The Representation of Object Distance: Evidence from Neuroimaging and Neuropsychology

Perceived distance in two-dimensional (2D) images relies on monocular distance cues. Here, we examined the representation of perceived object distance using a continuous carry-over adaptation design for fMRI. The task was to look at photographs of objects and make a judgment as to whether or not the item belonged in the kitchen. Importantly, this task was orthogonal to the variable of interest: the object's perceived distance from the viewer. In Experiment 1, whole brain group analyses identified bilateral clusters in the superior occipital gyrus (approximately area V3/V3A) that showed parametric adaptation to relative changes in perceived distance. In Experiment 2, retinotopic analyses confirmed that area V3A/B reflected the greatest magnitude of response to monocular changes in perceived distance. In Experiment 3, we report that the functional activations overlap with the occipito-parietal lesions in a patient with impaired distance perception, showing that the same regions monitor implied (2D) and actual (three-dimensional) distance. These data suggest that distance information is automatically processed even when it is task-irrelevant and that this process relies on superior occipital areas in and around area V3A

Insights from neuropsychology: pinpointing the role of the posterior parietal cortex in episodic and working memory

The role of posterior parietal cortex (PPC) in various forms of memory is a current topic of interest in the broader field of cognitive neuroscience. This large cortical region has been linked with a wide range of mnemonic functions affecting each stage of memory processing: encoding, maintenance, and retrieval. Yet, the precise role of the PPC in memory remains mysterious and controversial. Progress in understanding PPC function will require researchers to incorporate findings in a convergent manner from multiple experimental techniques rather than emphasizing a particular type of data. To facilitate this process, here, we review findings from the human neuropsychological research and examine the consequences to memory following PPC damage. Recent patient-based research findings have investigated two typically disconnected fields: working memory (WM) and episodic memory. The findings from patient participants with unilateral and bilateral PPC lesions performing diverse experimental paradigms are summarized. These findings are then related to findings from other techniques including neurostimulation (TMS and tDCS) and the influential and more abundant functional neuroimaging literature. We then review the strengths and weaknesses of hypotheses proposed to account for PPC function in these forms of memory. Finally, we address what missing evidence is needed to clarify the role(s) of the PPC in memory

Augmenting Exposure Therapy for Social Anxiety with tDCS

Purpose/Background: Exposure therapy is one of the most potent techniques available to treat social anxiety. However, studies suggest that exposure therapy only produces full remission in 20-50% of patients. Furthermore, laboratory conditioning and extinction studies suggest that fear responses toward individuals who differ from one\u27s own ethnicity/race may be more resistant to extinction. Because activation of the medial prefrontal cortex has been associated with facilitating fear reduction during exposure therapy, we expect that targeting activation of this region with a stimulation technique called transcranial direct current stimulation (tDCS) may improve outcomes from exposure therapy for social anxiety. The present study will therefore test the hypotheses that (1) fear responding at baseline will be greater toward an audience that does not match (vs matches) the participant\u27s own ethnicity, (2) pairing exposure therapy with active (vs sham) tDCS will facilitate alleviation of social anxiety symptoms, and (3) pairing exposure therapy with active (vs sham) tDCS facilitates extinction of fear response toward individuals who differ from the participant\u27s own ethnicity. Materials & Methods: We are recruiting Latino and non-Latino/Caucasian undergraduates with a fear of public speaking, the most commonly feared situation among individuals with social anxiety. Participants (N = 128) will receive either active/anodal (n = 64) or sham (n = 64) tDCS stimulation targeting the mPFC during an exposure therapy session delivered through virtual reality (VR). During exposure therapy, participants will complete six, 3-minute public speaking trials, alternating in a randomized order between audiences that are 75% matched to the participant\u27s ethnicity and 75% unmatched to the participant\u27s ethnicity. At one-month follow up, participants will complete two behavioral avoidance tests (BATs) parallel to therapy procedures, with one ethnic-matched trial and one ethnic-unmatched trial. Fear response during each BAT will be assessed behaviorally (duration of speech), physiologically (heart rate variability and electrodermal response), and subjectively (peak fear rating, on a 0 to 100 scale). At baseline and one-month follow-up, participants will also complete a battery of social anxiety questionnaires. Results: We will present methods and preliminary findings from the study. Results will include a preliminary examination of whether fear responding is greater toward individuals who differ from (vs match) the participant\u27s own ethnicity, whether pairing exposure therapy with active (vs sham) tDCS facilitates alleviation of social anxiety symptoms overall, and whether pairing exposure therapy with active (vs sham) tDCS facilitates alleviation of social anxiety responding toward individuals who differ from (vs match) the participant\u27s own ethnicity. Discussion/Conclusion: Findings point to key strategies to improve outcomes from exposure therapy for social anxiety, and could also have implications for improving response to exposure-based therapies for other anxiety disorders. Furthermore, if tDCS facilitates reductions in fear response toward ethnic/racial out-groups, minority/Latino individuals may experience better generalization of treatment effects for daily-life scenarios (in which they are surrounded by outgroup members), and ethnic/racial majority individuals will be better able to contribute to an inclusive social environment

Performance of the CMS Cathode Strip Chambers with Cosmic Rays

The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device in the CMS endcaps. Their performance has been evaluated using data taken during a cosmic ray run in fall 2008. Measured noise levels are low, with the number of noisy channels well below 1%. Coordinate resolution was measured for all types of chambers, and fall in the range 47 microns to 243 microns. The efficiencies for local charged track triggers, for hit and for segments reconstruction were measured, and are above 99%. The timing resolution per layer is approximately 5 ns

Performance and Operation of the CMS Electromagnetic Calorimeter

The operation and general performance of the CMS electromagnetic calorimeter using cosmic-ray muons are described. These muons were recorded after the closure of the CMS detector in late 2008. The calorimeter is made of lead tungstate crystals and the overall status of the 75848 channels corresponding to the barrel and endcap detectors is reported. The stability of crucial operational parameters, such as high voltage, temperature and electronic noise, is summarised and the performance of the light monitoring system is presented

Calibration of the CMS Drift Tube Chambers and Measurement of the Drift Velocity with Cosmic Rays

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CMS Data Processing Workflows during an Extended Cosmic Ray Run

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Impacts of the Tropical Pacific/Indian Oceans on the Seasonal Cycle of the West African Monsoon

The current consensus is that drought has developed in the Sahel during the second half of the twentieth century as a result of remote effects of oceanic anomalies amplified by local land–atmosphere interactions. This paper focuses on the impacts of oceanic anomalies upon West African climate and specifically aims to identify those from SST anomalies in the Pacific/Indian Oceans during spring and summer seasons, when they were significant. Idealized sensitivity experiments are performed with four atmospheric general circulation models (AGCMs). The prescribed SST patterns used in the AGCMs are based on the leading mode of covariability between SST anomalies over the Pacific/Indian Oceans and summer rainfall over West Africa. The results show that such oceanic anomalies in the Pacific/Indian Ocean lead to a northward shift of an anomalous dry belt from the Gulf of Guinea to the Sahel as the season advances. In the Sahel, the magnitude of rainfall anomalies is comparable to that obtained by other authors using SST anomalies confined to the proximity of the Atlantic Ocean. The mechanism connecting the Pacific/Indian SST anomalies with West African rainfall has a strong seasonal cycle. In spring (May and June), anomalous subsidence develops over both the Maritime Continent and the equatorial Atlantic in response to the enhanced equatorial heating. Precipitation increases over continental West Africa in association with stronger zonal convergence of moisture. In addition, precipitation decreases over the Gulf of Guinea. During the monsoon peak (July and August), the SST anomalies move westward over the equatorial Pacific and the two regions where subsidence occurred earlier in the seasons merge over West Africa. The monsoon weakens and rainfall decreases over the Sahel, especially in August.Peer reviewe

CMS physics technical design report : Addendum on high density QCD with heavy ions

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Aligning the CMS Muon Chambers with the Muon Alignment System during an Extended Cosmic Ray Run

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