No-How Generator: an artistic investigation of the event of choreographic performance as a site of embodied knowledge-generation

This written thesis is an exegesis of developments arising within my choreographic practice and thinking through the creation and performance of the choreographic work No-How Generator, an artistic investigation of the event of choreographic performance as a site of embodied knowledge-generation. Drawing on the cognitive science perspective of Guy Claxton and others, this thesis emphasises the embodied basis of knowing and argues that this grounds an understanding of knowledge-generation as intrinsic within the embodied context of choreography. This understanding foregrounds the integral presence and contributions of ways of knowing that are felt, more-than-rational and intuitive within the generation of knowing and intelligence. Insights are articulated into how these ways of knowing unfold in my choreographic practice, supported by specific conceptual and practical tools and orientations that I have developed in a choreographic context during this research. This includes no-how (drawn from Samuel Beckett via Sarat Maharaj’s writings on art-as-knowledge), which I use to name the particular kind of knowing that I consider this artistic research to be generative of, and Magic & Science (drawn from art-historian Aby Warburg) which I use to name the broader epistemological orientation that I situate choreographic no-how generation within. Drawing connections between Warburg’s work and my engagement with the work of choreographer Deborah Hay, this thesis emphasises that the catalytic dynamics of paradox are a generative and inherent part of the artistic and embodied landscape of what I term choreographic no-how generation. Drawing on humanities writers including Boaventura de Sousa Santos, the thesis emphasises that a continual, underlying attention to the social and political contexts within which choreographic no-how generation unfolds is an integral dimension of a choreographic engagement with it. Through its integrated embodiment of this particular multidisciplinary constellation of knowledges, this artistic research develops novel approaches to practicing and conceptualising the generation of knowing in choreographic contexts. This research works to broaden understandings, both within and beyond the field of dance, of the forms that knowledge-generation can and does take, and of the social and political relevance that such a broadening has.Supported by Midlands4Cities in partnership with Dance4 and Siobhan Davies Danc

Digitale Verwertungsformen in der Kultur- und Kreativwirtschaft und ihre Auswirkungen auf die Künstlersozialversicherung: Endbericht

Die Digitalisierung verändert die Arbeitswelt von Kreativen und Kulturschaffenden. Viele Kreativschaffende setzen heute schon auf digitale Vertriebswege. Es entstehen ständig neue Geschäftsmodelle, Wertschöpfungsketten und Kooperationen der Akteure. Es gibt jedoch große Unterschiede in Tempo und Ausmaß. Inhalteanbieter wandeln sich zu Technologieanbietern und umgekehrt. Inhalte und Technik rücken immer näher zusammen. Musik, Filme, Spiele, Literatur und journalistische Inhalte oder Produkte im Designbereich werden zunehmend im weltweiten Netz hergestellt, konsumiert und kommerziell verwertet. Vor diesem Hintergrund geht das Forschungsprojekt der Frage nach, wie die Wertschöpfungsleistungen von Urhebern, Darstellern, Verwertern, Plattformen und sonstigen intermediären Vermittlern in Zukunft entlang der digitalen Strukturen zu bewerten sein werden. Ziel dieser Untersuchung ist es daher, einen systematischen Überblick zu Formen der digitalen Verwertung zu geben. Darauf aufbauend gilt es, die Wirkungen der Digitalisierung auf die Teilmärkte der Kreativwirtschaft in Deutschland aufzuzeigen. Hierzu wird im Kern eine Literaturanalyse durchgeführt. Sie konzentriert sich auf diejenigen Teilbranchen, in denen die Entwicklung bereits stark vorangeschritten ist. Daher werden insbesondere die Teilmärkte Buch, Presse, Musik, Film, Games, Design und Werbung untersucht. In einem zweiten Schritt wird untersucht, welche Konsequenzen aus der Digitalisierung für die Abgabepflicht nach dem Künstlersozialversicherungsgesetz resultieren und wie der Gesetzgeber ggf. hierauf reagieren kann.Digitalisation is changing the working conditions of creative and cultural workers. Today many people engaged in the creative industry already rely on digital distribution channels. New business models, value chains and collaborations between the parties involved are constantly emerging. However, there are big differences in speed and extent. Content providers are changing into technology providers and vice versa. Content and technology are moving closer together. Music, films, games, literature and journalistic content or products in the design economy are increasingly produced, consumed and commercially exploited on the worldwide web. Hence, this research project investigates the question of how the value-added services of authors, performers, platforms and other intermediaries will be valued along the digital structures in future. The aim of this study is to provide a systematic overview of forms of digital exploitation. Building on this, the effects of digitalisation on the submarkets of the creative industries in Germany will be illustrated. Therefore, the submarkets book, press, music, film, games, design and advertising are examined. For this a literature analysis is carried out in the core. In a second step, the consequences of digitalization are examined in the context of the obligation to pay social security contributions under the Artists' Social Security Act and how the legislators may react to this proceed, if necessary

El escarpado camino hacia la legislación social: debates, contradicciones y crucijadas en el movimiento obrero y popular (Chile: 1901-1924).

<p>A. Overlayed time series for synchrony and enjoyment (top panel) and synchrony and heart rate (bottom panel). B: GC for synchrony and enjoyment. C. GC for synchrony and heart rate. The dashed line indicates a significance level of <i>p</i> < .05.</p

Thalamus and focal to bilateral seizures: A multiscale cognitive imaging study.

OBJECTIVE: To investigate the functional correlates of recurrent secondarily generalized seizures in temporal lobe epilepsy (TLE) using task-based fMRI as a framework to test for epilepsy-specific network rearrangements. Because the thalamus modulates propagation of temporal lobe onset seizures and promotes cortical synchronization during cognition, we hypothesized that occurrence of secondarily generalized seizures, i.e., focal to bilateral tonic-clonic seizures (FBTCS), would relate to thalamic dysfunction, altered connectivity, and whole-brain network centrality. METHODS: FBTCS occur in a third of patients with TLE and are a major determinant of disease severity. In this cross-sectional study, we analyzed 113 patients with drug-resistant TLE (55 left/58 right), who performed a verbal fluency fMRI task that elicited robust thalamic activation. Thirty-three patients (29%) had experienced at least one FBTCS in the year preceding the investigation. We compared patients with TLE-FBTCS to those without FBTCS via a multiscale approach, entailing analysis of statistical parametric mapping (SPM) 12-derived measures of activation, task-modulated thalamic functional connectivity (psychophysiologic interaction), and graph-theoretical metrics of centrality. RESULTS: Individuals with TLE-FBTCS had less task-related activation of bilateral thalamus, with left-sided emphasis, and left hippocampus than those without FBTCS. In TLE-FBTCS, we also found greater task-related thalamotemporal and thalamomotor connectivity, and higher thalamic degree and betweenness centrality. Receiver operating characteristic curves, based on a combined thalamic functional marker, accurately discriminated individuals with and without FBTCS. CONCLUSIONS: In TLE-FBTCS, impaired task-related thalamic recruitment coexists with enhanced thalamotemporal connectivity and whole-brain thalamic network embedding. Altered thalamic functional profiles are proposed as imaging biomarkers of active secondary generalization

Chicken TREM-B1, an Inhibitory Ig-Like Receptor Expressed on Chicken Thrombocytes

Triggering receptors expressed on myeloid cells (TREM) form a multigene family of immunoregulatory Ig-like receptors and play important roles in the regulation of innate and adaptive immunity. In chickens, three members of the TREM family have been identified on chromosome 26. One of them is TREM-B1 which possesses two V-set Ig-domains, an uncharged transmembrane region and a long cytoplasmic tail with one ITSM and two ITIMs indicating an inhibitory function. We generated specific monoclonal antibodies by immunizing a Balb/c mouse with a TREM-B1-FLAG transfected BWZ.36 cell line and tested the hybridoma supernatants on TREM-B1-FLAG transfected 2D8 cells. We obtained two different antibodies specific for TREM-B1, mab 7E8 (mouse IgG1) and mab 1E9 (mouse IgG2a) which were used for cell surface staining. Single and double staining of different tissues, including whole blood preparations, revealed expression on thrombocytes. Next we investigated the biochemical properties of TREM-B1 by using the specific mab 1E9 for immunoprecipitation of either lysates of surface biotinylated peripheral blood cells or stably transfected 2D8 cells. Staining with streptavidin coupled horse radish peroxidase revealed a glycosylated monomeric protein of about 50 kDa. Furthermore we used the stably transfected 2D8 cell line for analyzing the cytoplasmic tyrosine based signaling motifs. After pervanadate treatment, we detected phosphorylation of the tyrosine residues and subsequent recruitment of the tyrosine specific protein phosphatase SHP-2, indicating an inhibitory potential for TREM-B1. We also showed the inhibitory effect of TREM-B1 in chicken thrombocytes using a CD107 degranulation assay. Crosslinking of TREM-B1 on activated primary thrombocytes resulted in decreased CD107 surface expression of about 50-70%

Highlights From the Annual Meeting of the American Epilepsy Society 2022

With more than 6000 attendees between in-person and virtual offerings, the American Epilepsy Society Meeting 2022 in Nashville, felt as busy as in prepandemic times. An ever-growing number of physicians, scientists, and allied health professionals gathered to learn a variety of topics about epilepsy. The program was carefully tailored to meet the needs of professionals with different interests and career stages. This article summarizes the different symposia presented at the meeting. Basic science lectures addressed the primary elements of seizure generation and pathophysiology of epilepsy in different disease states. Scientists congregated to learn about anti-seizure medications, mechanisms of action, and new tools to treat epilepsy including surgery and neurostimulation. Some symposia were also dedicated to discuss epilepsy comorbidities and practical issues regarding epilepsy care. An increasing number of patient advocates discussing their stories were intertwined within scientific activities. Many smaller group sessions targeted more specific topics to encourage member participation, including Special Interest Groups, Investigator, and Skills Workshops. Special lectures included the renown Hoyer and Lombroso, an ILAE/IBE joint session, a spotlight on the impact of Dobbs v. Jackson on reproductive health in epilepsy, and a joint session with the NAEC on coding and reimbursement policies. The hot topics symposium was focused on traumatic brain injury and post-traumatic epilepsy. A balanced collaboration with the industry allowed presentations of the latest pharmaceutical and engineering advances in satellite symposia

Analysis of shared heritability in common disorders of the brain

ience, this issue p. eaap8757 Structured Abstract INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed study of phenotypes with different ages of onset, severity, and presentation poses a considerable challenge. Recently developed heritability methods allow us to accurately measure correlation of genome-wide common variant risk between two phenotypes from pools of different individuals and assess how connected they, or at least their genetic risks, are on the genomic level. We used genome-wide association data for 265,218 patients and 784,643 control participants, as well as 17 phenotypes from a total of 1,191,588 individuals, to quantify the degree of overlap for genetic risk factors of 25 common brain disorders. RATIONALE Over the past century, the classification of brain disorders has evolved to reflect the medical and scientific communities' assessments of the presumed root causes of clinical phenomena such as behavioral change, loss of motor function, or alterations of consciousness. Directly observable phenomena (such as the presence of emboli, protein tangles, or unusual electrical activity patterns) generally define and separate neurological disorders from psychiatric disorders. Understanding the genetic underpinnings and categorical distinctions for brain disorders and related phenotypes may inform the search for their biological mechanisms. RESULTS Common variant risk for psychiatric disorders was shown to correlate significantly, especially among attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder (MDD), and schizophrenia. By contrast, neurological disorders appear more distinct from one another and from the psychiatric disorders, except for migraine, which was significantly correlated to ADHD, MDD, and Tourette syndrome. We demonstrate that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine. We also identify significant genetic sharing between disorders and early life cognitive measures (e.g., years of education and college attainment) in the general population, demonstrating positive correlation with several psychiatric disorders (e.g., anorexia nervosa and bipolar disorder) and negative correlation with several neurological phenotypes (e.g., Alzheimer's disease and ischemic stroke), even though the latter are considered to result from specific processes that occur later in life. Extensive simulations were also performed to inform how statistical power, diagnostic misclassification, and phenotypic heterogeneity influence genetic correlations. CONCLUSION The high degree of genetic correlation among many of the psychiatric disorders adds further evidence that their current clinical boundaries do not reflect distinct underlying pathogenic processes, at least on the genetic level. This suggests a deeply interconnected nature for psychiatric disorders, in contrast to neurological disorders, and underscores the need to refine psychiatric diagnostics. Genetically informed analyses may provide important "scaffolding" to support such restructuring of psychiatric nosology, which likely requires incorporating many levels of information. By contrast, we find limited evidence for widespread common genetic risk sharing among neurological disorders or across neurological and psychiatric disorders. We show that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures. Further study is needed to evaluate whether overlapping genetic contributions to psychiatric pathology may influence treatment choices. Ultimately, such developments may pave the way toward reduced heterogeneity and improved diagnosis and treatment of psychiatric disorders