81 research outputs found
Analog front-end for pixel sensors in a 3D CMOS technology for the SuperB Layer0
This work is concerned with the design of two different analog channels for hybrid and monolithic pixels readout in view of applications to the SVT at the SuperB Factory. The circuits have been designed in a 130nm CMOS, vertically integrated technology, which, among others, may provide some advantages in terms of functional density and electrical isolation between the analog and the digital sections of the front-end
Comunicación, semillas para la integración
Esta Tesis llamada “Comunicación, semillas para la integración” se desarrolló en el ámbito del Instituto de Investigación y Desarrollo Tecnológico para la Pequeña Agricultura Familiar (IPAF), que pertenece al Instituto Nacional de Tecnología Agropecuaria (INTA) Para cumplir nuestra meta nos propusimos “conocer e indagar la realidad comunicacional del IPAF pampeano para analizar sus estrategias comunicacionales con el fin último de realizar un Plan de Comunicación consecuente con el PEI 2005- 2015”.
De esta idea general surgieron tres objetivos; en primer lugar analizar la comunicación interna y externa de la institución, lo que implicó tomar contacto con sus miembros y vincularnos con la organización en sí. El segundo objetivo consistió en evaluar si los miembros de la institución conocían los aspectos más relevantes del Discurso Identitario. El último objetivo residió en analizar los procesos de gestión del IPAF.
Al considerar el abordaje comunicacional - institucional que se plantea mediante las líneas de acción, buscamos enriquecer los lazos de comunicación del IPAF y contribuir a su labor de promover la agricultura familiar; de esta manera, comprendemos y damos a entender que la razón de ser del instituto es el pequeño agricultor familiar, plasmado como figura central en la presente tesis.Facultad de Periodismo y Comunicación Socia
Human equilibrative nucleoside transporter 1 (hENT1) levels predict response to gemcitabine in patients with biliary tract cancer (BTC)
Background and aim: Translational data suggest that nucleoside transporters, in particular human equilibrative nucleoside transporter 1 (hENT1), play an important role in predicting clinical outcome after gemcitabine chemotherapy for several types of cancer. The aim of this study was to retrospectively determine patients' outcome according to the expression of hENT1 in tumoral cells of patients receiving gemcitabine-based therapy. Materials and Methods: The immunohistochemistry analysis was performed on samples from thirty-one patients with unresectable biliary tract cancer (BTC) consecutively treated with first line gemcitabine-based regimens. Results: Positive hENT1 staining patients were 21 (67.7%); negative hENT1 staining patients were 10 (32.3%). Statistical analysis revealed no association between baseline characteristics, toxicities and tumor response to gemcitabine and hENT1 levels. In the univariate analysis, HENT1 expression was significantly correlated with time to progression (TTP) (p=0.0394; HR 2.902, 95%CI 1.053-7.996). The median TTP was 6.33 versus 2.83 months, respectively in patients with positive versus negative hENT1 staining. Moreover, patients with positive hENT1 expression showed a longer median overall survival when compared with patients with low hENT1 expression (14 versus 7 months, respectively), but this difference did not reach the statistical significance (p=0.128). Conclusions: Therefore, hENT1 may be a relevant predictive marker of benefit from gemcitabine-based therapies in patients with advanced BTC. © 2011 Bentham Science Publishers Ltd
Updating the National Baseline of Non-Indigenous Species in Spanish Marine Waters
The introduction of new non-indigenous species (NIS) in Spanish marine waters is addressed under Descriptor 2 of the European Union’s Marine Strategy Framework Directive. National baseline inventories of NIS have been compiled and updated for the three subregions (Western Mediterranean Sea, WMED; Bay of Biscay–Iberian Coast, ABI; Macaronesia, AMA) with data from 1800 to 2021. An overall of 574 species were identified with an alien, cryptogenic, crypto-expanding, or debatable status, mostly invertebrates (~65%) and primary producers (~22%). Of 412 alien species, 80.51% were reported in ABI, 67.82% in WMED, and 66.67% in AMA. Cryptogenic species are more abundant in the WMED (25.25%), compared to AMA (19.77%) and ABI (18.46%). ABI harbors more established species (62.56%) than AMA (45.2%) and WMED (43.56%), contrary to casual records (AMA 31.64%, WMED 23.76%, ABI 13.85%). Invasive species are more abundant (14.36%) in WMED. The ‘transport-stowaway’ pathway accounted for 142 (79.33%), 123 (67.58%), and 169 (85.21%) records in WMED, ABI, and AMA, respectively. The second most common pathway was ‘transport-contaminant’ related to mariculture (~10% of the total), prevalently in ABI with 42 species (23.08%). The Canary Islands stand out for species introduced through oil platforms from throughout the world. ‘Unaided’ was a relevant pathway of secondary introduction into the WMED, particularly of Lessepsian species progressing westwards. Temporal trends in newly introduced species show similar behavior among subregions.This research was funded by Ministerio para la Transición Ecológica y el Reto Demográfico, grant number 11_MM_ESMARES2. The APC was funded by the ESMARES2-C3 project
Соотношение токсичности и преимуществ использования бевацизумаба при метастатическом раке толстой кишки: метаанализ рандомизированных клинических испытаний
Проведен систематический обзор и метаанализ, изучающий использование
бевацизумаба (Бев) при метастатическом колоректальном раке. В анализ
включены данные исследований, в которых принимали участие 3385 пациентов.
Первичной конечной точкой была безопасность терапии, вторичными конечными
точками — общая выживаемость и выживаемость без прогрессирования
заболевания. Относительные риски (ОР) для побочных эффектов расчитывали
с 95% доверительным интервалом (ДИ), с использованием метода обратной
дисперсии. Для статистически значимых ОР определяли число обследуемых, которых
необходимо дополнительно включить в группу Бев для нанесения вреда
одному дополнительному пациенту в сравнении с контролем (number needed to
harm — NNH). Значимое повышение ОР наблюдалось только для гипертензии
(относительный риск 2,98, 95% ДИ 2,32–3,84), гастроинтестинальных перфораций
(5,04, 95% ДИ 1,72–14,79) и кровотечений (2,07, 95% ДИ 1,19–3,62).
Бев значимо улучшал как общую (ОР 0,80, 95% ДИ 0,71–0,91), так и беспрогрессивную
выживаемость (ОР 0,62, 95% ДИ 0,52–0,74). Количество пациентов,
которых необходимо дополнительно пролечить (number needed to treat —
NNT) в группе Бев для достижения 1 дополнительного случая ОВ в сравнении с
контролем составило 12, в то время как показатель NNH для разных побочных
эффектов колебался в пределах 2–124. Полученные результаты демонстрируют,
что преимущества терапии Бев перевешивают его возможную токсичность.
Данных достаточно для подтверждения целесообразности использования
Авастина при метастатическом колоректальном раке.A systematic review and meta-analysis investigating
bevacizumab in metastatic colorectal cancer were
performed. The primary endpoint was safety and secon dary
endpoints were overall survival and progression-free survival.
The relative risks for side effects were calcula ted with their
95% confidence interval (CI) using the inverse of variance
method. For statistically significant relative risks, number
needed to harm were calculated. Authors retrieved 6 out of
17 eligible papers encompassing 3385 patients. Only hypertension
(relative risk 2,98 95% CI 2,32-3,84), gastrointestinal
perforations (relative risk 5,04 95% CI 1,72–14,79)
and bleeding (relative risk 2,07 95% CI 1,19–3.62) were
significantly increased. Bevacizumab significantly improved
both overall survival (HR 0,80 95% CI 0,71–0,91) and
progression-free survival (hazard ratio (HR) 0,62 95% CI
0,52–0,74). Number needed to treat for overall survival is
12, whilst number needed to harms ranges from 2 to 14,286
Monitoring the complex benthic habitat on semi-dark underwater marine caves using photogrammetry-based 3D reconstructions
Marine caves are dark environments considered a priority habitat for conservation included
in the EU Habitats Directive (H8330). They harbor fragile benthic communities and
represent a major reservoir of marine biodiversity. However, there is a lack of knowledge of
these habitats due to the difficulties of creating detailed benthic maps and characterizing
the biodiversity, structure, and dynamics of their communities. The uniqueness of marine
caves fosters their popularity among recreational divers, who can cause disturbances
through abrasion of the biota, resuspension of sediment, and accumulation of exhaled air
bubbles in the caves' ceilings. This study aims to build a monitoring framework to
characterize the structure and temporal dynamics of this complex habitat using Structurefrom-
Motion (SfM) photogrammetry. SfM is a novel, non-invasive technique that allows a
major advancement in the monitoring of changes in the cave’s community assemblages. This
method relies on images acquired by 4K video footage to build fine-scaled 3D digital models
of the substrate using overlapping imagery. For this study, we combined SfM
photogrammetry and photo quadrats extracted from the video recordings. We evaluate the
effectiveness of this methodology in a marine cave highly frequented by divers, located in
Illa de l’Aire (Balearic Islands, Spain), and carried out two surveys before and after the
diving season (2019-2021). As a result, we found a loss of 25 colonies of bryozoans with
fragile skeletons, like Schizoretepora sp., and 8 individual sponges with globose
morphotypes. Our results indicate that this methodology enables accurate and efficient
monitoring of benthic communities in underwater caves that allow us to better understand
their dynamics and, therefore, to develop the need management measures
MAPPING COMMUNITY INTEREST HABITATS IN THE COLUMBRETES ARCHIPELAGO, AN EXTRAORDINARY HOT SPOT OF BIODIVERSITY
The Columbretes Archipelago and their submerged surroundings are part of an unusual,
Pleistocene volcanic field located in the Western Mediterranean designated as a Site of
Community Importance (SCI) of the Natura 2000 Network. In the present study, 4 benthic
habitats of community interest (1110, 1170, 1180 and 8330) have been identified by analyzing
several sources of information. Generalized additive models (GAMs) have been used to model
the potential distribution of reefs (1170) and maërl beds (1110). Our results highlight the
diversity and extent of these habitats and allow comparisons to other marine SCIs of Spain. This
can be attributed to the variability of the environment of this site. The Columbretes Islands
combine a relatively shallow environment with volcanic structures, hydrothermalism with active
degassing, current-driven sedimentary lobes and the influence of inland flows. Understanding
high biodiversity spots is crucial as they offer natural laboratories to describe how ecosystems
respond to the effects of global change. The knowledge obtained will be of paramount
importance for the conservation of species and habitats. Furthermore, it will establish a
baseline for future monitoring and assist in the development of effective management plans
Database of spatial distribution of non indigenous species in Spanish marine waters
Research in marine Spanish waters are focused on several actions to achieve an effectively management on protected areas, with the active participation of the stakeholders and research as basic tools for decision-making. Among these actions, there is one about the knowledge and control on NIS. One of its objectives is the creation of NIS factsheets, which are going to be added to the National Marine Biodiversity Geographical System (GIS) providing complementary information about taxonomic classification, common names, taxonomic synonyms, species illustrations, identification morphological characters, habitat in the native and introduced regions, biological and ecological traits, GenBank DNA sequences, world distribution, first record and evolution in the introduced areas, likely pathways of introduction, effects in the habitats and interaction with native species, and potential management measures to apply. The database will also provide data for (1) the European online platforms, (2) the environmental assessment for the Descriptor 2 (D2-NIS) of the EU Marine Strategy Framework Directive (MSFD), as well as (3) supporting decisions made by stakeholders. It is the result of extensive collaboration among scientist, manager’s and citizen science in the Spanish North-Atlantic, South-Atlantic, Gibraltar Strait-Alboran, Levantine-Balearic and Canary Islands marine divisions, providing an updated overview of the spatial distribution of relevant extended and invasive NIS of recent and established NIS introduced by maritime transport and aquaculture pathways, as well as on cryptogenic or native species in expansion due to the climatic water warming trend
Description and performance of track and primary-vertex reconstruction with the CMS tracker
A description is provided of the software algorithms developed for the CMS tracker both for reconstructing charged-particle trajectories in proton-proton interactions and for using the resulting tracks to estimate the positions of the LHC luminous region and individual primary-interaction vertices. Despite the very hostile environment at the LHC, the performance obtained with these algorithms is found to be excellent. For tbar t events under typical 2011 pileup conditions, the average track-reconstruction efficiency for promptly-produced charged particles with transverse momenta of pT > 0.9GeV is 94% for pseudorapidities of |η| < 0.9 and 85% for 0.9 < |η| < 2.5. The inefficiency is caused mainly by hadrons that undergo nuclear interactions in the tracker material. For isolated muons, the corresponding efficiencies are essentially 100%. For isolated muons of pT = 100GeV emitted at |η| < 1.4, the resolutions are approximately 2.8% in pT, and respectively, 10μm and 30μm in the transverse and longitudinal impact parameters. The position resolution achieved for reconstructed primary vertices that correspond to interesting pp collisions is 10–12μm in each of the three spatial dimensions. The tracking and vertexing software is fast and flexible, and easily adaptable to other functions, such as fast tracking for the trigger, or dedicated tracking for electrons that takes into account bremsstrahlung
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