Near-infrared Spectral Characterization of Solar-type Stars in the Northern Hemisphere

Although solar-analog stars have been studied extensively over the past few decades, most of these studies have focused on visible wavelengths, especially those identifying solar-analog stars to be used as calibration tools for observations. As a result, there is a dearth of well-characterized solar analogs for observations in the near-infrared, a wavelength range important for studying solar system objects. We present 184 stars selected based on solar-like spectral type and V-J and V-K colors whose spectra we have observed in the 0.8-4.2 micron range for calibrating our asteroid observations. Each star has been classified into one of three ranks based on spectral resemblance to vetted solar analogs. Of our set of 184 stars, we report 145 as reliable solar-analog stars, 21 as solar analogs usable after spectral corrections with low-order polynomial fitting, and 18 as unsuitable for use as calibration standards owing to spectral shape, variability, or features at low to medium resolution. We conclude that all but 5 of our candidates are reliable solar analogs in the longer wavelength range from 2.5 to 4.2 microns. The average colors of the stars classified as reliable or usable solar analogs are V-J=1.148, V-H=1.418, and V-K=1.491, with the entire set being distributed fairly uniformly in R.A. across the sky between -27 and +67 degrees in decl.Comment: 19 pages, 8 figures, 2 table

Radar Observations and the Shape of Near-Earth Asteroid 2008 EV5

We observed the near-Earth asteroid 2008 EV5 with the Arecibo and Goldstone planetary radars and the Very Long Baseline Array during December 2008. EV5 rotates retrograde and its overall shape is a 400 /pm 50 m oblate spheroid. The most prominent surface feature is a ridge parallel to the asteroid's equator that is broken by a concavity 150 m in diameter. Otherwise the asteroid's surface is notably smooth on decameter scales. EV5's radar and optical albedos are consistent with either rocky or stony-iron composition. The equatorial ridge is similar to structure seen on the rubble-pile near-Earth asteroid (66391) 1999 KW4 and is consistent with YORP spin-up reconfiguring the asteroid in the past. We interpret the concavity as an impact crater. Shaking during the impact and later regolith redistribution may have erased smaller features, explaining the general lack of decameter-scale surface structure.Comment: This paper has been accepted for publication in Icarus: http://www.sciencedirect.com/science/article/B6WGF-5207B2F-4/2/d87cd2ae4da00c2b277e2dc79a532c4

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Physical Modeling Of Triple Near-Earth Asteroid (153591) 2001 Sn263 From Radar And Optical Light Curve Observations

We report radar observations (2380-MHz, 13-cm) by the Arecibo Observatory and optical light curves observed from eight different observatories and collected at the Ondřejov Observatory of the triple near-Earth asteroid system (153591) 2001 SN263. The radar observations were obtained over the course of ten nights spanning February 12-26, 2008 and the light curve observations were made throughout January 12 - March 31, 2008. Both data sets include observations during the object\u27s close approach of 0.06558AU on February 20th, 2008. The delay-Doppler images revealed the asteroid to be comprised of three components, making it the first known triple near-Earth asteroid. Only one other object, (136617) 1994 CC is a confirmed triple near-Earth asteroid.We present physical models of the three components of the asteroid system. We constrain the primary\u27s pole direction to an ecliptic longitude and latitude of (309°, -80°)±15°. We find that the primary rotates with a period 3.4256±0.0002h and that the larger satellite has a rotation period of 13.43±0.01h, considerably shorter than its orbital period of approximately 6days. We find that the rotation period of the smaller satellite is consistent with a tidally locked state and therefore rotates with a period of 0.686±0.002 days (Fang et al. [2011]. Astron. J. 141, 154-168). The primary, the larger satellite, and the smaller satellite have equivalent diameters of 2.5±0.3km, 0.77±0.12km, 0.43±0.14km and densities of 1.1±0.2g/cm3, 1.0±0.4g/cm3, 2.3±1.3g/cm3, respectively

Radar And Lightcurve Shape Model Of Near-Earth Asteroid (1627) Ivar

We present our shape model of Amor class near-Earth asteroid (1627) Ivar. During Ivar\u27s apparition in 2013, in which it had a minimum distance of 0.32 AU, we obtained both CCD photometry and radar observations. The radar data consist of echo power spectra and delay-Doppler imaging with 300 m resolution and were obtained using the Arecibo Observatory\u27s 2380 MHz radar. Lightcurve data were gathered using the 0.35 m telescope at the Palmer Divide Station. Using these data, we constructed a detailed shape model of Ivar that reveals more surface detail than earlier models. Ivar was found to have a rotational period of 4.7951689 ± 0.0000026 hours with a pole located within 6° of ecliptic longitude and latitude 336° and 37° respectively. Ivar is an elongated asteroid with maximum extensions along the three body-fixed coordinates being 15.15 × 6.25 × 5.66 km ± 10%. The results of surface slope analysis suggest that Ivar is covered with a loose regolith. Ivar appears to reside in, or near, an optimum state with respect to its shape, spin, and bulk density, such that dynamic topography, surface slopes, and erosion rates on the body are near minimum levels and is therefore dynamically stable