The effect of a strong external radiation field on protostellar envelopes in Orion

We discuss the effects of an enhanced interstellar radiation field (ISRF) on the observables of protostellar cores in the Orion cloud region. Dust radiative transfer is used to constrain the envelope physical structure by reproducing SCUBA 850 micron emission. Previously reported 13CO, C17O and H2CO line observations are reproduced through detailed Monte Carlo line radiative transfer models. It is found that the 13CO line emission is marginally optically thick and sensitive to the physical conditions in the outer envelope. An increased temperature in this region is needed in order to reproduce the 13CO line strengths and it is suggested to be caused by a strong heating from the exterior, corresponding to an ISRF in Orion 10^3 times stronger than the "standard" ISRF. The typical temperatures in the outer envelope are higher than the desorption temperature for CO. The C17O emission is less sensitive to this increased temperature but rather traces the bulk envelope material. The data are only fit by a model where CO is depleted, except in the inner and outermost regions where the temperature increases above 30-40 K. The fact that the temperatures do not drop below approximately 25 K in any of the envelopes whereas a significant fraction of CO is frozen-out suggest that the interstellar radiation field has changed through the evolution of the cores. The H2CO lines are successfully reproduced in the model of an increased ISRF with constant abundances of 3-5x10^{-10}.Comment: 11 pages, 10 figures. Accepted for publication in A&

CCAT-prime: a novel telescope for submillimeter astronomy

The CCAT-prime telescope is a 6-meter aperture, crossed-Dragone telescope, designed for millimeter and sub-millimeter wavelength observations. It will be located at an altitude of 5600 meters, just below the summit of Cerro Chajnantor in the high Atacama region of Chile. The telescope's unobscured optics deliver a field of view of almost 8 degrees over a large, flat focal plane, enabling it to accommodate current and future instrumentation fielding >100k diffraction-limited beams for wavelengths less than a millimeter. The mount is a novel design with the aluminum-tiled mirrors nested inside the telescope structure. The elevation housing has an integrated shutter that can enclose the mirrors, protecting them from inclement weather. The telescope is designed to co-host multiple instruments over its nominal 15 year lifetime. It will be operated remotely, requiring minimum maintenance and on-site activities due to the harsh working conditions on the mountain. The design utilizes nickel-iron alloy (Invar) and carbon-fiber-reinforced polymer (CFRP) materials in the mirror support structure, achieving a relatively temperature-insensitive mount. We discuss requirements, specifications, critical design elements, and the expected performance of the CCAT-prime telescope. The telescope is being built by CCAT Observatory, Inc., a corporation formed by an international partnership of universities. More information about CCAT and the CCAT-prime telescope can be found at www.ccatobservatory.org.Comment: Event: SPIE Astronomical Telescope + Instrumentation, 2018, Austin, Texas, USA; Proceedings Volume 10700, Ground-based and Airborne Telescopes VII; 107005X (2018

Central Adjudication Identified Additional and Prognostically Important Myocardial Infarctions in Patients Undergoing Percutaneous Coronary Intervention

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Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead