Suplementação em excesso com Ácido Fólico durante o pré-natal: revisão da literatura / Excessive supplementation with Folic Acid during prenatal: literature review

A suplementação com ácido fólico para evitar defeitos no fechamento do tubo neural é recomendada como parte do cuidado pré-natal. As diretrizes recomendam administrar 400µg diários de AF, não podendo esta dose ultrapassar 1000µg diários. No entanto, não é incomum nos depararmos com casos em que a ingestão de AF supera as doses recomendadas, o que constitui uma realidade preocupante, uma vez que os efeitos decorrentes do uso crônico de doses elevadas desta vitamina ainda não são totalmente esclarecidos. Foi realizada uma análise da literatura dos últimos 10 anos, foram selecionados 09 artigos. Alguns dos malefícios que podem estar associados ao excesso de AF no pré-natal incluem aumento do risco de desenvolvimento de asma na infância, bem como infecções de via aérea superior e chiados; exacerbação de deficiência de B12; comprometimento do crescimento fetal; influência no desenvolvimento do cérebro (autismo); reações alérgicas (eczema); promoção do câncer (tumor de mama e adenoma colorretal); aumento resistência à insulina nas crianças; e risco de diabetes gestacional. Esse estudo alerta sobre a importância da adequação do SUS em fornecer comprimidos de AF na dose adequada para gestante, uma vez que os comprimidos ofertados pelo SUS são na dose de 5mg, o que é aproximadamente 10 vezes maior que o recomendado.

Management of the Class III malocclusion treated with maxillary expansion, facemask therapy and corrective orthodontic. A 15-year follow-up

The facial growth of Class III malocclusion worsens with age, in this case, the early orthopedic treatment, providing facial balance, modifying the maxillofacial growth and development. A 7.6-year old boy presented with Class III malocclusion associated with anterior crossbite; the mandible was shifted to the right and the maxilla had a transversal deficiency. Rapid maxillary expansion followed by facemask therapy was performed, to correct the anteroposterior relationship and improve the facial profile. The patient was followed for a 15-year period, after completion of the treatment, and stability was observed. Growing patients should be monitored following their treatment, so as to prevent malocclusion relapse

Comparison of epidemiological profile of leprosy from 2010 to 2020 in the city of Alfenas, state of Minas Gerais, with Brazil

Leprosy is an infectious disease caused by Mycobacterium leprae, a mycobacterium that affects skin cells and peripheral nerves and, when not treated properly, can cause skin lesions with loss of local sensitivity. Its study is still of great importance, as it is a stigmatizing disease, with impacts on public health in emerging countries such as Brazil, and prevalent cities such as the Alfenas city in Minas Gerais. Objective: To compare the epidemiological profile of patients affected by leprosy from 2010 to 2020 in Alfenas city, state of Minas Gerais, with Brazil. Method: This is a transversal and descriptive study with collected data for the period of 2010 to 2020 available in the DATASUS system. Result: The observed profile was characterized by men, aged over 15 years, incomplete Elementary School I and multibacillary type of the disease, however there was divergence in relation to the race/color of individuals affected by leprosy comparing the national scope with the municipal scope of Alfenas. This difference in data is due to the socioeconomic development process in the city of Alfenas since its population composition is similar to that of west Paulista by virtue of the coffee labor in the colonial period. The statistical analysis indicated a varied prevalence coefficients for Brazil and Alfenas, and a dependence between both variables, although relatively weak. Conclusion: With the high prevalence of leprosy cases and its consequences, such as skin lesions, it is of great importance to understand this disease, as well as its epidemiological patterns

Identification of heavy-flavour jets with the CMS detector in pp collisions at 13 TeV

Many measurements and searches for physics beyond the standard model at the LHC rely on the efficient identification of heavy-flavour jets, i.e. jets originating from bottom or charm quarks. In this paper, the discriminating variables and the algorithms used for heavy-flavour jet identification during the first years of operation of the CMS experiment in proton-proton collisions at a centre-of-mass energy of 13 TeV, are presented. Heavy-flavour jet identification algorithms have been improved compared to those used previously at centre-of-mass energies of 7 and 8 TeV. For jets with transverse momenta in the range expected in simulated $\mathrm{t}\overline{\mathrm{t}}$ events, these new developments result in an efficiency of 68% for the correct identification of a b jet for a probability of 1% of misidentifying a light-flavour jet. The improvement in relative efficiency at this misidentification probability is about 15%, compared to previous CMS algorithms. In addition, for the first time algorithms have been developed to identify jets containing two b hadrons in Lorentz-boosted event topologies, as well as to tag c jets. The large data sample recorded in 2016 at a centre-of-mass energy of 13 TeV has also allowed the development of new methods to measure the efficiency and misidentification probability of heavy-flavour jet identification algorithms. The heavy-flavour jet identification efficiency is measured with a precision of a few per cent at moderate jet transverse momenta (between 30 and 300 GeV) and about 5% at the highest jet transverse momenta (between 500 and 1000 GeV)

Evidence for the Higgs boson decay to a bottom quark–antiquark pair

info:eu-repo/semantics/publishe

Search for heavy resonances decaying to a top quark and a bottom quark in the lepton+jets final state in proton–proton collisions at 13 TeV

info:eu-repo/semantics/publishe

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI