
- Jones Alonzo
- Joseph Susan
- Juanatey Jose Ramon Gonzalez
- Judkins Christopher
- Kadel Christoph
- Kadokami Toshiaki
- Kafara Mariusz
- Kai Hisashi
- Kaiser‐Nielsen Peter
- Kajinami Kouji
- Kalarus Zbigniew
- Kalecinska‐Krystkiewicz Ewa
- Kalra Paul
- Kaluski Edo
- Kanda Junji
- Kania Grzegorz
- Kao John
- Karavidas Apostolos
- Karim Amin
- Karlstrom Patric
- Karpenko Oleksandr
- Karvounis Haralambos
- Kasai Toshio
- Kassiotis Christos
- Katz Richard
- Kawakami Hideo
- Kawamitsu Katsunori
- Kawasaki Tomohiro
- Kazemi Navid
- Kazinczy Rita
- Kearney Leighton
- Keeling Philip
- Kellnerova Ivana
- Khalife Wissam
- Kida Keisuke
- Killat Holger
- Kindel Carlos Conejeros
- King Anthony
- Kirma Cevat
- Kitaoka Hiroaki
- Klimsa Zdenek
- Klug Eric
- Kobalava Zhanna
- Kochiadakis George
- Koga Tokushi
- Koike Akihiro
- Koizumi Tomomi
- Koldas Zehra Lale
- Koleckar Pavel
- Komiyama Nobuyuki
- Kondo Nicholas
- Konieczynska Malgorzata
- Kono Alan
- Koo Charles
- Kopaczewski Jerzy
- Korczyk Dariusz
- Koren Michael
- Korzh Oleksii
- Kosmacheva Elena
- Kostenko Viktor
- Kotelnikov Mikhail
- Kowalski Robert
- Kracz Igor
- Krantz Mori
- Krishnamoorthy Arun
- Krupicka Jiri
- Kryza Radim
- Kubota Toru
- Kulibaba Elena
- Kulynych Oleksii
- Kurtz Christopher E.
- Kwan Michael
- Lader Ellis
- Lakatos Ferenc
- Lakshminarayanan Batlagundu
- Lancellotti Patrizio
- Lanfear David E.
- Lang Chim
- Lang Christopher
- Laperche Thierry
- Laszlo Zoltan
- Leaes Paulo Ernesto
- Lefebvre Jean‐Marie
- Legg Jason C.
- Leiro Maria Generosa Crespo
- Lelonek Malgorzata
- Lenartowska Lucyna
- Lenner Egon
- Leon Jose Luis Arenas
- Leonardi Sergio
- Lepor Norman
- LeWinter Martin
- Lewis Neil
- Li Dongye
- Li Jianjun
- Li Tianfa
- Li Weimin
- Li Yinjun
- Li Zhangquan
- Li Zhaoping
- Lighezan Daniel
- Lindholm Carl‐Johan
- Linssen Gerardus
- Liu Feng
- Llamas Edmundo Alfredo Bayram
- Llerena Sara
- Lohr Nicole
- Londono Juan
- Lopez Gabriel Arturo Ramos
- Lopez Luis Horacio Atehortua
- Lopez Rodrigo Botero
- Lovell Charles
- Ludman Andrew
- Luengas Carlos Alberto
- Lukacova Jana
- Lukyanov Yury
- Lund Marianne
- Lund Mayanna
- Lupkovics Geza
- Lupovitch Steven
- Luquez Hugo
- Lymar Yurii
- Lynch Mary
- Ma Shumei
- Macarie Cezar‐Eugen
- Macdonald Peter
- Macdonald Peter
- Machado Gustavo Francisco Mendez
- Machova Vilma
- Macias Leonardo
- Mackinnon Ignacio
- Maejima Yasuhiro
- Magro Michael
- Mahemuti Ailiman
- Mahmood Shahid
- Maia Lilia Nigro
- Majercak Ivan
- Majul Claudio Rodolfo
- Malhotra Sanjay
- Malhotra Vinay
- Malik Adnan
- Malik Fady I.
- Mamdani Shafiq
- Mancini Donna
- Manenti Euler Roberto Fernandes
- Manita Mamoru
- Manolis Athanasios
- Mantas Ioannis
- Mareev Vyacheslav
- Mareev Vyacheslav
- Margoczy Roman
- Margonato Alberto
- Mark Laszlo
- Marquez Lilia Luz Lobo
- Martindale Jeffrey
- Martinez Diego Felipe
- Martinez Laura Jordan
- Martinez Luis
- Martinez‐Arraras Joaquin
- Martinez‐Castrillon Melvin
- Marzouka George
- Masuda Seigo
- Matsumoto Takashi
- Mayer Nolan
- Mayoral Alejandro Recio
- McGrew Frank
- McKelvie Robert
- McKenzie Scott
- McLean Dalton
- McMurray John J.V.
- Menck Niels
- Mendoza Jose Luis Accini
- Mendoza Maria Alexandra Arias
- Merkely Bela
- Metra Marco
- Metra Marco
- Meyer Philippe
- Mi Yafei
- Michishita Ichiro
- Miekus Pawel
- Mielniczuk Lisa
- Mignone John
- Militaru Constantin
- Mincheva Valentina
- Mishchenko Larysa
- Mitrokhin Vladislav
- Mitrovic Veselin
- Mitsuo Kazuhisa
- Mittag Marcus
- Mitu Florin
- Miura Shinichiro
- Miyamoto Michael
- Miyamoto Nobuhide
- Miyazaki Tetsuro
- Moccetti Tiziano
- Mody Freny
- Moe Gordon
- Moertl Deddo
- Mohacsi Attila
- Mohapatra Robert
- Molina Beatriz Diaz
- Momiyama Yukihiko
- Momomura Shin‐ichi
- Monhart Zdenek
- Montana Oscar Romano
- Monteiro Pedro
- Moodley Rajendran
- Mori Masuki
- Morita Yukiko
- Morrow John Andrew
- Mortara Andrea
- Mostovoy Yuriy
- Motovska Zuzana
- Motylev Igor
- Mouhaffel Asad
- Muderrisoglu Ibrahim Haldun
- Mueller Christian
- Murray David
- Muthumala Amal
- Myasnikov Roman
- Nadar Venkatesh
- Nagy Laszlo
- Nair Nandini
- Naka Katerina
- Nakamura Akihiro
- Nakamura Kentaro
- Nalbantgil Sanem
- Nechvatal Libor
- Nelson William
- Nessler Jadwiga
- Nguyen Viviane
- Nicolosi Liliana
- Nielsen Tonny
- Niu Wentang
- Node Koichi
- Noll Georg
- Nosov Vladimir
- Novaretto Leonardo
- Numaguchi Kotaro
- Nyolczas Noemi
- Nyvad Ole
- O'Brien Terrence
- O'Meara Eileen
- O'Meara Eileen
- Ogawa Tomohiro
- Oishi Shogo
- Okishige Kaoru
- Okumura Takahiro
- Okumura Yasuo
- Okuyan Ertugrul
- Oliveira Soares Manue Martinez‐Selles D
- Oliveira Luis
- Olsen Stephanie
- Onoue Kenji
- Onrat Ersel
- Ooi Henry
- Orgera Marisa
- Ortiz Aurelio
- Osipova Irina
- Osorio Wilder Castaño
- Ovize Michel
- Padron Antonio Lara
- Paiva Maria Sanali
- Palomas Juan Luis Bonilla
- Pandey A Shekhar
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- Parissis John
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- Taylor Justin
- Teerlink John R.
- Terasaki Toshiro
- Terasawa Akihiro
- Tereschenko Sergey
- Timofeev Alexander
- Tisheva‐ Gospodinova Snezhanka
- Tocchetti Carlo Gabriele
- Todorov Georgi
- Tognon Alexandre
- Tomcsanyi Janos
- Tomcsanyi Janos
- Toth Kalman
- Treasure Charles
- Trebacz Jaroslaw
- Trevelyan Jasper
- Triana Miguel Urina
- Trichon Benjamin
- Trochu Jean Noel
- Tsabedze Nqoba
- Tsao Lana
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- Tsioufis Konstantinos
- Tsujimoto Mitsuru
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- Turgut Okan Onur
- Tyl Petr
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- Van Zyl Louis
- Vandekerckhove Hans
- Vandekerckhove Hans
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- Vasilyeva Larysa
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- Vazquez Eduardo Salcido
- Vega Mario
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- Venegas Manuel Eduardo Rodriguez
- Videbaek Lars
- Vidotti Maria Helena
- Vijay Nampalli
- Vilamajo Oscar Alberto Gomez
- Vilchez Francisco Gonzalez
- Villani Giovanni Quinto
- Villoch Mario
- Villota Julio Eduardo Nuñez
- Vinanska Daniela
- Vincenzi Antonella
- Vinereanu Dragos
- Vinereanu Dragos
- Vishnevsky Alexander
- Voevoda Mikhail
- Vogel Daniel
- Voicu Olga‐Cristina
- Volterrani Maurizio
- Voors Adriaan
- Voors Adriaan A.
- Voronkov Leonid
- Vraa Soren
- Wada Atsuyuki
- Wahid Faisal
- Wal Ruud
- Wang Yi
- Wang Zhifang
- Watanabe Naoki
- Wei Yu
- Weir Robin
- Westenfeld Ralf
- Wheeler Matthew
- Whellan David
- Wiggers Henrik
- Wilkett Matt
- Willems Frank
- Williams Celeste
- Wlodarczyk Aleksander
- Wodlin Peter
- Wong Kenneth
- Wozakowska‐Kaplon Beata
- Wu Weiheng
- Yagensky Andriy
- Yamamoto Mitsutaka
- Yan Jing
- Yang Ping
- Yang Xuming
- Yang Zhenyu
- Yeoman Gary
- Yigit Zerrin
- Yilmaz Mehmet B.
- Yoshida Takeshi
- Yoshikawa Masaki
- Yousuf Kabir
- Yuan Zuyi
- Yuge Masaru
- Zabowka Maciej
- Zaca Valerio
- Zaidman Cesar
- Zanetti Fernando Tomas Lanas
- Zannad Faiez
- Zapata Gerardo
- Zdrenghea Dumitru
- Zeman Kamil
- Zeymer Uwe
- Zhang Jinguo
- Zhang Lily
- Zhang Shouyan
- Zhang Xuelian
- Zhang Yuhui
- Zhang Yuqing
- Zheng Yang
- Zheng Zhe
- Zhou Changyong
- Zieroth Shelley
- Zilahi Zsolt
- Zimmet Hendrik
- Zolty Ronald
- Zrazhevskiy Konstantin
- Zwaan Coenraad
- Publication venue
- 'Wiley'
- Publication date
- 01/11/2020
- Field of study
Aims:
The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials.
Methods and Results:
Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594).
Conclusions:
GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alonso Veronica
- Alqallaf Abdullah
- Alqaseer Asma
- Alrayes Bourhan
- Alsefri Maryam
- Alser Osaid
- Alsharif Mohammed
- Alsori Mohamed
- Altaf Abdulmalik
- Altinel Yuksel
- Altiner Saygin
- Altouny Ahmad
- Altun Demet
- Alvarez Natalia
- Alvarez-Lozada Luis Adrian
- Alvi Abdul
- Alwael Athari
- Alwash Mohammed
- Alyami Ziyad
- Alyousef Mohammed
- Alzahrani Saud
- Alzerwi Nasser
- Amin Shivang
- Amir Mohammed
- Ammar Ahmed Siddique
- Ammendola Michele
- Amores Remedios Revilla
- Amrayev Sultan
- Anastasiadou Sofia
- Ancans Guntis
- Anderson Caroline
- Andreani Lorenzo
- Andreotti Dario
- Andreuccetti Jacopo
- Andrianakis Alexandros
- Andro Christophe
- Anesi Alexandre
- Angamuthu Stephen
- Angeles Martina Aida
- Angelico Roberta
- Angelis Fragkiskos
- Angelou Dimitrios
- Angelou Kyveli
- Angulo Victor Pinto
- Anjum Arfa
- Anjum Muhammad Ayyub
- Annicchiarico Alfredo
- Anoldo Pietro
- Ansaloni Luca
- Anthoulakis Christos
- Antonelli Amedeo
- Anwar Mohamed
- Anwar Sumadi Lukman
- Anwer Mariyah
- Anyanwu Lofty-John
- Apostolou Christos
- Apostolou Konstantinos
- Appiah-Kubi Adu
- Aprea Giovanni
- Arbab Hana
- Archer James
- Ardura Francisco
- Aremu Muyiwa
- Arif Tahera
- Arkani Samara
- Armatura Giulia
- Armijos Daniel
- Arnaout Ali
- Arnaoutoglou Eleni
- Arnaud Alexis P.
- Arneja Jugpal
- Arrangoiz Rodrigo
- Arshad Muhammad
- Arthur Joshua
- Ashcroft James
- Ashford Bruce
- Ashraf Fariha
- Asiimwe Daniel
- Asirifi Samuel Amoako
- Asla Amir
- Aslam Ramisha
- Aspide Raffaele
- Ataya Karim
- Ateca Ibabe Villalabeitia
- Atici Semra Demirli
- Atis Gokhan
- Atkins William
- Atkinson Kate
- Attwood Joseph
- Auerkari Aino
- Augestad Knut Magne
- Augustin Goran
- Aujayeb Avinash
- Avella Pasquale
- Awad Ahmed K.
- Awad Hadeel
- Awad Rabih
- Awad Selmy
- Ayad Kusay
- Ayana Birhanu
- Aydin Yener
- Ayeni Funbi
- Aytac Erman
- Azab Ahmed
- Azami Rizwan
- Azize Diallo Abdoul
- Azzam Ahmed Y.
- Azzis Olivier
- Baba Yabasin Iddrisu
- Babis George
- Bacalbasa Nicolae
- Badiani Sarit
- Badran Saif
- Baduell Albert
- Baeesa Saleh
- Baertschiger Reto
- Bafaquh Mohammed
- Bahassan Omar Mohammed
- Bahrami-Hessari Michael
- Baia Marco
- Baidoo Ebikela Ivie
- Bailey Karen
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Baiocchi Glauco
- Baiyewu Lateef Ayodele
- Bajaj Ankur
- Bajunaid Khalid
- Balagobi Balasingam
- Balasubramanian Ishwarya
- Balduzzi Alberto
- Baldwin Alexander
- Balla Andrea
- Balogh Zsolt J.
- Balogun James A.
- Balogun Simon
- Baloyiannis Ioannis
- Ban Vin Shen
- Bandyopadhyay Samik Kumar
- Bandyopadhyay Soham
- Banerjee Sumit
- Banipal Gurpreet Singh
- Banky Balazs
- Bannone Elisa
- Bansal Sujesh
- Barberis Andrea
- Barbosa-Breda Joao
- Bareka Metaxia
- Barišić Tatjana
- Barlas Aziz Mutlu
- Barlow Ciaran
- Barmayehvar Behrad
- Baroffio Paolo
- Barone Mirko
- Barra Fabio
- Barranquero Alberto G.
- Barugola Giuliano
- Basendowah Mohammed
- Bashir Mahmod
- Basnayake Oshan
- Bass Gary Alan
- Basu Somprakas
- Bateman Antony
- Bateman Kellie
- Batista Sylvia
- Batstone Martin
- Bauer Marlies
- Bauset Juan Carlos Catalá
- Bawa Ashvind
- Bawa Sayesha
- Bayhan Hüseyin
- Bayo Heura Llaquet
- Bazzi Nagham
- Beamish Andrew
- Beasley Nigel
- Beatty Jasmine Winter
- Becerra Angel
- Bedada Alemayehu Ginbo
- Bedzhanyan Arkady
- Begum Farzana
- Beisenov Bekzat
- Bellio Gabriele
- Bello Usman Mohammed
- Bellés Ana Ciscar
- Belzile Etienne
- Benamar Safia
- Bence Matthew
- Benshetrit Guy
- Bensoltane Khadidja
- Bergkvist David Julià
- Beristain-Hernandez Jose-Luis
- Bernante Paolo
- Bernardi Daniele
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- Berselli Bruno
- Berselli Mattia
- Bertelli Giacomo
- Bertoglio Pietro
- Bertolaccini Luca
- Beswick Daniel
- Bette Birgit
- Bezirci Rifat
- Bhangu Aneel
- Bharathan Rasiah
- Bhat Vivek
- Bhatti Khalid
- Bianchi Valentina
- Bianco Francesco
- Bianco Giuseppe
- Bijou Walid
- Bilfaqirah Majed
- Biloslavo Alan
- Bin Alhassan Baba Alhaji
- Binnawara Muhannud
- Bissacco Daniele
- BİŞGİN TAYFUN
- Blair James
- Blanco Jose
- Blencowe Natalie
- Bloemers Frank
- Board Timothy
- Bobak Peter
- Boccalatte Luis
- Boedo Maria Jesus Maroño
- Bohmer Rob
- Boira Mar Achalandabaso
- Boisson Matthieu
- Boligo Sofia
- Bolton William
- Bombardini Cristina
- Bonavina Luigi
- Bonci Eduard-Alexandru
- Bondurri Andrea
- Bonilla Antonio Ramos
- Bonsaana Gilbert Batieka
- Booth L.
- Borg Elaine
- Borges Miguel Fróis
- Borges Nuno
- Bork Ulrich
- Borselle Dominika
- Bortul Marina
- Botelho Pedro
- Bottari Andrea
- Bouchagier Konstantinos
- Bouliaris Konstantinos
- Bowan Antoinette Bediako
- Bowen Joel
- Bozbiyik Osman
- Bracale Umberto
- Brachini Gioia
- Bramis Konstantinos
- Branagan Graham
- Branzan Daniela
- Brasset Camille
- Bratus Dejan
- Bravo Ana Maria Minaya
- Bravo Sybil Lizanne
- Bright Tim
- Brisinda Giuseppe
- Brodkin Edgar
- Broglia Alessandro
- Brolese Alberto
- Browning Rebecca
- Bruzzaniti Placido
- Brzeszczyński Filip
- Bsisu Isam
- Bua Emmanuel
- Budd Gabrielle
- Bukhari Syed Imran
- Bulian Dirk Rolf
- Bumbasirevic Uros
- Bumber Boris
- Burgos-Blasco Barbara
- Burlov Nikita
- Bussu Francesco
- Bàmbina Fabrizio
- Börner Nikolaus
- Böttcher Arne
- Cabeza Leticia
- Cabrera Marino
- Cais Simon
- Cakmak Guldeniz Karadeniz
- Calabretto Francesca
- Calabrò Marcello
- Calavia Pablo
- Calculli Federica
- Calini Giacomo
- Callan Rory
- Callcut Rachael
- Calu Valentin
- Calvache Jose Andres
- Calvache Nieto
- Calvo Francisco Javier Redondo
- Cama Jitoko
- Camacho Barbosa
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- Camargo-Parra Katherin
- Cammarata Emanuele
- Cammarata Francesco
- Cammarata Roberto
- Campagnaro Tommaso
- Campanelli Michela
- Campennì Paola
- Campisi Giuseppina
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- Campuzano Nicolas
- Cano-Trigueros Emiliano
- Capella Stefano
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- Capobianco Mattia
- Capolupo Gabriella Teresa
- Capozzi Enrico
- Cappuccio Micaela
- Capuano Marianna
- Carannante Filippo
- Carbone Fabio
- Carbone Ludovico
- Caretto Marta
- Caricato Chiara
- Caricato Marco
- Carpenter Holly
- Carreras-Castañer Anna
- Carretero Manuel Moriche
- Caruana Edward J.
- Carvello Michele
- Casagranda Biagio
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- Castaldi Antonio
- Castaño Mario
- Castaño-Leon Ana M.
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- Christodoulou Prokopis
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- Cisneros Juan Roberto Torres
- Ciubotaru Cezar
- Claireaux Henry
- Clancy Cillian
- Claret Guillem
- Clegg Rachael
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- Kauppila Joonas H
- Kaur Amanjot
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- Kazan Ozgur
- Kealey Joshua
- Kebede Ephrem
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- Kent Alistair J
- Keramati Mohammad Reza
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- Martins Paulo N.
- Martínez Daniel Fernández
- Martínez Eunate Ganuza
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- Matthews Emily
- Mauriello Claudio
- Maurus Christine
- Mayer Horacio F.
- Mayo-Yáñez Miguel
- Mazzarella Gennaro
- Mbodi Langanani
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- Meead Adullah
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- Musadaq Muhammad
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- Mustafa Hamid
- Muthu Sathish
- Mutlu Özgecan Piril Zanbak
- Mutter Didier
- Mvukiyehe Jean Paul
- Mwenda Aruyaru Stanley
- Myrelid Par
- Myriokefalitaki Eva
- Méndez Patricia Serrano
- Nabil Fatma
- Nachelleh Emmanuel Aadereyir
- Nacion Aeris Jane D.
- Nadi Khaldoun
- Naegele Felix
- Naga Hani
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- Naggs Taryn
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- Nakano Luis
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- Narvaez-Rojas Alexis Rafael
- Nassar Mahmoud A.
- Nasser Sara
- Nastos Constantinos
- Natale Joseph
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- Navarrete-Peón Alberto
- Navarro-Barrios Alvaro
- Nazer Ahmed
- Nazimi Abd Jabar
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- Neal-Smith Gregory
- Neary Colm
- Negoi Ionut
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- Nepogodiev Dmitri
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- Spiers Harry V. M.
- Spina Alfio
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- Squiers John
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- Starr Nichole
- Stather Philip
- Stevens Sean
- Stevenson Andrew
- Stewart Grant D.
- Stijns Jasper
- Stogowski Piotr Tomasz
- Stoleriu Mircea Gabriel
- Stoyanov Vladislav
- Street John
- Strotmann Johanna Josefine
- Stroumpoulis Konstantinos
- Su Yu-Xiong
- Suarez Sara Busto
- Subramani Yamini
- Subramaniam Sentilnathan
- Sue-Chue-Lam Colin
- Suer Muhammed Salih
- Sulaiman Bilal
- Sultania Mahesh
- Sundarraju Shalini
- Sungurtekin Hulya
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- Tripathi Manjul
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- Trulson Alexander
- Trungu Sokol
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- Tuech Jean Jacques
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- Valeanu Liana
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- Vallve-Bernal Marc
- Van Acker Jill
- Van Den Eynde Jef
- Van Goor Harry
- Van Vliet Helen
- Van Wyk Naomi Natasha
- Vanni Camilla
- Vas Aurelia
- Vasarhelyi Edward
- Vaschetti Roberto
- Vassiliu Panteleimon
- Vatansever Dogan
- Vatish Jamie
- Vaughan-Shaw Peter G.
- Vaysburg Dennis
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- Velten Markus
- Velázquez Maria Jose Martinez
- Venkatappa Sunil Kumar
- Venketeswaran Meenakshi
- Venskutonis Donatas
- Verbic Milena Senica
- Verdi Daunia
- Vergara-Fernandez Omar
- Verhoeff Kevin
- Veroux Massimiliano
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- Verre Luigi
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- Viglietta Edoardo
- Vijay Vardhini
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- Villanueva Julio
- Vilz Tim O.
- Vincent Elizabeth
- Vinci Danilo
- Viola Simona
- Violante Tommaso
- Vishnoi Jeewan Ram
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- Vives Josep Maria Muñoz
- Vizzielli Giuseppe
- Vohra Lubna
- Vokshi Ismail
- Vosinakis Christos
- Vásquez Javier Alberto Gutiérrez
- Vázquez Gil
- Vázquez Irene Ortega
- Vǎcǎraşu Andrei Bogdan
- Wade Ryckie
- Wafi Omar
- Wagner Gabriela
- Wallis Christopher
- Wanjara Samuel
- Waqar Shahzad Hussain
- Warden Claire
- Warner Christian
- Wasim D.
- Wason Shaun
- Wasserman Isaac
- Watcyn-Jones Tom
- Waterson Ben
- Watson David
- Watson Matthew
- Weber Clemens
- Wheatstone P.
- Wheeler James
- Wheldon Luke
- White Michelle
- White Stuart
- White William
- Wickramasinghe Dakshitha
- Widmer Lukas Werner
- Wiedemann Dominik
- Wiesinger Clemens Georg
- Wijekoon Naveen
- Wijenayake Wasantha
- Wijeyaratne Manuk
- Wijeysundera Duminda
- Wiles Matthew
- Wilkin Richard
- Wilkins Alex
- Wilkins James
- William Tinka George
- Williams Omolara Modupe
- Williams Shekinah
- Windsor John
- Winnand Philipp
- Wittmann Maria
- Wolde Amanuel
- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
- Wurm Markus
- Xenaki Sofia
- Yadev Ip
- Yahaya Ahmad Shuib
- Yakubu Mustapha
- Yang Wah
- Yanik Özge
- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Duverger's Law, Penrose's Power Index and the Unity of the UK
- Author
- Alistair McMillan
- Butler D. E.
- Butler D. E.
- Coleman J. S.
- Cox G.
- Craig F. W. S.
- Craig F. W. S.
- Curtice J.
- Dennis Leech
- Duverger M.
- Felsenthal D. S.
- Garrett G.
- Iain McLean
- Jackson A.
- Johnston R.
- Kellas J. G.
- Kendall M. G.
- Leech D.
- McLean I.
- McLean I.
- Morley J.
- Parker Smith J.
- Penrose L. S.
- Ramsden J.
- Riker W. H.
- Rossiter D. J.
- Rossiter D. J.
- Stenton M.
- Publication venue
- Publication date
- 01/10/2005
- Field of study
As predicted by Duverger’s Law, the UK has two-party competition in each electoral district. However, there can be different patterns of two-party competition in different districts (currently there are five), so that there have usually been more than two effective parties in the Commons. Since 1874 it has always contained parties fighting seats in only one of the non-English parts of the Union. These parties wish to change the Union by strengthening, weakening, or dissolving it. By calculating the Penrose power index for all parties in the House of Commons for all General Elections since 1874, we identify the occasions on which a party that wished to modify the Union was pivotal. We explain various acts (e.g, the Crofters Act 1886; the first three Irish Home Rule Bills; the Parliament Act 1911) and non-acts (e.g. the failure to enact female suffrage before 1914) by reference to the Penrose indices of the non-English parties. The indices also explain how and why policy towards Scotland, Wales and Northern Ireland changed, and did not change, in the 1970s