34 research outputs found
Reconstructing the Deep Population History of Central and South America
- Author
- Alan Cooper
- Alberto Barioni
- Amalia Nuevo Delaunay
- Amorim
- Andersen Liryo
- André Strauss
- Anja Furtwängler
- Ann Marie Lawson
- Bardill
- Bastien Llamas
- Brendan J. Culleton
- Briggs
- Cardich
- Chala-Aldana
- Chuan-Chao Wang
- Clara Scabuzzo
- Claudia R. Plens
- Cosimo Posth
- Crawford
- César Méndez
- Dabney
- Daniel Corach
- Danilo V. Bernardo
- David Reich
- DeBlasis
- Dillehay
- Domingo C. Salazar-García
- Douglas J. Kennett
- Edgar
- Eisenmann
- Eliane N. Chim
- Elizabeth Nelson
- Elsa Tomasto-Cagigao
- Emilie Bertolini
- Fehren-Schmitz
- Fehren-Schmitz
- Felsenstein
- Fiedel
- Fu
- Fumagalli
- Gansauge
- Goldberg
- Grieder
- Gustavo Politis
- Herrera
- Hogg
- Hubbe
- Hubbe
- Hugo Reyes-Centeno
- Iosif Lazaridis
- Iriarte
- Jackson
- Jakob Sedig
- Jean-Jacques Hublin
- Johannes Krause
- Jonas Oppenheimer
- Jostins
- Judith Beier
- Jónsson
- Kamberov
- Katerina Harvati
- Kathrin Nägele
- Keith M. Prufer
- Kelly Harkins
- Kennett
- Korlević
- Korneliussen
- Kristin Stewardson
- Kurt Rademaker
- Lars Fehren-Schmitz
- Lazaridis
- Lazaridis
- Lazaridis
- Letunic
- Levy Figuti
- Li
- Li
- Li
- Lindo
- Lindo
- Lipson
- Lisiane Müller Plumm Gomes
- Llamas
- Lohse
- Mallick
- Marcony L. Alves
- Mariana Inglez
- Mario A. Rivera
- Mark Hubbe
- Mark Robinson
- Markus Reindel
- Matthew Ferry
- Megan Michel
- Michael Francken
- Moreno-Mayar
- Moreno-Mayar
- Nadin Rohland
- Nahuel A. Scheifler
- Nasreen Broomandkhoshbacht
- Nathan Nakatsuka
- Nick Patterson
- Nicole Adamski
- Pablo G. Messineo
- Patterson
- Patterson
- Paulo DeBlasis
- Pearson
- Peltzer
- Perego
- Peter Kaulicke
- Plens
- Plens
- Politis
- Pontus Skoglund
- Pucciarelli
- Racimo
- Rademaker
- Raghavan
- Ramsey
- Rasmussen
- Reich
- Reich
- Reimer
- Reimer
- Renaud
- Rodrigo E. Oliveira
- Roewer
- Rohland
- Sabine Eggers
- Sahra Talamo
- Said M. Gutierrez
- Scheib
- Schubert
- Silverman
- Skoglund
- Skoglund
- Stephan Schiffels
- Strauss
- Swapan Mallick
- Talamo
- Tamm
- Tamura
- Thiseas C. Lamnidis
- Thomas K. Harper
- Tiago Ferraz
- Torroni
- Tábita Hünemeier
- Veronica Wesolowski
- Vianello
- Villagran
- von Cramon-Taubadel
- Ward
- Willa R. Trask
- Williams
- Wolfgang Haak
- Yang
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
We report genome-wide ancient DNA from 49 individuals forming four parallel time transects in Belize, Brazil, the Central Andes, and the Southern Cone, each dating to at least 9,000 years ago. The common ancestral population radiated rapidly from just one of the two early branches that contributed to Native Americans today. We document two previously unappreciated streams of gene flow between North and South America. One affected the Central Andes by 4,200 years ago, while the other explains an affinity between the oldest North American genome associated with the Clovis culture and the oldest Central and South Americans from Chile, Brazil, and Belize. However, this was not the primary source for later South Americans, as the other ancient individuals derive from lineages without specific affinity to the Clovis-associated genome, suggesting a population replacement that began at least 9,000 years ago and was followed by substantial population continuity in multiple regions
Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
- Author
- Abbas Jalal
- Abraham Sybil
- Ackert Jessica
- Adams Patricia
- Aggarwala Gaurav
- Aher Nutan
- Ahlqvist Jørn
- Ahn Chul Woo
- Akers Teresa
- Akhras Ronald
- Akhter Faiq
- Aksentyev Sergey
- Al Kawas Firas
- Alexander Karen
- Althouse Denise
- Altobelli Desma
- Alvarisqueta Andres
- Ambrosy Andrew
- Andersen James
- Andersen Ulla
- Anderson Michelle
- Anglade Moise
- Arbañil Hugo
- Arciszewska Malgorzata
- Argoud Georges
- Ariani Mehrdad
- Ashdji Reswan
- Avogaro Angelo
- Avramidis Iakovos
- Axthelm Christoph
- Aye Myint
- Babi Charleen
- Bachus Erasmus
- Baik Sei-Hyun
- Bailey Matt
- Bakhtari Ladan
- Baksi Arun
- Balasubramani Mathangi
- Baldovino Jorge
- Banach Marek
- Banerjee Subhash
- Bartlett Andrew
- Bartone Susan
- Baum Howard
- Bays Harold
- Bazhan Larysa
- Beasley Richard
- Beaudry Yves
- Beaulieu Gail
- Beboso Ronnie
- Bedard Jacques
- Beijerbacht Hugo Peter
- Belfort de Aguiar Renata
- Benjamin Sabrina
- Berger Dirk
- Berlingieri Joseph
- Berndtsson Blom Katarina
- Besada Diego
- Bethel M Angelyn
- Bhagwat Ravi
- Bhargava Anuj
- Bhosale Archana
- Bieler Tasso
- Bijata-Bronisz Renata
- Birkeland Kare
- Birkenfeld Andreas
- Blagden Mark
- Bloomfield Gerald
- Bode Bruce
- Boemi Massimo
- Bonadonna Riccardo
- Bondar Irina
- Bott Jochen
- Bousboulas Stavros
- Boye Alain
- Bratcher Christina
- Breneman Jody
- Briskin Toby
- Bristianou Magdalini
- Brockmyre Andrew
- Broughton Raymond
- Brown Judith
- Brown Kim
- Brychta Tomas
- Brønnum-Schou Jens
- Budhraja Madhusudan
- Bull Georgina
- Bundy Charles
- Burgess Lesley
- Busch Klaus
- Caca Karel
- Cadinot Didier
- Calderon Jorge
- Calella Pedro
- Califf Robert M
- Calvo Gómez Carlos
- Camacho Luis
- Cannon Kevin
- Cano Rodríguez Isidoro
- Cantero Maria Cecilia
- Carr Jewell
- Casson Ed
- Castaño Patricia
- Castro Conde Almudena
- Cathcart Harold
- Cavale Arvind
- Cech Vladimir
- Cequier Fillat Angel
- Cervantes-Escárcega Jose-Luis
- Cha Bong-Soo
- Chau Tuan
- Chaykin Louis
- Chehayeb Raja
- Chen David
- Chen Jung-Fu
- Chertkoff Alejandro
- Cheung Deanna
- Cheung Stephen
- Chevts Julia
- Chiang Chern-En
- Childress Richard
- Christian Tamra
- Chung Choon-Hee
- Coetzee Kathleen
- Cohen Allan
- Coker Rebecca
- Cole Joanna
- Collier Jeannie
- Condit Jonathan
- Consoli Agostino
- Conway James
- Cooksey Erin
- Cookson Tobias
- Cooper John
- Cooper Lauren
- Copland Allan
- Cornel Jan
- Cornett George Mitchell
- Crenier Laurent
- Cuadrado Jesus
- Cuatrecasas Cambra Guillem
- Cusson Jean
- D'Agostino Ralph B
- D'Agostino Ralph B.
- Daga Shruti
- Damyanova Velichka
- Dauber Ira
- Davila William
- Dawood Saleem
- De Armas Luis
- De Cosmo Salvatore
- De Loredo Luis
- De Teresa Parreño Luis
- de Álvaro Moreno Fernando
- Dean Julius
- Debroye Corinne
- Del Prato Stefano
- Del Prato Stefano
- Delgado Lista Javier
- Della Siega Anthony
- DeMets David
- Demidova Irina
- Derezinski Tadeusz
- Deshpande Sameer
- Detweiler Robert
- Devore Adam
- Di Bartolo Paolo
- Di Giovanna Michael
- Diaz Ernesto
- Dimitriadis Georgios
- Dimitrov Stefan
- Distiller Larry
- Dombrowski Keith
- Dominguez Andrea
- Domínguez Escribano José Ramón
- Donaldson Jill
- Donaubauer Torsten
- Dor Isaac
- Dotta Francesco
- Dreval Alexander
- Drummond Waymon
- Dumas Richard
- Dumbre Snehal
- Dungan Kathleen
- Durán García Santiago
- Duyck Francis
- Dvorakova Eva
- Dzongowski Peter
- Eagerton Donald
- Eapen Zubin
- Earl John
- Eaton Charles
- Ebo Geraldine
- Edelsberger Tomas
- Eliasson Bjorn
- Eliasson Ken
- Elisaf Moses
- Ellison Howard
- Elvira González Javier
- Emslie-Smith Alistair
- Endsley Patricia
- Enns Robert
- Erlinger Rudolf
- Ershova Olga
- Español Maria Vanesa
- Espinoza Augusto Dextre
- Farris Neil
- Ferguson Murdo
- Fernandez-Salazar Eva
- Fernández Rodríguez José María
- Fiel Thomas
- Finkelstein Hernan
- Firek Anthony
- First Brian
- Fleming John
- Flota-Cervera Luis Fernando
- Forgosh Les
- Frechtel Gustavo
- French William
- Fretes Jose
- Friedman Daniel
- Frontoni Simona
- Funke Klaus
- Fushtey Ivan
- Gadzinski Waldemar
- Gajek Jacek
- Galatius Søren
- Galetta Marianna
- Galstyan Gagik
- Gambineri Alessandra
- Gandy Winston
- Garcia Ronald
- Garganeeva Alla
- Garrido Santos Natalia
- Garrido Elizabeth
- Garvey Louisa
- Gaudet Daniel
- Gazzaruso Carmine
- Gentry Tracy
- Giaccari Andrea
- Gill Santosh
- Giorgino Francesco
- Goday Arno Alberto
- Godse Rupali
- Gomez Huelgas Ricardo
- Gonzales Rolando Vargas
- Gonzalez Joaquin
- González Juanatey José Ramón
- González-González José Gerardo
- Goodman Shaun
- Gordon Murray
- Gouet Didier
- Grachova Mariya
- Granger Christopher B
- Granger Christopher B.
- Green Fiona
- Green Jennifer B
- Green Jennifer B
- Greene Deb
- Greene Stephen
- Grondin Francois
- Grosskopf Josef
- Groutars Reginald G.E.J.
- Guerci Bruno
- Guice Michael
- Guimaraes Patricia
- Gulseth Hanne
- Gummadi Siva
- Gunstone Anthony
- Gupta Anil
- Gupta Milan
- Gupta Nikita
- Guttormsen Gaute
- Ha JuYoung
- Hackenyos Jonathan
- Haddock Trevorlyn
- Hagenow Andreas
- Hairston Kristen
- Hajdú Csaba
- Halciakova Katarina
- Halperin Frank
- Haluzik Martin
- Hamann Monika
- Hanson Lenita
- Haque Ghazala
- Harcsa Eleonóra
- Harris Tara
- Harrison Lindsay
- Harrison Rob
- Hartard Manfred
- Hartman Israel
- Heitner John
- Hejeebu Srini
- Henry Patrick
- Hereghty Belinda
- Hermany Paul
- Hernandez Mijares Antonio
- Hernandez Adrian F
- Hernandez Adrian F.
- Hernandez-Cassis Carlos
- Heymer Peter
- Hidalgo Horacio
- Higgins Alexander
- Hoek Boudewijn A
- Holman Rury
- Hoogslag Pieter A.M.
- Houle Pierre-Alain
- Hove Jens
- Howell Christina
- Hramiak Irene
- Huppertz Wolfgang
- Hutayanon Pisit
- Ibrahim Hassan
- Illies Gabriele
- Issa Basil
- Izmozherova Nadezhda
- Jackson-Voyzey Ewart
- Jacob Stephan
- Jacobs Shahram
- James Kourtnei
- James Rachel
- Jang Hak Chul
- Janmohamed Salim
- Janmohamed Salim
- Jarosz Marie
- Jenkins Wendy
- Jensen Jan Skov
- Jerjes-Díaz Carlos Sánchez
- Jiménez Díaz Víctor Alfonso
- Jintapakorn Woravut
- Jodar Gimeno Esteban
- Johnson Andrew
- Johnson David
- Johnson Megan
- Jones Michael
- Jones Nigel P
- Jones Nigel P
- Jordan Dedrick
- Joshi Parag
- Jung Thomas
- Kadgaonkar Neha
- Kahrmann Gerd
- Karetnikova Victoria
- Karka Mounika
- Karmalkar Anisha
- Kast Petra
- Kaster Steven
- Katerenchuk Vitaliy
- Kellerer Monika
- Kellum Daniel
- Kelly Aoife
- Kempe Hans-Peter
- Kessler Laurence
- Khandelwal Chaitali
- Kharakhulakh Marina
- Khariouzov Andrei
- Khokhlov Aleksandr
- Kim Chong-Jin
- Kim Christopher
- Kim Ellen
- Kim Hye Soon
- Kim In Joo
- Kirby William
- Klausmann Gerhard
- Klein Christiane
- Kleinecke-Pohl Uwe
- Kleinertz Klaus
- Klodawska Katarzyna
- Knouse Albert
- Kobalava Zhanna
- Kober Lars
- Koch Thorsten
- Kocsis Gyozo
- Kolls Brad
- Kong David
- Konyves Laszlo
- Kooy Adriaan
- Korpachev Vadym
- Kosch Christine
- Koshelskaya Olga
- Kosiborod Mikhail
- Koskinen Pekka
- Kosmacheva Elena
- Kostin Vladimir
- Kotsa Kalliopi
- Kouz Simon
- Kovacheva Snezhina
- Kovacs Christopher
- Koziolova Natalia
- Kragten Johannes A.
- Kravchun Nonna
- Kristiansen Ole Peter
- Krizova Jarmila
- Krzyzagorska Ewa
- Kulback Steven
- Kulkarni Mangesh
- Kumar Mariananda
- Kumar Rakesh
- Kumar Somesh
- Kumari Aditi
- Kuruvanka Tulsidas
- Kuzin Anatoly
- Labroo Ajay
- Lalau Jean-Daniel
- Landry Daniel
- Larin Oleksandr
- Larnefeldt Hans
- Lasswell William
- Lastuvka Jiri
- Lauder Steven
- Lauro Davide
- Lee Eun Young
- Lee Hyoung Woo
- Lee Kwan-Woo
- Lee Moon Kyu
- Leiter Lawrence A
- Leiter Lawrence A.
- Lentz John
- Lenzmeier Thomas
- Lesnov Victor
- Lewis David
- Li Wenyan
- Li Zhaoping
- Lieverse Aloysius G.
- Lif-Tiberg Cornelia
- Lillestol Michael
- Linderfalk Carina
- Lindsay Alistair
- Little Raymond
- Litvak Marcos
- Llamas Edmundo-Alfredo Bayram
- Lokhngina Yuliya
- Lombard Landman
- Longley Troy
- Lonn Eva
- Lopes Renato
- Lopez-Sendon Jose
- Lorimer Jamie
- Lorra Babette
- Lorraine Richard
- Loureyro Juan
- Lozanov Lachezar
- Lucas Morante Tomás
- Luedemann Joerg
- Luna Alejandro
- Lund Gustav
- Lund Per
- Lundman Pia
- Luttermann Matthias
- Lysenko Tatyana
- Maclean Malcolm
- Madej Andrzej
- Maffei Laura
- Makotoko Ellen
- Maldonado Natacha
- Mandal Trisha
- Mandawat Aditya
- Mankovsky Boris
- Manrique Helard
- Marazuela Monica
- Margaritov Viktor
- Markov Valentin
- Marquess Marsha
- Martell Claros Nieves
- Mathews Robin
- Mathieu Chantal
- Mauricio Puente Didac
- Maxeiner Stephan
- Mayorov Alexander
- McGuire Darren
- McKeown-Biagas Cecilia
- McKnight John
- McLaughlin Patricia
- McMurray John J.V.
- McMurray John J.V.
- McNeill Robert
- Mehta Anand
- Mehta Rajendra
- Melchior Thomas
- Melidonis Andreas
- Melloni Chiara
- Mena Ribas Elena
- Merino Torres Juan Francisco
- Mezquita Raya Pedro
- Mhambrey Ankita
- Miekus Pawel
- Migdalis Ilias
- Mihaylova-Shumkova Rositsa
- Milek Karsten
- Miller Alan
- Miller Diane
- Mitrakou Asimina
- Moelle Andrea
- Mohr Gasparini Diego
- Moiseev Sergey
- Moodley Rajendran
- Moon Keon-Woong
- Morales-Palomares Ellen
- Moran Joseph
- Morawski Emily
- Moris Linda
- Mucsi János
- Murphy Karen
- Muzulu Solomon
- Muñoz Ernesto German Cardona
- Myasoedova Svetlana
- Mykhalchyshyn Galyna
- Myshanych Halyna
- Nadar Madhumitha
- Nadar Venkatesh
- Naicker Pallavi
- Namgung June
- Nauck Michael
- Neumann Gerhard
- Nikolaeva Antoaneta
- Nischik Ruth
- Noronha Drusilla
- Nubiola Calonge Andreu
- Nyvad Ole
- O'Connell Ian
- O'Connor Thomas
- O'Mahony William
- Odio Alberto
- Oehrig-Pohl Edith
- Oleksyk Olga
- Olesinska-Mader Martyna
- Olsson Åke
- Oosthuysen Wessels
- Opiela Jaroslaw
- Ordoñez Sánchez Xavier
- Orio Silvia
- Orlenko Valeriia
- Orsi Emanuela
- Overton Robert
- Oyesile Babatunde
- Ozaki Risa
- Pagkalos Emmanouil
- Paolisso Giuseppe
- Papanas Nikolaos
- Pappas Angelos
- Park Kyong Soo
- Parker Reginald
- Pascoe-Gonzalez Sara
- Pascual Izuel Jose Maria
- Pashkovska Nataliia
- Patel Chetan
- Patel Prashant
- Patel Rajesh
- Patel Rajivkumar
- Patel Vickas
- Patil Ashwini P
- Patil Suradnya
- Patterson Catherine
- Pauker Zsolt
- Pearson Ewan
- Pelayo-Orozco Emilia Susana
- Perea Castilla Verónica
- Perez Manghi Federico
- Perez Soto Isabel
- Perez Kathleen
- Perriello Gabriele
- Pertseva Nataliia
- Pesarchick Jean
- Peterson Sean
- Petit Catherine
- Petrosyan Olena
- Petró Gizella
- Petunina Nina
- Philip Sam
- Phillips Lawrence
- Phrommintikul Arintaya
- Piatti Piermarco
- Pinto Miguel
- Piperek Martin
- Plassmann Georg
- Plés Zsolt
- Pohlmeier Lars
- Pontiroli Antonio
- Ponzani Paola
- Pope Connie
- Potnis Omkar
- Povsic Thomas
- Prakash Rahul
- Price Lauren
- Price-Olsen Emma
- Proepper Felix
- Prymkova Vera
- Pérez Pérez Antonio
- Quesada Charneco Miguel
- Quesada Simón Angustias
- Raad George
- Raclavska Lea
- Rahman Aref
- Raikhel Marina
- Raisinghani Ajit
- Rajan Raj
- Ramirez-Diaz Santiago-Paulino
- Raorane Amruta
- Rasouli Neda
- Rauzi Frank
- Rebrov Andrey
- Redón Mas Josep
- Regner Stefan
- Rego Iraeta Antonia
- Reich Dennis
- Rethaford Renee
- Revesz Katalin
- Revoredo Frederick Massucco
- Rich Jenny
- Richards Jackie
- Riddle Matthew
- Rieker Werner
- Rincon Luis Zapata
- Rivellese Angela Albarosa
- Rodriguez Alvarez Maria
- Rodriguez Papini Nelson
- Rodríguez Rodríguez Irene
- Roe Matthew
- Rohr Kathryn
- Romanczuk Piotr
- Rose Ludger
- Roseman Hal
- Rosenberg Anne
- Rosenberg Anne E
- Rosenbloom Alan
- Ross Jorge
- Roush Jennifer
- Rovner Sergio
- Russell Rachael
- Ruyatkina Ludmila
- Saba Fadi
- Sabol Mary Beth
- Sabán Ruiz José
- Sachson Richard
- Sahu Shruti
- Sala Jorgelina
- Saldana-Mendoza Arturo
- Salmonsson Staffan
- Samer Holger
- Samoylova Julia
- Sampanis Christos
- Sandhu Chamandeep
- Sanmartin Berglund Johan
- Sansanayudh Nakarin
- Sarvan Mohamed
- Saswadkar Aarti
- Sauter Joachim
- Sazonova Olga
- Schabauer Alex
- Schaper Frank
- Scheen André
- Schiffer Clemens
- Schleiden Debra
- Schmidt Juergen
- Schneider Ricky
- Scholz Bernd-M.
- Schou Morten
- Schubert Jessica
- Schuchard Timothy
- Schultheis Ron
- Schulze Joerg
- Schuyler Jones William
- Schygiel Pablo
- Sedani Sangeeta
- Segner Alexander
- Sensenbrenner John
- Sesti Giorgio
- Seufert Jochen
- Shaik Fayaz
- Shannon Jennifer
- Sharma Abhinav
- Sharma Richa
- Shavadia Jay
- Shestakova Marina
- Shilkina Natalia
- Shinde Rakesh
- Shitut Aditi
- Shlesinger Yshay
- Siegel Anna
- Sigal Helena
- Sigmon Kristina
- Sigmon Kristina N
- Silhova Elena
- Sinay Isaac
- Singh Narendra
- Sivalingam Kanagaratnam
- Sjöberg Folke
- Skokowska Ewa
- Smirnov Ivan
- Smith Paul
- Smith Peter
- Soffer Joseph
- Sokolova Nadezhda
- Solanki Sheetal
- Somerville Matthew
- Somerville Matthew C
- Soto González Alfonso
- Sowell Margaret
- Sposetti Georgina
- Srimahachota Suphot
- St-Maurice Francois
- Stankiewicz Andrzej
- Stasinska Teresa
- Stead Janet
- Steindorf Joerg
- Stewart Murray
- Stockhausen Juergen
- Stone Allegra
- Stonesifer Larry
- Storey Daniel
- Stoyanova Zhasmina
- Stuebler Petra
- Suh David
- Sukumaran Usha
- Swart Hendrik P.
- Sándor Vangel
- Söderberg Stefan
- Taeschner Heidrun
- Taft Lin
- Tahir Mohammed
- Tan Anjanette
- Tan Choon Beng Kathryn
- Tan Marilyn
- Taylon Alain
- Tentolouris Nikolaos
- Tews Dietrich
- Thakkar Maitreya
- Thomas Betsy
- Thorpe Karl
- Thorpe Karl M
- Thuan Jean-Francois
- Tien Kai Jen
- Tinahones Madueno Francisco
- Tirador Louie
- Tonolo Giancarlo
- Torres-Colores Jose Juan
- Torstensson Ingemar
- Trescoli Serrano Carlos
- Trevisan Roberto
- Tricoci Pierluigi
- Tripathy Devjit
- Trznadel-Morawska Iwona
- Tsapas Apostolos
- Tschoepe Diethelm
- Tseng Shih-Ting
- Tu Shih-Te
- Tugwell Barna
- Tzatzagou Glykeria
- Ulied Armiñana Angels
- Ulla Maria
- Urbanek Robin
- Uwaifo Gabriel
- Van Gaal Luc
- Vandyne Beth
- Vaphare Ashok
- Vasilevskaya Olga
- Vass Viktor
- Vedere Amarnath
- Vemulapalli Sreekanth
- Venugopal Chandra
- Verbovaya Nelli
- Vercammen Chris
- Verra Fernando
- Vidrio-Velázquez Maricela
- Viergever Eric P.
- Villagordoa-Mesa Juan
- Vishneva Elena
- Vizel Saul
- Vlasenko Maryna
- Vo Anthony
- Voinot Christel
- Vorobyev Sergey
- Vorokhobina Natalya
- Vouillarmet Julien
- Vrkoc Jan
- Wang Chih-Yuan
- Wang Ji-Hung
- Watson Anthony
- Watson David
- Welch Michelle
- Welker James
- White Alexander
- Wilhelm Karl
- Willis John
- Wilson Matt
- Wilson Tim
- Witek Robert
- Wium Cecilie
- Womer Terese
- Woo Vincent
- Wraight Ella
- Wynne Alan
- Xing Weibing
- Yamwong Sukit
- Yazdani Shahram
- Ye June
- Yoo Soon Jib
- Yordanov Victor
- Yu Jaemyung
- Zabalua Silvina
- Zaidman Cesar
- Zang Eddie
- Zanozina Olga
- Zeller-Stefan Helga
- Zhdanova Elena
- Zlova Tetiana
- Zubiate Carlos
- Zykova Tatyana
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background:
Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke.
Methods:
We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515.
Findings:
Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p<0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (<1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (<1%) deaths in the albiglutide group.
Interpretation:
In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes.
Funding:
GlaxoSmithKline
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
- Author
- Aase Handberg
- Abhijna R Ballal
- Abhimanyu Thakur
- Abuelreich Sarah
- Achille Anselmo
- Adam L Maddox
- Adityas Purnianto
- Adrian E Morelli
- Adrian L Harris
- Adriana F Paes Leme
- Adriana T Larregina
- Afrodité Németh
- Afsareen Bano
- Agnieszka Razim
- Agustin Enciso-Martinez
- Ahmed Ge Ibrahim
- Ahmed Somaida
- Aija Linē
- Ainhoa Alberro
- Ajay P Singh
- Akbar L Marzan
- Akhil Srivastava
- Akira Yokoi
- Al Charest
- Alain R Brisson
- Alan J Zimmerman
- Albano Cáceres-Verschae
- Aled Clayton
- Aleksandra Inic-Kanada
- Aleksei Tikhonov
- Alena Ivanova
- Alessandra Ciullo
- Alessandro Gori
- Alessio Noghero
- Alex J Rai
- Alexander Otahal
- Alexander R Ivanov
- Alexis G Murillo Carrasco
- Alice Gualerzi
- Alicia Galinsoga
- Alicia Llorente
- Aliosha I Figueroa-Valdés
- Alireza Fazeli
- Alissa M Weaver
- Alok Raghav
- Alvaro Compañ-Bertomeu
- Amanda Khoo
- Amanda Salviano-Silva
- Amandine Bonifay
- Amankeldi A Salybekov
- Amélie Nadeau
- Amin Zakeri
- Amirmohammad Nasiri Kenari
- Amit K Srivastava
- Amy A Baxter
- Amy C Kauffman
- Amy H Buck
- An Hendrix
- Ana C Torrecilhas
- Ana I Salazar-Puerta
- Ana O'Loghlen
- Anabela Cordeiro-da-Silva
- Anaïs Bécot
- Anders T Boysen
- Andras G Miklosi
- Andras Saftics
- András I Försönits
- Andre J van Wijnen
- Andrea Galisova
- Andrea Ridolfi
- Andrea Zendrini
- Andreas Möller
- Andreia M Silva
- Andreina Schoeberlein
- Andreu Matamoros-Angles
- Andrew Devitt
- Andrew F Hill
- Andrew Lai
- Andrew Rowland
- André Cronemberger-Andrade
- André Görgens
- Andries Zijlstra
- Angela M Zivkovic
- Angelica Ortiz
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- Ann M Wehman
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- Antje M Zickler
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- Sasha J Kweskin
- Saugstad Julie A.
- Saumya Das
- Sayam Ghosal
- Scott M Langevin
- Sean M Davidson
- Seiko Ikezu
- Seoyoon Bae
- Serena Cavallero
- Setty M Magaña
- Seung W Oh
- Sébastien Banzet
- Shalini Mishra
- Sharad Kumar
- Sheila Spada
- Shekari Faezeh
- Sherif A Ibrahim
- Shikha Rani
- Shilpa Buch
- Shin-Ichi Kano
- Shirley Potter
- Shivakumar K Reddy
- Shuai Chen
- Siew Ling Ong
- Sigrun Lange
- Silvia Picciolini
- Silvia Sánchez Martín
- Silvio Kau-Strebinger
- Simon J Powis
- Simon Swift
- Simona Taverna
- Simonides I van de Wakker
- Siyu Chen
- Sneha Raju
- Soazig Le Lay
- Sofija Glamočlija
- Solange Landreville
- Somchai Chutipongtanate
- Sonal Sukreet
- Soo Kim
- Sophie Cavallero
- Sophie Rome
- Soren Jacobsen
- Ssang-Goo Cho
- Stanley M Lemon
- Stanley S Stylli
- Stefan Schneider
- Stefania Raimondo
- Stefano Forte
- Steffi Bosch
- Stella Kourembanas
- Stephanie F Rutter
- Stephanie Jung
- Stephanie M Bollard
- Stephen Lenzini
- Stephen Redenti
- Steven J Biller
- Steven M Jay
- Stuart Hunt
- Subbaya Subramanian
- Subhadip Ghatak
- Sujan K Mondal
- Sujata Mohanty
- Sukhbir Kaur
- Suman Dutta
- Sun Young Lee
- Suresh Mathivanan
- Surya Shrivastava
- Susann Allelein
- Susanne Gabrielsson
- Susanne Krasemann
- Susmita Sahoo
- Suvendra N Bhattacharyya
- Sveva Bollini
- Swasti Tiwari
- Swift Simon
- Sylwia Bobis-Wozowicz
- Syrine Arif
- Tae Ryong Lee
- Taeyoung Kang
- Takahiro Ochiya
- Takanori Eguchi
- Tamás Beke-Somfai
- Tamás Visnovitz
- Tania Limongi
- Tania Martins-Marques
- Tanina Arab
- Tara Thompson-Felix
- Taral R Lunavat
- Tatiane De Rossi
- Tatu Rojalin
- Tecla Marangon
- Teena Kjb Gamage
- Ter‐Ovanesyan Dmitry
- Thabiso E Motaung
- Thanh Kha Phan
- Theresa L Whiteside
- Théry Clotilde
- Thibaud Dauphin
- Thomas Kislinger
- Thomas Michael Shiju
- Thupten Tsering
- Tiana F Koukoulis
- Tijana Jovanovic-Talisman
- Timothea Konstantinou
- Timothy V Domashevich
- Tine Hiorth Schøyen
- Tobias Tertel
- Tom Ap Driedonks
- Tom G Keulers
- Tommaso Neri
- Tomofumi Yamamoto
- Tong Wang
- Torrecilhas Ana C.
- Tosar Juan P.
- Trude Aspelin
- Tsuneya Ikezu
- Ursula S Sandau
- Useckaite Zivile
- Uta Erdbrügger
- Valentina R Minciacchi
- Valentina Zappulli
- Valeria Barreca
- Valle Francesco
- van der Pol Edwin
- van Herwijnen Martijn J. C.
- Varga Zoltan
- Vasiliki Mahairaki
- Vasiliy S Chernyshev
- Vatsal Deliwala
- Veer Bala Gupta
- Vendula Pospichalova
- Vengala Rao Yenuganti
- Venkatesh Kumar Chetty
- Vera A Tang
- Vera Mugoni
- Vera Tscherrig
- Verity J Ford
- Verline Justilien
- Veronica Huber
- Veronika Kralj-Iglic
- Veronika Stoka
- Victor Bodart-Santos
- Vijaya Sunkara
- Vikramsingh Gujar
- Viktoria Szeifert
- Viktoria Weber
- Vincent Hyenne
- Vincent Yeung
- Vincenza Dolo
- Violaine Moreau
- Vito G D'Agostino
- Vivek Kumar Gupta
- Vladimir Bokun
- Vroniqa Ku'ulei-Lyn Faustino
- Vytautas Žėkas
- Wai-Leng Lee
- Wanessa F Altei
- Wauben Marca H. M.
- Wehman Ann M.
- Wei Duan
- Wei Guo
- Wei Seong Toh
- Welsh Joshua A.
- Wen-Wei Chang
- Wilfrid Boireau
- Wilfried W Bazié
- Willem Stoorvogel
- Williams Sarah
- Witwer Kenneth W.
- Wolfgang Holnthoner
- Wyatt N Vreeland
- Xabier Osteikoetxea
- Xandra O Breakefield
- Xavier Loyer
- Xiaomei Yan
- Xiaoqin Wang
- Xinhua Lei
- Xinlei Li
- Xiuming Liang
- Yagmur Yildizhan
- Yang You
- Yasuo Inoshima
- Yi Wen
- Yinghong Zhou
- Yingtang Gao
- Yiyao Huang
- Yoel Sadovsky
- Yohan Kim
- Yong Song Gho
- Yongkang Yang
- Yonis Bare
- Yoon-Kyoung Cho
- Yoshinobu Takakura
- Young-Gyun Park
- Yu Fujita
- Yu Xiao
- Yuki Yamamoto
- Yumi Kumagai
- Yunjie Wu
- Yunxi Chen
- Yusuke Yamamoto
- Yusuke Yoshioka
- Yvan Courageux
- Yvonne Couch
- Zach Troyer
- Zendrini Andrea
- Zheng Lei
- Zheng Zhao
- Zijlstra Andries
- Zimmerman Alan J.
- Zivile Useckaite
- Zoltan Varga
- Zoltán Varga
- Zoltán Wiener
- Zucai Suo
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly
Ten millennia of hepatitis B virus evolution
- Author
- Akar Murat
- Alonso-Fernández Carmen
- Alt Kurt W.
- Altena Eveline
- Alvarez Calmet Micaela
- Amkreutz Luc
- Arcusa Magallón Héctor
- Aron Franziska
- Atabiev Biaslan Ch.
- Baird Douglas
- Balanovsky Oleg
- Barquera Rodrigo
- Batieva Elena
- Beckett Jessica F.
- Beckett Sophie
- Beisenov Arman Z.
- Belinskiy Andrej B.
- Binder Didier
- Bos Kirsten
- Boyadzhiev Kamen
- Boyadzhiev Yavor
- Burger Richard L.
- Buzhilova Alexandra
- Carmona Ballestero Eduardo
- Chaplygin Mikhail S.
- Chinique de Armas Yadira
- Chizhevsky Andrey A.
- Clarke Rachel
- Cucca Francesco
- Danielisová Alžběta
- de Knijff Peter
- Deguilloux Marie-France
- Djansugurova Leyla B.
- Dobeš Miroslav
- Dobrovolskaya Maria
- Eisenmann Stefanie
- Erdal Yilmaz Selim
- Ernée Michal
- Fehren-Schmitz Lars
- Feldman Michal
- Fernández Domínguez Eva
- Ferraz Tiago
- Francken Michael
- Friederich Susanne
- García Atiénzar Gabriel
- García-Martínez-de-Lagrán Íñigo
- Garrido-Pena Rafael
- Ghalichi Ayshin
- Giffin Karen
- Gnecchi-Ruscone Guido Alberto
- Gretzinger Joscha
- Guevara Evelyn K.
- Haak Wolfgang
- Hallgren Fredrik
- Hansen Svend
- Herbig Alexander
- Hernandez Godoy Silvia Teresita
- Hernández-Zaragoza Diana I.
- Hübler Ron
- Ingman Tara
- Jiménez Echevarría Javier
- Kacki Sacha
- Kalmykov Alexey A.
- Kantorovich Anatoly R.
- Karapetian Marina K.
- Kaverzneva Elena
- Keller Marcel
- Key Felix M.
- Khartanovich Valery
- Khokhlov Aleksandr A.
- Khussainova Elmira
- Kitov Egor P.
- Kocher Arthur
- Kochkina Anna F.
- Kostka Michal
- Krause Johannes
- Krauß Raiko
- Kufterin Vladimir V.
- Kühnert Denise
- Küßner Mario
- Lai Luca
- Langová Michaela
- Lefranc Philippe
- Limburský Petr
- Llamas Bastien
- Loe Louise
- Lyons Alice
- Lösch Sandra
- Majander Kerttu
- Makarov Nikolaj
- Mannermaa Kristiina
- Mannino Marcello
- Maslov Vladimir E.
- Massy Ken
- Mazzarello Vittorio
- Meller Harald
- Michel Megan
- Miguel Ibáñez María Paz de
- Mittnik Alissa
- Moiseyev Vyacheslav
- Mortimer Richard
- Musralina Lyazzat
- Márquez-Morfín Lourdes
- Navruzbekov Masnav
- Nelson Elizabeth A.
- Neumann Gunnar U.
- Nováček Jan
- Nägele Kathrin
- Onkamo Päivi
- Papac Luka
- Parker Cody
- Pearson Jessica
- Penske Sandra
- Pfefferkorn Maria
- Popescu Elizabeth
- Posth Cosimo
- Prüfer Kay
- Rademaker Kurt
- Ramsl Peter C.
- Read Chris
- Reinhold Sabine
- Rivollat Maïté
- Rohrlach Adam B.
- Rojo-Guerra Manuel A.
- Roksandic Mirjana
- Romero Alejandro
- Rosenstock Eva
- Rottier Stéphane
- Royo-Guillén José I.
- Sabin Susanna
- Sagona Claudia
- Saintot Sylvie
- Sajantila Antti
- Salazar Lucy C.
- Salazar-García Domingo C.
- Salter Susannah J.
- Samashev Zainolla
- Sayer Duncan
- Schiffels Stephan
- Schimmenti Vittoria
- Schultz Michael
- Semal Patrick
- Shishlina Natalia
- Shnaider Svetlana
- Skeates Robin
- Skourtanioti Eirini
- Slavchev Vladimir
- Sperduti Alessandra
- Spyrou Maria A.
- Stahl Raphaela
- Stashenkov Dmitry A.
- Steiner Hubert
- Stockhammer Philipp W.
- Tejedor-Rodríguez Cristina
- Tukhbatova Rezeda I.
- Tung Tiffiny A.
- Utrilla Pilar
- van Bömmel Florian
- van de Loosdrecht Marieke S.
- Van de Vijver Katrien
- Van Twest Melanie
- Vasilev Dmitry V.
- Velemínský Petr
- Villalba-Mouco Vanessa
- von Heyking Kristin
- Warinner Christina
- Wissgott Antje
- Yener K. Aslihan
- Zilivinskaya Emma D.
- Zoledziewska Magdalena
- Publication venue
- American Association for the Advancement of Science (AAAS)
- Publication date
- 01/01/2021
- Field of study
Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic
Multi-ancestry genome-wide association meta-analysis of Parkinson?s disease
- Author
- Aasly Jan O.
- Ahmad-Annuar Azlina
- Akpalu Albert
- Albin Roger
- Alcalay Roy
- Alvarez Ignacio
- Amod Ferzana
- Amouri Rim
- Anderson Tim J.
- Arboleda Gonzalo
- Aslibekyan Stella
- Atadzhanov Masharip
- Auton Adam
- Avenali Micol
- Awad Paula Saffie
- Azmin Shahrul
- Baak A. Nazl
- Babalola Elizabeth
- Bale Claire
- Bandres-Ciga Sara
- Bardien Soraya
- Beach Thomas
- Bell Robert K.
- Beyer Katrin
- Bielenberg Jessica
- Blauwendraat Cornelis
- Borgohain Rupam
- Brice Alexis
- Brolin Kajsa
- Bryc Katarzyna
- Bullis Emily
- Bustamante Maria Leonor
- Camargos Sarah
- Cannon Paul
- Carr Jonathan
- Carroll Camille
- Casey Bradford
- Chahine Lana M.
- Chan Germaine Hiu-Fai
- Chan Phillip
- Chan Piu
- Chana Pedro
- Chen Honglei
- Cheung Nelson Yuk-Fai
- Chowdhury Sohini
- Coker Daniella
- Comart Charisse
- Cornejo-Olivas Mario
- Corvol Jean-Christophe
- Cruchaga Carlos
- Cubo Esther
- Dadiotis Efthymios
- Dagklis Ioannis
- Das Sayantan
- Dean Marissa
- del Rio Marlene Jimenez
- Dey Sumit
- Dhamija Devika
- Divya K. P.
- Doquenia Maria Leila
- Dumanis Sonya
- El-Sadig Sarah
- Ellis Melina
- Elson Sarah L.
- Eriksson Nicholas
- Ertan Sibel
- Espay Alberto
- Faghri Faraz
- Fang Zih-Hua
- Filshtein Teresa
- Fiske Brian
- Fitch Alison
- Fletez-Brant Kipper
- Fon Edward A.
- Fon Ted
- Fontanillas Pierre
- Foo Jia Nee
- Foroud Tatiana
- Freyman Will
- Funayama Manabu
- Galleguillos Benjamin Pizarro
- Gasser Thomas
- Gatto Emilia M.
- Genc Gencer
- Granka Julie M.
- Groppa Sergiu
- Grosset Donald
- Guo Jifeng
- Hadjigorgiou Georgios
- Hall Deborah
- Hardy John
- Hattori Nobutaka
- Heilbron Karl
- Hernandez Alejandro
- Hernandez Alvaro
- Hernandez Dena
- Hicks Barry
- Hinds David A.
- Hoenicka Janet
- Hopfner Franziska
- Houlden Henry
- Hunter Julie
- Höglinger Günter
- Iakovenko Elena
- Ibanez Laura
- Illarionova Anastasia
- Inca-Martinez Miguel
- Ip Nancy
- Iwaki Hirotaka
- Jankovic Joseph
- Jasaityte Simona
- Jeon Beomseok
- Jewett Ethan M.
- Jiang Yunxuan
- Jonas Cabell
- Junker Johanna
- Kaishibayeva Gulnaz
- Kaiyrzhanov Rauan
- Kamel Walaa A.
- Karimova Altynay
- Kauffman Marcelo
- Khachatryan Samson
- Kieburtz Karl
- Kim Jonggeol Jeffrey
- Kim Yun Joong
- Kishore Asha
- Klein Christine
- Koks Sulev
- Koretsky Mathew
- Krack Paul
- Krüger Rejko
- Kuhl Maggie
- Kukar Katelyn
- Kukkle Prashanth Lingappa
- Kumar Kishore
- Kung Pin-Jui
- Kwong Alan
- Lake Julie
- Lange Lara M.
- Leonard Hampton
- Levine Kristin S.
- Lewis Patrick Alfryn
- Lian Michelle Mulan
- Lim Shen-Yang
- Lin Chin-Hsien
- Lin Keng-Han
- Llamas Bianca A.
- Lohmann Katja
- Louie Naomi
- Love Seth
- Lowe Maya
- Lubbe Steven
- Luo Wei
- Madoev Harutyun
- Makarious Mary B.
- Marek Kenneth
- Markopoulou Katerina
- Marsili Luca
- Martinez-Ramirez Daniel
- Martínez-Carrasco Alejandro
- Mata Ignacio
- Mata Ignacio F.
- McCreight Jey C.
- McIntyre Matthew H.
- Medina Alex
- Mencacci Niccolò Emanuele
- Micheletti Steven J.
- Miranda Marcelo
- Mohamed Wael
- Mok Kin Ying
- Mollenhauer Brit
- Monchi Oury
- Moreno Meghan E.
- Morris Huw R.
- Mubarak Bashayer Al
- Murad Nor Azian Abdul
- Murphy Kaileigh
- Nalls Mike A.
- Nandakumar Priyanka
- Nguyen Dominique T.
- Nguyen Duan
- Nguyen Toan
- Noblin Elizabeth S.
- Norlinah Mohamed Ibrahim
- Noyce Alastair J.
- Nuytemans Karen
- O'Connell Jared
- O'Grady Alyssa
- Obese Vida
- Ojha Rajeev
- Ojo Oluwadamilola
- Okubadejo Njideka
- Okunoye Olaitan
- Olguin Patricio
- Orozc Jorge
- Otani Diego Véliz
- Pal Pramod
- Pantazis Caroline B.
- Parnetti Lucilla
- Partida Gabriel Cuellar
- Pastor Pau
- Periñan Maria Teresa
- Petrakovitz Aaron A.
- Pihlstrøm Lasse
- Pitcher Toni L.
- Poznik G. David
- Puckelwartz Megan J.
- Quattrone Andrea
- Rajan Roopa
- Rentería Miguel E.
- Reyes-Pérez Paula
- Reynoso Alexandra
- Rieder Carlos
- Riley Ekemini
- Rizig Mie
- Rodriguez-Violante Mayela
- Rosales Raymond
- Ruffrage Lauren
- Salama Mohamed
- Salari Mehri
- Sanyaolu Arinola
- Sarmiento Ignacio Juan Keller
- Sassi Samia Ben
- Schapira Anthony
- Schirinzi Tommaso
- Schloetter Madeleine
- Schrag Anette
- Schumacher Morgan
- Schumacher-Schuh Artur F.
- Screven Laurel
- Serrano Geidy E.
- Shambetova Cholpon
- Shang Huifang
- Sharma Manu
- Shastri Anjali J.
- Shelton Janie F.
- Shepherd Claire E.
- Sherer Todd
- Shi Jingchunzi
- Shiamim Ejaz
- Shiraishi Tomotaka
- Shringarpure Suyash
- Shulman Joshua
- Shulman Lisa
- Siddiqi Bernadette
- Singleton Andrew B.
- Sobering Andrew K.
- Solle Justin C.
- Solsberg Caroline Warly
- Song Yeajin
- Stafford Eleanor J.
- Stamelou Maria
- Stefanis Leonidas
- Stott Simon
- Su Qiaojuan Jane
- Tan Ai Huey
- Tan Eng-King
- Tan Manuela
- Tang Beisha
- Tarnanas Ioannis
- Tat Susana A.
- Tavadyan Zaruhi
- Tay Yi Wen
- Tchakouté Christophe Toukam
- Tinkhauser Gerd
- Tran Vinh
- Trinh Joanne
- Tserensodnom Bayasgalan
- Tumas Vitor
- Tung Joyce Y.
- Umair Muhammad
- Ur-Rehman Shoaib
- Valente Enza Maria
- Veliz-Otani Diego
- Vinuela Angel
- Vitale Dan
- Vollstedt Eva-Juliane
- Walker Ruth
- Wang Wei
- Wang Xin
- Wegel Claire
- Weil Rimona
- Weldon Catherine H.
- Westenberger Ana
- Williams Nigel
- Williamson Jared
- Wilton Peter
- Wong Corinna D.
- Wood Nicholas
- Wu Hsiu-Chuan
- Wu Ruey-Meei
- Wu Yihru
- Xie Tao
- Xiromerisiou Georgia
- Zewde Yared Z.
- Zhou Xiaopu
- Zimprich Alexander
- Zweier Christiane
- Çakmak Özgür Öztop
- Publication venue
- Nature Research
- Publication date
- 31/01/2024
- Field of study
Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L.
- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
- AVALLONE Guerino
- Azrad D.
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Baier Jeremy
- Baiotti Luca
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Dániel
- Bartoletti A. M.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
- Bates D. E.
- Bawaj Mateusz
- Baxi P.
- Bayley Joseph
- Baylor Amanda
- Baynard II. P. A.
- Bazzan M.
- Bedakihale V. M.
- Beirnaert Freija
- Bejger Michał
- Belardinelli Daniele
- Bell Angus
- Benedetto V.
- Benoit William
- Bentley Joe
- Bera Sayantani
- Berbel Marina
- Bergamin Fabio
- Berger Beverly
- Bernuzzi Sebastiano
- Beroiz Martin
- Berry Christopher P. L.
- Bersanetti Diego
- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bevins Nathaniel
- Bhandare R.
- Bhardwaj Uddipta
- Bhatt R.
- Bhattacharjee Dripta
- Bhaumik Shubhagata
- Bhowmick S.
- Bianchi A.
- Bilenko I. A.
- Billingsley GariLynn
- Binetti Alberto
- Bini Sophie
- Birnholtz Ofek
- Bisht A.
- Bitossi Massimiliano
- Blackburn Kent
- Blagg L. A.
- Blair C. D.
- Blair D. G.
- Bobba F.
- Bode Nina
- Boileau Guillaume
- Boldrini Mattia
- Bolingbroke Georgia
- Bolliand A.
- Bondarescu Ruxandra
- Bondu François
- Bonilla Carrasquel Edgard
- Bonino A.
- Bonnand Romain
- Booker P.
- Borchers A.
- Boschi Valerio
- Bose S.
- Bossilkov V.
- Boudart Vincent
- Boudon A.
- Bozzi A.
- Bradaschia C.
- Brady Patrick R.
- Braglia Matteo
- Branch A.
- BRANCHESI Marica
- Brandt J.
- Braun I.
- Breschi Matteo
- Briant Tristan
- Brillet A.
- Brinkmann M.
- Brockill P.
- Brockmüller Eike
- Brooks Aidan
- Brown B. C.
- Brown D. D.
- Brunett S.
- Bruno G.
- Bruntz Robert
- Bryant J.
- Bucci F.
- Buchanan J.
- Bulashenko Oleg
- Bulik T.
- Bulten H. J.
- Buonanno Alessandra
- Burtnyk K.
- Buscicchio Riccardo
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- Yasui H.
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- Yelikar A. B.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuan S.
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- Zheng Yanyan
- Zhong Haowen
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- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badalyan A.
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
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- Baltus Grégory
- Banagiri Sharan
- Banerjee Biswajit
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- Carpinelli Massimo
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- Cavaglia Marco
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- Cella Giancarlo
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- Chang R. -J.
- Chang W.
- Chanial Pierre
- Chao Shiuh
- Chapman-Bird Christian
- Charlton E. L.
- Charlton Philip
- CHASSANDE-MOTTIN Eric
- Chastain L.
- Chatterjee Chayan
- Chatterjee Debarati
- Chatterjee Deep
- Chaturvedi M.
- Chaty Sylvain
- Chatziioannou Katerina
- Chen A.
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- Chen Hsin-Yu
- Chen Junxin
- Chen K. H.
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- Chessa Piero
- Chia H. Y.
- Chiadini Francesco
- Chiang C.
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- Chiba A.
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- Chierici R.
- Chincarini Andrea
- Chiofalo M. L.
- Chiummo Antonino
- Chou C.
- Choudhary Sunil
- Christensen Nelson
- Chua Sheon S. Y.
- Chun Lung Chan Juno
- Chung K. W.
- Ciani Giacomo
- Ciecieląg Paweł
- Cieślar Marek
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- Ciobanu A. A.
- Ciolfi Riccardo
- Clara F.
- Clark James
- Clarke Teagan
- Clasey Essick Reed
- Claudio Diaz Mario
- Clearwater P.
- Clesse S.
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- Coccia E.
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- Colombo Alberto
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- Concetta Tringali Maria
- Conti Livia
- Cooper Sam
- Corbitt Thomas
- Cordero-Carrión Isabel
- Corezzi S.
- Cornish Neil
- Corsi Alessandra
- Cortese Stefano
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- Cottingham R.
- Coughlin Michael
- Couineaux A.
- Coulon J. -P.
- Countryman S. T.
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- Cousins Bryce
- Couvares Peter
- Coward D. M.
- Cowart M. J.
- Cowburn B. D.
- Coyne Dennis
- Coyne Robert
- Craig K.
- Creighton Jolien
- Creighton T. D.
- Criswell Alexander
- Crockett-Gray J. C. G.
- Croquette Michaël
- Crouch R.
- Crowder S. G.
- Cudell Jean-René
- Cullen T. J.
- Cumming Alan
- Cuoco E.
- Curyło M.
- Cusinato Marco
- D'Angelo Beatrice
- D'Antonio S.
- d'Emilio V.
- D'Onofrio Luca
- D'Urso D.
- Dabadie P.
- Dal Canton Tito
- DALL'OSSO Simone
- Danilishin Stefan
- Danzmann K.
- Darroch K. E.
- Darsow-Fromm Christian
- Dartez L. P.
- Dasgupta A.
- Datta Sayantani
- Dattilo V.
- Daumas A.
- Dave I.
- Davenport A.
- Davier M.
- Davis Derek
- Davis Michael C.
- Daw Edward
- Dax Maximilian
- De Laurentis Martina
- De Lillo Federico
- de Lluc Planas Maria
- De Marco F.
- De Matteis F.
- De Pietri Roberto
- De Rosa Rosario
- de rossi camilla
- De Simone R.
- de Souza Melo S. Assis
- Deenadayalan M.
- Degallaix Jerome
- Del Pozzo W.
- Delfavero Vera
- Dell'Aquila Daniele
- Deléglise Samuel
- Demos N.
- Dent Thomas
- Depasse Antoine
- Dhurandhar S.
- Di Fiore L.
- Di Fronzo Chiara
- di giovanni Fabrizio
- Di Giovanni M.
- Di Girolamo Tristano
- Di Michele Alessandro
- Di Renzo Francesco
- DI. PALMA Irene
- Diab R.
- Diamond P. Z.
- Diaz J. Casanueva
- Didio N. A.
- Diego Bonavena Luis
- Dietrich Tim
- Diksha D.
- Ding Jacques
- Divyajyoti
- Dmitriev Artemiy
- Doctor Zoheyr
- Dohmen E.
- Doleva P. P.
- Donahue L.
- Donovan F.
- Dooley Katherine L.
- Dooney T.
- Doravari Suresh
- Dorosh O.
- Drago Marco
- Driggers Jennifer C.
- Drori Y.
- Du H.
- Ducoin J. -G.
- Dunn Liam
- Dupletsa U.
- Duval Hannah
- Duverne P. -A.
- Dwyer S. E.
- Dálya Gergely
- Eassa C.
- Ebersold Michael
- Eckhardt Tobias
- Eddolls Graeme
- Edelman Bruce
- Edo T. B.
- Edy Oliver
- Effler Anamaria
- Eichholz Johannes
- Einsle H.
- Eisenmann M.
- Eisenstein R. A.
- Ejlli Aldo
- Eka Setyawati Yoshinta
- Elizabeth Ramirez Guevara Karla
- Engelby E.
- Engl A. J.
- Erasmo Peña Arellano Fabián
- Errico L.
- error error
- error error
- error error
- error error
- Estellés Estrella Héctor
- Estevez Dimitri
- Etzel T.
- Evans C. R.
- Evans Matthew J.
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- Steinlechner J.
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- UCHIKATA NAMI.
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- Vahlbruch Henning
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- Xiao Liting
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- Yang Yang
- Yang Yi
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- Yarbrough Zach
- Yeh S. -W.
- Yelikar A. B.
- Yeung S. M. C.
- Yeung T. Y.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhang Yanqi
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
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- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
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- Antier Sarah
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- Willetts K.
- Williams Daniel
- Williams Michael J.
- Williams N. S.
- Willis Joshua
- Willke Benno
- Wils Milan
- Wipf C. C.
- Woan Graham
- Woehler J.
- Wofford Jared
- Wolfe N. E.
- Won Lee Hyung
- Won Seo Jin
- Wong D.
- Wong Henry T.
- Wright J. L.
- Wright Mick
- Wu Chien-Ming
- Wu David S.
- Wu Hsun-Chung
- Wysocki Daniel
- Xiao Liting
- Xu Victoria
- Xu Yumeng
- Yaala M. Ben
- Yadav Nikesh
- Yakovlev Alexey
- Yamamoto Hiroaki
- Yamamoto Kazuhiro
- Yamamoto M.
- Yamamoto Takahiro
- Yamamoto Takahiro S.
- Yamamura S.
- Yamazaki Ryo
- Yan S.
- Yan T.
- Yang F.
- Yang Fengwei
- Yang Kate Z.
- Yang L. -C.
- Yang Yi
- Yarbrough Zach
- Yeh S. -W.
- Yelikar A. B.
- Yeung S. M. C.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zeoli M.
- Zerrad M.
- Zevin Michael
- Zhang A. C.
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
Acute and Chronic Changes in Gene Expression After CMV DNAemia in Kidney Transplant Recipients.
- Author
- Publication venue
- eScholarship, University of California
- Publication date
- 01/01/2021
- Field of study
Cytomegalovirus (CMV) viremia continues to cause significant morbidity and mortality in kidney transplant patients with clinical complications including organ rejection and death. Whole blood gene expression dynamics in CMV viremic patients from onset of DNAemia through convalescence has not been well studied to date in humans. To evaluate how CMV infection impacts whole blood leukocyte gene expression over time, we evaluated a matched cohort of 62 kidney transplant recipients with and without CMV DNAemia using blood samples collected at multiple time points during the 12-month period after transplant. While transcriptomic differences were minimal at baseline between DNAemic and non-DNAemic patients, hundreds of genes were differentially expressed at the long-term timepoint, including genes enriching for pathways important for macrophages, interferon, and IL-8 signaling. Amongst patients with CMV DNAemia, the greatest amount of transcriptomic change occurred between baseline and 1-week post-DNAemia, with increase in pathways for interferon signaling and cytotoxic T cell function. Time-course gene set analysis of these differentially expressed genes revealed that most of the enriched pathways had a significant time-trend. While many pathways that were significantly down- or upregulated at 1 week returned to baseline-like levels, we noted that several pathways important in adaptive and innate cell function remained upregulated at the long-term timepoint after resolution of CMV DNAemia. Differential expression analysis and time-course gene set analysis revealed the dynamics of genes and pathways involved in the immune response to CMV DNAemia in kidney transplant patients. Understanding transcriptional changes caused by CMV DNAemia may identify the mechanism behind patient vulnerability to CMV reactivation and increased risk of rejection in transplant recipients and suggest protective strategies to counter the negative immunologic impact of CMV. These findings provide a framework to identify immune correlates for risk assessment and guiding need for extending antiviral prophylaxis
NK and CD8 T cell phenotypes predict onset and control of CMV viremia post-kidney transplant
- Author
- Publication venue
- eScholarship, University of California
- Publication date
- 08/11/2021
- Field of study
CMV causes mostly asymptomatic but lifelong infection. Primary infection or reactivation in immunocompromised individuals can be life-threatening. CMV viremia often occurs in solid organ transplant recipients and associates with decreased graft survival and higher mortality. Furthering understanding of impaired immunity that allows CMV reactivation is critical to guiding antiviral therapy and examining the effect of CMV on solid organ transplant outcomes. This study characterized longitudinal immune responses to CMV in 31 kidney transplant recipients with CMV viremia and matched, nonviremic recipients. Recipients were sampled 3 and 12 months after transplant, with additional samples 1 week and 1 month after viremia. PBMCs were stained for NK and T cell markers. PBMC transcriptomes were characterized by RNA-Seq. Plasma proteins were quantified by Luminex. CD8+ T cell transcriptomes were characterized by single-cell RNA-Seq. Before viremia, patients had high levels of IL-15 with concurrent expansion of immature CD56bright NK cells. After viremia, mature CD56dim NK cells and CD28-CD8+ T cells upregulating inhibitory and NK-associated receptors were expanded. Memory NK cells and NK-like CD28-CD8+ T cells were associated with control of viremia. These findings suggest that signatures of innate activation may be prognostic for CMV reactivation after transplant, while CD8+ T cell functionality is critical for effective control of CMV