Análisis de vibración en entrepisos patrimoniales de madera.

This rigorous study focused on the structural health analysis of the former Febres Cordero educational unit, particularly the wooden mezzanine in the auditorium located in the heritage block. Significant pathologies were identified, including woodworm, rot, and structural damage, underlining a critical need for intervention. Compression and bending tests were carried out, revealing a substantial decrease in the capacity of the heritage wood compared to new wood: 39.394% in compression, 52.74% in bending, and 79.535% in elasticity modules. In addition, a vibratory and deflection analysis showed that the structure was undergoing considerable wear. In response to these challenges, an integral reinforcement using steel elements of sections C 150x50x4mm and tubes of 50x50x3mm was proposed. This reinforcement strategy aims to reduce the vibration and deflection of the mezzanine to a recommended standard of L/480, protect and preserve the heritage wood, and improve the safety and durability of the building. An analysis of the interaction between the wood and steel was carried out, optimizing the distribution of stresses to protect the wood. This study highlights the importance of conservation and rehabilitation interventions in heritage structures, focusing not only on the preservation of these buildings for future generations, but also on ensuring their stability and safety.Este estudio riguroso se centró en el análisis de la salud estructural de la ex unidad educativa Febres Cordero de la ciudad de Cuenca, particularmente en el entrepiso de madera del auditorio situado en el bloque patrimonial. Se identificaron patologías significativas, incluyendo polillas, pudrición, y daños estructurales, subrayando una necesidad crítica de intervención. Se llevaron a cabo pruebas de compresión y flexión, revelando una disminución considerable en la capacidad de la madera patrimonial en comparación con una madera nueva: 39.394% en compresión2.74% en flexión, y 79.535% en los módulos de elasticidad. Además, un análisis vibratorio y de deflexiones demostró que la estructura estaba sometida a un desgaste considerable. Como respuesta a estos retos, se propuso un refuerzo integral utilizando elementos de acero de secciones C 150x50x4mm y tubos de 50x50x3mm. Esta estrategia de refuerzo tiene como objetivo reducir la vibración y la deflexión del entrepiso a un estándar recomendado de L/480, proteger y conservar la madera patrimonial, y mejorar la seguridad y durabilidad de la edificación. Se llevó a cabo un análisis de la interacción entre la madera y el acero, optimizando la distribución de esfuerzos para proteger la madera. Este estudio destaca la importancia de las intervenciones de conservación y rehabilitación en las estructuras patrimoniales, enfocándose no solo en la preservación de estos edificios para las generaciones futuras, sino también en asegurar su estabilidad y seguridad

Investigating mutations in the genes GDF9 and BMP15 in Pelibuey sheep through the amplification-refractory mutation system with tetra-primers

Single Nucleotide Polymorphisms (SNP) or mutations are variations with a broad distribution in the genome and, as part of genetic studies, SNP allow the identification of allelic variants related to characteristics of economic importance in sheep production. However, the identification of SNP and their genotypes through sequencing is expensive, as it requires specialized materials and equipment. The objective of this study was to identify polymorphisms and their genotypes in the growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) genes in Pelibuey sheep using the tetra-primer amplification-refractory mutation system through polymerase chain reaction (T-ARMS-PCR). DNA extraction and amplification of BMP15 and GDF9 were conducted from blood samples contained in WhatmanTM FTATM cards from 60 multiparous Pelibuey ewes with reproductive records. The T-ARMS-PCR methodology allowed the identification of wild-type genotypes and mutated homozygous genotypes in polymorphisms G4 and G6 of GDF9, whereas mutations in the BMP15 gene were not found. These results were confirmed by sequencing. In conclusion, the T-ARMS-PCR methodology allowed the identification of mutated and wild-type genotypes in SNP G4 and G6 of GDF9, although no mutations were found in BMP15 in Pelibuey sheep. This technique was found to be reliable, rapid, and easily applied to identify polymorphic genotypes

Modelo estratégico integral para el mejoramiento del Sistema de Gestión de la Seguridad y Salud en el Trabajo (SG-SST). Empresa Concesión Vial de los Llanos

Para esta investigación se eligió la empresa Concesión Vial de los Llanos, la cual está a cargo del estudio, diseño, construcción, operación mejoramiento y mantenimiento de la malla vial del Meta. La investigación estará enfocada al área de talento humano en cuanto a la implantación del Sistema de Gestión de la Seguridad y Salud en el Trabajo (SG-SST), siendo una normatividad de vital importancia para las organizaciones Es importante esta investigación pues se va a establecer las acciones de mejora al área de talento humano en la empresa, entre ellas al SG-SST, el cual integra todas las herramientas, acciones y elementos que le van a permitir a la empresa fortaleces sus capacidades internas, sus relaciones laborales, su imagen, su posicionamiento en el sector y el cumplimiento de sus metas y objetivos.For this research the company Concesión Vial de los Llanos was chosen, which is in charge of the study, design, construction, operation, improvement and maintenance of the road network of Meta. The research will be focused on the area of ​​human talent in terms of the implementation of the Occupational Health and Safety Management System (SG-SST), being a regulation of vital importance for organizations This research is important because it is going to establish the improvement actions to the area of ​​human talent in the company, including the SG-SST, which integrates all the tools, actions and elements that will allow the company to strengthen its capabilities internal, their labor relations, their image, their positioning in the sector and the fulfillment of their goals and objective

Reproductive characterization of hair ewe in the American tropics: a review part 1

Objective: to make a reproductive characterization of the hair sheep breeds in the American tropics. Design/methodology/approach: reproductive variables information was collected from scientific search engines, such as Web of Science, Redalyc, Dialnet, PubMed, SciELO and Latindex. Results: the age of puberty in ewe lambs is highly variable. Similar results were found in adult ewes regarding estrus duration and incidence, estrous cycle length, seasonal anestrus, ovulation rate, fertility, gestation, and prolificacy. Limitations on study/implications: information on reproductive variables of hair sheep breeds is poorly known or non-existent. Findings/conclusions: puberty onset in ewe lambs ranges from 175 to 335 d of age when animals weight 15 to 43 kg. The length of the estrous cycle of hair sheep in Mexico is 17 d during the autumn-winter and 21 d in spring-summer. In Brazil, it lasts 17 d in spring-summer and 18 d in autumn-winter. In the United States of America and Venezuela, the estrous cycle length was similar in both periods of the year. The estrous occurrence was 97.1% in autumn-winter and 76.5 % in spring-summer. The estrous duration ranges from 16 to 52 hours. Seasonal anestrous occurs from May to July. The ovulation rate ranges from 1 to 3 oocytes. Fertility is 80 to 100 % in temperate and 37 % in warm months. Gestation length ranges from 144 to 152 d. Prolificacy ranges from 1.0 to 2.2 offspring per ewe. The lambing interval range from 244 to 294 d.Objective: To carry out a reproductive characterization of the breeds of hair ewe in the tropical region of the Americas. Design/Methodology/Approach: A search of scientific information about the reproductive variables of breeds of hair ewe was carried out and the results were analyzed in the Web of Science, Redalyc, Dialnet, PubMed, SciELO, and Latindex databases. Results: We described and discussed the highly-variable onset of puberty in ewe lambs. Similar results were found in adult ewes regarding the duration and occurrence of the estrous, estrous cycle length, seasonal anestrous, ovulation rate, fertility, gestation, and prolificacy. Study Limitations/Implications: Information about the reproductive variables of breeds of hair ewe is poorly known or non-existent. Findings/Conclusions: The onset of puberty in 15-43 kg ewe lambs ranges from 175 to 335 d of age. The estrous cycle of hair ewe in Mexico lasts 17 d in autumn-winter and 21 d in spring-summer. In Brazil, this cycle lasts 17 d in spring-summer and 18 d in autumn-winter. In the United States of America and Venezuela, the estrous cycle length was similar in both periods of the year. The occurrence of the estrous reached 97.1 % in autumn-winter and 76.5 % in spring-summer. The duration of the estrous ranges from 16 to 52 hours. Seasonal anestrous occurs from May to July. The ovulation rate ranges from 1 to 3 oocytes. The percentage of fertility fluctuates between 80 and 100 % in temperate months and reaches 37 % in warm ones. Gestation lasts from 144 to 152 d. Prolificacy ranges from 1.0 to 2.2 offspring per ewe. The lambing interval ranges from 244 to 294 d

5to. Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad. Memoria académica

El V Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad, CITIS 2019, realizado del 6 al 8 de febrero de 2019 y organizado por la Universidad Politécnica Salesiana, ofreció a la comunidad académica nacional e internacional una plataforma de comunicación unificada, dirigida a cubrir los problemas teóricos y prácticos de mayor impacto en la sociedad moderna desde la ingeniería. En esta edición, dedicada a los 25 años de vida de la UPS, los ejes temáticos estuvieron relacionados con la aplicación de la ciencia, el desarrollo tecnológico y la innovación en cinco pilares fundamentales de nuestra sociedad: la industria, la movilidad, la sostenibilidad ambiental, la información y las telecomunicaciones. El comité científico estuvo conformado formado por 48 investigadores procedentes de diez países: España, Reino Unido, Italia, Bélgica, México, Venezuela, Colombia, Brasil, Estados Unidos y Ecuador. Fueron recibidas un centenar de contribuciones, de las cuales 39 fueron aprobadas en forma de ponencias y 15 en formato poster. Estas contribuciones fueron presentadas de forma oral ante toda la comunidad académica que se dio cita en el Congreso, quienes desde el aula magna, el auditorio y la sala de usos múltiples de la Universidad Politécnica Salesiana, cumplieron respetuosamente la responsabilidad de representar a toda la sociedad en la revisión, aceptación y validación del conocimiento nuevo que fue presentado en cada exposición por los investigadores. Paralelo a las sesiones técnicas, el Congreso contó con espacios de presentación de posters científicos y cinco workshops en temáticas de vanguardia que cautivaron la atención de nuestros docentes y estudiantes. También en el marco del evento se impartieron un total de ocho conferencias magistrales en temas tan actuales como la gestión del conocimiento en la universidad-ecosistema, los retos y oportunidades de la industria 4.0, los avances de la investigación básica y aplicada en mecatrónica para el estudio de robots de nueva generación, la optimización en ingeniería con técnicas multi-objetivo, el desarrollo de las redes avanzadas en Latinoamérica y los mundos, la contaminación del aire debido al tránsito vehicular, el radón y los riesgos que representa este gas radiactivo para la salud humana, entre otros

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

Background: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke. Methods: We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515. Findings: Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p&lt;0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (&lt;1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (&lt;1%) deaths in the albiglutide group. Interpretation: In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes. Funding: GlaxoSmithKline

Centrality evolution of the charged-particle pseudorapidity density over a broad pseudorapidity range in Pb-Pb collisions at root s(NN)=2.76TeV

Peer reviewe

Impacto de una intervención educativa sobre el nivel de conocimiento de infecciones de transmisión sexual en adolescentes de institucion educativa de Huancayo 2017-2018

Introduction: sexually transmitted infections are considered a global public health problem and it is considered an epidemic that reaches the whole world. Objective: evaluate the results of an educational intervention on the knowledge of prevention of infections sexually transmitted in adolescents. Material and Methods: is a study experimental educational intervention type pre before/after no group control, the students of the institution educational Chinchaysuyo of the District of Sapallanga - Huancayo, Junín, 2017 to 2018, the study group was consisting of the total of students in 5 th grade school that agreed to participate in the research. The study consisted of 3 stages: a diagnostic which applied a survey where evaluated prior knowledge of the subject; Another intervention to apply the educational program and the end of evaluation where it was confirmed the effectiveness of the intervention. Results were expressed in number and percent being subjected to statistical analysis. Results: 21.7% of students showed insufficient knowledge on the identification of STI, the 79.7% of sexual transmission, the 69.6% If symptoms go to the health center, the 53.6% on delaying the onset of relations sex and the 59.4% the advantages of the use of the condom, which increased after the educational program. Conclusions: applied education program contributed significantly to elevate them knowledge about prevention of sexually transmitted infections and infection per adolescent human immunodeficiency virus.Introducción: Las infecciones de transmisión sexual se consideran un problema de salud pública mundial y se consideran como una epidemia que afecta a todo el mundo. Objetivo: Evaluar los resultados de una intervención educativa sobre el conocimiento de la prevención de infecciones de transmisión sexual en adolescentes. Material y métodos: Es un estudio experimental de intervención educativa tipo pre / posterior sin control grupal, los alumnos de la institución educativa Chinchaysuyo del Distrito de Sapallanga - Huancayo, Junín, 2017 a 2018, el grupo de estudio estuvo conformado por el total de alumnos en Escuela de 5º grado que acordó participar en la investigación. El estudio consistió en 3 etapas: un diagnóstico que aplicó una encuesta donde se evaluó el conocimiento previo del tema; una intervención para aplicar el programa educativo y el final de la evaluación donde se confirmó la efectividad de la intervención. Los resultados se expresaron en números y porcentaje sometidos a análisis estadístico. Resultados: El 21.7% de los estudiantes mostró conocimiento insuficiente sobre la identificación de ITS, el 79.7% de transmisión sexual, el 69.6% si los síntomas van al centro de salud, el 53.6% al retrasar el inicio de las relaciones sexuales y el 59.4% las ventajas de El uso del condón, que aumentó después del programa educativo. Conclusiones: el programa de educación aplicada contribuyó significativamente a elevar en los alumnos su conocimiento sobre la prevención de infecciones de transmisión sexual y la infección por virus de inmunodeficiencia humana adolescente