822 research outputs found
The Fate of Chrysotile-Induced Multipolar Mitosis and Aneuploid Population in Cultured Lung Cancer Cells
- Author
- A Xu
- A Xu
- Alfredo Caceres
- AR Brody
- AR Brody
- B Burmeister
- BA Cortez
- BA Weaver
- BA Weaver
- Beatriz de Araujo Cortez
- BT Mossman
- BT Mossman
- C Lengauer
- CG Jensen
- D Bernstein
- DP Cahill
- E Bourke
- E Dopp
- E Dopp
- F Bonaldo Mde
- F Cassiola
- Glaucia Maria Machado-Santelli
- GM Machado-Santelli
- Gonzalo Quassollo
- JC Ame
- JP Borojerdi
- K Fukasawa
- K Hede
- K Kawamura
- K Suzuki
- LM Sargent
- P Duesberg
- R Kuriyama
- R Li
- R Okayasu
- Robert Qi
- S Hanks
- S Pathak
- ST Liu
- TR Quinlan
- V Levresse
- V Levresse
- WC Hahn
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Chrysotile is one of the six types of asbestos, and it is the only one that can still be commercialized in many countries. Exposure to other types of asbestos has been associated with serious diseases, such as lung carcinomas and pleural mesotheliomas. The association of chrysotile exposure with disease is controversial. However, in vitro studies show the mutagenic potential of chrysotile, which can induce DNA and cell damage. The present work aimed to analyze alterations in lung small cell carcinoma cultures after 48 h of chrysotile exposure, followed by 2, 4 and 8 days of recovery in fiber-free culture medium. Some alterations, such as aneuploid cell formation, increased number of cells in G2/M phase and cells in multipolar mitosis were observed even after 8 days of recovery. The presence of chrysotile fibers in the cell cultures was detected and cell morphology was observed by laser scanning confocal microscopy. After 4 and 8 days of recovery, only a few chrysotile fragments were present in some cells, and the cellular morphology was similar to that of control cells. Cells transfected with the GFP-tagged Îą-tubulin plasmid were treated with chrysotile for 24 or 48 h and cells in multipolar mitosis were observed by time-lapse microscopy. Fates of these cells were established: retention in metaphase, cell death, progression through M phase generating more than two daughter cells or cell fusion during telophase or cytokinesis. Some of them were related to the formation of aneuploid cells and cells with abnormal number of centrosomes
Intramedullary spinal cord paracoccidioidomycosis: report of two cases
- Author
- Andrade JJAF
- AraĂşjo JC
- Barbosa W
- Benedicto Oscar Colli
- Braga FM
- Campos EC
- Canelas HM
- Carmine Porcelli Salvarani
- Colli BO
- Colli BO
- Del Negro G
- Farage M Filho
- FĂĄbio dos Santos
- Hutzler RU
- HĂŠlio Rubens Machado
- JosĂŠ Fernando de Castro Figueiredo
- JoĂŁo Alberto Assirati Jr
- Leila Chimelli
- Lima NS
- Maffei WE
- Marchiori E
- Marcondes J
- Minguetti G
- Minguetti G
- Morato-Fernandez RN
- Moura LP
- Negroni R
- Negroni R
- NĂłbrega JPS
- Pedro RJ
- Pereira JM
- Pereira WC
- Pereira WC
- Pimenta AM
- Raphael A
- Restrepo A
- Ritter FH
- Stevens DA
- Teive HAG
- Volker JL
- Wittig EO
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Observation of associated near-side and away-side long-range correlations in âsNN=5.02ââTeV proton-lead collisions with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdel Khalek S
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
- Abolins M
- Abouzeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akesson TP
- Akimoto G
- Akimov AV
- Alam MA
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Allbrooke BM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso F
- Altheimer A
- Alvarez Gonzalez B
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Anduaga XS
- Angelidakis S
- Anger P
- Angerami A
- Anghinolfi F
- Anisenkov A
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoki M
- Aperio Bella L
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Arce AT
- Arfaoui S
- Arguin JF
- Argyropoulos S
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnal V
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Ask S
- Asman B
- Asquith L
- Assamagan K
- Astalos R
- Astbury A
- Atkinson M
- ATLAS Collaboration The
- Auerbach B
- Auge E
- Augsten K
- Aurousseau M
- Avolio G
- Axen D
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
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- Bachacou H
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- Backus Mayes J
- Badescu E
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- Bailey DC
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- Zaidan R
- Zaitsev AM
- Zambito S
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zenin O
- ZeniĹĄ T
- Zerwas D
- Zevi Della Porta G
- Zhang D
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- Zhao Z
- Zhemchugov A
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- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
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- ZivkoviÄ L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- American Physical Society
- Publication date
- 01/01/2012
- Field of study
Two-particle correlations in relative azimuthal angle (ÎĎ) and pseudorapidity (ÎΡ) are measured in âsNN=5.02ââTeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1ââÎźb-1 of data as a function of transverse momentum (pT) and the transverse energy (ÎŁETPb) summed over 3.1<Ρ<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|ÎΡ|<5) ânear-sideâ (ÎĎâź0) correlation that grows rapidly with increasing ÎŁETPb. A long-range âaway-sideâ (ÎĎâźĎ) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ÎŁETPb, is found to match the near-side correlation in magnitude, shape (in ÎΡ and ÎĎ) and ÎŁETPb dependence. The resultant ÎĎ correlation is approximately symmetric about Ď/2, and is consistent with a dominant cosâĄ2ÎĎ modulation for all ÎŁETPb ranges and particle pT
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at sâ=8 TeV with the ATLAS detector
- Author
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- Musheghyan H
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- Schorlemmer ALS
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- Schroeder TV
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- Schwanenberger C
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- Selbach KE
- Seliverstov DM
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- Severini H
- Sfiligoj T
- Sforza F
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- Shabalina E
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- Shan LY
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- Sjursen TB
- Skottowe HP
- Skovpen KY
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- Sliwa K
- Smakhtin V
- Smart BH
- Smestad L
- Smirnov SY
- Smirnov Y
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- Smizanska M
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- Subramaniam R
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- Sundermann JE
- Suruliz K
- Susinno G
- Sutton MR
- Suzuki Y
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- Swedish S
- Swiatlowski M
- Sykora I
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- Ta D
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- Teoh JJ
- Terada S
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- Therhaag J
- Theveneaux-Pelzer T
- Thomas JP
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- Thompson EN
- Thompson PD
- Thompson PD
- Thomsen LA
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- Thong WM
- Thun RP
- Tian F
- Tibbetts MJ
- Tikhomirov VO
- Tikhonov YA
- Timoshenko S
- Tiouchichine E
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- Tsipolitis G
- Tsirintanis N
- Tsiskaridze S
- Tsiskaridze V
- Tskhadadze EG
- Tsukerman II
- Tsulaia V
- Tsuno S
- Tsybychev D
- Tudorache A
- Tudorache V
- Tuna AN
- Tupputi SA
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- Turecek D
- Turra R
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- Ueda I
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- Urbaniec D
- Urquijo P
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- Vachon B
- Valencic N
- Valentinetti S
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- Valladolid Gallego E
- Vallecorsa S
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- van der Geer R
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- van Huysduynen LH
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- van Vulpen I
- van Woerden MC
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- Vandelli W
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- Vermeulen JC
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- Viazlo O
- Vichou I
- Vickey T
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- Vivarelli I
- Vlachos S
- Vladoiu D
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- Vogel A
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- Vokac P
- Volpi G
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- von der Schmitt H
- von Radziewski H
- von Toerne E
- Vorobel V
- Vorobev K
- Vos M
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- Vossebeld JH
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- Vrba V
- Vreeswijk M
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- Vukotic I
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- Wagner P
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- Weingarten J
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- Wells PS
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- Wiglesworth C
- Wiik-Fuchs LAM
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- Wilson JA
- Wingerter-Seez I
- Winklmeier F
- Winter BT
- Wittgen M
- Wittig T
- Wittkowski J
- Wollstadt SJ
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- Wolters H
- Wong KHY
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wozniak KW
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- Wu SL
- Wu X
- Wu Y
- Wulf E
- Wyatt TR
- Wynne BM
- Xella S
- Xiao M
- Xu D
- Xu L
- Yabsley B
- Yacoob S
- Yamada M
- Yamaguchi H
- Yamaguchi Y
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamauchi K
- Yamazaki Y
- Yan Z
- Yang H
- Yang H
- Yang UK
- Yang Y
- Yanush S
- Yao L
- Yao W-M
- Yasu Y
- Yatsenko E
- Ye J
- Ye S
- Yen AL
- Yildirim E
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJS
- Youssef S
- Yu DR
- Yu J
- Yu J
- Yu JM
- Yuan L
- Yurkewicz A
- Yusuff I
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang X
- Zhang Z
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
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- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1fbâ1 of protonâproton collision data at âs = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via tËâtĎË01 or tËâ bĎËÂą1 âbW(â)ĎË01 , where ĎË01 (ĎËÂą1 ) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of tË â tĎË01 . For a branching fraction of 100%, top squark masses in the range 270â645 GeV are excluded for ĎË01 masses below 30 GeV. For a branching fraction of 50% to either tË â tĎË01 or tË â bĎËÂą1 , and assuming the ĎËÂą1 mass to be twice the ĎË01 mass, top squark masses in the range 250â550 GeV are excluded for ĎË01 masses below 60 GeV
Search for R-parity-violating supersymmetry in events with four or more leptons in sqrt(s) =7 TeV pp collisions with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Khalek SA
- Abdelalim AA
- Abdinov O
- Aben R
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- Ye J
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- Yilmaz M
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- Zerwas D
- della Porta GZ
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- Zhemchugov A
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- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
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- Zimmermann S
- Ziolkowski M
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- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Collaboration ATLAS
- Publication venue
- Springer Verlag
- Publication date
- 01/01/2008
- Field of study
A search for new phenomena in final states with four or more leptons (electrons or muons) is presented. The analysis is based on 4.7 fbâ1 of sâ=7TeV proton-proton collisions delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in two signal regions: one that requires moderate values of missing transverse momentum and another that requires large effective mass. The results are interpreted in a simplified model of R-parity-violating supersymmetry in which a 95% CL exclusion region is set for charged wino masses up to 540 GeV. In an R-parity-violating MSUGRA/CMSSM model, values of m 1/2 up to 820 GeV are excluded for 10 < tan β < 40
Search for high-mass resonances decaying to dilepton final states in pp collisions at sâ=7 TeV with the ATLAS detector
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- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamazaki T
- Yamazaki Y
- Yan Z
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- Yanush S
- Yao L
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- Yildiz HD
- Yilmaz M
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- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
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- Zenin O
- Zenis T
- Zerwas D
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- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
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- Zhu H
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- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Springer
- Publication date
- 23/11/2012
- Field of study
The ATLAS detector at the Large Hadron Collider is used to search for high-mass resonances decaying to an electron-positron pair or a muon-antimuon pair. The search is sensitive to heavy neutral ZⲠgauge bosons, Randall-Sundrum gravitons, Z * bosons, techni-mesons, Kaluza-Klein Z/Îł bosons, and bosons predicted by Torsion models. Results are presented based on an analysis of pp collisions at a center-of-mass energy of 7 TeV corresponding to an integrated luminosity of 4.9 fbâ1 in the e + e â channel and 5.0 fbâ1 in the Îź + Îź âchannel. A Z Ⲡboson with Standard Model-like couplings is excluded at 95 % confidence level for masses below 2.22 TeV. A Randall-Sundrum graviton with coupling k/MPl=0.1 is excluded at 95 % confidence level for masses below 2.16 TeV. Limits on the other models are also presented, including Technicolor and Minimal ZⲠModels
A Genetic Screen for Anchorage-Independent Proliferation in Mammalian Cells Identifies a Membrane-Bound Neuregulin
- Author
- A Citri
- AC Lloyd
- AI McClatchey
- AI McClatchey
- Alison C. Lloyd
- AN Garratt
- AW Lin
- C Birchmeier
- C Taveggia
- CA Cremona
- Catherine A. Cremona
- D Hanahan
- Davide Danovi
- DL Falls
- DT Leicht
- Gisela Machado-da-Silva
- J Zhu
- JA Gomez-Sanchez
- JC Montero
- JM Funes
- JT Jones
- JY Wang
- K Adlkofer
- KA Nave
- Luke A. Noon
- LV Lotti
- M Serrano
- ME Bottazzi
- MR Hansen
- MS Stonecypher
- MS Stonecypher
- Neil A. Hotchin
- NF Mathon
- PJ Mitchell
- PW Frohnert
- RM Esper
- RP Huijbregts
- S Britsch
- S Cockerill
- Simona Parrinello
- SL Carroll
- Sreya Basu
- VH Freedman
- WC Hahn
- WH Ho
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Anchorage-independent proliferation is a hallmark of oncogenic transformation and is thought to be conducive to proliferation of cancer cells away from their site of origin. We have previously reported that primary Schwann cells expressing the SV40 Large T antigen (LT) are not fully transformed in that they maintain a strict requirement for attachment, requiring a further genetic change, such as oncogenic Ras, to gain anchorage-independence. Using the LT-expressing cells, we performed a genetic screen for anchorage-independent proliferation and identified Sensory and Motor Neuron Derived Factor (SMDF), a transmembrane class III isoform of Neuregulin 1. In contrast to oncogenic Ras, SMDF induced enhanced proliferation in normal primary Schwann cells but did not trigger cellular senescence. In cooperation with LT, SMDF drove anchorage-independent proliferation, loss of contact inhibition and tumourigenicity. This transforming ability was shared with membrane-bound class III but not secreted class I isoforms of Neuregulin, indicating a distinct mechanism of action. Importantly, we show that despite being membrane-bound signalling molecules, class III neuregulins transform via a cell intrinsic mechanism, as a result of constitutive, elevated levels of ErbB signalling at high cell density and in anchorage-free conditions. This novel transforming mechanism may provide new targets for cancer therapy
Avaliação da qualidade de vida de mulheres com HIV/AIDS atravÊs do HAT-QoL
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Genetic and Functional Role of TNF-alpha in the Development Trypanosoma cruzi Infection
- Author
- A Alter
- A Prata
- A Rassi Jr
- A Talvani
- AG Wilson
- AG Wilson
- AM Bilate
- BMN Brinkman
- C Wanidworanun
- CJ Schofield
- CLW Fong
- Cristina Wide Pissetti
- CW Pissetti
- D Lio
- Dalmo Correia
- DD Reis
- DJ Conway
- ECS Lima
- FS Machado
- G Bouma
- GE Nedwin
- GNR Vespa
- JGF Gonçalves
- JM RodrĂguez-PĂŠrez
- JP Bayley
- KM Kroeger
- LO Andrade
- M Kovacvovics-Bankowski
- Marly Aparecida Spadotto Balarin
- MaurĂcio Manoel Llaguno
- MC Cuturi
- MC Vinhaes
- MM Villela
- PR Vanderborght
- Rafael Faria de Oliveira
- RC Ferreira
- Ricardo T. Gazzinelli
- RL Silva-Grecco
- RL Tarleton
- Roseane Lopes Silva-Grecco
- S D'Alfonso
- SA Drigo
- SA Drigo
- T HĂśhler
- V Rodrigues
- Virmondes Rodrigues
- WC Van Voorhis
- Y BeraĂşn
- ZA Andrade
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
TNF-alpha plays an important role in trypanocidal mechanisms and is related to tissue injury. This cytokine has been detected in the heart of human chagasic patients where it is associated with tissue damage. This study investigated whether TNF-alpha levels and the presence of genetic polymorphisms are associated with the presence of T. cruzi infection and/or with the development of the cardiac form in chronic chagasic patients. Genomic DNA of 300 subjects from an endemic area was extracted and analyzed by PCR using specific primers. TNF-alpha was assayed in culture supernatants by ELISA. An association was observed between the absence of the TNF-238A allele and negative serology. Furthermore, seropositive individuals carrying the TNF-238A allele produced significantly higher TNF-alpha levels without stimulation (pâ=â0.04) and after stimulation with LPS (pâ=â0.007) and T. cruzi antigens (pâ=â0.004). The present results suggest that the polymorphism at position -238 influences susceptibility to infection and that this allele is associated with higher TNF-alpha production in seropositive individuals
Distribution of guppies Poecilia reticulata (Peters, 1860) and Phalloceros caudimaculatus (Hensel, 1868) along a polluted stretch of the ParaĂba do Sul River, Brazil
- Author
- AMORIN MC.
- ARANHA JMR.
- ARAĂJO FG.
- ARAĂJO JRS.
- AZCUE JMP.
- BARROSO LV.
- BCT. Pinto
- BISAZZA A.
- BISAZZA A.
- BIZERRIL CRSF.
- BRITTON RH.
- CARVALHO CEV.
- COELHO VMB.
- FG. AraĂşjo
- GARCIA AM.
- HARRIS JH.
- HENN AW.
- HUGHES RM.
- KRUMHOLZ LA.
- MACHADO G.
- MAGURRAN AE.
- MAGURRAN AE.
- MARTIN-SMITH KM.
- MATTHEWS WJ.
- MEADOR MR.
- MENEZES MS.
- MG. Peixoto
- MUNDAHL ND.
- NARAHARA MY.
- NEGREIROS DH.
- NELSON JS.
- NIKOLSKY GV.
- PARENTI LR.
- PFEIFFER WC.
- PINTO BCT.
- PINTO BCT.
- PINTO BCT.
- REZNICK DN.
- RINGUELET RA.
- SILVEIRA RSA.
- SOTO-GALERA E.
- TEIXEIRA TP.
- TP. Teixeira
- VILA-GISPERT A.
- ZAR JH.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
- âŚ